Sclerosis MOAs - LARVOL Sigma

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Sclerosis

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Phase N/A 1 2 3 4 Products	0	5	10	15	20	25	30	35	40	45	50



Myelin protein stim




NF-κB inhib




NMDAR antag




Norepinephrine reuptake inhib




Substance P release inhib




Tubulin polymerization inhib




µ-opioid agon




α4β1 integrin antag




β2 adrenergic receptor agon




AHR agon




ATP inhib




Amyloid β protein inhib




Angiogenesis inhib




BChE inhib




Bone morphogenetic protein receptor type II mod




Bone resorption factor inhib




Brain derived neurotrophic factor mod




CACNA2D1 protein mod




CDK6 inhib




COX2 inhib




CXCL12 inhib




Ca2+ channel antag




Calcineurin inhib




Carbonic anhydrase inhib




Complement C5 inhib




Connective tissue growth factor inhib




Cytomegalovirus replication inhib




DGAT inhib




DGAT-1 inhib




DHODH inhib




Endothelin B receptor antag




Estrogen receptor agon




FAK inhib




FGFR3 inhib




Fatty acid inhib




GPCR mod




GnRH agon




HIF-1 inhib




HSP mod




IL-13 antag




IL-17A inhib




IL-2R antag




Immunoglobulin inhib




Ion channel mod




LINGO1 inhib




LOXL2 inhib




LPA1 receptor antag




Lymphotoxin-β inhib




MAOB inhib




Macrophage inhib



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