Sarcopenia
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  • ||||||||||  Journal:  An Artificial Intelligence Approach for Test-Free Identification of Sarcopenia. (Pubmed Central) -  Dec 11, 2024   
    We developed an artificial intelligence model that can assist in the identification of sarcopenia, particularly in settings lacking the necessary resources for a comprehensive diagnosis. These findings offer potential for improving decision-making and facilitating the development of novel management strategies of sarcopenia.
  • ||||||||||  sirolimus / Generic mfg.
    Preclinical, Journal:  Short-chain fatty acids enhance muscle mass and function through the activation of mTOR signalling pathways in sarcopenic mice. (Pubmed Central) -  Dec 11, 2024   
    As the new AWGC cachexia criteria will result in a significantly larger proportion of patients being diagnosed with cachexia, the implementation of the criteria in clinical practice requires further consideration. This study demonstrated that bacterial metabolites SCFAs could attenuate age-related muscle loss and dysfunction, and protein synthesis-related mTOR signalling pathways were involved both in vivo and in vitro.
  • ||||||||||  Journal:  The Impact of SGLT1 Inhibition on Frailty and Sarcopenia: A Mediation Mendelian Randomization Study. (Pubmed Central) -  Dec 11, 2024   
    This study demonstrated that bacterial metabolites SCFAs could attenuate age-related muscle loss and dysfunction, and protein synthesis-related mTOR signalling pathways were involved both in vivo and in vitro. SGLT1 inhibition potentially mitigated frailty and sarcopenia through several biological mediators, shedding new light for therapeutic intervention.
  • ||||||||||  Review, Journal:  Sarcopenia interventions in long-term care facilities targeting sedentary behaviour and physical inactivity: A systematic review. (Pubmed Central) -  Dec 11, 2024   
    The findings led to the development of a novel logic model detailing essential components for interventions aimed at managing sarcopenia in long-term care facilities, with a focus on addressing sedentary behaviour and physical inactivity. Future sarcopenia interventions in long-term care facilities should fully attend to sedentary behaviour, enhance adherence to interventions through improved education, monitoring, tailoring and motivation and establish an agreed standard set of outcome measures.
  • ||||||||||  Journal:  High-Intensity Interval Training Mitigates Sarcopenia and Suppresses the Myoblast Senescence Regulator EEF1E1. (Pubmed Central) -  Dec 11, 2024   
    Future sarcopenia interventions in long-term care facilities should fully attend to sedentary behaviour, enhance adherence to interventions through improved education, monitoring, tailoring and motivation and establish an agreed standard set of outcome measures. This study highlights the potential of HIIT as a promising approach to prevent and treat sarcopenia while also highlighting EEF1E1 as a potential intervention target.
  • ||||||||||  Biomarker, Journal:  Sphingolipid metabolites as potential circulating biomarkers for sarcopenia in men. (Pubmed Central) -  Dec 11, 2024   
    SM (16:0), reflecting low muscle strength, and CER (24:1) and SM (16:0), reflecting low muscle mass, are potential circulating biomarkers for sarcopenia in men. Further research on sphingolipid metabolites is required to confirm these results and provide additional insights into the metabolomic changes relevant to the pathogenesis and diagnosis of sarcopenia.
  • ||||||||||  Journal:  Breathlessness, frailty, and sarcopenia in older adults. (Pubmed Central) -  Dec 11, 2024   
    These findings suggest that frailty and sarcopenia strongly contribute to breathlessness in community-dwelling older adults. Measuring sarcopenia and frailty in older adults may offer opportunities to prevent age-related breathlessness.
  • ||||||||||  Review, Journal:  Associations between gut microbiota and sarcopenia or its defining parameters in older adults: A systematic review. (Pubmed Central) -  Dec 11, 2024   
    Sarcopenia and low muscle parameters are also associated with different GM-taxa at multiple levels, but results were heterogeneous and no causal conclusions could be made due to the cross-sectional design of the studies. This emphasizes the need for uniformly designed cross-sectional and longitudinal trials with appropriate GM confounder control in large samples of persons with sarcopenia and clearly defined core outcome sets in order to further explore changes in GM-taxa and to determine a sarcopenia-specific GM-signature.
  • ||||||||||  Observational data, Journal:  Body composition parameters in initial CT imaging of mechanically ventilated trauma patients: Single-centre observational study. (Pubmed Central) -  Dec 11, 2024   
    This emphasizes the need for uniformly designed cross-sectional and longitudinal trials with appropriate GM confounder control in large samples of persons with sarcopenia and clearly defined core outcome sets in order to further explore changes in GM-taxa and to determine a sarcopenia-specific GM-signature. In a multivariable analysis of mechanically ventilated trauma patients, CT-defined sarcopenia was significantly associated with 30-day mortality whereas no associations of body composition parameters with ICU LOS and duration of mechanical ventilation were observed.
  • ||||||||||  Journal:  Peculiarities of neurovegetative regulation in children and adolescents with sarcopenia according to heart rate variability indicators. (Pubmed Central) -  Dec 11, 2024   
    Completion of SET was associated with significant improvements in adverse limb outcomes in patients with IC, concomitant sarcopenia, and CMM. Registration of a standard 5-minute rhythmocardiogram against the background of spontaneous breathing should be supplemented with a 1-minute breathing test in the diaphragmatic breathing mode with an imposed rhythm of 6 breathing movements per minute, which allows for assessing the presence or absence of parasympathetic dysfunction.
  • ||||||||||  Review, Journal:  What's new about hydration in dementia? (Pubmed Central) -  Dec 11, 2024   
    These guidelines emphasize the importance of early detection, personalized interventions, and consistent monitoring to ensure that dehydration is identified and treated promptly. Furthermore, the current literature supports the need for a specific terminology for dementia management using nutrition and hydration to improve patients' health outcomes.
  • ||||||||||  Review, Journal:  Kwashiorkor and sarcopenic obesity: Two Sides Of The Same Coin? (Pubmed Central) -  Dec 11, 2024   
    Both are forms of malnutrition, and have common features in causation, clinical presentation, comorbidities and complications, as well as strategies for management. In this review, we discuss whether kwashiorkor and obesity, especially sarcopenic obesity, are two sides of the same coin or not.
  • ||||||||||  Journal:  Ergonomic endocrinology. (Pubmed Central) -  Dec 11, 2024   
    We describe the various domains of ergonomic endocrinology, using the classification rubric of physical, cognitive and organizational ergonomics. We highlight ways in which endocrinology can contribute to the enhancement of ergonomics.
  • ||||||||||  Preclinical, Journal:  Lactobacillus paragasseri SBT2055 attenuates obesity via the adipose tissue-muscle-gut axis in obese mice. (Pubmed Central) -  Dec 10, 2024   
    Changes in the Bacteroidota showed a negative correlation with body fat and plasma free fatty acid (FFA) while exhibiting a positive correlation with lean body mass, grip strength, and hind leg thickness. Our results demonstrated the anti-obesity effects of LG2055 through the white adipose tissue (WAT)-muscle-gut axis, suggesting its potential as an anti-obesity agent.
  • ||||||||||  Review, Journal:  Neurological complications caused by SARS-CoV-2. (Pubmed Central) -  Dec 10, 2024   
    Furthermore, the mechanisms underlying SARS-CoV-2-induced neurological disorders were also discussed, including entering the brain through retrograde neuronal or hematogenous routes, disrupting the normal function of the CNS through cytokine storms, inducing cerebral ischemia or hypoxia, thus leading to neurological complications. Moreover, an overview of long-COVID-19 symptoms is provided, along with some recommendations for care and therapeutic approaches of COVID-19 patients experiencing neurological complications.
  • ||||||||||  Journal:  Association of food group with the changes in sarcopenia parameters over 1 (Pubmed Central) -  Dec 10, 2024   
    Moreover, an overview of long-COVID-19 symptoms is provided, along with some recommendations for care and therapeutic approaches of COVID-19 patients experiencing neurological complications. Sugar, sweeteners, and beverages are associated with worsened sarcopenia parameters, whereas consumption of legumes, vegetables, and fruits is associated with a lower risk.
  • ||||||||||  Journal:  Age Is Just a Number for Older Kidney Transplant Patients. (Pubmed Central) -  Dec 10, 2024   
    Emphasizing the need for a comprehensive evaluation that extends beyond chronological age, we explore alternative aging metrics such as frailty, sarcopenia, and cognitive function, underscoring their potential role in enhancing the KT evaluation process. Most importantly, we aim to contribute to the ongoing discourse, fostering an optimized approach to KT for the rapidly growing population of older adults.
  • ||||||||||  Review, Journal:  The Organ-Joint Axes in Osteoarthritis: Significant Pathogenesis and Therapeutic Targets. (Pubmed Central) -  Dec 10, 2024   
    The organ-joint crosstalk is integral to the complex pathogenesis of OA, highlighting the multifactorial nature of OA and the potential for targeted therapeutic interventions. By integrating these multidimensional perspectives, we aim to enhance our understanding of OA pathogenesis and explore potential pharmacological targets.