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17 Mechanisms of Action |
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- | Journal: Higher systemic immune-inflammation index is associated with sarcopenia in individuals aged 18-59 (Pubmed Central) - Dec 13, 2023
There was a significant positive linear relationship between SII and sarcopenia, indicating that higher SII values can increase the risk of sarcopenia in individuals aged 18-59 in the United States. The findings of this study will be beneficial in promoting the use of SII alone or in combination with other tools for the risk screening of sarcopenia in communities or large populations.
- | Journal, Surgery: Prognostic significance of Ishii's sarcopenia screening score for patients undergoing curative surgery for obstructive colorectal cancer after intraluminal decompression. (Pubmed Central) - Dec 13, 2023
The findings of this study will be beneficial in promoting the use of SII alone or in combination with other tools for the risk screening of sarcopenia in communities or large populations. A high Ishii's score was independently associated with poorer TTR in patients with non-metastatic OCRC.
- | Journal: Psoas muscle mass index and peak expiratory flow as measures of sarcopenia: relation to outcomes of elderly patients with resectable esophageal cancer. (Pubmed Central) - Dec 13, 2023
Sarcopenia was identified as an unfavorable prognostic factor for overall survival, with a hazard ratio of 1.51 (P < 0.05). Preoperative sarcopenia diagnosed by psoas muscle mass index
- | Journal: Coexistence of sarcopenia and self-reported weight loss is a powerful predictor of mortality in older patients with heart failure. (Pubmed Central) - Dec 13, 2023
The coexistence of sarcopenia and self-reported weight loss is a powerful predictor of mortality in HF patients. Geriatr Gerontol Int 2023;
- | Journal: Dynamic elevation of aromatic amino acids in Hepatitis C Virus induced cirrhosis after a standard meal. (Pubmed Central) - Dec 13, 2023
This impairment correlates with porto-systemic shunting. Further evaluation of AAA in compensated liver disease might further the understanding of the liver-muscle- axis and the role it may play in development of sarcopenia in liver disease.
- || Retrospective data, Review, Journal: Sarcopenia is a risk factor for post-transjugular intrahepatic portosystemic shunt hepatic encephalopathy and mortality: A systematic review and meta-analysis. (Pubmed Central) - Dec 12, 2023
Presence of sarcopenia should be considered when weighing the risks and benefits of performing TIPS in patients with cirrhosis. Further studies are needed to determine the clinical utility of important risk factors such as sarcopenia on post-TIPS outcomes.
- || Retrospective data, Review, Journal: Are sarcopenia and its individual components linked to all-cause mortality in heart failure? A systematic review and meta-analysis. (Pubmed Central) - Dec 12, 2023
Further studies are needed to determine the clinical utility of important risk factors such as sarcopenia on post-TIPS outcomes. Compared to patients with
- | New trial: Radiological Evaluation of Sarcopenia in Patient Received Chemotherapy (clinicaltrials.gov) - Dec 12, 2023
P=N/A, N=72, Not yet recruiting, Sponsor: Assiut University
- | Enrollment open: Evaluation of Sarcopenia in Patients Receiving Home Health Care (clinicaltrials.gov) - Dec 12, 2023
P=N/A, N=120, Recruiting, Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Compared to patients with Not yet recruiting --> Recruiting
- | Journal: Gender Differences in the Association Between Sarcopenia and Depressive Symptoms Among Community-Dwelling Older People in a Chinese Suburban Area. (Pubmed Central) - Dec 11, 2023
Our study found that sarcopenia and its diagnostic elements were significantly associated with depressive symptoms in men or women. Interventions for muscle mass and physical performance are necessary for sarcopenia to prevent the development of depressive symptoms timely.
- | Journal: Associations of sarcopenia, sarcopenia parameters and motoric cognitive risk syndrome in Chinese older adults. (Pubmed Central) - Dec 11, 2023
Sarcopenia, lower HGS, and higher FTSSTT are associated with MCR among older adults in China, while the latter two exhibit a dose-response relationship with MCR. It is suggested that timely identification and management of sarcopenia and its parameters may help delay the progression of cognitive impairment and promote healthy aging.
- || Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Review, Journal, HEOR: Factors Affecting and Promoting Health-related Quality of Life in Patients With Liver Cirrhosis: An Underestimated Domain in Patient Care. (Pubmed Central) - Dec 11, 2023
The present study recommends more prospective or randomized control trials with interventions including health education, yoga, psychotherapy, and other potential factors promoting HRQoL in patients with liver cirrhosis. The present study also emphasizes that the treating physician should consider taking HRQoL into account when prescribing medical therapy.
- | Observational data, Journal: Association between the sarcopenia index and abnormal liver function in the adult population in the United States: a cross-sectional study. (Pubmed Central) - Dec 11, 2023
Moreover, in the gender-stratified subgroup analysis, after meticulous adjustment for confounding factors, notable differences in this association emerged (males: OR?=?0.8, 95% CI: 0.66-0.98; females: OR?=?0.61, 95% CI: 0.47-0.79). This cross-sectional study yields robust evidence indicating a negative correlation between the sarcopenia index and abnormal liver function, predominantly observed among females.
- | Journal: Effects of nutritional supplementation stabilizing muscle mass loss in older patients on hemodiafiltration. (Pubmed Central) - Dec 11, 2023
This cross-sectional study yields robust evidence indicating a negative correlation between the sarcopenia index and abnormal liver function, predominantly observed among females. Nutritional supplementation in older and malnourished individuals undergoing hemodiafiltration mitigates the loss of the SMM index and benefits survival rate.
- | Journal: The relationships between sarcopenia, frailty, bioelectrical impedance analysis, and anthropometry in patients with type two intestinal failure. (Pubmed Central) - Dec 11, 2023
We demonstrated SARC-F is correlated with PA and HGS with comparable sensitivity and specificity to its original use in older individuals. There is a role for SARC-F as a means of rapidly assessing muscle quality and function in hospitalised patients with IF with RCFS providing some useful information about muscle function.
- | Journal: Osteosarcopenia later in life: Prevalence and associated risk factors. (Pubmed Central) - Dec 11, 2023
The risk factors associated with the two outcomes were malnutrition and potassium level, as well as other risk factors, such as alcohol consumption and low vitamin D level. These findings may contribute to the prevention or treatment of this health condition in older adults.
- | Journal: Establishment of a quantitative assessment model and web-based calculation tool for the skeletal muscle index in children. (Pubmed Central) - Dec 11, 2023
We established a quantitative assessment model for SMI and validated the model's generalizability and clinical usefulness. We generated an easy-to-use calculation tool for Z-scores from skeletal muscle area obtained from computed tomography images, age, and height information; it has been made publicly available (http://square.umin.ac.jp/ped-muscle-calc/index.html).
- ||| Retrospective data, Review, Journal, Adverse events: Prevalence of sarcopenic obesity in patients with diabetes and adverse outcomes: A systematic review and meta-analysis. (Pubmed Central) - Dec 11, 2023
The systematic review and meta-analysis revealed a prevalence of 27% for SO in patients with diabetes, and it is associated with potential serious adverse outcomes. Therefore, we should attach importance to the screening of SO in patients with diabetes and early detection of susceptible groups, then selecting appropriate interventions to reduce the occurrence of it and various adverse outcomes in this demographic.
- | Observational data, Journal: Association between dietary knowledge and muscle mass in Chinese older adults: a cross-sectional and longitudinal study. (Pubmed Central) - Dec 11, 2023
Therefore, we should attach importance to the screening of SO in patients with diabetes and early detection of susceptible groups, then selecting appropriate interventions to reduce the occurrence of it and various adverse outcomes in this demographic. Sufficient dietary knowledge may play a protective role in maintaining normal muscle mass in Chinese adults aged 60 or above.
- | Journal: Perioperative Strategy of Fluid and Nutrition in the Compromised Patients After Lung Resection (Pubmed Central) - Dec 11, 2023
In addition, along with the increasing number of the elderly patients, particular concerns must be given to the patients with the sarcopenia or frailty. The appropriate nutritional support following lung surgery is necessary to reduce surgical morbidity and morbidity especially for the malnourished and elderly patients.
- | Journal: Frailty Syndrome and sarcopenia in older adults with and without type 2 diabetes mellitus in the municipality of Sinop, Mato Grosso: an epidemiological study. (Pubmed Central) - Dec 11, 2023
The appropriate nutritional support following lung surgery is necessary to reduce surgical morbidity and morbidity especially for the malnourished and elderly patients. older adults with diabetes have a higher vulnerability to develop Frailty Syndrome, necessitating the adoption of preventive measures in primary healthcare.
- | Journal: Heart Failure and Sarcopenia: What is in between? (Pubmed Central) - Dec 11, 2023
older adults with diabetes have a higher vulnerability to develop Frailty Syndrome, necessitating the adoption of preventive measures in primary healthcare. No abstract available
- | Journal, HEOR: Assessment of the components of sarcopenia and quality of life perceived of individuals on hemodialysis. (Pubmed Central) - Dec 11, 2023
No abstract available sarcopenia was expressive, and the aspects of functionality determine the physical impairment in this population.
- | Journal: Development and validation of a rapid sarcopenia screening questionnaire: The Otassha study. (Pubmed Central) - Dec 11, 2023
Rapid sarcopenia screening does not require physical function measurements, making it a useful and accessible tool among older adults to detect sarcopenia. Geriatr Gerontol Int 2023; 23: 945-950.
- | Journal: Combined ultrasound of m. quadriceps and diaphragm to determine the occurrence of sarcopenia and prolonged ventilation in a COVID-19 ICU cohort: The COVID-SARCUS trial. (Pubmed Central) - Dec 11, 2023
Geriatr Gerontol Int 2023; 23: 945-950. Muscle atrophy and decline in muscle strength appear in the earliest stages after admission to the intensive care unit and are related to functional outcome.
- | Observational data, Journal: Association of possible sarcopenia with major chronic diseases and multimorbidity among middle-aged and older adults: Findings from a national cross-sectional study in China. (Pubmed Central) - Dec 11, 2023
People with two or more chronic diseases have a greater likelihood of PSA compared with those without chronic diseases, and the association between PSA and the number of chronic diseases largely depended on sex and age. Geriatr Gerontol Int 2023; 23: 925-931.
- | Journal: Telomere length among Chinese aged 75+ years. (Pubmed Central) - Dec 11, 2023
TL was not associated with age-related diseases, frailty, and sarcopenia in this age group. TL may not be a biological marker of aging among older individuals.
- | Journal: The aspartate aminotransferase to alanine aminotransferase ratio: A novel indicator for skeletal muscle mass in Chinese community adults. (Pubmed Central) - Dec 11, 2023
TL may not be a biological marker of aging among older individuals. In general, the high AST/ALT ratio was an independent adverse indicator of the presence of LMM.
- | Journal: A Metamaterial Computational Multi-Sensor of Grip-Strength Properties with Point-of-Care Human-Computer Interaction. (Pubmed Central) - Dec 11, 2023
Two elderly female schizophrenic patients are participated in the real-time interactive point-of-care grip assessment and training for potentially sarcopenia screening. The attractive features of this advanced intelligent metamaterial computational sensing system are crucial to establish a point-of-care biomechanical platform and advancing the human-computer interactive healthcare, ultimately contributing to a global health ecosystem.
- | Journal: Coexistent GLIM-defined malnutrition and sarcopenia increase the long-term mortality risk in hospitalized patients with decompensated cirrhosis. (Pubmed Central) - Dec 11, 2023
Malnutrition and sarcopenia had superimposed negative impacts on inpatients with decompensated cirrhosis. It is imperative to identify this vulnerable subset to provide prompt therapeutic intervention for better prognosis.
- Biomarker, Clinical, Observational data, Retrospective data, Review, Journal: Explorative Clustering of the Nitrogen Balance Trajectory in Critically Ill Patients: A Preliminary post hoc Analysis of a Single-Center Prospective Observational Study. (Pubmed Central) - Dec 11, 2023
The nitrogen balance trajectory in critically ill patients may be classified into 4 classes for clinical practice. Among patients emergently admitted to the ICU, the positive conversion of the nitrogen balance might be delayed over 10 days.
- | Journal: Effectiveness of locomotion training in patients with rheumatoid arthritis: a prospective clinical trial. (Pubmed Central) - Dec 11, 2023
[Conclusion] The current study demonstrated that locomotion training for 6 months improved physical function, certain aspects of quality of life, and sarcopenia in patients with RA. We believe that locomotion training should be recommended as a non-pharmacological therapeutic option for improving physical function in patients with RA.
- | Journal: Depression and sarcopenia-related traits: A Mendelian randomization study. (Pubmed Central) - Dec 11, 2023
We believe that locomotion training should be recommended as a non-pharmacological therapeutic option for improving physical function in patients with RA. Depression was causally related to decreased muscle mass, and declined muscle strength might lead to a higher risk of depression.
- | Journal: Correlation between temporal muscle thickness and grip strength in hemiplegic patients with acute stroke. (Pubmed Central) - Dec 11, 2023
Measuring TMT using cranial MR images during the initial stages of stroke could help predict a patient's pre-stroke muscle strength status. Further studies are required to apply TMT in pre-stroke sarcopenia diagnosis.
- | Journal: Reevaluation of the Protein Requirement in Chinese Elderly Adults without Sarcopenia with the Indicator Amino Acid Oxidation Technique. (Pubmed Central) - Dec 11, 2023
Further studies are required to apply TMT in pre-stroke sarcopenia diagnosis. The RNI derived using various derivation approaches are all greater than the current RNI [0.98 g/(kg
- ||| Journal, Adverse events: Quantitative Association between Computed-Tomography-Based L1 Skeletal Muscle Indices and Major Adverse Clinical Events Following Percutaneous Coronary Intervention. (Pubmed Central) - Dec 9, 2023
In multivariable analysis, the lower L1 SMI quartiles independently predicted 3-year all-cause mortality and MACEs (lowest vs. highest quartiles, respectively: OR 4.90 (95% CI 1.54-15.5), p = 0.007; and OR 12.3 (95% CI 4.99-30.4), p < 0.001). In conclusion, CT-based L1 SMI demonstrated a distinct dose-dependent relationship with future MACEs in CAD patients undergoing percutaneous coronary intervention, thereby enhancing cardiovascular risk stratification.
- | Observational data, Journal, HEOR: Associations between N-Terminal Pro-B-Type Natriuretic Peptide, Body Fluid Imbalance and Quality of Life in Patients Undergoing Hemodialysis: A Cross-Sectional Study. (Pubmed Central) - Dec 9, 2023
The higher NT-proBNP group experienced muscle attenuation and/or inflammation and an enlarged left atrium. Consequently, the elevated NT-proBNP by such an imbalance in body fluid composition is associated with lower health-related QOL.
- | Biomarker, Journal: Sarcopenia and Mediastinal Adipose Tissue as a Prognostic Marker for Short- and Long-Term Outcomes after Primary Surgical Treatment for Lung Cancer. (Pubmed Central) - Dec 9, 2023
Sarcopenia, quantified with the skeletal muscle index, is shown to be a risk factor for postoperative morbidity and reduced survival in primary lung cancer. Efforts should be taken to pre-emptively screen for sarcopenia and start countermeasures (e.g., physical prehabilitation, protein-rich nutrition, etc.) during the preoperative workup phase.
- | Journal, Checkpoint inhibition, IO biomarker, Metastases: Association between Immune Checkpoint Inhibitor Treatment Outcomes and Body Composition Factors in Metastatic Renal Cell Carcinoma Patients. (Pubmed Central) - Dec 9, 2023
Efforts should be taken to pre-emptively screen for sarcopenia and start countermeasures (e.g., physical prehabilitation, protein-rich nutrition, etc.) during the preoperative workup phase. Sarcopenia was associated with a lower response and shorter survival rates in patients with mRCC who received first-line ICI-based therapy.
- || Review, Journal: Cancer Cachexia: New Insights and Future Directions. (Pubmed Central) - Dec 9, 2023
Thus, a better understanding of the complexity of cancer cachexia phenomena and its main pathophysiological mechanism is much needed. Our review highlights the most important information about cancer cachexia, aiming to disseminate updated research findings about this highly deadly condition.
- | Journal: Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological Outcomes. (Pubmed Central) - Dec 9, 2023
Our review highlights the most important information about cancer cachexia, aiming to disseminate updated research findings about this highly deadly condition. The evaluation of preoperative OVF is a useful prognostic factor for risk stratification and clinical decision-making for patients with CRLM.
- Pretreatment Sarcopenia Predicts Outcomes Post TACE () - Dec 9, 2023 - Abstract #SIR2024SIR_1206;
The evaluation of preoperative OVF is a useful prognostic factor for risk stratification and clinical decision-making for patients with CRLM. The presence of sarcopenia, as determined through standard pre-transarterial chemoembolization (TACE) abdominal CT scans, is correlated with mortality following TACE.
- | Journal, Video: Sit-to-Stand Video Analysis-Based App for Diagnosing Sarcopenia and Its Relationship With Health-Related Risk Factors and Frailty in Community-Dwelling Older Adults: Diagnostic Accuracy Study. (Pubmed Central) - Dec 8, 2023
P=N/A
Individuals with sarcopenia diagnosed by the app showed more odds of having health-related risk factors and frailty compared to their respective counterparts. These results highlight the potential use of this app in clinical settings.
- | Journal: Relationship between quadriceps muscle computed tomography measurement and motor function, muscle mass, and sarcopenia diagnosis. (Pubmed Central) - Dec 8, 2023
These results highlight the potential use of this app in clinical settings. In the diagnosis of sarcopenia based on skeletal muscle index, CSA (area under the curve (AUC) 0.935) and CSA
- | Journal: The prevalence of excessive daytime sleepiness and associated factors in older diabetic patients. (Pubmed Central) - Dec 8, 2023
There was a significant relationship between EDS and drug use, anticholinergic drug burden, impaired excretory functions, sarcopenia, decreased functional capacity, falls, gait-balance disorder, and cognitive dysfunction. The recognization of EDS and the implementation of interventions may be helpful in the management of geriatric syndromes.
- | Journal: The psoas muscle index as a useful predictor of total hip arthroplasty outcomes. (Pubmed Central) - Dec 8, 2023
The PMI, which is associated with nutritional status and global sagittal spinal deformity, does predict THA outcomes. Therefore, it can be useful when discussing THA expectations with patients.
- || Review, Journal, Metastases: The association of body composition on chemotherapy toxicities in non-metastatic colorectal cancer patients: a systematic review. (Pubmed Central) - Dec 7, 2023
However, quality evidence on the role of adiposity is limited and heterogeneous. More studies are needed to confirm these associations with an emphasis on a more coherent body composition definition and an approach to its assessment, especially regarding sarcopenia.
- | Journal: Enhanced serum levels of tumor necrosis factor-?, interleukin-1?, and -6 in sarcopenia: alleviation through exercise and nutrition intervention. (Pubmed Central) - Dec 7, 2023
Sarcopenic patients exhibit elevated levels of TNF-?, IL-1?, and IL-6, which declined after nutrition support and exercise interventions. However, further research is necessary to evaluate the long-term impact of these interventions on cytokine levels.
- || Review, Journal: Insights into the Notch signaling pathway in degenerative musculoskeletal disorders: Mechanisms and perspectives. (Pubmed Central) - Dec 7, 2023
The review focuses on four major degenerative musculoskeletal disorders (osteoarthritis, intervertebral disc degeneration, osteoporosis, and sarcopenia) and summarizes the pathophysiological functions of Notch signaling in these disorders, especially its role in stem/progenitor cells in each disorder. Finally, a conclusion will be presented to explore the research and application of the perspectives on Notch signaling in degenerative musculoskeletal disorders.
- | Retrospective data, Journal: Association of Sarcopenia with a Poor Prognosis and Decreased Tumor-Infiltrating CD8-Positive T Cells in Pancreatic Ductal Adenocarcinoma: A Retrospective Analysis. (Pubmed Central) - Dec 7, 2023
Finally, a conclusion will be presented to explore the research and application of the perspectives on Notch signaling in degenerative musculoskeletal disorders. No abstract available