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|||||||||| Journal, Pleural effusion: Pleural Effusion and Malnutrition Are Associated With Worse Early Outcomes After Liver Transplant. (Pubmed Central) - Jan 8, 2024
Pleural effusion was associated with worse outcomes for all clinical measures. Risk factors for the development of pleural effusion included higher MELD score (>20), re-transplantation, alcoholic liver disease, and poor nutrition status, including poor muscle mass.

|||||||||| Journal: Sarcopenia in Patients With Rectal Adenocarcinoma: An Opportunity for Preoperative Rehabilitation. (Pubmed Central) - Jan 8, 2024
Risk factors for the development of pleural effusion included higher MELD score (>20), re-transplantation, alcoholic liver disease, and poor nutrition status, including poor muscle mass. The presence of sarcopenia at diagnosis and its association with post-NACRT sarcopenia suggests an opportunity for a high-impact intervention.

|||||||||| Journal: Effect of Sarcopenia on Mortality and Morbidity in Patients With Fournier's Gangrene. (Pubmed Central) - Jan 8, 2024
The presence of sarcopenia at diagnosis and its association with post-NACRT sarcopenia suggests an opportunity for a high-impact intervention. Based on this large retrospective study, sarcopenia is a strong and independent predictor of postoperative mortality after Fournier's treatment for gangrene.

|||||||||| Journal: Assessment of lower limb muscle strength can predict fall risk in patients with chronic liver disease. (Pubmed Central) - Jan 8, 2024
This study found that decreased LMS was an independent risk factor for falls. Assessment of LMS may be used as a better marker associated with the risk of falls in patients with CLD.

|||||||||| Journal: Community-based prevalence and associated factors of sarcopenia in the Vietnamese elderly. (Pubmed Central) - Jan 8, 2024
Apart from social demographic characteristics including age, education, employment and family economic status, frailty appeared to be an important risk factor. Early screening, referral, and treatment of sarcopenia among the elderly having a high risk of sarcopenia are recommended.

|||||||||| Observational data, Journal: Association between sarcopenia and osteoarthritis among the US adults: a cross-sectional study. (Pubmed Central) - Jan 8, 2024
Subgroup analysis revealed that the association between sarcopenia and OA was more pronounced in smoker. Further well-designed prospective cohort studies are needed to assess our results.

|||||||||| Trial primary completion date: Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis (clinicaltrials.gov) - Jan 8, 2024
P=N/A, N=44, Not yet recruiting, Sponsor: University of Alabama at Birmingham
Further well-designed prospective cohort studies are needed to assess our results. Trial primary completion date: Dec 2024 --> Jun 2025

|||||||||| Journal: Leukocyte telomere length and sarcopenia-related traits: A bidirectional Mendelian randomization study. (Pubmed Central) - Jan 7, 2024
The current MR analysis supported a causal relationship between shorter telomere length and both low muscle mass and strength. Additionally, walking pace may affect LTL through T2DM.

|||||||||| Journal, Machine learning: A machine learning model for prediction of sarcopenia in patients with Parkinson's Disease. (Pubmed Central) - Jan 7, 2024
Using smartphone app and machine learning technique, our study revealed gait parameters that are associated with sarcopenia and that help predict sarcopenia in PD. Our study showed potential application of advanced technology in clinical research.

|||||||||| Effect of adipose-related parameters on survival in patients with cirrhosis: a meta-analysis () - Jan 6, 2024 - Abstract #APASL2024APASL_2422;
Our study showed potential application of advanced technology in clinical research. Different adipose parameters exhibited varying prognostic value: decreased SATI or MR, increased VSR, and concurrent myosteatosis or SO were independently associated with a higher risk of mortality in patients with cirrhosis.

|||||||||| EFFICACY OF HOME-BASED EXERCISE AND BRANCHED-CHAIN AMINO ACIDS FOR TREATMENT SARCOPENIA IN CIRRHOSIS (New Hall) - Jan 6, 2024 - Abstract #APASL2024APASL_2342;
A 12-week supervised home-based exercise program and BCAA supplementation was effective for the treatment of sarcopenia in cirrhotic patients. This intervention also resulted in an improvement in functional capacity in these patients.

|||||||||| Impacts of muscle and adipose mass on male hepatocellular carcinoma patients undergoing resection (New Hall) - Jan 6, 2024 - Abstract #APASL2024APASL_2195;
Sarcopenia, myosteatosis, and subcutaneous adiopopenia can independently predict survival in male HCC patients undergoing surgical resection. These findings help to establish surveillance and nutrition support strategies to optimize patients' outcomes.

|||||||||| Lenvima (lenvatinib) / Eisai, Merck (MSD)
Pre-Sarcopenia predicts the outcome of hepatocellular carcinoma patients with first-line Lenvatinib (New Hall) - Jan 6, 2024 - Abstract #APASL2024APASL_2084;
These findings help to establish surveillance and nutrition support strategies to optimize patients' outcomes. In clinical practice, pre?sarcopenia was shown to be a significant prognostic factor in patients treated with first-line lenvatinib for unresectable HCC.

|||||||||| Analysis of the incidence of sarcopenia among cirrhotic patients with portal hypertension (New Hall) - Jan 6, 2024 - Abstract #APASL2024APASL_2072;
In clinical practice, pre?sarcopenia was shown to be a significant prognostic factor in patients treated with first-line lenvatinib for unresectable HCC. In cirrhotic patients complicated with portal hypertension, the incidence of sarcopenia was thought to be relatively high in elderly woman without obesity, suggesting that muscle mass evaluation might be desirable.

|||||||||| The Therapeutic Strategy for Patients Developing Covert Hepatic Encephalopathy Based on Zinc Levels () - Jan 6, 2024 - Abstract #APASL2024APASL_2047;
Cirrhotic patients without a history of OHE exhibit a high risk of developing CHE if serum zinc levels are below 58 ?g/dL regardless blood ammonia levels. These patients are at a high risk of developing OHE in the short term, and early zinc supplementation are recommended for prevention of OHE development.

|||||||||| The Role of L3-Pmi in The Prognostic Evaluation of Patients with Acute-On-Chronic Liver Failure (Room 05, C-1) - Jan 6, 2024 - Abstract #APASL2024APASL_1931;
These patients are at a high risk of developing OHE in the short term, and early zinc supplementation are recommended for prevention of OHE development. L3-PMI has important clinical application value for evaluating the prognosis of ACLF patients related to hepatitis B liver cirrhosis.

|||||||||| Predictive Performance Concerning Distinct Smi Cut-offs of Sarcopenia for Mortality Among Cirrhosis (Room 04, E) - Jan 6, 2024 - Abstract #APASL2024APASL_1882;
L3-PMI has important clinical application value for evaluating the prognosis of ACLF patients related to hepatitis B liver cirrhosis. Our findings provide strong evidence to develop continent-based SMI cut-offs to identify sarcopenic cirrhotic patients, considering its prognostic importance.

|||||||||| Understanding The Current Status of Zinc DefICIency in Patients with Chronic Liver Disease (Room 04, E) - Jan 6, 2024 - Abstract #APASL2024APASL_1663;
This highlights clinicians' limited awareness. Early diagnosis and supplementation of zinc deficiency may prevent the onset and progression of sarcopenia.

|||||||||| Prevalence of sarcopenia and its related factors among patients with HCC: A meta-analysis () - Jan 6, 2024 - Abstract #APASL2024APASL_1531;
Early diagnosis and supplementation of zinc deficiency may prevent the onset and progression of sarcopenia. Sarcopenia is highly prevalent, and the prevalence of sarcopenia was linearly and independently related to the selected cutoffs for sarcopenia in HCC patients.

|||||||||| Developing a Multidisciplinary Palliative Care Model for Patients with Liver Cirrhosis (New Hall) - Jan 6, 2024 - Abstract #APASL2024APASL_1516;
A multidisciplinary palliative care model will address the physical, psychoemotional, social and spiritual domains of our patients with liver cirrhosis. More studies will be required to review the impact of this shared model of care.

|||||||||| Myosteatosis and Sarcopenic Obesity independently Predict Mortality of Patients with PBC (Room 14, I) - Jan 6, 2024 - Abstract #APASL2024APASL_1357;
More studies will be required to review the impact of this shared model of care. Myosteatosis and sarcopenic obesity were independent risk factors for mortality of PBC patients.

|||||||||| Impact of the growth hormone-insulin like growth factor on complications and prognosis in cirrhosis (New Hall) - Jan 6, 2024 - Abstract #APASL2024APASL_1328;
Reduced IGF-1 levels are associated with sarcopenia, frailty, autonomic dysfunction, increased severity, and mortality in stable decompensated cirrhosis. Modulation of GH-IGF1 axis is a potentially disease modifying target in cirrhosis.

|||||||||| Correlation between skeletal muscle mass index and NAFLD and liver fibrosis in patients with T2D (New Hall) - Jan 6, 2024 - Abstract #APASL2024APASL_1155;
Modulation of GH-IGF1 axis is a potentially disease modifying target in cirrhosis. Among patients with T2DM, the incidence of NAFLD and significantly liver fibrosis was higher in people with low ASMI%.

|||||||||| Impact of Sarcopenia on the Prognosis in Cirrhotic Patients Complicated with SBP Hye () - Jan 6, 2024 - Abstract #APASL2024APASL_1067;
Sarcopenia did not show a significant difference in initial treatment response and short-term mortality in cirrhotic patients with SBP. However, sarcopenia is more likely to affect long-term prognosis when considering the long-term mortality.

|||||||||| Sarcopenia is Associated with the Risk of Minimal Hepatic Encephalopathy in Patients with Cirrhosis (Room 7: Swan) - Jan 6, 2024 - Abstract #APASL2024APASL_1040;
However, sarcopenia is more likely to affect long-term prognosis when considering the long-term mortality. Sarcopenia is not uncommon among outpatients and is an independent risk factor for MHE in cirrhotic patients.

|||||||||| ursodeoxycholic acid / Generic mfg.
Association of Sarcopenia with Treatment Response and Outcomes in Non-Cirrhotic PBC Patients (Room 08, F) - Jan 6, 2024 - Abstract #APASL2024APASL_929;
Concomitant sarcopenia may adversely affect the biochemical responses to UDCA treatment of PBC patients without cirrhosis. However, the exact role of sarcopenia in the progression and outcomes of PBC requires further investigation.

|||||||||| Hepatic Encephalopathy After Tips in Cirrhosis and Sarcopenia: A Systematic Review and Meta-Analysis (Room 14, I) - Jan 6, 2024 - Abstract #APASL2024APASL_855;
However, the exact role of sarcopenia in the progression and outcomes of PBC requires further investigation. The study demonstrated that sarcopenia was strongly linked to an increased likelihood post-TIPS HE among cirrhotic patients.

|||||||||| Psoas Muscle-to-Spine ratio predicts overall survival in Patients with Hepatocellular Carcinoma () - Jan 6, 2024 - Abstract #APASL2024APASL_793;
The study demonstrated that sarcopenia was strongly linked to an increased likelihood post-TIPS HE among cirrhotic patients. The psoas muscle-to-spine ratio was an independent prognostic predictor for HCC patients and can be applied to the staging of patients with HCC.

|||||||||| No Impact of Sarcopenia in Prognosis of Transarterial Chemoembolization for Hepatocellular Carcinoma (Room 07, Swan) - Jan 6, 2024 - Abstract #APASL2024APASL_772;
The psoas muscle-to-spine ratio was an independent prognostic predictor for HCC patients and can be applied to the staging of patients with HCC. Our data suggest that sarcopenia has no impact on the prognosis of TACE for intermediate-stage HCC.

|||||||||| A Predictive Model to Assess Recent Recurrence After Hepatectomy for Hepatocellular Carcinoma (Room 07, Swan) - Jan 6, 2024 - Abstract #APASL2024APASL_741;
Sarcopenia is associated with recent recurrence after hepatectomy for HCC. A nutritional status-based prediction model is first established for postoperative recurrence of HCC, which is superior to other models and contributes to prognosis prediction.

|||||||||| Meld-Sarcopenia Score Predicts Short-Term Readmission of Patients with Hepatic Encephalopathy (Room 13, B-2) - Jan 6, 2024 - Abstract #APASL2024APASL_556;
A nutritional status-based prediction model is first established for postoperative recurrence of HCC, which is superior to other models and contributes to prognosis prediction. The MELD-sarcopenia score and SMD were identified as predictive factors for short-term readmission in patients diagnosed as HE.

|||||||||| Impact of Sarcopenic Obesity and Myosteatosis on Intrahepatic Cholangiocarcinoma After Surgery () - Jan 6, 2024 - Abstract #APASL2024APASL_482;

|||||||||| Dysphagia Impairs Health-Related Quality of Life in Patients with Chronic Liver Disease (Room 04, E) - Jan 6, 2024 - Abstract #APASL2024APASL_475;
Dysphagia was prevalent in approximately 10% of patients with CLD and associated with a risk of sarcopenia and malnutrition. Dysphagia screening is essential in daily practice as dysphagia impairs HRQOL in patients with CLD.

|||||||||| Prevalence of Osteosarcopenia and Liver Frailty Index (LFI) in patients with Cirrhosis (New Hall) - Jan 6, 2024 - Abstract #APASL2024APASL_473;
Early detection and timely intervention of these conditions are important to reduce the associated consequences. All patients with cirrhosis should be assessed for Osteosarcopenia and frailty both at baseline and longitudinally.

|||||||||| Sarcopenia and Covert Hepatic Encephalopathy in the Latency Period of Abnormal Ammonia Metabolism (New Hall) - Jan 6, 2024 - Abstract #APASL2024APASL_443;
All patients with cirrhosis should be assessed for Osteosarcopenia and frailty both at baseline and longitudinally. NH3 and zinc level were suggested to be possible predictors of CHE in LAM.

|||||||||| Biomarker, Journal: Deep learning-based radiomics allows for a more accurate assessment of sarcopenia as a prognostic factor in hepatocellular carcinoma. (Pubmed Central) - Jan 6, 2024
According to a "North American Expert Opinion Statement on Sarcopenia," SM index (SMI) is the preferred measure of sarcopenia (Carey et al., 2019). The variability between morphometric muscle indexes revealed that they have different clinical relevance and are generally not applicable to broader populations (Esser et al., 2019).

|||||||||| Retrospective data, Journal: Discussions Concerning the Generalist-Specialist Combination Management Model of Chronic Kidney Disease (Pubmed Central) - Jan 6, 2024
Patients with complications such as diabetes, hypertension, and sarcopenia could access treatments with better precision. It is necessary to carry out the generalist-specialist integrated management of CKD, which is worthy of further development and improvement.

|||||||||| Journal: Physical activity and nutritional status in women with rheumatoid arthritis and sarcopenic phenotype of body composition (Pubmed Central) - Jan 6, 2024
52% of women with RA had moderate ?r low PA levels, and 50% of patients were at risk of malnutrition. The risk of sarcopenic phenotype associated with a low frequency of vigorous PA, low walking time, risk of malnutrition, body mass index <25 kg/m and insufficient calcium intake.

|||||||||| Journal: Model of disease severity in alcoholic hepatitis and novel prognostic insights. (Pubmed Central) - Jan 5, 2024
Amongst consecrated prognostic models, MDF and Lille scores were representative for our study, while ABIC, GAHS and MELD-Na did not attain statistical significance. Our score is unique by the addition of CRP and this could prove to be a useful tool in AH severity stratification.

|||||||||| Journal: Sarcopenia and diabetes-induced dementia risk. (Pubmed Central) - Jan 5, 2024
Notably, the use of statins was linked to a reduced risk of dementia. This research underscores the need to identify and address modifiable risk factors for dementia in elderly type 2 diabetes mellitus patients, offering valuable insights for targeted interventions and healthcare policies.

|||||||||| bortezomib / Generic mfg., oxandrolone / Generic mfg.
Review, Journal: Persistent inflammation, immunosuppression, and catabolism syndrome (PICS): a review of definitions, potential therapies, and research priorities. (Pubmed Central) - Jan 4, 2024
Future research should focus on expanding knowledge on underlying pathophysiological mechanisms of PICS to identify and validate other potential endotypes of chronic critical illness and subsequent treatable traits. There is unlikely to be a universal treatment for PICS, and a multimodal, timely, and personalised therapeutic strategy will be needed to improve outcomes for this growing cohort of patients.

|||||||||| LOW MUSCLE MASS IS ASSOCIATED WITH LONG-TERM DISABILITY IN CRITICALLY ILL PATIENTS WITH SEPSIS () - Jan 4, 2024 - Abstract #SCCM2024SCCM_2219;
It is not independently predictive of short- or long-term (one-year) mortality, but rather with motor and functional impairment which may be exacerbated by sepsis. This information may guide the need for additional physical rehabilitation in at-risk patients, thus minimizing long-term morbidity.

|||||||||| PERSONALIZED NUTRITION IN CRITICALLY ILL OLDER ADULT TRAUMA PATIENTS () - Jan 4, 2024 - Abstract #SCCM2024SCCM_1177;
This information may guide the need for additional physical rehabilitation in at-risk patients, thus minimizing long-term morbidity. This pilot study investigates the SeND Home program

|||||||||| Journal: Editorial: Community series - reducing the burden of age-related disease in relation to osteoporosis, sarcopenia and osteosarcopenia, volume II. (Pubmed Central) - Jan 4, 2024
This pilot study investigates the SeND Home program No abstract available

|||||||||| Observational data, Journal: The prevalence, risk factors and clinical implications of dehydration in older patients: a cross-sectional study. (Pubmed Central) - Jan 4, 2024
Dehydration is common among older adults and is associated with a dependency, probable sarcopenia, and an increased risk of falling. Screening for dehydration and taking preventive measures may be beneficial in avoiding the negative consequences associated with dehydration.

|||||||||| Journal: Myosteatosis as a novel predictor of new-onset diabetes mellitus after kidney transplantation. (Pubmed Central) - Jan 4, 2024
Screening for dehydration and taking preventive measures may be beneficial in avoiding the negative consequences associated with dehydration. Myosteatosis could be a new risk factor used to predict new-onset diabetes mellitus.

|||||||||| Journal: Physical and psychological effects of outdoor fitness equipment training on middle-aged and older adults: study protocol of a randomised controlled trial. (Pubmed Central) - Jan 4, 2024
After that, sarcopenia, osteoporosis and fracture risk will be calculated. The results derived from this research will increase the knowledge of the effectiveness of OFE training for improving the health of healthy community-dwelling middle and older adults.

|||||||||| Review: Prevalence and prognostic value of baseline sarcopenia in hematologic malignancies: a systematic review. (Pubmed Central) - Jan 3, 2024
Sarcopenia has a prevalence of over 30% in malignant hematologic patients and is associated with a poorer prognosis. Future studies with a standardized sarcopenia diagnostic criterion were needed to investigate sarcopenia's prevalence and prognostic effects in hematologic malignancies.

|||||||||| Journal: Editorial: Nutrition, sarcopenia, and sarcopenic obesity. (Pubmed Central) - Jan 3, 2024
Future studies with a standardized sarcopenia diagnostic criterion were needed to investigate sarcopenia's prevalence and prognostic effects in hematologic malignancies. No abstract available

|||||||||| Journal: Familial Correlation and Heritability of Hand Grip Strength in Korean Adults (Korea National Health and Nutrition Examination Survey 2014 to 2019). (Pubmed Central) - Jan 3, 2024
HGS exhibits a familial correlation and significant heritable tendency in Korean adults. Therefore, Asian adults, especially women, who have parents with weak HGS, need to pay special attention to their muscle health with the help of healthy environmental stimuli.



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