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17 Mechanisms of Action |
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756 Trials |
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22406 News |
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- | Journal: Temporal muscle thickness has no prognostic relevance in patients with high-grade glioma compared to functional scales. (Pubmed Central) - Sep 20, 2023
Only female gender, but no other clinical, histological, or molecular marker showed any interrelation with TMT. Functional scores outclass measuring TMT as a reliable prognostic factor for predicting OS in patients with high-grade glioma.
- | Journal: Applicability of the seated step test for assessing thigh muscle sarcopenia in older individuals. (Pubmed Central) - Sep 20, 2023
In the single regression analysis, the seated step test significantly predicted KEPT, KFPT, and SMI. These results suggest that up-down seated step test can be a reliable method to estimate lower limb muscle size and function in older individuals.
- | Journal: Impact of sarcopenia on S1 adjuvant chemotherapy and prognosis in pancreatic cancer patients. (Pubmed Central) - Sep 20, 2023
In conclusions, age and sarcopenia were critical risk factors for the failure of 6 months of adjuvant chemotherapy. Among elderly patients, sarcopenia can predict the poor success rate of AC.
- | Journal: Neurosurgical perioperative management of frail elderly patients. (Pubmed Central) - Sep 20, 2023
Therefore, due attention must be paid to neurosurgical frailty and muscle assessment in elderly patients. Specialized interventions in the perioperative period of neurosurgery in frail elderly patients may improve their postoperative prognosis.
- || Review, Journal: Optimizing outdoor fitness equipment training for older adults: Benefits and future directions for healthy aging. (Pubmed Central) - Sep 20, 2023
Additionally, suggested modifications could render the machines more effective and safer. The primary objective is to enhance this type of machinery to encourage its use in outdoor spaces, thus aiding adults and older individuals in achieving overall health and enjoying a healthy aging process.
- | Journal, Surgery: Sarcopenia at the upper instrumented vertebra is more significantly associated with proximal junctional kyphosis after long fusion for adult spinal deformity surgery than osteopenia. (Pubmed Central) - Sep 20, 2023
The primary objective is to enhance this type of machinery to encourage its use in outdoor spaces, thus aiding adults and older individuals in achieving overall health and enjoying a healthy aging process. Logistic regression analysis identified FI% of PSM as a significant independent factor of PJK (odds ratio, 1.973; 95% confidence interval, 1.290-5.554; P
- | Journal: Human primary myoblasts derived from paraspinal muscle reflect donor age as an experimental model of sarcopenia. (Pubmed Central) - Sep 20, 2023
Logistic regression analysis identified FI% of PSM as a significant independent factor of PJK (odds ratio, 1.973; 95% confidence interval, 1.290-5.554; P Myoblasts isolated from human paraspinal muscle preserve myogenic potential that correlates with donor age, providing an in vitro model of sarcopenia.
- || Retrospective data, Review, Journal: Association between sarcopenia with incident cardio-cerebrovascular disease: A systematic review and meta-analysis. (Pubmed Central) - Sep 20, 2023
In conclusion, sarcopenia and sarcopenic obesity are significantly associated with an elevated risk of developing CCVD. However, further prospective cohort studies are warranted to validate this relationship while controlling for confounding factors.
- | Journal: Muscle Reference Values From Thoracic and Abdominal CT for Sarcopenia Assessment: The Framingham Heart Study. (Pubmed Central) - Sep 19, 2023
This study established age- and sex-specific reference values for CT-based muscle metrics at thoracic and lumbar vertebral levels. These values may be used in future research investigating the role of muscle mass and attenuation in health and disease, and to identify sarcopenia.
- | Journal: Increased adipose tissue is associated with improved overall survival, independent of skeletal muscle mass in non-small cell lung cancer. (Pubmed Central) - Sep 19, 2023
These values may be used in future research investigating the role of muscle mass and attenuation in health and disease, and to identify sarcopenia. Increased subcutaneous fat index and pericardial fat index were associated with a higher 5-year overall survival rate, independent of sarcopenia, in non-small cell lung cancer and may indicate a reduced risk of non-cancer-related death.
- | Journal: Effects of sarcopenia and frailty on postoperative recovery in elderly patients: A prospective cohort study. (Pubmed Central) - Sep 19, 2023
Sarcopenia and frailty were associated with higher risks of postoperative 90-day morbidity in elderly patients alone and in combination. Sex, body mass index, pre-operative albumin and operative stress were also independent factors for postoperative morbidity within 90
- | Journal: Association of body composition and surgical outcomes in patients with early-stage breast cancer. (Pubmed Central) - Sep 19, 2023
Compared with those undergoing lumpectomy or mastectomy without reconstruction, patients undergoing mastectomy with reconstruction were more likely to experience postoperative complications and obesity was associated with higher risk of complication in the latter group. We did not identify a correlation between sarcopenia and rate of adverse surgical outcomes.
- || Clinical, Journal: The association of vitamin D with bone microarchitecture, muscle strength, and mobility performance in older women in long-term care. (Pubmed Central) - Sep 19, 2023
We did not identify a correlation between sarcopenia and rate of adverse surgical outcomes. Our study found in older women who are residents of long-term care facilities, vitamin D level is associated with bone microarchitecture and mobility performance.
- | Journal: Associations of sarcopenic obesity vs either sarcopenia or obesity alone with cognitive impairment risk in patients requiring maintenance hemodialysis. (Pubmed Central) - Sep 19, 2023
Participants with SO are at significantly higher risk of CI than those with sarcopenia or obesity alone. Furthermore, this association is consistent across different subgroups.
- | Journal: Prevalence of nutrition disorders and nutrition-related conditions in older patients with Alzheimer's disease. (Pubmed Central) - Sep 19, 2023
Furthermore, this association is consistent across different subgroups. In conclusion, nutrition disorders and nutrition-related conditions can present concurrently in patients with all stages of Alzheimer's disease; therefore, these frequent problems should be screened and diagnosed accordingly.
- | Journal: Transversal psoas muscle thickness measurement is associated with response and survival in patients with HCC undergoing immunotherapy. (Pubmed Central) - Sep 18, 2023
In conclusion, nutrition disorders and nutrition-related conditions can present concurrently in patients with all stages of Alzheimer's disease; therefore, these frequent problems should be screened and diagnosed accordingly. Evaluation of sarcopenia using TPMT measurement is reliable and identifies HCC patients with a dismal prognosis and response to immunotherapy.
- | Observational data, Journal: Association of dietary inflammatory index with sarcopenia in asthmatic patients: a cross-sectional study. (Pubmed Central) - Sep 18, 2023
Compared with T1 group, T3 group had higher risk of sarcopenia (T2: OR: 1.39, 95%CI: 0.88-2.18, p?=?0.157; T3: OR: 2.37, 95%CI: 1.47-3.83, p?<?0.001). There was a significant positive correlation between DII and the risk of sarcopenia.
- || Clinical, Retrospective data, Review, Journal: Effectiveness of Creatine in Metabolic Performance: A Systematic Review and Meta-Analysis. (Pubmed Central) - Sep 18, 2023
When these results were added together, we found that taking Cr supplements demonstrated statistically significant benefits over PLA. In conclusion, the present MA has found evidence that Cr has positive effects on metabolic outcomes for people who consume it.
- | Journal, Surgery: Our Experience With Left Colon and Rectal Cancer Surgery and the Impact of Preoperative Sarcopenia on Complication Rates. (Pubmed Central) - Sep 18, 2023
In consequence, the results of our study provide evidence that preoperative sarcopenia status is an important parameter to determine the risk status of the patient, and patients with preoperative sarcopenia should be monitored more closely. Thus, we may be able to diagnose and intervene early in the complications.
- || Biomarker, Clinical, Journal: Empowering frail older adults: multicomponent elastic-band exercises and BCAA supplementation unleash physical health and preserve haematological biomarkers. (Pubmed Central) - Sep 18, 2023
The findings, demonstrating the potential pro-immune effect and maintenance of MCH and MCHC levels, highlight the relevance of incorporating exercise and nutritional strategies to promote healthy aging. This study contributes to the achievement of the United Nations Sustainable Development Goals 3 (good health and well-being) and 10 (reduced Inequalities) for all.
- | Journal: Vulnerability among rural older adults in southern Brazil: population-based study. (Pubmed Central) - Sep 18, 2023
This study contributes to the achievement of the United Nations Sustainable Development Goals 3 (good health and well-being) and 10 (reduced Inequalities) for all. Vulnerability is common among rural community-dwelling older adults and is associated with sociodemographic and health characteristics.
- | Journal: New age sarcopenia: is strength more important than mass? (Pubmed Central) - Sep 18, 2023
Vulnerability is common among rural community-dwelling older adults and is associated with sociodemographic and health characteristics. No abstract available
- | Retrospective data, Journal, Surgery: Is the measurement of sarcopenia associated with oncological disease in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy? (Pubmed Central) - Sep 18, 2023
Pre-emptive identification of sarcopenia may be a useful prognostic indicator and predictor of post-operative outcomes in CRS and HIPEC. For oncological patients, sarcopenia may be an indicator of patients requiring targeted pre-operative rehabilitation, or advanced disease requiring further treatment.
- | Journal: MAFLD might be better in identifying subjects with sarcopenia or cardiovascular risk than NAFLD: A nationwide study. (Pubmed Central) - Sep 18, 2023
The risks of sarcopenia and CVD were significantly higher in MAFLD group but did not differ according to fibrotic burden in non-MR NAFLD group. The MAFLD criteria might be better for identifying high-risk fatty liver disease than the NAFLD criteria.
- | Journal, Metastases: Can sarcopenia predict survival in locally advanced rectal cancer patients? (Pubmed Central) - Sep 18, 2023
The MAFLD criteria might be better for identifying high-risk fatty liver disease than the NAFLD criteria. Sarcopenia was found to be an independent risk factor for worse overall survival, but not recurrence free survival, in patients with locally advanced rectal cancer undergoing neo-adjuvant chemo-radiotherapy and surgery with curative intent.
- || Review, Journal: Exercise and Protein Supplementation Recommendations for Older Adults With Sarcopenic Obesity: A Meta-Review. (Pubmed Central) - Sep 18, 2023
In the meantime, protein recommendations should align with general sarcopenia recommendations. Based upon available findings, tentative exercise recommendations to optimize health outcomes in this population are proposed.
- | New trial: Microbiota, Sarcopenia, and Hepatic Encephalopathy Change in Cirrhotic Patients Before and After Rehabilitation (clinicaltrials.gov) - Sep 18, 2023
P=N/A, N=120, Recruiting, Sponsor: Chang Gung Memorial Hospital
- | New trial: Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sarcopenia) and Brain-derived Neurotrophic Factor (clinicaltrials.gov) - Sep 18, 2023
P=N/A, N=100, Not yet recruiting, Sponsor: Chung Shan Medical University
- | Journal: Effect of Muscle Forces on Femur During Level Walking Using a Virtual Population of Older Women. (Pubmed Central) - Sep 17, 2023
The generation of a virtual population is a feasible approach to augment anatomical variations based on a small population that could mimic variations seen in a larger cohort. This is a valuable alternative to overcome the limitation or the need to collect dataset from a large population, which is both time and resource consuming.
- | Journal: Letter to the Editor: Disentangling Mortality Associations: An In-depth Comparative Study of Possible Sarcopenia versus Sarcopenia of AWGS 2019. (Pubmed Central) - Sep 17, 2023
This is a valuable alternative to overcome the limitation or the need to collect dataset from a large population, which is both time and resource consuming. No abstract available
- | Journal: Talking to Experts: Multicomponent Strategies and Sarcopenia. (Pubmed Central) - Sep 17, 2023
No abstract available No abstract available
- | Journal: Human skeletal muscle tissue chip autonomous payload reveals changes in fiber type and metabolic gene expression due to spaceflight. (Pubmed Central) - Sep 16, 2023
Our muscle tissue chip platform provides an approach to studying the cell autonomous effects of spaceflight on muscle cell biology that may not be appreciated on the whole organ or organism level and sets the stage for continued data collection from muscle tissue chip experimentation in microgravity. We also report on the challenges and opportunities for conducting autonomous tissue-on-chip CubeLab payloads on the ISS.
- | Journal: Effect of perioperative airway management on postoperative outcomes of colorectal cancer patients with sarcopenia. (Pubmed Central) - Sep 16, 2023
We also report on the challenges and opportunities for conducting autonomous tissue-on-chip CubeLab payloads on the ISS. The perioperative airway management program implemented at our center was easy to perform and can effectively improve short-term postoperative outcomes in colorectal cancer patients with sarcopenia.
- | Journal: Editorial: (Osteo)Sarcopenia & sarcopenic obesity. (Pubmed Central) - Sep 15, 2023
The perioperative airway management program implemented at our center was easy to perform and can effectively improve short-term postoperative outcomes in colorectal cancer patients with sarcopenia. No abstract available
- || Review, Journal: Sarcopenic obesity and hypertension in elderly patients: a narrative review of pathophysiology and management strategies. (Pubmed Central) - Sep 15, 2023
Addressing arterial stiffness is paramount in managing these conditions effectively. Lifestyle modifications, including weight management and physical activity, remain central to the treatment of sarcopenic obesity, while additional research is needed to explore potential pharmacological options.
- | Journal: Editorial: Transient ischemic attack: standard-of-care model. (Pubmed Central) - Sep 15, 2023
Lifestyle modifications, including weight management and physical activity, remain central to the treatment of sarcopenic obesity, while additional research is needed to explore potential pharmacological options. No abstract available
- | Journal: The predictive value of computerized tomography-assessed sarcopenia for complicated appendicitis in geriatric patients. (Pubmed Central) - Sep 15, 2023
Comorbidities are also important risk factors. Surgeons should be aware of factors leading to complicated appendicitis, which may cause higher morbidity and mortality rates in elderly patients.
- || Review, Journal: Frailty after COVID-19: The wave after? (Pubmed Central) - Sep 15, 2023
Regarding the underlying mechanisms, a multicausal genesis can be assumed, involving both direct viral effects and indirect effects, particularly from the imposed lockdowns with devastating consequences for the elderly: decreased physical activity, altered diet, sarcopenia, fatigue, social isolation, neurological problems, inflammation, and cardiovascular morbidity are among the possible mediators. Since the COVID-19 pandemic is leading to an increase in frailty in the elderly, there is an urgent need to raise awareness of this still little-known problem of potentially great public health importance and to find appropriate prevention and treatment measures.
- | Journal: Mini Nutrition Assessment-Short Form score is associated with sarcopenia even among nourished people - A result of a feasibility study of a registry. (Pubmed Central) - Sep 15, 2023
Sarcopenia assessment in people with MNA-SF?<?13 can be beneficial. Developing a tool to identify the risk of malnutrition and sarcopenia at the same time based on MNA-SF can be considered.
- | New trial, Metastases: Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial (clinicaltrials.gov) - Sep 15, 2023
P=N/A, N=80, Not yet recruiting, Sponsor: Dana-Farber Cancer Institute
- | Journal: Re. "Association between dietary diversity and sarcopenia in community dwelling older adults". (Pubmed Central) - Sep 15, 2023
Developing a tool to identify the risk of malnutrition and sarcopenia at the same time based on MNA-SF can be considered. No abstract available
- || Review, Journal: Evaluation and management of body composition changes in cancer patients. (Pubmed Central) - Sep 15, 2023
As more evidence highlighting the importance of body composition has emerged, it is imperative to apply a more precise evaluation of nutritional status and a more targeted approach to provide nutritional support for cancer patients. In this review, we will discuss the modalities for evaluating body composition and how to manage body composition changes in cancer patients.
- | Retrospective data, Journal: Sarcopenia prevalence in patients with cancer and association with adverse prognosis: A nationwide survey on common cancers. (Pubmed Central) - Sep 15, 2023
Age is the most important risk factor for sarcopenia even in patients with cancer. Sarcopenia is strongly associated with a poor quality of life and reduced overall survival.
- | allopurinol / Generic mfg.
Journal: The association of allopurinol with persistent physical disability and frailty in a large community based older cohort. (Pubmed Central) - Sep 15, 2023
Sarcopenia is strongly associated with a poor quality of life and reduced overall survival. Allopurinol use in older adults with gout is associated with a reduced risk of persistent physical disability but not associated with risk of frailty.
- | Enrollment change, Trial completion date, Trial primary completion date: The Shape Regulation Mechanism of Yam Pill on Patients With Sarcopenia Based on Intestine-muscle-brain Axis (clinicaltrials.gov) - Sep 14, 2023
P=N/A, N=136, Not yet recruiting, Sponsor: Fujian University of Traditional Chinese Medicine
Allopurinol use in older adults with gout is associated with a reduced risk of persistent physical disability but not associated with risk of frailty. N=94 --> 136 | Trial completion date: Apr 2024 --> Apr 2025 | Trial primary completion date: Apr 2024 --> Sep 2023
- | New trial: Multicomponent Intervention in Women at Risk of Sarcopenia (clinicaltrials.gov) - Sep 14, 2023
P=N/A, N=14, Completed, Sponsor: Coordinaci
- | Journal: Causal associations of sarcopenia-related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study. (Pubmed Central) - Sep 14, 2023
Causal findings from the inverse-variance weighted method were validated by sensitivity analyses. These findings support improving sarcopenia-related traits as precautions against major cardiometabolic diseases and Alzheimer's disease, with particular emphasis on insulin resistance as a target in the intervention of sarcopenia-related cardiometabolic risk.
- | Journal: Sex Differences and Positive Dose-Response Relationships between Serum Osteocalcin Levels and Low Muscle Strength. (Pubmed Central) - Sep 14, 2023
Higher serum osteocalcin is associated with increased risks of impaired handgrip strength and impaired physical performance. Dose-dependent associations were found especially in postmenopausal women but not in men.
- | Biomarker, Journal: Effects of COVID-19 Lockdown on Nutritional, Functional and Frailty Biomarkers of People Living in Nursing Homes. A Prospective Study. (Pubmed Central) - Sep 14, 2023
However, many of the residents were pre-frail after the lockdown. This fact highlights the need for preventive strategies to reduce the impact of future social and physical stressors on these vulnerable individuals.
- | Journal, Causal relationship: Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study. (Pubmed Central) - Sep 14, 2023
This fact highlights the need for preventive strategies to reduce the impact of future social and physical stressors on these vulnerable individuals. The present study suggests that SP may have a causal effect on OA through changes in muscle composition rather than muscle strength, while little evidence was provided for the causal effect of OA on SP.