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|||||||||| Review, Journal: Sarcopenic Obesity Phenotypes in Patients With HIV: Implications for Cardiovascular Prevention and Rehabilitation. (Pubmed Central) - Dec 4, 2023
There was a large variability in incidence and prevalence of SO phenotypes. The presence of SO may have important implications for cardiovascular prevention and cardiac rehabilitation of PWH who suffered events.

|||||||||| Review, Journal: The use of non-invasive imaging modalities for the assessment of skeletal muscle quantity and quality in people with HIV: A narrative review. (Pubmed Central) - Dec 4, 2023
The use of non-invasive imaging techniques to evaluate skeletal muscle, such as dual X-ray absorptiometry, computer tomography and magnetic resonance imaging, has increased in popularity in recent years. This narrative review synthesizes the use of these techniques and summarizes the associations between outcomes from these imaging modalities and physical function in PWH.

|||||||||| Journal: Analysis of Risk Factors for Heart Failure with Preserved Ejection Fraction and Observations on Blood Lipid Metabolism. (Pubmed Central) - Dec 4, 2023
Age, sex, sarcopenia, and lipid levels emerge as independent factors contributing to the onset of HFpEF. Moreover, HFpEF patients manifest apparent irregularities in blood lipid metabolism.

|||||||||| Journal: Gripwise (Pubmed Central) - Dec 4, 2023
The correlation of the Gripwise with the Jamar was confirmed in aged inpatients. However, lower values recorded with the Gripwise require alternate cutoffs for a relevant low HGS diagnosis.

|||||||||| Journal: Predicting slow walking speed from a pooled cohort analysis: sarcopenia definitions, agreement and prevalence in Australia and New Zealand. (Pubmed Central) - Dec 4, 2023
Grip strength is the primary discriminating characteristic for slow walking speed in ANZ women and men, consistent with findings from the SDOC. Sarcopenia Definitions and Outcomes Consortium and EWGSOP2 definitions showed no agreement suggesting these proposed definitions measure different characteristics and identify people with sarcopenia differently.

|||||||||| Journal: Application of progressive resistance exercise in elderly patients with type 2 diabetes mellitus complicated with sarcopenia. (Pubmed Central) - Dec 4, 2023
Sarcopenia Definitions and Outcomes Consortium and EWGSOP2 definitions showed no agreement suggesting these proposed definitions measure different characteristics and identify people with sarcopenia differently. No abstract available

|||||||||| Journal: Prevalence and factors influencing slow gait speed among geriatric patients at outpatient clinic of a tertiary care hospital. (Pubmed Central) - Dec 4, 2023
Increasing age, presence of CVA, and cognitive decline were associated with slow GS. Interventions concentrating on the amendable factors might help to reduce unfavorable health consequences.

|||||||||| Review, Journal: Ubiquitin-proteasome pathway in skeletal muscle atrophy. (Pubmed Central) - Dec 4, 2023
Furthermore, by drawing from recent scholarly advancements, we draw associations between the ubiquitin-proteasome pathway and specific pathological conditions linked to muscle atrophy. Our exploration seeks to shed light on the ubiquitin-proteasome pathway's significance in skeletal muscle dynamics, aiming to pave the way for innovative therapeutic strategies against muscle atrophy and affiliated muscle disorders.

|||||||||| Journal: Communications to the International Sarcopenia Translational Research Conference 2023. (Pubmed Central) - Dec 4, 2023
Our exploration seeks to shed light on the ubiquitin-proteasome pathway's significance in skeletal muscle dynamics, aiming to pave the way for innovative therapeutic strategies against muscle atrophy and affiliated muscle disorders. No abstract available

|||||||||| Journal: Validation of SARC-F-Proxy for the Screening of Sarcopenia in Older Patients with Cognitive Impairment. (Pubmed Central) - Dec 4, 2023
the proxy-reported SARC-F questionnaire can be applied as a surrogate for the SARC-F in the screening of sarcopenia in hospitalised community-dwelling older people with known or suspected cognitive impairment. Second, the results in this study suggest a higher reliability when the proxy-reported questionnaire is performed by the formal caregiver.

|||||||||| Observational data, Retrospective data, Journal: The diagnostic cut-off points for components of sarcopenia in Finnish Caucasian women: A retrospective cross-sectional study. (Pubmed Central) - Dec 4, 2023
The distributions of GS and QS were statistically significantly different between REFERENCE and all OSTPRE measurement points (p<0.001 in Chi-squared). The diagnostic cut-offs for components of sarcopenia are RSMI 5.1 kg/m, grip strength 26.4 kg, and quadriceps strength 29.8 kg in Finnish Caucasian women.

|||||||||| Journal: Muscle quality an evolving concept. (Pubmed Central) - Dec 4, 2023
Biological and adaptative changes to ageing must be considered when interpretation of muscle quality assessment is done in a clinical or research context. One of the conditions that requires an adequate homologation in terminology is sarcopenia, to establish definition and cut-off points.

|||||||||| Journal: Addressing the Main Barrier to Sarcopenia Identification: Utility of Practical Office-Based Bioimpedance Tools Vs. Dual Energy X-ray Absorptiometry (DXA) Body Composition for Identification of Low Muscle Mass in Older Adults. (Pubmed Central) - Dec 4, 2023
Low cost, readily available, direct-to-consumer BIA BC scales, especially with hand sensors, provide immediate, reliable information on muscle and fat mass. This can prompt appropriate investigation and/or intervention for sarcopenia or sarcopenic obesity.

|||||||||| Observational data, Journal: Co-existence of malnutrition and sarcopenia and its related factors in a long-term nursing care facility: A cross-sectional study. (Pubmed Central) - Dec 4, 2023
Of particular note, potentially inappropriate medication was an independent factor in the multivariate analysis. Co-MS is prevalent in long-term nursing care facilities; thus, healthcare workers should pay attention to relevant factors to identify patients at risk of co-MS and to provide appropriate care and intervention.

|||||||||| Trial completion, Trial completion date: Impact of Fish Oil Dose on Tissue Content and Function (clinicaltrials.gov) - Dec 4, 2023
P=N/A, N=28, Completed, Sponsor: University of Stirling
Co-MS is prevalent in long-term nursing care facilities; thus, healthcare workers should pay attention to relevant factors to identify patients at risk of co-MS and to provide appropriate care and intervention. Active, not recruiting --> Completed | Trial completion date: Feb 2024 --> Jun 2023

|||||||||| Trial completion date, Trial primary completion date: Muscular Deficits of Diabetic Myopathy (clinicaltrials.gov) - Dec 4, 2023
P=N/A, N=108, Recruiting, Sponsor: University of Aarhus
Active, not recruiting --> Completed | Trial completion date: Feb 2024 --> Jun 2023 Trial completion date: Nov 2024 --> Dec 2025 | Trial primary completion date: Nov 2024 --> Sep 2025

||||||||||  Prolia (denosumab) / Amgen
New P3 trial:  Clinical Controlled Study on the Efficacy of Denosumab in Treating Osteoporosis in the Domestic Population and Its Impact on Sarcopenia-related Outcomes (clinicaltrials.gov) -  Dec 3, 2023
P3, N=86, Not yet recruiting,  Sponsor: Wuhan Union Hospital, China
Trial completion date: Nov 2024 --> Dec 2025 | Trial primary completion date: Nov 2024 --> Sep 2025 .

|||||||||| Journal, Causal relationship: The causal relationship between sarcopenic obesity factors and benign prostate hyperplasia. (Pubmed Central) - Dec 3, 2023
BMR and ALM are risk factors for BPH. The decrease in BMR and ALM signified the onset and progression of SO, thus SO is a protective factor for BPH.

|||||||||| Journal: Editorial: (Osteo)sarcopenia & sarcopenic obesity, volume II. (Pubmed Central) - Dec 3, 2023
The decrease in BMR and ALM signified the onset and progression of SO, thus SO is a protective factor for BPH. No abstract available

|||||||||| Journal: Indices of sarcopenic obesity are important predictors of finite element analysis-derived bone strength in older adults with obesity. (Pubmed Central) - Dec 3, 2023
These findings demonstrate that lower muscle mass and strength and higher fat mass may impair bone quality. Therefore, interventions that focus on preserving muscle mass and strength while reducing fat mass may be important to decrease fracture risk when older adults with obesity undertake lifestyle intervention therapy.

|||||||||| Observational data, Journal: Triglyceride to high-density lipoprotein cholesterol ratio was negatively associated with relative grip strength in older adults: a cross-sectional study of the NHANES database. (Pubmed Central) - Dec 3, 2023
Furthermore, the increased TG/HDL-C ratio was also related to the decreased relative grip strength in those who were women, not having DM, and having CVD (all p?<?0.05). With the increase in the TG/HDL-C ratio, the relative grip strength of older adults decreased significantly, indicating that the TG/HDL-C ratio could be closely monitored in the older adult population and may be associated with the prevention and control of sarcopenia.

|||||||||| Journal: Editorial: Sarcopenia and frailty: the role of physical activity for better aging. (Pubmed Central) - Dec 3, 2023
With the increase in the TG/HDL-C ratio, the relative grip strength of older adults decreased significantly, indicating that the TG/HDL-C ratio could be closely monitored in the older adult population and may be associated with the prevention and control of sarcopenia. No abstract available

|||||||||| Journal: The impact of obesity on static and proactive balance and gait patterns in sarcopenic older adults: an analytical cross-sectional investigation. (Pubmed Central) - Dec 3, 2023
Obesity induces added complexities for older adults with sarcopenia, particularly during the regulation of steady-state and proactive balance and gait. The percentage of lean body mass has emerged as a crucial determinant, highlighting a significant impact of reduced muscle mass on the observed alterations in static postural control and gait among older adults with SO.

|||||||||| Journal: Research progress on the predictive role of sarcopenia in the course and prognosis of inflammatory bowel disease. (Pubmed Central) - Dec 3, 2023
Furthermore, there is a scarcity of studies establishing the precise criteria for diagnosing sarcopenia in these patients. This article summarizes the evaluation of sarcopenia and its recent advancements in predicting the course and prognosis of IBD.

|||||||||| Journal: Diabetes mellitus, malnutrition, and sarcopenia: The bond is not explained by bioelectrical impedance analysis in older adults. (Pubmed Central) - Dec 3, 2023
A multivariate analysis highlighted that LDL (coefficient -0.006, p=0.01) was negatively associated, while bone mass (coefficient 0.498, p=0.0042) was positively associated with DM uncontrol. Our study shows that BIA may not be the ideal tool for distinguishing between elderly individuals with and without DM, as it can be affected by numerous covariates, including potential differences in glucometabolic and cardiovascular control.

|||||||||| Journal: A bidirectional Mendelian randomization study of sarcopenia-related traits and inflammatory bowel diseases. (Pubmed Central) - Dec 3, 2023
In addition, genetically predicted usual walking pace may reduce the risk of Crohn's disease. These findings have clinical implications for sarcopenia and inflammatory bowel disease management.

|||||||||| Journal: Physical Activity Mediates the Relationship Between Sarcopenia and Cognitive Function Among Older Adults in Nursing Homes. (Pubmed Central) - Dec 3, 2023
The results of the study suggest physical activity may partially buffer the adverse effects of sarcopenia on cognitive impairment among the older adults in nursing homes. Accordingly, engagement in physical activity can help to preserve cognitive function among those with sarcopenia.

|||||||||| Journal: Geriatric Services Hub - A Collaborative Frailty Management Model between The Hospital and Community Providers. (Pubmed Central) - Dec 1, 2023
The GSH programme demonstrates a new local model of partnering with community service providers to bring comprehensive population level frailty screening and interventions to pre-frail and frail older adults. Our study found high rates of frailty, sarcopenia and fear of falling in community-dwelling older adults who were not presently known to geriatric care services.

|||||||||| Retrospective data, Review, Journal: The Effect of Sarcopenia on Postoperative Outcomes Following Emergency Laparotomy: A Systematic Review and Meta-Analysis. (Pubmed Central) - Dec 1, 2023
Sarcopenia predicts poor outcomes following emergency laparotomy. We suggest assessment of sarcopenia should be incorporated into acute surgical assessment to identify high risk patients and inform clinical decision-making prior to an emergency laparotomy.

|||||||||| Journal: The Association of Bone Turnover Markers with Muscle Function, Falls, and Frailty in Older Women in Long-Term Care. (Pubmed Central) - Dec 1, 2023
In older women residing in LTC facilities, CTX was associated with gait speed, falls history, and frail phenotype, whereas P1NP was only associated with frail phenotype. These findings suggest a relationship between bone remodeling and muscle function.

|||||||||| Journal: Strengthening Muscle Health of Community-Dwelling Older Adults in Singapore: Evidence Towards Clinical Implementation. (Pubmed Central) - Dec 1, 2023
Further high-quality research on interventions and their outcomes is important to determine the optimal strategy in different patient populations and to demonstrate clinical significance and value of addressing sarcopenia. Having local champions within healthcare institution would facilitate the much-needed change in healthcare culture where muscle health is a part of routine clinical practice.

|||||||||| Journal: Changes in Lower Extremity Muscle Quantity and Quality in Patients with Subacute Stroke. (Pubmed Central) - Dec 1, 2023
Only paretic VL and GCM muscle quality changed in subacute stroke patients and muscle's property related to lower limb functions. Therefore, the lower extremity requires an approach to muscle quality rather than quantity for subacute stroke patients.

|||||||||| Journal: Decreased serum musclin concentration is independently associated with the high prevalence of sarcopenia in Chinese middle-elderly patients with type 2 diabetes mellitus. (Pubmed Central) - Dec 1, 2023
Therefore, the lower extremity requires an approach to muscle quality rather than quantity for subacute stroke patients. The serum musclin concentration is an independent protective factor for sarcopenia in Chinese middle-elderly patients with type 2 diabetes mellitus.

|||||||||| Review, Journal: Frailty and sarcopenia: A bibliometric analysis of their association and potential targets for intervention. (Pubmed Central) - Nov 30, 2023
Their pathogenesis involved cellular aging and endocrine metabolism regulation pathways, including AMPK, cell senescence, and the endocrine resistance pathway. This study identified an intimate correlation between frailty and sarcopenia in pathogenesis, prevention, and treatment measures, establishing a foundation for exploring shared prevention and treatment strategies for these two disorders.

|||||||||| Journal: Impact of Sarcopenia on Survival of Patients With Malignant Salivary Glands Tumors. (Pubmed Central) - Nov 30, 2023
The early detection of sarcopenia in patients with negative prognostic factors could be used to implement the support therapeutic strategies aimed at restore the clinical conditions of the patients. Sarcopenia may be routinely investigated before surgery to suggest the implementation of precautionary therapeutic strategies to improve the standard treatment response, reducing possible complications.

|||||||||| Retrospective data, Review, Journal: Is moderate resistance training adequate for older adults with sarcopenia? A systematic review and network meta-analysis of RCTs. (Pubmed Central) - Nov 30, 2023
MVRT had greater benefits on muscle mass, lower extremity strength, and physical performance compared to MRT. Increasing RT intensity may be recommended for sarcopenic older adults.

|||||||||| Enrollment closed, Trial completion date, Trial primary completion date: Mi-HIIT: Assessing the Impact of Age, and a Short-term High-intensity Interval Training (HIIT) on Skeletal Muscle Mass and Mitochondrial Activity (clinicaltrials.gov) - Nov 30, 2023
P=N/A, N=32, Active, not recruiting, Sponsor: University of Nottingham
Increasing RT intensity may be recommended for sarcopenic older adults. Recruiting --> Active, not recruiting | Trial completion date: Jul 2023 --> Mar 2024 | Trial primary completion date: Jul 2023 --> Dec 2023

|||||||||| Journal: Body composition in male lifelong trained strength, sprint and endurance athletes and healthy age-matched controls. (Pubmed Central) - Nov 30, 2023
This is achieved in strength athletes by emphasizing muscle mass, while sprint and endurance athletes demonstrate low fat mass levels. However, all older athlete groups showed higher fat mass than the young groups, suggesting that exercise alone may not be sufficient to manage fat mass.

|||||||||| Journal: Influence of sarcopenia on postoperative complications in patients undergoing autologous microsurgical breast reconstruction: an inverse probability of treatment weighting analysis. (Pubmed Central) - Nov 30, 2023
However, after IPTW adjustment, the rates of recipient site infection and hematoma were significantly higher in participants with sarcopenia than in those without sarcopenia (p < 0.001 and p = 0.014, respectively). Preoperative sarcopenia may influence certain complications of autologous free-flap breast reconstruction surgery.

|||||||||| Journal, Metastases: Liver Disease-Related Sarcopenia: A Predictor of Poor Prognosis by Accelerating Hepatic Decompensation in Advanced Chronic Liver Disease. (Pubmed Central) - Nov 30, 2023
Conclusions In ACLD, both portal hypertension and liver disease-related sarcopenia were found to occur at ?4 kPa. Sarcopenia was accompanied by mildly decreased sodium levels and contributed to the early development of ascites and poor prognosis, independent of liver function.

|||||||||| Retrospective data, Journal: The relationship between skeletal muscle mass to visceral fat area ratio and metabolic dysfunction-associated fatty liver disease subtypes in middle-aged and elderly population: a single-center retrospective study. (Pubmed Central) - Nov 30, 2023
The lowest quartile of SVR also increases the risk of MAFLD fibrosis in both males and females. Our study concluded that a decrease in SVR (appendicular skeletal muscle mass divided by visceral fat area) is significantly associated with an increased prevalence of developing MAFLD subtypes and liver fibrosis in middle-aged and older persons of both genders.

|||||||||| Journal: Factors associated with osteoarthritis in menopausal women: A registry study of osteoporosis sarcopenia and osteoarthritis. (Pubmed Central) - Nov 30, 2023
Knee osteoarthritis was associated with lumbar spine bone density. This study provides the initial information required to develop clinical algorithms for the early identification of potential high-risk populations, as well as essential information for the development of policies for the detection and prevention of osteoarthritis in menopausal women.

|||||||||| Review, Journal: Targeting Epigenetic Regulators with HDAC and BET Inhibitors to Modulate Muscle Wasting. (Pubmed Central) - Nov 29, 2023
Thus, epigenetic drugs targeting HDACs and BET proteins may emerge as promising strategies to reverse the catabolic phenotype associated with cachexia and sarcopenia. Further preclinical studies are warranted to delve deeper into the molecular mechanisms associated with the functions of HDACs and BET proteins in muscle atrophy and to establish whether their epigenetic inhibitors represent a prospective therapeutic avenue to alleviate muscle wasting.

|||||||||| Review, Journal: The Molecular Role of Polyamines in Age-Related Diseases: An Update. (Pubmed Central) - Nov 29, 2023
In this review, we provide a new perspective on the participation of Pas in the cellular and molecular processes related to age-related diseases, focusing our attention on important degenerative diseases such as Alzheimer?s disease, Parkinson?s disease, osteoarthritis, sarcopenia, and osteoporosis. This new perspective leads us to propose that Pas function as novel biomarkers for age-related diseases, with the main purpose of achieving new molecular alternatives for healthier aging.

|||||||||| Journal: Minimal Detectable Changes in the Five Times Sit-to-Stand Test in Older Japanese Adults with Sarcopenia Requiring Long-Term Care. (Pubmed Central) - Nov 29, 2023
Despite the limitation of the data being only from this study population, we found that a change of ?3.12 s or ?24.0% in the FTSST of older adults with sarcopenia was clinically meaningful and may help to determine the effectiveness of sarcopenia treatment. The improvement or decline in older Japanese adults with sarcopenia should be determined by changes in the FTSST over a longer period of time than that for other conditions.

|||||||||| Journal: Vitamin D3 Exerts Beneficial Effects on C2C12 Myotubes through Activation of the Vitamin D Receptor (VDR)/Sirtuins (SIRT)1/3 Axis. (Pubmed Central) - Nov 29, 2023
significantly reduced the mtDNA copy number in the C2C12 myotube, whereas the presence of 1,25VD3 effectively prevented this decrease. These results support that 1,25VD3 could serve as a potential preventive or therapeutic agent against age-related muscle atrophy by enhancing the VDR/SIRT1/SIRT3 axis.

|||||||||| Observational data, Journal: Relationship between Hydration Status and Muscle Catabolism in the Aged Population: A Cross-Sectional Study. (Pubmed Central) - Nov 29, 2023
These results support that 1,25VD3 could serve as a potential preventive or therapeutic agent against age-related muscle atrophy by enhancing the VDR/SIRT1/SIRT3 axis. Dehydration is a highly prevalent clinical condition in aged populations, increases with age, and is associated with muscle catabolism but not sarcopenia.

|||||||||| Retrospective data, Review, Journal: Long-term impact of sarcopenia in older patients undergoing gastrectomy for gastric cancer: a systematic review and meta-analysis. (Pubmed Central) - Nov 29, 2023
Preoperative evaluation and intervention for skeletal muscle loss should be considered. Further studies of sarcopenic impact on disease-related survival are required.

|||||||||| Review, Journal: Muscle-bone crosstalk via endocrine signals and potential targets for osteosarcopenia-related fracture. (Pubmed Central) - Nov 29, 2023
However, no pharmacological agent is available to treat fracture patients with osteosarcopenia. This review summarizes the role of several myokines and osteokines in the development and treatment of osteosacropenia and fracture, as well as discusses their potential as intervention targets for osteosarcopenia-related fracture, which provides a novel and promising strategy for future osteosarcopenia-related fracture treatment.

|||||||||| Journal: Correlation between MRI-based spinal muscle parameters and the vertebral bone quality score in lumbar fusion patients. (Pubmed Central) - Nov 29, 2023
This review summarizes the role of several myokines and osteokines in the development and treatment of osteosacropenia and fracture, as well as discusses their potential as intervention targets for osteosarcopenia-related fracture, which provides a novel and promising strategy for future osteosarcopenia-related fracture treatment. After adjusting for age and BMI, a significant negative correlation was seen between the VBQ score and psoas FCSA at L3 (?



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