Sarcopenia
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  • ||||||||||  Journal:  A bibliometric analysis of inflammation in sarcopenia from 2007 to 2022. (Pubmed Central) -  Nov 20, 2023   
    The interaction between oxidative stress, insulin resistance and inflammation in sarcopenia is regarded as the current research priorities. As sarcopenia becomes more prevalent, a focus will be placed on determining the molecular mechanisms and therapeutic targets for regulating inflammation to intervene in sarcopenia.
  • ||||||||||  Journal:  CHALLENGES IN LIVER TRANSPLANT 2023 (Pubmed Central) -  Nov 19, 2023   
    The main challenges after liver transplantation are the metabolic syndrome and its complications, renal failure and malignancy. An aggressive, early preventive approach is highly recommended to promote a healthy lifestyle, optimize medical therapy and screen for malignancy.
  • ||||||||||  Observational data, Journal:  Motor Reaction Time, Sarcopenia and Functional Skills in Elderly Women: A Cross-Sectional Study. (Pubmed Central) -  Nov 18, 2023   
    If our hypothesis is correct and shows that a multicomponent, individualized and progressive exercise program is an effective therapy for improving the capacity of acutely hospitalized older patients compared to usual care, a change in the current system of hospitalization may be justified in oncogeriatric patients. Sarcopenic elderly women present increased motor reaction time, that is, slowed motor responses due to decreased muscle mass, strength and impaired musculature, which generate functional deficits that contribute to an increased risk of falls.
  • ||||||||||  Review, Journal:  The Implication of Nutrition on the Prevention and Improvement of Age-Related Sarcopenic Obesity: A Systematic Review. (Pubmed Central) -  Nov 18, 2023   
    Future research should implement nutrition risk screening in primary care settings with subsequent assessment and treatment for at risk clients to determine if nutrition interventions implemented post screening can delay age-related losses in strength and performance. Studies suggest that dietary factors, such as overall dietary quality, appropriate intake of calories and protein, consumption of antioxidant nutrients, vegetables, fruits, and protein, may be linked to sarcopenic obesity.
  • ||||||||||  Journal:  Relationship between Lean Tissue Mass and Muscle Function in Women with Obesity. (Pubmed Central) -  Nov 18, 2023   
    In summary, although a reduction in appendicular LTM and muscle performances occurred with age and resulted in an increase in the prevalence of SO, the number of women with obesity affected by SO remained low (n ? 15), even in those older than 60 years.
  • ||||||||||  Journal:  Nutrition Care after Hospital Discharge in Singapore: Evidence-Based Best-Practice Recommendations. (Pubmed Central) -  Nov 18, 2023   
    Information on why nutrition is important for good health and how it can be achieved should also be provided to all patients and their caregivers before and after hospital discharge. With the above recommendations, we seek to improve upon the current nutrition care processes at discharge for healthcare institutions in Singapore.
  • ||||||||||  Review, Journal:  The multifaceted role of macrophages in homeostatic and injured skeletal muscle. (Pubmed Central) -  Nov 17, 2023   
    As macrophages are actively involved in the progression of many muscle diseases, manipulating their functional activation has become a promising therapeutic approach, which requires comprehensive knowledge of the cellular and molecular mechanisms underlying the diverse activation. To this end, we discuss here the current knowledge of multifaceted role of macrophages in skeletal muscle homeostasis, injury, and repair.
  • ||||||||||  Making Sense of Muscle Wasting (CC 220-222; In-Person) -  Nov 16, 2023 - Abstract #AAPMR2023AAPMR_363;    
    Our session proposal this year brings together experts actively tackling the clinical challenges of diagnosing and treating muscle wasting. In this proposal, we will explore avenues for physiatry leaders to develop a consensus statement and a pragmatic treatment algorithm.Learning Objectives: Compare and contrast existing classification of muscle wasting conditions (frailty, cachexia, sarcopenia)Define the interdisciplinary team for assessment and treatment of muscle wasting, highlighting the specific role of physiatry in muscle wasting management.Describe how biology, therapeutics, and rehabilitation have different implications for assessment and treatment of muscle wasting.Identify the most clinically relevant factors in muscle wasting diagnosis and treatment that can be easily implemented in the rehabilitation community.
  • ||||||||||  Assessing health and function by combating age-related sarcopenia, chronic disease, and weight stigma: it's more than BMI (CC 206-207; In-Person) -  Nov 16, 2023 - Abstract #AAPMR2023AAPMR_288;    
    That being said, patients seen as "overweight" or "obese" may be treated differently from those with a more traditional athlete appearance. It is important that clinicians can properly assess health status without relying simply on appearance or weight.Finally, the influence of certain industries, such as the food and pharmaceutical industries, on medical research and education may also contribute to a lack of knowledge about the role of exercise and nutrition in health and disease and what "health" actually looks like.Learning Objectives: Discuss the role of nutrition and exercise in the management of chronic diseases, including diabetes and cardiovascular disease.Explain the benefits of strength training and cardio exercise for improving muscle function and preventing muscle loss.Identify strategies for incorporating exercise into the treatment plans of older adults, including the use of assistive devices and modifications for individuals with chronic conditions.Develop a plan for discussing the importance of exercise and nutrition with patients and providing guidance on making lifestyle changes.Assess health status of an individual beyond merely weight or BMIMeet the needs of overweight/larger bodied athlete community historically marginalized by the medical community, through improving physical exam and procedural skills, and by challenging our assumptions
  • ||||||||||  Observational data, Journal:  Substantial Loss of Skeletal Muscle Mass Occurs After Femoral Fragility Fracture. (Pubmed Central) -  Nov 16, 2023   
    We found that older adults with femoral fragility fractures lost substantial skeletal muscle mass and physical function. Participants with adequate baseline nutrition actually lost more muscle mass than those who were malnourished, indicating that future investigations of interventions to prevent muscle loss should focus on older adults regardless of nutritional status.
  • ||||||||||  Camzyos (mavacamten) / BMS
    Journal:  Cardiomyocyte external mechanical unloading activates modifications of ?-actinin differently from sarcomere-originated unloading. (Pubmed Central) -  Nov 16, 2023   
    Unloading of the cellular substrate by myosin inhibition (1??m mavacamten), or cessation of cyclic strain (1?Hz, 10% strain) after preconditioning, led to significant disassembly of sarcomeric ?-actinin by 6?h...These results demonstrate a link between mechanical feedback and sarcomere protein homeostasis via PTMs of ?-actinin that exemplify how cardiomyocytes exhibit differential responses to the origin of force. The implications of sarcomere regulation governed by PTMs of ?-actinin are discussed with respect to cardiac atrophy and heart failure.
  • ||||||||||  Journal:  Participation in youth sports influences sarcopenia parameters in older adults. (Pubmed Central) -  Nov 15, 2023   
    Our findings suggest that engaging in sports activities in youth can make a difference with sarcopenia parameters. Although we found no differences in PA and SB habits between participants with AH and NAH, participants with an athlete history performed better results in sarcopenia parameters.
  • ||||||||||  Review, Journal:  Locomotor and respiratory muscle abnormalities in HFrEF and HFpEF. (Pubmed Central) -  Nov 15, 2023   
    This review will provide a contemporary summary of the clinical and molecular alterations currently known to occur in the skeletal muscles of both HFrEF and HFpEF, and thereby differentiate the effects on locomotor and respiratory muscles, in particular the diaphragm. Moreover, current and future therapeutic options to address skeletal muscle weakness will be discussed focusing mainly on the effects of exercise training.
  • ||||||||||  Journal:  Cold-induced muscle atrophy in zebrafish: Insights from swimming activity and gene expression analysis. (Pubmed Central) -  Nov 15, 2023   
    These findings suggest that zebrafish can serve as a valuable model organism for studying muscle atrophy and can be utilized in drug screening for muscle atrophy-related disorders. Cold-reared zebrafish provide a practical and ethical approach to inducing disuse muscle atrophy, providing valuable insights into potential therapeutic strategies for addressing skeletal muscle atrophy.
  • ||||||||||  Trial completion:  MESSAGE: Ultrasound (US) Measurement of Sarcopenia in the Elder Subject (clinicaltrials.gov) -  Nov 15, 2023   
    P=N/A,  N=200, Completed, 
    The present study revealed that the main factor affecting methylation, telomeres length and level of total oxidant stress was age. Recruiting --> Completed
  • ||||||||||  Review, Journal:  Mass Spectrometry-Based Proteomic Technology and Its Application to Study Skeletal Muscle Cell Biology. (Pubmed Central) -  Nov 14, 2023   
    Mass spectrometric studies over the last two decades have decisively improved our general cell biological understanding of protein diversity and the heterogeneous composition of individual myofibers in skeletal muscles. This detailed proteomic knowledge can now be integrated with findings from other omics-type methodologies to establish a systems biological view of skeletal muscle function.