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46 Companies |
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12 Products |
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17 Mechanisms of Action |
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756 Trials |
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22406 News |
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- | New trial: LT: Efficacy of Virtual Reality Exercises on Sarcopenia in Patients With Liver Transplantation (clinicaltrials.gov) - Jan 17, 2024
P=N/A, N=60, Not yet recruiting, Sponsor: Cairo University
- | Trial completion, Reflex: The Bone-Myoregulation Reflex and Development of Sarcopenia in Osteoporosis (clinicaltrials.gov) - Jan 17, 2024
P=N/A, N=60, Completed, Sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Recruiting --> Completed
- | New trial: Sarcopenia in Head and Neck Cancer Patients Treated With Curative Hadrontherapy (clinicaltrials.gov) - Jan 16, 2024
P=N/A, N=70, Recruiting, Sponsor: CNAO National Center of Oncological Hadrontherapy
- | Observational data, Journal: Functional fitness and risk factors of older patients with diabetes combined with sarcopenia and/or frailty: A cross-sectional study. (Pubmed Central) - Jan 16, 2024
The patients in the combined group had significantly lower level of red blood cell, haemoglobin, haematocrit, and higher level of platelet and blood urea nitrogen. Apart from calf circumference, physical activity, and insulin injection treatment, 6-min walk distance was the factor associated with diabetes combined with sarcopenia and/or frailty.
- | Journal: A Pilot Study of Nutritional Supplementation in Soft Tissue Sarcoma Patients. (Pubmed Central) - Jan 16, 2024
Patients who did not receive supplementation had a significant decline in post-operative psoas index following operative sarcoma removal. Level of Evidence: III.
- | Journal: What Are the Barriers to Incorporating Nutrition Interventions Into Care of Older Adults With Femoral Fragility Fractures? (Pubmed Central) - Jan 16, 2024
Our goal is to guide future nutrition intervention research in older adults with femoral fragility fractures. Level of Evidence: V.
- | Observational data, Journal: Sedentary Lifestyle of Older Adults and Its Associated Factors: A Multicentre Cross-Sectional Study During COVID-19 Pandemic in Indonesia. (Pubmed Central) - Jan 16, 2024
The prevalence of sedentary lifestyle varied across ethnic groups. Adequate and appropriate food intake may be crucial to keep older adults active, preventing them from entering vicious cycle of malnutrition, sarcopenia, and frailty.
- | Retrospective data, Journal: Percent vital capacity predicts postoperative sarcopenia after esophagectomy in initially nonsarcopenic esophageal cancer patients: a retrospective cohort study. (Pubmed Central) - Jan 16, 2024
Adequate and appropriate food intake may be crucial to keep older adults active, preventing them from entering vicious cycle of malnutrition, sarcopenia, and frailty. Based on the findings of this study, %VC was a simple but valuable factor for predicting sarcopenia induced by esophagectomy.
- || Review, Journal: Advances in the research on myokine-driven regulation of bone metabolism. (Pubmed Central) - Jan 16, 2024
Myokines are widely involved in bone metabolism, influencing bone resorption and formation by interacting with factors related to bone cell secretion or influencing bone metabolic pathways. Here, we review the research progress on the myokine regulation of bone metabolism, discuss the mechanism of myokine regulation of bone metabolism, explore the pathophysiological relationship between sarcopenia and osteoporosis, and provide future perspectives on myokine research, with the aim of identify potential specific diagnostic markers and therapeutic entry points.
- | New trial: Prehabilitative Exercise Prior to Immobilization (clinicaltrials.gov) - Jan 16, 2024
P=N/A, N=48, Recruiting, Sponsor: Bispebjerg Hospital
- | Journal: Sarcopenia predicts postoperative complications and survival in colorectal cancer patients with GLIM-defined malnutrition: Analysis from a prospective cohort study. (Pubmed Central) - Jan 16, 2024
Sarcopenia predicts postoperative complications and survival in patients with colorectal cancer with GLIM-defined malnutrition. Preoperative assessment of sarcopenia is still necessary when nutritional assessment has been well performed.
- | Journal: THE FRAMEWORK OF THE PILOT PROJECT FOR TESTING A TELEMEDICINE MODEL IN THE FIELD OF GERIATRICS - HEALTH CHALLENGES AND JUSTIFICATION OF THE PROJECT IMPLEMENTATION. (Pubmed Central) - Jan 15, 2024
The implementation of telemedicine solutions creates an opportunity for geriatric patients and their families by improving access to specialized medical care. This project will support patients, but also caregivers, who (through training and telemedicine) will be better able to provide care services with the ability to reconcile them with their own work.
- | Observational data, Journal: Association between pulse pressure and low muscle mass in Korean adults: A nationwide cross-sectional study. (Pubmed Central) - Jan 15, 2024
A high PP is significantly associated with a higher prevalence of low muscle mass. Therefore, PP monitoring may help identify individuals at risk of sarcopenia and guide interventions to improve health outcomes.
- | Journal: Lower creatinine to cystatin C ratio is associated with an increased risk of MASLD: A cross-sectional and prospective study of 368,634 UK Biobank participants. (Pubmed Central) - Jan 15, 2024
Therefore, PP monitoring may help identify individuals at risk of sarcopenia and guide interventions to improve health outcomes. Our results indicated that lower CCR was significantly associated with higher risk of MASLD, based on which predictive models can be developed to screen populations at high risk of developing MASLD.
- || Retrospective data, Review, Journal, HEOR: Quality of life in sarcopenia measured with the SarQoL questionnaire: A meta-analysis of individual patient data. (Pubmed Central) - Jan 15, 2024
The level of evidence was moderate. This meta-analysis of individual patient data suggested that sarcopenia is associated with lower health-related quality of life measured with SarQoL.
- | Journal: Pulmonary function and sarcopenia as predictors of dysphagia in cervical spinal cord injury. (Pubmed Central) - Jan 15, 2024
Older age, low FVC (% predicted), and low skeletal muscle index can be predictors of dysphagia in patients with CSCI. On follow-up VFSS, individuals with improved PA demonstrated greater improvement in FVC (% predicted).
- || Review, Journal: Assessing nutrition status, sarcopenia, and frailty in adult transplant recipients. (Pubmed Central) - Jan 15, 2024
Finally, for frailty assessment, the Short Physical Performance Battery is useful for evaluating physical frailty, and for a multidimensional evaluation, the Fried frailty phenotype can be used. Specifically for liver transplant candidates, the use of Liver Frailty Index is recommended.
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Journal: Blockade of angiotensin II modulates insulin-like growth factor 1-mediated skeletal muscle homeostasis in experimental steatohepatitis. (Pubmed Central) - Jan 15, 2024
Moreover, ARB increased the hepatic and plasma IGF-1 levels and improved steatohepatitis, leading to enhanced skeletal muscle protein synthesis mediated by IGF-1/ AKT/ mechanistic target of rapamycin signaling. Collectively, combined ARB and IGF-1 replacement could be a promising new therapeutic target for NASH-derived skeletal muscle wasting.
- || Review, Journal: Malnutrition, sarcopenia, and frailty assessment in pediatric transplantation. (Pubmed Central) - Jan 15, 2024
Recently, the addition of a variety of validated nutrition and functional assessment techniques has assisted with appropriate assessment of these conditions. The objective of this narrative review is to provide an overview of the current literature for pediatric assessment of malnutrition, sarcopenia, and frailty in the setting of solid organ transplantation and provide practicing nutrition clinicians a solid foundation for learning how to effectively assess these conditions with the current literature available.
- | Journal: Interactive effects of physical activity and sarcopenia on incident ischemic heart disease: Results from a nation-wide cohort study. (Pubmed Central) - Jan 15, 2024
These results suggest a synergistic interaction between lack of PA and sarcopenia on the risk of IHD. Findings from this study may help facilitate more effective primary prevention of IHD.
- | Journal: Risk factors for sarcopenia in patients with head and neck cancer. (Pubmed Central) - Jan 15, 2024
Findings from this study may help facilitate more effective primary prevention of IHD. Male sex, advanced age, and excess body fat were identified as risk factors for sarcopenia in patients with HNC, whereas a higher BMI and TBW/FFM acted as protective factors against sarcopenia in these patients.
- | Observational data, Journal: Association between normal-weight obesity and bone mineral density in older Korean adults: A population-based cross-sectional study. (Pubmed Central) - Jan 15, 2024
Male sex, advanced age, and excess body fat were identified as risk factors for sarcopenia in patients with HNC, whereas a higher BMI and TBW/FFM acted as protective factors against sarcopenia in these patients. However, no significant association between normal-weight obesity and bone mineral density was observed among people between the ages of 70 and 89
- | Journal: Calf circumference predicts sarcopenia in maintenance hemodialysis. (Pubmed Central) - Jan 15, 2024
Low muscle mass and potentially low muscle strength in HD patients can be accurately identified through the use of CC measurements. Specifically, a CC measurement below 31?cm has found to be a useful indicator to identify individuals on maintenance HD.
- | Journal: The relationship between skeletal muscle mass and exercise capacity in patients undergoing hemodialysis: An exploratory secondary-analysis. (Pubmed Central) - Jan 15, 2024
Specifically, a CC measurement below 31?cm has found to be a useful indicator to identify individuals on maintenance HD. There was no significant correlation observed between exercise capacity and skeletal muscle mass in patients undergoing hemodialysis, indicating the factors influencing exercise capacity in this patient population are complex and that increasing skeletal muscle mass may not necessarily involve solely addressing the improvement of exercise capacity.
- | Observational data, Journal: Prevalence and influencing factors of muscle mass loss in adults with diabetes and a high body fat percentage: A cross-sectional study. (Pubmed Central) - Jan 15, 2024
Muscle mass loss is more prevalent in adults with T2DM and a high PBF. Body mass index, body fat index, and limb fat are the protective factors of muscle mass loss in adult patients with T2DM and obesity.
- | Journal, HEOR: Factors influencing health-related quality of life in older adult women with sarcopenia: analysis of the Korean National Health and Nutrition Examination Survey 2019. (Pubmed Central) - Jan 15, 2024
Body mass index, body fat index, and limb fat are the protective factors of muscle mass loss in adult patients with T2DM and obesity. Based on study findings that the HRQoL of older adult women with sarcopenia were influenced by difficulty climbing stairs and working, as well as good perceived health status, healthcare providers should assist elderly women to maintain physical activities in their daily lives.
- || Review, Journal: Regulation of Satellite Cells Functions during Skeletal Muscle Regeneration: A Critical Step in Physiological and Pathological Conditions. (Pubmed Central) - Jan 15, 2024
It examines the changes in the activity of SCs in three of the most common and severe muscle disorders: sarcopenia, muscular dystrophy, and cancer cachexia. Understanding the molecular mechanisms involved in their dysregulations is essential for improving current treatments, such as exercise, and developing personalized approaches to reactivate SCs.
- | Journal: Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation. (Pubmed Central) - Jan 15, 2024
Lastly, we assessed the expression level of Slc7a2 during aging in humans and mice and found an upregulation of Slc7a2 expression during the aging process. These findings collectively suggest that the arginine transporter SLC7A2 plays a critical role in facilitating skeletal muscle differentiation and may hold potential as a therapeutic target for sarcopenia.
- | Journal: Design and Verification of Integrated Circuitry for Real-Time Frailty Monitoring. (Pubmed Central) - Jan 15, 2024
To address this, the designed analyzer introduces variables like Smoothness and Percussion to provide more information and objectify measurements in the assessment of stand-up/sit-down actions. Both the analyzer and the proposed variables offer additional information that can objectify assessments depending on the clinical eye of the physicians.
- || Review, Journal: Relationship of Low Vitamin B6 Status with Sarcopenia, Frailty, and Mortality: A Narrative Review. (Pubmed Central) - Jan 15, 2024
Furthermore, the modulation of PLP-dependent enzymes due to B6 deficiency is associated with impaired metabolic processes, affecting energy utilization, imidazole peptide production, and hydrogen sulfide production, as well as the kynurenine pathway, all of which play vital roles in skeletal muscle health and pathophysiology. This narrative review provides an up-to-date assessment of our current understanding of the potential role of nutritional B6 status in combating sarcopenia, frailty, and mortality.
- || Review, Journal: The Vicious Cycle of Type 2 Diabetes Mellitus and Skeletal Muscle Atrophy: Clinical, Biochemical, and Nutritional Bases. (Pubmed Central) - Jan 15, 2024
Based on the evidence, we conclude that effective treatment of patients with T2DM-SMA depends on the restoration and maintenance of muscle mass. We thus propose that regular intake of key functional nutrients, along with guidance for physical activity, can help maintain euglycemia and improve muscle status in all patients with T2DM and SMA.
- | Preclinical, Journal: Ashwagandha Ethanol Extract Attenuates Sarcopenia-Related Muscle Atrophy in Aged Mice. (Pubmed Central) - Jan 15, 2024
Mechanistically, WSE balanced muscle protein synthesis/degradation, promoted fiber differentiation, and enhanced mitochondrial biogenesis through the IGF-1/Akt/mTOR pathway. This study provides compelling evidence for the anti-sarcopenic effects of WSE, positioning it as a promising candidate for preventing sarcopenia pending further clinical validation.
- || Clinical, Journal: Mediterranean Diet, Vitamin D, and Hypercaloric, Hyperproteic Oral Supplements for Treating Sarcopenia in Patients with Heart Failure-A Randomized Clinical Trial. (Pubmed Central) - Jan 15, 2024
This study provides compelling evidence for the anti-sarcopenic effects of WSE, positioning it as a promising candidate for preventing sarcopenia pending further clinical validation. Nutritional support with hypercaloric, hyperproteic OS, Mediterranean diet, and vitamin D supplementation were associated with decreased NT-proBNP and improvements in LVEF, functionality, and quality of life in patients with HF, despite a significant decrease in hospital admissions.
- || Review, Journal: Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age. (Pubmed Central) - Jan 15, 2024
The review comprehensively addresses key elements for the clinical definition and diagnostic criteria of sarcopenia, the pathophysiological correlation be-tween T2D, sarcopenia, and related outcomes, a critical review of the role of antihyperglycemic treatment on skeletal muscle health, and perspectives on the role of specific treatment targeting myokine signaling pathways involved in glucose control and the regulation of skeletal muscle metabolism and trophism. Prompt diagnosis and adequate management, including lifestyle inter-vention, health diet programs, micronutrient supplementation, physical exercise, and pharmaco-logical treatment, are needed to prevent or delay skeletal muscle deterioration in T2D.
- || Review, Journal: Portal Hypertension in Malnutrition and Sarcopenia in Decompensated Cirrhosis-Pathogenesis, Implications and Therapeutic Opportunities. (Pubmed Central) - Jan 15, 2024
This review details the specific mechanisms by which portal hypertension directly contributes to the development of malnutrition and sarcopenia in cirrhosis. We summarise the existing literature describing treatment strategies that specifically aim to reduce portal pressures and their impact on nutritional and muscle outcomes, which is particularly relevant to those with end-stage disease awaiting liver transplantation.
- || Review, Journal: Nutritional Assessments by Bioimpedance Technique in Dialysis Patients. (Pubmed Central) - Jan 15, 2024
Importantly, reduction in LTM has been associated with increased risk of frailty, hospitalization, and mortality in dialysis patients, whereas the prognostic value of ATM remains debatable. Further studies are needed to determine whether modifications of bioimpedance-derived body composition parameters through nutrition intervention can result in clinical benefits.
- | Journal: Influence of the Results of Control of Intakes, Proteins and Anthropometry Nutritional Screening, Sarcopenia and Body Composition on the Clinical Evolution of Hospitalized Patients. (Pubmed Central) - Jan 15, 2024
(4) In hospitalized patients, malnutrition independently and combined with sarcopenia is associated with a worse prognosis but not body composition. Low HGS is related to a higher length of stay.
- || Review, Journal: Therapeutic applications of ginseng for skeletal muscle-related disorder management. (Pubmed Central) - Jan 15, 2024
Ginsenoside compounds are also used for obesity management, and their anti-obesity effects are attributed to peroxisome proliferator activated receptor gamma (PPAR?) inhibition, AMPK activation, glucose transporter type 4 (GLUT4) translocation, and increased phosphorylations of insulin resistance (IR), insulin receptor substrate-1 (IRS-1), and Akt. This review was undertaken to provide an overview of the use of ginseng-related compounds for the management of SM-related disorders.
- ||| Journal, Adverse events: Reduced thoracic skeletal muscle size is associated with adverse outcomes in diabetes patients with heart failure and reduced ejection fraction: quantitative analysis of sarcopenia by using cardiac MRI. (Pubmed Central) - Jan 14, 2024
With respect to diabetes patients with HFrEF, thoracic SMI is a novel alternative for evaluating muscle wasting in sarcopenia that can be obtained by a readily available routine cardiac MRI protocol. A reduction in thoracic skeletal muscle size predicts poor outcomes in the context of DM with HFrEF.
- | Journal: Poor mobility and lower limb weakness are associated with three distinct depressive symptom trajectories over 6?years in older people. (Pubmed Central) - Jan 14, 2024
Timed Up and Go test times, Five Times Sit-to-Stand test performance, planned physical activity levels and knee extension strength are associated with three discrete depressive symptom trajectories. These clinical tests may help identify older adults aged 70-90?years at risk of developing depressive symptoms and help guide subsequent strength and mobility interventions.
- | Journal, Surgery: Development and validation of a preoperative CT-based risk scoring system for predicting recurrence-free survival in patients undergoing curative surgery for gastric cancer. (Pubmed Central) - Jan 12, 2024
These clinical tests may help identify older adults aged 70-90?years at risk of developing depressive symptoms and help guide subsequent strength and mobility interventions. The developed preoperative risk scoring system demonstrated the ability to predict RFS following curative resection in GC patients.
- || Review, Journal: Frailty and Erectile Dysfunction: An Understudied Correlation. (Pubmed Central) - Jan 12, 2024
The present investigation has revealed a significant association of frailty, exacerbated by advancing age, with the occurrence of ED. Our findings lead to the conclusion that the condition of frailty becomes more pronounced as individuals advance in age.
- | Journal: Case-finding for Sarcopenia in Community-Dwelling Older Adults: Comparison of Mini Sarcopenia Risk Assessment with SARC-F and SARC-CalF. (Pubmed Central) - Jan 12, 2024
The poor diagnostic performances of the MSRA-5 and MSRA-7 in our study suggest limitations of self-reported questionnaires for assessing general and dietary risk factors for sarcopenia in healthy and culturally diverse community-dwelling older adults. Studies in different populations are needed to ascertain the utility of the MSRA for the community detection of sarcopenia.
- | Journal: Prognostic value of the serum creatinine/cystatin C ratio in patients with chronic obstructive pulmonary disease. (Pubmed Central) - Jan 12, 2024
The serum Cr/CysC ratio could be a valuable clinical parameter for identifying sarcopenia and severe airflow obstruction. The study findings highlight the utility of this ratio as a prognostic predictor in patients with COPD.
- | Retrospective data, Journal, Surgery: Association between Sarcopenia and Survival in Patients Undergoing Gamma Knife Surgery for Brain Metastasis from Breast Cancer: A Retrospective Single-centre Cohort Study. (Pubmed Central) - Jan 12, 2024
The study findings highlight the utility of this ratio as a prognostic predictor in patients with COPD. Sarcopenia could be a risk factor for short- and long-term mortality in patients undergoing GKRS for brain metastasis from breast cancer.
- | Biomarker, Journal: Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising biomarkers of sarcopenia in various models. (Pubmed Central) - Jan 12, 2024
What's more, ROC analysis based on human aging-related datasets indicated Acss1, Mtfp1, Oxct1 had outstanding diagnostic capabilities for sarcopenia. In general, we identified three hub genes (Acss1, Mtfp1 and Oxct1) that are strongly associated with mitochondrial dysfunction in sarcopenia and may provide novel and reliable indicators for screening, diagnosis, and prognosis, as well as potential therapeutic targets for patients with sarcopenia.
- | New trial, HEOR: The Relationships of Resistance Exercise, Walking, Myokine Secretion, Sarcopenia, Muscle Loss, Quality of Life, and Predictors in Cancer Patients Receiving Chemoradiotheray (clinicaltrials.gov) - Jan 12, 2024
P=N/A, N=96, Recruiting, Sponsor: Taipei Medical University
- || Review, Journal: Body composition and chemotherapy toxicities in breast cancer: a systematic review of the literature. (Pubmed Central) - Jan 11, 2024
Toxicities due to chemotherapy can result in treatment being unable to be completed as planned, potentially resulting in poorer survival outcomes. Improved knowledge in this area may give rise to a more reliable way of individualizing chemotherapy dosage to help mitigate this risk.
- | Journal: Establishment of a risk prediction model for residual low back pain in thoracolumbar osteoporotic vertebral compression fractures after percutaneous kyphoplasty. (Pubmed Central) - Jan 11, 2024
We have created a novel numerical model capable of accurately predicting the potential risk factors associated with the occurrence of residual LBP following PKP in thoracolumbar OVCFs patients. This model serves as a valuable tool for guiding specific clinical decisions for patients with OVCFs.
- | Journal: Association of phase angle with sarcopenia and muscle function in patients with COPD: a case-control study. (Pubmed Central) - Jan 11, 2024
This model serves as a valuable tool for guiding specific clinical decisions for patients with OVCFs. Although further studies are suggested, phase angle might be considered an indicator of sarcopenia and muscle function in COPD patients.