Sarcopenia
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  • ||||||||||  Journal:  Bibliometric Analysis of Comprehensive Geriatric Assessment from 2004 to 2023. (Pubmed Central) -  Dec 16, 2024   
    Our bibliometric analysis reveals significant growth in CGA research over the past two decades, with a shift from cancer-focused studies to chronic conditions like frailty and sarcopenia. These findings highlight evolving priorities in geriatric care and underscore the need for future research to integrate technological advancements, such as AI, to enhance the precision, scalability, and cost-effectiveness of CGA in diverse settings.
  • ||||||||||  Journal:  Sarcopenia is associated with neoplasm of bone and articular cartilage: findings from Mendelian randomized study. (Pubmed Central) -  Dec 15, 2024   
    There were also no reverse causal correlation between neoplasm of bone and articular cartilage and traits related sarcopenia. Conclusions In European populations, better appendicular lean body mass is positively associated with the risk of benign neoplasm of bone and articular cartilage, representing the possibility that sarcopenia may be a protective factor against neoplasm of bone and articular cartilage.
  • ||||||||||  Preclinical, Journal:  Functional food mixture extricates D-galactose-induced skeletal muscle impairment in rats. (Pubmed Central) -  Dec 15, 2024   
    Interestingly, supplementation with the functional food mixture prevented galactose-induced alterations in the muscle. The observed anti-inflammatory, insulin-sensitizing, mitochondria-protective, and antiapoptotic effects of the functional food could be the underlying mechanisms in displaying positive effects against galactose-induced muscle atrophy and, hence, may be useful for the prevention of age-related muscle disorders.
  • ||||||||||  Biomarker, Journal:  EXPRESS: CT-BASED SARCOPENIA ASSESSMENT: PREDICTING OUTCOMES IN ACUTE INFECTION PATIENTS. (Pubmed Central) -  Dec 13, 2024   
    CT-based muscle indices serve as independent prognostic factors in medical patients admitted with acute infection. Incorporating radiological assessments of sarcopenia into routine care for hospitalized patients with acute infection may enable risk stratification and early intervention in reversible conditions.
  • ||||||||||  Review, Journal:  What do we really know about the external urethral sphincter? (Pubmed Central) -  Dec 13, 2024   
    Electromyography and Urethral Pressure Profile recordings are pivotal to understanding the function and dysfunction of the EUS and for clinical evaluation of e.g. urinary retention. Pre-clinical and clinical studies have revealed that age- or disease-related tissue remodelling that lead to filling/voiding disorders may be mitigated with emerging therapeutic approaches.
  • ||||||||||  Journal:  Association between residual cholesterol and sarcopenia in American adults. (Pubmed Central) -  Dec 13, 2024   
    The sensitivity and supplementary analyses supported the main findings. This study demonstrates a significant positive association between RC levels and the prevalence of sarcopenia in U.S. adults, offering novel evidence that RC may serve as a valuable indicator for sarcopenia assessment.
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    Preclinical, Journal:  Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibility. (Pubmed Central) -  Dec 12, 2024   
    We use a model of inducible and reversible skeletal muscle SOD2 knockdown to demonstrate that elevated matrix superoxide reversibly impairs mitochondrial substrate flexibility characterized by impaired pyruvate oxidation. Despite the bioenergetic effect, the limited change in gene expression suggests that the elevated redox stress in this model is confined to the mitochondrial matrix.
  • ||||||||||  Journal:  Sarcopenia may predict recurrence in patients with head and neck cancer. (Pubmed Central) -  Dec 12, 2024   
    Defining sarcopenia as a low skeletal muscle index at the third cervical vertebra is clinically relevant. This study demonstrates that low SMI at this level, and thus sarcopenia, was strongly associated with higher rates of recurrence.
  • ||||||||||  Journal:  Sarcopenia diagnosis using skeleton-based gait sequence and foot-pressure image datasets. (Pubmed Central) -  Dec 12, 2024   
    As a baseline evaluation, the accuracies of sarcopenia classification performance from foot-pressure image using Resnet-18 and skeleton sequences using ST-GCN were identified as 77.16 and 78.63%, respectively. The experimental results demonstrated the potential applications of sarcopenia and non-sarcopenia classifications based on foot-pressure images and skeleton sequences.
  • ||||||||||  Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Pulmonary Rehabilitation in End-Stage Liver Disease (clinicaltrials.gov) -  Dec 12, 2024   
    P=N/A,  N=4, Terminated, 
    Future research should further unpick these complex relationships. N=50 --> 4 | Trial completion date: Dec 2026 --> Dec 2024 | Recruiting --> Terminated | Trial primary completion date: Dec 2026 --> Dec 2024; difficulty recruiting
  • ||||||||||  Enrollment open:  Stress Urinary Incontinence and Sarcopenia in Postmenopausal Osteoporosis (clinicaltrials.gov) -  Dec 12, 2024   
    P=N/A,  N=100, Recruiting, 
    It is tempting to speculate that stress-induced chronic elevations of endogenous glucocorticoids also compromise human health due to the protracted augmentation of circulating DBI/ACBP concentrations. Not yet recruiting --> Recruiting