Sarcopenia News - LARVOL Sigma

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|||||||||| Preclinical, Journal: Aged gastrocnemius muscle of mice positively responds to a late onset adapted physical training. (Pubmed Central) - Nov 29, 2023
Results and Data demonstrate that muscles can respond to adapted physical training started at old age, positively modulating their morphology and the proteomic profile fostering protective and saving mechanisms either involving the extracellular compartment as well as muscle cell components and pathways (i.e., mitochondrial processes, cytoplasmic translation pathways, chaperone-dependent protein refolding, regulation of skeletal muscle contraction). Therefore, this study provides important insights on the targets of adapted physical training, which can be regarded as suitable benchmarks for future in vivo studies further exploring the effects of this type of physical activity by functional/metabolic approaches.

|||||||||| enzalutamide capsule / Generic mfg., abiraterone acetate / Generic mfg.
Journal, Metastases: Profiling of Skeletal Muscle and Adipose Tissue Depots in Men with Advanced Prostate Cancer Receiving Different Forms of Androgen Deprivation Therapy. (Pubmed Central) - Nov 29, 2023
Abiraterone and enzalutamide are associated with losses in muscle mass compared with luteinizing hormone-releasing hormone agonists. These treatments impact subcutaneous and visceral fat mass, suggesting distinct roles of androgens in these tissues.

|||||||||| Journal: DIMINISHED HAND GRIP STRENGTH AND CIRRHOSIS: PREVALENCE AND ASSOCIATED FACTORS. (Pubmed Central) - Nov 29, 2023
In our study, we obtained a diminished HG strength variation of 35-52%, which was related to higher MELD scores, suggesting an association with worse clinical outcomes. Therefore, the presence of reduced muscle strength in cirrhotic patients may be linked to prognostic factors and should be valued as clinical data in the management of these patients.

|||||||||| Journal: Creatine Supplementation and Resistance Training in Patients With Breast Cancer (CaRTiC Study): Protocol for a Randomized Controlled Trial. (Pubmed Central) - Nov 29, 2023
Therefore, the presence of reduced muscle strength in cirrhotic patients may be linked to prognostic factors and should be valued as clinical data in the management of these patients. This intervention will help to better understand the potential of nonpharmacological treatment for improving strength and well-being values in patients with breast cancer with and without creatine supplementation.

|||||||||| Journal: Attitudes and barriers to resistance exercise training for older adults living with multiple long-term conditions, frailty, and a recent deterioration in health: qualitative findings from the Lifestyle in Later Life - Older People's Medicine (LiLL-OPM) study. (Pubmed Central) - Nov 29, 2023
Despite a range of barriers, this group appear willing to engage in RE if they are appropriately supported. There is a need to co-design and deliver effective strategies, including education, to raise awareness and understanding of RE, as well as promote engagement in RE, in this group of older adults.

|||||||||| Trial completion date: Taurine Supplementation Associated or Not With Exercise: Effect on Browning of White Adipose Tissue in Elderly Women With Sarcopenic Obesity (clinicaltrials.gov) - Nov 29, 2023
P=N/A, N=40, Active, not recruiting, Sponsor: University of Sao Paulo
There is a need to co-design and deliver effective strategies, including education, to raise awareness and understanding of RE, as well as promote engagement in RE, in this group of older adults. Trial completion date: Sep 2023 --> Jun 2024

|||||||||| Enrollment open: MASK: Middle Age muScle Krill Study (clinicaltrials.gov) - Nov 29, 2023
P=N/A, N=92, Recruiting, Sponsor: University of Glasgow
Trial completion date: Sep 2023 --> Jun 2024 Not yet recruiting --> Recruiting

|||||||||| Trial completion: Association Between Sarcopenia and Urinary Incontinence And Effect Of Physical Activity Among Over 50 Years Old Adults (clinicaltrials.gov) - Nov 29, 2023
P=N/A, N=330, Completed, Sponsor: University of Pecs
Not yet recruiting --> Recruiting Enrolling by invitation --> Completed

|||||||||| Retrospective data, Journal: Meld-sarcopenia score and skeletal muscle density predicts short-term readmission of patients with hepatic encephalopathy. (Pubmed Central) - Nov 29, 2023
Enrolling by invitation --> Completed The MELD-sarcopenia score and SMD were identified as predictive factors for short-term readmission in patients diagnosed as HE.

|||||||||| Journal: The longitudinal association between indoor air pollution and sarcopenia in China: the mediating role of depression. (Pubmed Central) - Nov 29, 2023
Indoor heating using solid fuels is associated with a higher risk of sarcopenia, while prolonged exposure to household air pollution is found to be positively correlated with this increased risk. Furthermore, depression plays a mediating role in this relationship.

|||||||||| Review, Journal: Understanding the development of sarcopenic obesity. (Pubmed Central) - Nov 29, 2023
While the etiology of sarcopenic obesity is complex, we present data on the underlying pathophysiological mechanisms that are hypothesized to promote its development, including age-related changes in body composition, hormonal changes, chronic inflammation, and genetic predisposition. We describe emerging areas of future research that will likely be needed to advance this nascent field, including changes in clinical infrastructure, an enhanced understanding of the lifecourse, and potential treatments.

|||||||||| Review, Journal: Effectiveness of Combined Exercise and Nutrition Interventions in Preventing and Improving Sarcopenia in Frail or Healthy Older Adults: A Systematic Review. (Pubmed Central) - Nov 29, 2023
In healthy older adults, two indicators improved and showed statistically significant differences: handgrip, 2.15 kg; and 6-Minute Walking Test, 9.71 m. Combined exercise and nutritional interventions can improve skeletal muscle quality, strength, and physical performance in frail and healthy older adults. [Research in Gerontological Nursing, xx(x), xx-xx.].

|||||||||| Trial completion date, Trial initiation date, Trial primary completion date: COOLEY- Study: ACute on ChrOnic Liver FailurE Using the CYtosorb Device (clinicaltrials.gov) - Nov 29, 2023
P=N/A, N=20, Not yet recruiting, Sponsor: University Hospital, Antwerp
[Research in Gerontological Nursing, xx(x), xx-xx.]. Trial completion date: Dec 2025 --> Jun 2026 | Initiation date: Oct 2023 --> Jan 2024 | Trial primary completion date: Sep 2025 --> Dec 2025

|||||||||| New trial: Effectiveness of Individual Physical Activity Programs to Prevent Sarcopenia and Frailty Among Older Adults (clinicaltrials.gov) - Nov 29, 2023
P=N/A, N=360, Completed, Sponsor: Ministry of Health, Thailand

|||||||||| Journal, Adherence: Association between Japanese Diet Adherence and Muscle Weakness in Japanese Adults Aged ?50 Years: Findings from the JSTAR Cohort Study. (Pubmed Central) - Nov 28, 2023
This association was consistent in sensitivity analyses with multiple imputations of missing values. Closely following the Japanese dietary pattern appears to reduce the occurrence of muscle weakness among the aging population in this study, suggesting it may prevent frailty and sarcopenia in the aging population.

|||||||||| Journal: Associations between Power Training-Induced Changes in Body Composition and Physical Function in Older Men: A Pre-Test-Post-Test Experimental Study. (Pubmed Central) - Nov 28, 2023
The present study's findings indicate that participants with a body composition of ~20% body fat displayed the highest level of physical function at baseline. Furthermore, despite small pre-post changes in body fat, the results indicate that those who either preserved their body fat percentage or experienced minor alterations observed the greatest improvements in physical function.

|||||||||| Review, Journal: Age Is Just a Number: Progress and Obstacles in the Discovery of New Candidate Drugs for Sarcopenia. (Pubmed Central) - Nov 28, 2023
The types of drugs examined include mitochondria-targeting compounds, anti-diabetes agents, small molecules that target non-coding RNAs, protein therapeutics, natural products, and repositioning candidates. In light of the large number of drugs and targets being reported, it can be envisioned that clinically approved pharmaceuticals to prevent the progression or even mitigate sarcopenia may be within reach.

|||||||||| carboplatin / Generic mfg., paclitaxel / Generic mfg.
Journal: Re-Evaluating Chemotherapy Dosing Strategies for Ovarian Cancer: Impact of Sarcopenia. (Pubmed Central) - Nov 28, 2023
This study highlights the importance of considering lean body mass instead of body weight or surface area in chemotherapy dosing formulas for sarcopenic women with advanced EOC. Further research is needed to optimize chemotherapy strategies based on individual body composition, potentially leading to improved dosing strategies in this population.

|||||||||| Journal: Low Muscle Strength as Risk Factor for Non-Alcoholic Fatty Liver Disease in Different Metabolic Conditions. (Pubmed Central) - Nov 28, 2023
This study demonstrated that low muscle strength is correlated with a risk of NAFLD. This relationship was independent of insulin resistance and metabolic syndrome but was dependent on the presence of central obesity.

|||||||||| Journal: Muscle fatigue, bioenergetic responses and metabolic economy during load- and velocity-based maximal dynamic contractions in young and older adults. (Pubmed Central) - Nov 28, 2023
This relationship was independent of insulin resistance and metabolic syndrome but was dependent on the presence of central obesity. Overall, regardless of age or task type, acidosis, but not ME, was the primary mechanism for fatigue in

|||||||||| Review, Journal: Sarcopenia in Chronic Liver Disease (Pubmed Central) - Nov 28, 2023
Providing sufficient calorie and protein intake is crucial for preventing and treating sarcopenia. In addition, engaging in appropriate exercise and addressing concurrent hormonal and metabolic changes can be helpful.

|||||||||| Journal: Sarcopenia Screened with SARC-F and Subjective Memory Complaints Are Independently Associated with Increased Risk of Incident Dementia among Cognitively Unimpaired Older Adults. (Pubmed Central) - Nov 28, 2023
Our results indicate that sarcopenia screened with SARC-F and SMCs independently predict the cognitively unimpaired older adults at risk of incident dementia. Our findings highlight the importance of screening not only for cognitive but also muscle deficits to identify those at increased risk of incident dementia.

|||||||||| Journal: Associations of Body-Roundness Index and Sarcopenia with Cardiovascular Disease among Middle-Aged and Older Adults: Findings from CHARLS. (Pubmed Central) - Nov 28, 2023
Coexistence of sarcopenia and high BRI was associated with higher risk of CVD. Early identification and intervention for sarcopenia and BRI not only allows the implementation of therapeutic strategies, but also provides an opportunity to mitigate the risk of developing CVD.

|||||||||| Journal: Cross-Sectional and Longitudinal Associations of Creatinine-to-Cystatin C Ratio with Sarcopenia Parameters in Older Adults. (Pubmed Central) - Nov 28, 2023
It may be used for sarcopenia screening even in older adults whose physical function is difficult to assess. However, further longitudinal studies are needed to determine whether CCR can be a predictor of future sarcopenia.

|||||||||| Journal: Characteristics and Therapeutic Needs of Older Patients with Oropharyngeal Dysphagia Admitted to a General Hospital. (Pubmed Central) - Nov 28, 2023
Hospitalized older OD patients have impaired safety of swallow, frailty, malnutrition, dehydration, low functional capacity and poor OH and high risk of respiratory infections. They need a multimodal intervention including fluid thickening, TMD, thickened oral nutritional supplementation and OH care to improve health status and reduce OD-associated complications.

|||||||||| Clinical, Retrospective data, Review, Journal: The Effects of Different Exercise Training Types on Body Composition and Physical Performance in Older Adults with Sarcopenic Obesity: A Systematic Review and Meta-Analysis. (Pubmed Central) - Nov 28, 2023
Resistance, combined, and aerobic training evoked divergent results between the variables analyzed. Although promising, our results should be considered sparingly, but may guide additional exercise recommendations to improve specific health parameters in older adults with SO.

|||||||||| Journal: Letter to the Editor: Analyzing Global Sarcopenia Research: Revealing Trends and Hotspots through Bibliometric Analysis and Visualization (1997-2022). (Pubmed Central) - Nov 28, 2023
Although promising, our results should be considered sparingly, but may guide additional exercise recommendations to improve specific health parameters in older adults with SO. No abstract available

|||||||||| Journal: Evaluation of the cachexia index using a bioelectrical impedance analysis in elderly patients with non-Hodgkin's lymphoma: A single-center prospective study. (Pubmed Central) - Nov 28, 2023
Low-CXI was associated with poor outcomes in elderly NHL and the CXI may be a clinical useful index for predicting prognosis. Further large prospective studies are needed to verify this conclusion.

|||||||||| Enrollment closed: HEROS: Oral Nutritional Supplementation With HMB Enhance Muscle Quality in Sarcopenic Surgical Patients (clinicaltrials.gov) - Nov 28, 2023
P=N/A, N=50, Active, not recruiting, Sponsor: Sengkang General Hospital
Further large prospective studies are needed to verify this conclusion. Recruiting --> Active, not recruiting

|||||||||| Journal: MicroRNAs and Diet-induced Weight Loss: What's the Link? (Pubmed Central) - Nov 28, 2023
This could be the key to identifying the optimal endocrine profile in high respond-ers, the assessment of musculoskeletal status, and long-term management. In this review, we summarize the state of the art regarding miRNAs as a function of weight loss and as a mechanistic regulator of the effectiveness of the nutritional program.

|||||||||| Review, Journal: Insight on sarcopenic obesity and epicatechin as a promising treatment option. (Pubmed Central) - Nov 28, 2023
The goal of this review is to update the scientific community on the therapeutic potential of epicatechin in SO and age-related factors. Conduction of clinical and pre-clinical trials, also drug dosage optimization may provide with insights on the use of epicatechin in SO.

|||||||||| Enrollment closed: A Comparison of the Effects of Krill Oil and Fish Oil Supplementation on Muscle Function in Older Adults (clinicaltrials.gov) - Nov 28, 2023
P=N/A, N=61, Active, not recruiting, Sponsor: University of Glasgow
Conduction of clinical and pre-clinical trials, also drug dosage optimization may provide with insights on the use of epicatechin in SO. Recruiting --> Active, not recruiting

|||||||||| Trial completion date, Trial primary completion date: Pulmonary Rehabilitation in End-Stage Liver Disease (clinicaltrials.gov) - Nov 27, 2023
P=N/A, N=50, Recruiting, Sponsor: Mayo Clinic
Recruiting --> Active, not recruiting Trial completion date: Dec 2024 --> Dec 2026 | Trial primary completion date: Dec 2024 --> Dec 2026

|||||||||| Observational data, Journal: Targeted optimum care approach for osteoporotic fragility fractures: tailored strategy based on risk stratification to reduce incidents of falls-an initiative by the Egyptian Academy of bone health based on the FLS national register. (Pubmed Central) - Nov 27, 2023
This study highlighted the importance of falls risk stratification in osteoporotic patients presenting with fragility fractures. Identification of the patients at increased risk of falls should be a component of the standard practice.

|||||||||| Journal: Causal associations between hand grip strength and pulmonary function: a two-sample Mendelian randomization study. (Pubmed Central) - Nov 27, 2023
Our study provides support at the genetic level that HGS is positively causally associated with FVC and FEV1, but not with FEV1/FVC. Interventions for HGS in PF impairment deserve further exploration as potential indicators of PF assessment.

|||||||||| Biomarker, Journal: Plasma acylcarnitine in elderly Taiwanese: as biomarkers of possible sarcopenia and sarcopenia. (Pubmed Central) - Nov 27, 2023
This metabolomic study raises the importance of acylcarnitines on muscle mass and function. It suggests that age, BMI, BUN, KYN, and C4/Cr can be important evaluation markers for LPF (AUC: 0.766), S (AUC: 0.787), and SS (AUC: 0.919).

|||||||||| Journal, Real-world evidence, Real-world: Metabolic associated fatty liver disease and sarcopenia additively increase mortality: a real-world study. (Pubmed Central) - Nov 27, 2023
Sarcopenia in individuals with MAFLD portends increased mortality and significant liver fibrosis. Novel therapeutic strategies targeting at increasing skeletal muscle mass should be explored for patients with MAFLD.

|||||||||| Journal: Dietary patterns from mid-through later-life in relation to sarcopenia risk over 20 years among Chinese community-dwelling oldest old individuals. (Pubmed Central) - Nov 27, 2023
Novel therapeutic strategies targeting at increasing skeletal muscle mass should be explored for patients with MAFLD. Our findings highlight the importance of maintaining healthy dietary habits throughout life to reduce the risk of sarcopenia in old age.

|||||||||| Journal: Lactose malabsorption and intolerance: What is the correct management in older adults? (Pubmed Central) - Nov 27, 2023
Moreover, in the latest years, different lines of evidence have highlighted an association between dairy intake and prevention of chronic diseases as well as all-cause mortality. The aim of this opinion paper is to provide an overview of lactose malabsorption and intolerance in the older adults and their implications in clinical practice.

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Preclinical, Journal: An experimental study for quantitative assessment of fatty infiltration and blood flow perfusion in quadriceps muscle of rats using IDEAL-IQ and BOLD-MRI for early diagnosis of sarcopenia. (Pubmed Central) - Nov 27, 2023
Imaging parameters PDFF, R2*, and T2 can be used to sensitively evaluate early pathological changes in sarcopenia. The successful construction of a sarcopenia rat model can be assessed when PDFF exceeds 1.25, R2* exceeds 53.85, and T2 exceeds 33.88.

|||||||||| Journal: Dietary protein intake and changes in muscle mass measurements in community-dwelling middle-aged and older adults: A prospective cohort study. (Pubmed Central) - Nov 27, 2023
P=N/A
The successful construction of a sarcopenia rat model can be assessed when PDFF exceeds 1.25, R2* exceeds 53.85, and T2 exceeds 33.88. Higher dietary protein intake, regardless of animal or plant sources, is associated with less muscle loss and a lower prevalence of sarcopenia in middle-aged and older Chinese, particularly women.

|||||||||| Biomarker, Journal: Predictive Value of CT Biomarkers in Lung Transplantation Survival: Preliminary Investigation in a Diverse, Underserved, Urban Population. (Pubmed Central) - Nov 27, 2023
Pre-transplantation CT biomarkers had predictive value in lung transplant survival and varied by sex. The absence of sarcopenia in women, lower visceral fat attenuation and area in men, and higher vertebral body density in both sexes predicted survival in our diverse, urban population.

|||||||||| Journal: Cullin-3 intervenes in muscle atrophy in the elderly by mediating the degradation of nAchRs ubiquitination. (Pubmed Central) - Nov 27, 2023
Taken together, Cul3 may mediate the ubiquitination degradation of nAChRs protein at the NMJ site in aged mice, leading to NMJ degeneration and accelerated atrophy of fast-twitch muscle fibers in aged muscle. As a prominent element to maintain the stability of NMJ, Cul3 is supposed to be one of candidate intervention targets in sarcopenia.

|||||||||| Retrospective data, Review, Journal: Association of sarcopenia with oncologic outcomes of primary treatment among patients with oral cavity cancer: A systematic review and meta-analysis. (Pubmed Central) - Nov 27, 2023
Over one-third of oral cavity cancer patients may present with sarcopenia. Pre-treatment sarcopenia is associated with significantly worse overall and disease-free survival.

|||||||||| Review, Journal: Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors. (Pubmed Central) - Nov 27, 2023
Therefore, this review emphasizes the interplay between genetic and environmental factors, elucidating their cumulative role in exacerbating the progression of sarcopenia beyond their individual effects. The unique contribution of this review lies in synthesizing the latest evidence on the genetic factors and their interaction with environmental factors, aiming to inform the development of novel therapeutic or preventive interventions for sarcopenia.

|||||||||| Journal, Metastases: Different computed tomography parameters for defining myosteatosis in patients with advanced non-small cell lung cancer. (Pubmed Central) - Nov 27, 2023
Both SMD-defined and IMAT-defined myosteatosis are highly prevalent in patients with advanced NSCLC and may serve as independent prognostic factors for OS. The diagnosis of myosteatosis might consider a combination of low SMD and high IMAT because this would help identify patients at a higher risk of mortality.

|||||||||| Journal: The potential use of perioperative rectus femoris ultrasonography in guiding prehabilitation strategies. (Pubmed Central) - Nov 27, 2023
The diagnosis of myosteatosis might consider a combination of low SMD and high IMAT because this would help identify patients at a higher risk of mortality. No abstract available

|||||||||| Review, Journal: Sodium-glucose co-transporter 2 inhibitors and Sarcopenia: A (Pubmed Central) - Nov 27, 2023
In this systematic review, we extensively reviewed the experimental and clinical studies regarding the impact of SGLT2i on muscle mass and related metabolic alterations. Importantly, studies are heterogeneous and there is unmet need to highlight the alterations in muscle during SGLT2i use.

|||||||||| Journal: Does Botulinum Toxin Injection Exacerbate Sarcopenia and Bone Mass in Individuals With Cerebral Palsy? (Pubmed Central) - Nov 27, 2023
Importantly, studies are heterogeneous and there is unmet need to highlight the alterations in muscle during SGLT2i use. The present study showed that BoNT does not exacerbate sarcopenia and low bone mass in individuals with spastic CP.

|||||||||| Journal: Clinical validation of SARC-F by proxy as a practical tool to evaluate sarcopenia in dependent older adults. (Pubmed Central) - Nov 27, 2023
Our results suggest that it can be used instead of standard SARC-F to screen sarcopenia in older patients with communication problems. Further validation studies in different populations are warranted to support our findings.



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