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|||||||||| Journal: Plant-based polyphenol rich protein supplementation attenuated skeletal muscle loss and lowered the LDL level via gut microbiota remodeling in Taiwan's community-dwelling elderly. (Pubmed Central) - Nov 1, 2023
In summary, BSKP attenuated age-related sarcopenia by inducing antioxidant enzymes and SCFAs via gut microbiota regulation. Therefore, BSKP holds potential as a high-quality nutrient source for Taiwan's elderly, especially in conditions such as sarcopenia.

|||||||||| Journal: Low lean mass with obesity in older adults with hypertension: prevalence and association with mortality rate. (Pubmed Central) - Nov 1, 2023
Patients with both LLM and obesity had a higher risk of all-cause mortality. Further large, prospective, cohort studies are warranted to validate these findings and uncover underlying mechanisms.

|||||||||| Journal: Baseline Nutritional Status and In-Hospital Step Count are Associated with Muscle Quantity, Quality, and Function: Results of an Exploratory Study. (Pubmed Central) - Nov 1, 2023
Step count was associated with baseline patient-reported physical function (<900 37.1, ?900 44.5; p?=?0.010). There was a significant interaction between nutrition, step count, and time for skeletal muscle mass (Janssen equation) (p?=?0.022).

|||||||||| Journal: VEGFA Promotes Skeletal Muscle Regeneration in Aging. (Pubmed Central) - Nov 1, 2023
There was a significant interaction between nutrition, step count, and time for skeletal muscle mass (Janssen equation) (p?=?0.022). ML228, a hypoxia signaling activator known to increase VEGFA levels, augments muscle VEGFA levels and increases average CSA of regenerating fibers in both old mice (25% increase, p

|||||||||| Clinical, Journal: The Optimal Definition of Sarcopenia for Predicting Postoperative Pneumonia after Esophagectomy in Patients with Esophageal Cancer. (Pubmed Central) - Nov 1, 2023
ML228, a hypoxia signaling activator known to increase VEGFA levels, augments muscle VEGFA levels and increases average CSA of regenerating fibers in both old mice (25% increase, p Preoperative sarcopenia by modified EWGSOP criteria could be the best indicator using BIA for predicting PP after esophagectomy in patients with EC.

|||||||||| Retrospective data, Journal: Improved Muscle Mass and Function With Protein Supplementation in Older Adults With Sarcopenia: A Meta-Analysis. (Pubmed Central) - Oct 31, 2023
Preoperative sarcopenia by modified EWGSOP criteria could be the best indicator using BIA for predicting PP after esophagectomy in patients with EC. : Nutritional supplementation with protein increased appendicular muscle mass in older adults with sarcopenia and improved handgrip strength and SPPB scores.

|||||||||| Review, Journal: E-Health Interventions for Older Adults With Frailty: A Systematic Review. (Pubmed Central) - Oct 31, 2023
: This systematic review found insufficient evidence to support the efficacy of e-Health interventions. Nevertheless, the studies included in this review showed positive effects of e-Health interventions on improving muscle strength, physical activity, and quality of life in older adults with frailty.

|||||||||| Journal: Sarcopenic Dysphagia and Simplified Rehabilitation Nutrition Care Process: An Update. (Pubmed Central) - Oct 31, 2023
Both cycles should be done simultaneously. The nutrition diagnosis of undernutrition, overnutrition/obesity, sarcopenia, and goal setting of rehabilitation and body weight are implemented collaboratively.

|||||||||| Journal: The value of ultrasound measurement of muscle thickness at different sites and shear wave elastography in Parkinson's disease with sarcopenia: a pilot study. (Pubmed Central) - Oct 31, 2023
Male patients, low BMI and gastrocnemius MT were identified as valid predictors of low ASMI in PD patients. The findings of this study provide important insights into the use of muscle ultrasound in the diagnosis of PD with sarcopenia.

|||||||||| Journal: How long were older people expected to live with or without sarcopenia? Multistate modeling of a national cohort study. (Pubmed Central) - Oct 31, 2023
The results improved our understanding of the relationship between sarcopenia and life expectancy. We suggested that targeted strategies should be considered in high-risk populations and underdeveloped regions to prevent sarcopenia and improve non-sarcopenic life years for the older population.

|||||||||| New trial: MaSS-CKD: Multimorbidity and Sarcopenia Feasibility Study in Chronic Kidney Disease (clinicaltrials.gov) - Oct 31, 2023
P=N/A, N=80, Not yet recruiting, Sponsor: University Hospitals of Derby and Burton NHS Foundation Trust

|||||||||| Retrospective data, Journal: Association of fat-to-muscle ratio with non-alcoholic fatty liver disease: a single-centre retrospective study. (Pubmed Central) - Oct 30, 2023
In this study, we found a significant association between FMR and NAFLD. A higher FMR indicates a higher risk of NAFLD in the study population and a higher risk of liver fibrosis and ASCVD in NAFLD patients.

|||||||||| Journal: The significance of nutritional strategies in patients with inflammatory bowel disease in the context of malnutrition and the development of malnourished obesity. (Pubmed Central) - Oct 30, 2023
We assume that diet is modifiable factor that is related to nutritional status and healthy body weight. In addition, the current knowledge on the relationship between nutrition strategies, obesity and IBD will be demonstrated.

|||||||||| Retrospective data, Journal: Integrating Chinese Herbal Medicine into Conventional Care Was Related to Lower Risk of Sarcopenia Among Rheumatid Arthritis Patients: A Retrospective, Population-Based Study. (Pubmed Central) - Oct 30, 2023
Prescriptions of several herbal formulae may benefit the reduction of sarcopenia risk, such as Yan-Hu-Suo, Bei-Mu, Da-Huang, Huang Qin, Ping-Wei-San (PWS), Shu-Jing-Huo-Xue-Tang (SJHXT) and Chuan-Xiong-Cha-Tiao-San (CXCTS). This study produced new evidence as it is the first to show that the longer duration of CHM use was correlated to reduced risk of sarcopenia in a dose-dependent manner, implying that CHM treatment could be embraced as a routine care strategy for preventing sarcopenia.

|||||||||| Journal, HEOR: Sarcopenia is associated with osteopenia and impaired quality of life in children with genetic intrahepatic cholestatic liver disease. (Pubmed Central) - Oct 30, 2023
While sarcopenia did not predict transplant-free survival, LT and death were infrequent events. Future studies may define mechanisms of sarcopenia in genetic intrahepatic cholestasis.

|||||||||| Journal: Association between sarcopenia-related traits and cardiovascular diseases: a bi-directional Mendelian randomization study. (Pubmed Central) - Oct 30, 2023
There is a unidirectional causal relationship between sarcopenia and CVD. The loss of muscle mass and strength has a significant causal role in promoting the occurrence and development of CVD, providing a reference for the prevention and treatment of comorbidities in older people.

|||||||||| Journal: Prospective sarcopenia outcomes associated with physical performance in individuals aged 55?years and over in Malaysia. (Pubmed Central) - Oct 30, 2023
Despite HGS being a commonly used test to assess strength capacity in older adults, we advocate alternative strength measures, such as the sit-to-stand test, to be included in the assessment. Future studies should incorporate imaging modalities in the classification of sarcopenia to corroborate current study findings.

|||||||||| Review, Journal, Adverse events: Benefits and side effects of protein supplementation and exercise in sarcopenic obesity: A scoping review. (Pubmed Central) - Oct 30, 2023
However, it also highlights the need for caution when it comes to high amounts of protein intake prescription. Future research is warranted to investigate the optimal exercise design for this population, given the limited research conducted in this specific area.

|||||||||| Biomarker, Journal: Comparison of the serum creatinine- and cystatin-C-based indices as screening biomarkers for sarcopenia in community-dwelling older adults. (Pubmed Central) - Oct 30, 2023
Furthermore, a higher pSMI was strongly associated with a decreased risk of sarcopenia compared to TBMM. These findings suggest pSMI as a potential biomarker for sarcopenia screening in community-dwelling older adults.

|||||||||| Journal: Myosteatosis independently predicts transplant-free survival in patients with primary sclerosing cholangitis. (Pubmed Central) - Oct 30, 2023
P=N/A
IMFF is independently associated with TFS in patients with PSC and may identify patients with more urgent need for LT. NCT03584204.

|||||||||| Review, Journal: Validated Tools for Screening Sarcopenia: A Scoping Review. (Pubmed Central) - Oct 30, 2023
More than 50 validated tools are currently available for screening sarcopenia in different clinical settings. The results of this review may help clinicians and researchers in selecting optimal tools for sarcopenia in different clinical scenarios and in developing future tools.

|||||||||| Journal: Association Between Changes in Depressive Symptoms and Sarcopenia: Findings From a Nationwide Cohort Study. (Pubmed Central) - Oct 30, 2023
People with increased depressive symptoms and persistent depressive symptoms may have a higher risk of developing sarcopenia over time. In the future, more research is needed to confirm the mechanism by which long-term changes in depression contribute to the risk of sarcopenia, and to propose preventive measures accordingly.

|||||||||| Journal: Clinical practice for sarcopenia in Asia: Online survey by the Asian Working Group for Sarcopenia. (Pubmed Central) - Oct 30, 2023
Many geriatricians collaborate with other healthcare professionals to appropriately manage sarcopenia. In the future, educating all medical staff on the proper management of sarcopenia is necessary.

|||||||||| Journal, HEOR: A prospective study on the differential association of sarcopenia and frailty with health outcomes in cirrhotic patients. (Pubmed Central) - Oct 30, 2023
Co-occurrence of sarcopenia and frailty increased the risk of death in cirrhosis, but these two conditions didn't have a significant interaction association. Frailty, but not sarcopenia, was associated with more adverse outcomes in cirrhotic patients.

|||||||||| Retrospective data, Review, Journal: Prognostic value of sarcopenia in older adults with transcatheter aortic valve implantation: A systematic review and meta-analysis. (Pubmed Central) - Oct 30, 2023
Frailty, but not sarcopenia, was associated with more adverse outcomes in cirrhotic patients. Although there are substantial differences in diagnostic criteria, sarcopenia is highly prevalent in patients undergoing TAVI and its linked to increased long-term mortality after TAVI.

|||||||||| Journal: The Health, Aging, and Body Composition (Health ABC) Study - Ground-breaking science for 25 years and counting. (Pubmed Central) - Oct 30, 2023
Although there are substantial differences in diagnostic criteria, sarcopenia is highly prevalent in patients undergoing TAVI and its linked to increased long-term mortality after TAVI. The Health ABC provides a knowledge base for the prevention of disability and promotion of mobility in older adults.

|||||||||| Biomarker, Journal: Development of multiple biomarker panels for prediction of sarcopenia in community-dwelling older adults. (Pubmed Central) - Oct 30, 2023
The Health ABC provides a knowledge base for the prevention of disability and promotion of mobility in older adults. Multi-biomarker risk score, which was a combination of eight biomarkers with different pathophysiologies, better discriminated the presence of sarcopenia than a single biomarker, and it could further predict the incidence of sarcopenia over two years in older adults.

|||||||||| Biomarker, Journal: RNA-sequencing analysis identification of potential biomarkers for diagnosis of sarcopenia. (Pubmed Central) - Oct 30, 2023
We have discovered potential biomarkers for the diagnosis of sarcopenia. Further refinement may lead to their future practical use in clinical use.

|||||||||| Journal: Frequency and functional consequences of low appendicular lean mass and sarcopenic obesity in patients with asthma referred for pulmonary rehabilitation. (Pubmed Central) - Oct 30, 2023
Among the obese patients, a significant proportion presented SO. Low ALM and SO were associated with worse functional outcomes.

|||||||||| Journal: Benefits of Cardiac Rehabilitation in Cardio-Renal Patients With Heart Failure With Reduced Ejection Fraction. (Pubmed Central) - Oct 30, 2023
Cardiac rehabilitation is beneficial in patients with HFrEF with CKD regardless of CKD stage. The presence of CKD should not prevent the prescription of CR in patients with HFrEF.

|||||||||| Journal: The Study of Muscle, Mobility and Aging (SOMMA). A Unique Cohort Study about the Cellular Biology of Aging and Age-related Loss of Mobility. (Pubmed Central) - Oct 30, 2023
The presence of CKD should not prevent the prescription of CR in patients with HFrEF. SOMMA will provide the foundation for discoveries in the biology of human aging and mobility.

|||||||||| Journal: Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8 and their Binding Proteins Follistatin and Follistatin-like protein-3 with Measures of Skeletal Muscle Mass, Muscle Strength and Physical Function in Older Adults. (Pubmed Central) - Oct 30, 2023
SOMMA will provide the foundation for discoveries in the biology of human aging and mobility. GDF-8 and its binding proteins, follistatin and FSTL-3, may constitute a counterregulatory system (chalones) to restrain age-related loss of muscle mass and strength.

|||||||||| Trial completion date, Trial primary completion date: CHRONOS-SARC: High-definition Surface Electromyography Markers for the Diagnosis of Sarcopenia (clinicaltrials.gov) - Oct 30, 2023
P=N/A, N=50, Recruiting, Sponsor: Assistance Publique - H
GDF-8 and its binding proteins, follistatin and FSTL-3, may constitute a counterregulatory system (chalones) to restrain age-related loss of muscle mass and strength. Trial completion date: May 2023 --> Jun 2025 | Trial primary completion date: May 2023 --> May 2025

||||||||||  isomyosamine (MYMD-1) / MyMD Pharma, Akers Biosci
Trial completion:  Evaluation of Efficacy, Tolerability, and Pharmacokinetics of MYMD1 for Chronic Inflammation and Sarcopenia/Frailty (clinicaltrials.gov) -  Oct 30, 2023
P2, N=40, Completed,  Sponsor: MyMD Pharmaceuticals, Inc.
Trial completion date: May 2023 --> Jun 2025 | Trial primary completion date: May 2023 --> May 2025 Recruiting --> Completed

|||||||||| Retrospective data, Journal: Associations among Preoperative Malnutrition, Muscle Loss, and Postoperative Walking Ability in Intertrochanteric Fractures: A Retrospective Study. (Pubmed Central) - Oct 29, 2023
Preoperative low skeletal muscle mass and malnutrition were risk factors for postoperative poor walking ability. Further preventive interventions focusing on skeletal muscle mass and nutritional status are required.

|||||||||| Journal, Epigenetic controller: DNA methylation of insulin signaling pathways is associated with HOMA2-IR in primary myoblasts from older adults. (Pubmed Central) - Oct 29, 2023
Further preventive interventions focusing on skeletal muscle mass and nutritional status are required. These findings suggest that insulin resistance is associated with differential DNA methylation in human primary myoblasts with both muscle mass and body composition making a significant contribution to the methylation changes associated with IR.

|||||||||| Review, Journal: Current evidence on the association of tongue strength with cognitive decline in older adults and the known risk factors of frailty, sarcopenia and nutritional health: a scoping review protocol. (Pubmed Central) - Oct 29, 2023
The scoping review does not require ethics approval as data will be from publicly available sources. Results will be disseminated in workshops and conferences and a peer-reviewed journal paper.

|||||||||| Journal: Anorexia of aging: An international assessment of healthcare providers' knowledge and practice gaps. (Pubmed Central) - Oct 28, 2023
Findings from this international assessment highlight the challenges in the care of older adults with or at risk for anorexia of aging. Identifying professional practice gaps between individual HCPs and team-based gaps can provide a basis for healthcare education that is addressed at root causes, targeted to specific audiences and developed to improve individual and team practices that contribute to improving patient outcomes.

|||||||||| Preclinical, Journal: Various Organ Damages in Rats with Fetal Growth Restriction and Their Slight Attenuation by Bifidobacterium breve Supplementation. (Pubmed Central) - Oct 28, 2023
In conclusion, this rat model could be useful for investigating the mechanisms of how FGR-LBW leads to future health problems and for developing interventions for these problems. Supplementation with B. breve in early life may modestly attenuate these problems.

|||||||||| Biomarker, Journal: Tissue Circular RNA_0004018 and 0003570 as Novel Prognostic Biomarkers for Hepatitis B-Related Hepatocellular Carcinoma. (Pubmed Central) - Oct 28, 2023
High expression levels of hsa_circ_0003570 (hazard ratio (HR), 0.437; p = 0.009) and hsa_circ_0004018 (HR, 0.435; p = 0.005) were inversely independent risk factors for overall and progression-free survival in patients with HBV-HCC, whereas the combination group was also an inversely independent risk factor for overall (HR, 0.399; p = 0.005) and progression-free survival (HR, 0.422; p = 0.003) in patients with HBV-HCC. The combination of hsa_circ_0003570 and hsa_circ_0004018 may be a potential prognostic biomarker for HBV-HCC.

|||||||||| Preclinical, Journal: Verbascoside Elicits Its Beneficial Effects by Enhancing Mitochondrial Spare Respiratory Capacity and the Nrf2/HO-1 Mediated Antioxidant System in a Murine Skeletal Muscle Cell Line. (Pubmed Central) - Oct 28, 2023
We found that verbascoside (1) improved mitochondrial function by increasing mitochondrial spare respiratory capacity; (2) mitigated the decrease in cell viability induced by HO and reduced ROS levels; (3) promoted the phosphorylation of Nrf2 and its nuclear translocation; (4) increased the transcription levels of HO-1 and, in myoblasts but not in myotubes, those of PGC-1?. These findings contribute to explaining verbascoside's ability to relieve muscular fatigue and could have positive repercussions for the development of therapies aimed at counteracting muscle weakness and mitochondrial dysfunction.

|||||||||| Review, Journal: Upper Tract Urothelial Carcinoma (UTUC) Diagnosis and Risk Stratification: A Comprehensive Review. (Pubmed Central) - Oct 28, 2023
Post-operative nomograms, which help decide on adjuvant chemotherapy and plan follow-up are explored. Finally, a revision of the current stratification of UTUC patients is endorsed.

|||||||||| Journal, Immune cell: Characteristics of Age Classification into Five-Year Intervals to Explain Sarcopenia and Immune Cells in Older Adults. (Pubmed Central) - Oct 28, 2023
This study reaffirmed that sarcopenia and immune cell function decline with each successive 5-year increase in age. Considering these findings, the importance of implementing programs aimed at ensuring a high-quality extension of life for the elderly is strongly underscored.

|||||||||| Journal: Calsarcin-2 May Play a Compensatory Role in the Development of Obese Sarcopenia. (Pubmed Central) - Oct 28, 2023
Although calsarcin-2 facilitated myoblast differentiation, the serum calsarcin-2 concentration was negatively related to skeletal muscle mass index in mice and human subjects. Taken together, calsarcin-2 might facilitate myoblast differentiation and appear to play a compensatory role in sarcopenia.

|||||||||| Journal: Assessing Stroke-Related Sarcopenia in Chronic Stroke: Identification of Clinical Assessment Tools-A Pilot Study. (Pubmed Central) - Oct 28, 2023
The five-times sit-to-stand test, SPPB, and gait speed can lead clinicians to detect stroke-related sarcopenia. Maximum handgrip shows a trend of low values for men and women in the SG, however, CC did not detect sarcopenia in our sample.

|||||||||| Journal: Estimation of Sarcopenia Indices in Women from Saudi Arabia in Relation to Menopause and Obesity: Cross-Sectional Comparative Study. (Pubmed Central) - Oct 28, 2023
We suggest that EWGSOP2 cut-offs may not be adaptable for Saudi women. Considering body composition differences between Saudis and Caucasians, our proposed HGS cut-offs appear more relevant.

|||||||||| Journal: Dynapenia and Sarcopenia in Post-COVID-19 Syndrome Hospitalized Patients Are Associated with Severe Reduction in Pulmonary Function. (Pubmed Central) - Oct 28, 2023
Considering body composition differences between Saudis and Caucasians, our proposed HGS cut-offs appear more relevant. In post-COVID-19 syndrome, dynapenia and sarcopenia-both with and without obesity-have been associated with lower lung function.

|||||||||| Journal, HEOR: Longitudinal Changes in Physical Function and Their Impact on Health Outcomes in COVID-19 Patients. (Pubmed Central) - Oct 28, 2023
This study highlights the prevalence of reduced physical function among COVID-19 survivors and emphasises the importance of early identification and intervention to optimise their long-term health. Monitoring HGS, a simple and reliable tool, can provide valuable insights into patients' overall physical function, aiding in tailored care and improved outcomes.

|||||||||| Journal: Incidence of the Risk of Malnutrition and Excess Fat Mass, and Gait Speed as Independent Associated Factors in Community-Dwelling Older Adults. (Pubmed Central) - Oct 28, 2023
RM diagnosed by MNA-LF was significantly less likely to occur among subjects with excess fat mass, and a significant association emerged between low gait speed and RM after 4.1 years of follow-up in these community-dwelling older adults. These results confirm the association between some alterations of body composition and impaired physical performance with the risk of malnutrition and highlight that excess fat mass and low gait speed precede the risk of malnutrition, not vice versa.

|||||||||| Preclinical, Review, Journal: The Role of Vitamin D in Skeletal Muscle Repair and Regeneration in Animal Models and Humans: A Systematic Review. (Pubmed Central) - Oct 28, 2023
Finally, human studies reported the benefits of vitamin D supplementation and achieving optimal serum vitamin D levels in muscle recovery after eccentric exercise and surgery. However, there were no benefits in rotator cuff injury studies, suggesting that repair mechanisms for muscle/ligament tears may be less reliant on vitamin D. In summary, vitamin D plays a crucial role in skeletal muscle function, structural integrity, and regeneration, potentially offering therapeutic benefits to patients with musculoskeletal diseases and in post-operative recovery.



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