Sarcopenia
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  • ||||||||||  Impact of Spilanthol Supplementation with Balance Training on Neuromuscular Performance in Healthy Men (Poster Hall) -  Feb 16, 2024 - Abstract #MDA2024MDA_547;    
    In summary, the findings of this investigation provide empirical evidence supporting the proposition that spilanthol supplementation, when integrated with BAL training, can exert a more pronounced impact on select facets of neuromuscular function. Furthermore, this combined regimen demonstrates potential in mitigating sarcopenia and other degenerative conditions.
  • ||||||||||  Trial completion date, Trial primary completion date:  Electrical Stimulation of Human Myocytes in Microgravity (clinicaltrials.gov) -  Feb 15, 2024   
    P=N/A,  N=75, Active, not recruiting, 
    With an ODD granted (US and EU), Biophytis intends to start a clinical development in non-ambulatory DMD patients in 2024. Trial completion date: Dec 2023 --> Jun 2024 | Trial primary completion date: Dec 2023 --> Jun 2024
  • ||||||||||  Enrollment change, Trial termination:  CovExc: Muscular Rehabilitation by Eccentric Exercise After Severe COVID-19 Infection (clinicaltrials.gov) -  Feb 15, 2024   
    P=N/A,  N=60, Terminated, 
    Trial completion date: Jan 2024 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024 N=120 --> 60 | Recruiting --> Terminated; Stop premature due to futility
  • ||||||||||  MG132 / Jilin University, Dorothy M. Davis Heart and Lung Research Institute
    Journal:  Role of the ubiquitin-proteasome system in the sarcopenic-like phenotype induced by CCL5/RANTES. (Pubmed Central) -  Feb 15, 2024   
    We used the MG132 inhibitor to elucidate the role of the 20S proteasome in the CCL5-induced sarcopenic-like effect...These findings indicate that CCL5 actively modulates the UPS. Moreover, our results show the direct participation of UPS in the sarcopenic-like phenotype induced by CCL5.
  • ||||||||||  Journal:  Association Between Nut Consumption and Low Muscle Strength Among Korean Adults. (Pubmed Central) -  Feb 14, 2024   
    After adjustment for age, body mass index, total energy intake, household income, alcohol consumption, smoking, resistance exercise, medical history, and dietary protein intake, nut consumption was associated with the lower risk of low muscle strength among older adults ?65y (men: OR 0.55, 95% CI 0.38, 0.79; women: OR 0.69, 95% CI 0.51, 0.93); however, this association was not observed among younger adults 19-39y or middle-aged adults 40-64y. Our results suggest that consuming nuts might be beneficial in lowering the risk of low muscle strength among Korean older adults.
  • ||||||||||  Review, Journal:  Pathophysiological-Based Nutritional Interventions in Cirrhotic Patients with Sarcopenic Obesity: A State-of-the-Art Narrative Review. (Pubmed Central) -  Feb 14, 2024   
    International nutrition and liver diseases societies strongly agree on recommending the use of food as an integral part of the healing process in the comprehensive management of these patients, including a reduction in caloric intake, protein and micronutrient supplementation and sodium restriction. Based on the pathophysiological paths shared by cirrhosis and SO, this narrative review aims to highlight the nutritional interventions currently advocated by international guidelines, as well as to provide hints on the possible role of micronutrients and nutraceuticals in the treatment of this multifaceted clinical condition.
  • ||||||||||  Journal:  Comparison of the performance of four screening tools for sarcopenia in patients with chronic liver disease. (Pubmed Central) -  Feb 14, 2024   
    Ishii score is more suitable for screening sarcopenia in patients with chronic liver disease than the SARC-F, SARC-CalF, and MSRA-7, based on the AWGS 2019 criteria. Nursing professionals can use Ishii score as a clinical tool to screen for sarcopenia in patients with chronic liver disease, providing an indication cue for the final diagnosis of sarcopenia, improving diagnostic efficiency, and enabling early identification and prevention of complications resulting from sarcopenia.
  • ||||||||||  Journal:  The Effect of Web-Based Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults: Randomized Controlled Trial. (Pubmed Central) -  Feb 13, 2024   
    P=N/A
    These studies could include an interdisciplinary staff, different recruitment strategies, and different muscle mass measurements. Future research is needed to determine if this intervention is sustainable in the long term and should incorporate a follow-up to determine program efficacy on several long-term behavioral and health outcomes, including if the participants can sustain their heightened protein intake and how their cooking skills have changed.
  • ||||||||||  ASSESSMENT OF SARCOPENIA IN PATIENTS WITH SYSTEMIC SCLEROSIS: A MULTIDISCIPLINARY APPROACH (Poster Area) -  Feb 13, 2024 - Abstract #SSWC2024SSWC_196;    
    Sarcopenia emerges as a relatively frequent and severe complication in SSc, with important repercussions on the physical-dynamic sphere and a deep interrelationship with nutritional status. A multidisciplinary approach is essential for an accurate diagnosis of sarcopenia in potentially high-risk individuals such as those with SSc.
  • ||||||||||  MUSCLE FUNCTION IMPAIRMENT IN SYSTEMIC SCLEROSIS  (Poster Area) -  Feb 13, 2024 - Abstract #SSWC2024SSWC_185;    
    There was a statistical difference between positive screening and handgrip strength test, chair stand test and the 4-meter walk gait speed test, suggesting that they are good objective tests to be performed on an outpatient basis. Our study emphasizes the relevance of evaluating sarcopenia in the clinical practice in SSc.
  • ||||||||||  Journal:  Association between macro- and microvascular damage and sarcopenia index in individuals with type 2 diabetes mellitus. (Pubmed Central) -  Feb 12, 2024   
    Multivariate logistic regression analysis revealed that when taking the top tertile of SI as a reference, an increasing trend of the prevalence of DR, MAU, DPN, and LEAD were presented (all Pfor trend < 0.05), where the OR (95% CI) for DR prevalence was 1.967 (1.252-3.090) in T2, 2.195 (1.278-3.769) in T1, for MAU was 1.805 (1.149-2.837) in T2, 2.537 (1.490-4.320) in T1, for DPN was 2.244 (1.485-3.391) in T2, 3.172 (1.884-5.341) in T1, and for LEAD was 2.017 (1.002-4.057) in T2, 2.405 (1.107-5.225) in T1 (all P < 0.05). Patients with lower SI were more inclined to have an increased risk of macro- and microvascular damage in T2DM population, which may be related to sarcopenia.
  • ||||||||||  Retrospective data, Review, Journal:  Sarcopenia in Breast Cancer Patients: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Feb 10, 2024   
    In the neoadjuvant setting, a higher rate of pCR was observed among sarcopenic patients (49%) (OR 2.74, 95% CI 0.92-8.22). (4) Our meta-analysis confirms the correlation between sarcopenia and negative outcomes, especially in terms of higher toxicity.
  • ||||||||||  Journal:  Korean Nationwide Exploration of Sarcopenia Prevalence and Risk Factors in Late Middle-Aged Women. (Pubmed Central) -  Feb 10, 2024   
    These results are expected to contribute to the existing literature on sarcopenia and identify potential risk factors associated with the development of sarcopenia in late middle-aged females. By acknowledging prevalence and recognized risk factors, healthcare professionals may augment their proficiency in recognizing and discerning potential instances of sarcopenia in female patients.
  • ||||||||||  Review, Journal:  Diagnostic Criteria and Measurement Techniques of Sarcopenia: A Critical Evaluation of the Up-to-Date Evidence. (Pubmed Central) -  Feb 10, 2024   
    Various scientific groups, including the European Working Group of Sarcopenia in Older People (EWGSOP), the International Working Group on Sarcopenia (IWGS), the Asian Working Group on Sarcopenia (AWGS), the American Foundation for the National Institutes of Health (FNIH) and the Sarcopenia Definition and Outcomes Consortium (SDOC), have published consensus papers outlining diverse definitions of sarcopenia. The choice of diagnostic criteria should be aligned with the specific objectives of the study or clinical practice, considering the characteristics of the study population and available resources.
  • ||||||||||  Journal, HEOR:  Secondary Sarcopenia and Spinal Cord Injury: Clinical Associations and Health Outcomes. (Pubmed Central) -  Feb 10, 2024   
    The mean number of comorbidities was 2.7 in the sarcopenia group. Gender, type of injury, presence of multiple comorbidities and age were directly associated with sarcopenia; meanwhile, surprisingly, spasticity level and the presence of immobilization osteoporosis were not.
  • ||||||||||  Trial completion, Enrollment change:  Using Exergame-based Program in Elders of Rural LTCF (clinicaltrials.gov) -  Feb 9, 2024   
    P=N/A,  N=60, Completed, 
    No abstract available Recruiting --> Completed | N=40 --> 60