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12 Products |
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17 Mechanisms of Action |
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756 Trials |
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22406 News |
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- | Journal, Surgery: Sarcopenia in paraspinal muscle as a risk factor of proximal junctional kyphosis and proximal junctional failure after adult spinal deformity surgery. (Pubmed Central) - Mar 4, 2024
Paraspinal muscle atrophy was identified as a significant risk factor for PJK and PJF, especially PJF. The possibility of PJK and PJF development should be considered when long-segment fusion is planned for patients with paraspinal muscle atrophy.
- | Journal: Optimal serum 25-hydroxyvitamin D level to prevent sarcopenia in patients with heart failure: Insights from a dose-response relationship. (Pubmed Central) - Mar 4, 2024
A U-shaped relationship exists between serum 25(OH)D levels and sarcopenia probability in patients with HF. Maintaining serum 25(OH)D levels between 14.6 and 31.4
- | Journal: The relationship between serum creatinine/cystatin C ratio and mortality in hypertensive patients. (Pubmed Central) - Mar 4, 2024
We found that low muscle mass shown by lower Cr/CysC ratio was an independent risk factor for poor prognosis in hypertensive patients. We recommend routine screening of Cr/CysC ratio in hypertensive patients and early intervention for low muscle mass or sarcopenia.
- | Journal: A body shape index is useful for BMI-independently identifying Japanese patients with obesity at high risk of cardiovascular disease. (Pubmed Central) - Mar 4, 2024
ABSI was deemed useful for BMI-independently identifying Japanese patients with overweight/obese at high risk of CVD based on having multiple MetS components and skeletal muscle loss. Clinical trials (the unique trial number and the name of the registry) ID: UMIN000042726.
- | Journal: Potential nutritional strategies to prevent and reverse sarcopenia in aging process: role of fish oil-derived ?-3 polyunsaturated fatty acids, wheat oligopeptide and their combined intervention. (Pubmed Central) - Mar 4, 2024
The combination of fish oil-derived ?-3 PUFA and wheat oligopeptide was found to be a promising nutritional support to prevent and reverse sarcopenia. The potential mechanism involved the promotion of protein synthesis and muscle regeneration, as well as the enhancement of muscle strength.
- | Journal: The effect of sarcopenic obesity and age-associated ophthalmopathology on patients' daily activities. (Pubmed Central) - Mar 4, 2024
The potential mechanism involved the promotion of protein synthesis and muscle regeneration, as well as the enhancement of muscle strength. However, regardless of the nosology of the ophthalmic disease, in both clinical groups, the leading limitations of activities in daily life were needle threading (1,84
- ||| Retrospective data, Journal, Adverse events: Sarcopenic obesity is associated with adverse outcomes after kidney transplantation: a retrospective cohort study. (Pubmed Central) - Mar 3, 2024
However, regardless of the nosology of the ophthalmic disease, in both clinical groups, the leading limitations of activities in daily life were needle threading (1,84 The presence of sarcopenic obesity prior to kidney transplantation represents an independent risk factor for mortality, and it is also linked to a range of unfavorable outcomes.
- | Retrospective data, Journal: Prevalence and risk factors of sarcopenia after radical gastrectomy for gastric cancer (Pubmed Central) - Mar 3, 2024
Development of sarcopenia following radical gastrectomy demands attention. Older age, higher education, poor exercise habits, hypoproteinemia, hypertension, and total gastrectomy are risk factors for its development post-radical gastrectomy.
- ROLE OF SARCOPENIA ON OUTCOMES IN LIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA (Americana Foyer) - Mar 2, 2024 - Abstract #AHPBA2024AHPBA_382;
- | Journal: The bioelectrical impedance analysis and sarcopenia: Devices (Pubmed Central) - Mar 2, 2024
Older age, higher education, poor exercise habits, hypoproteinemia, hypertension, and total gastrectomy are risk factors for its development post-radical gastrectomy. No abstract available
- | Journal: Sex-specific association of low-renin hypertension with metabolic and musculoskeletal health in Korean older adults. (Pubmed Central) - Mar 2, 2024
Notably, LRH in postmenopausal women was linked to lower femur neck T-scores and degraded TBS, indicating sex-specific effects of LRH on bone health. Larger prospective studies are required to elucidate how changes in the RAAS affect metabolic and musculoskeletal outcomes in older adults.
- | Trial primary completion date: MANO PO: Managing the Nutritional Needs of Older Filipino With Due Attention to Protein Nutrition and Functional Health Study (clinicaltrials.gov) - Mar 2, 2024
P=N/A, N=72, Enrolling by invitation, Sponsor: Food and Nutrition Research Institute, Philippines
Larger prospective studies are required to elucidate how changes in the RAAS affect metabolic and musculoskeletal outcomes in older adults. Trial primary completion date: Dec 2023 --> Aug 2024
- || Trial completion date, Trial initiation date, Trial primary completion date: COOLEY- Study: ACute on ChrOnic Liver FailurE Using the CYtosorb Device (clinicaltrials.gov) - Mar 2, 2024
P=N/A, N=20, Not yet recruiting, Sponsor: University Hospital, Antwerp
Trial primary completion date: Dec 2023 --> Aug 2024 Trial completion date: Jun 2026 --> Jun 2027 | Initiation date: Jan 2024 --> Apr 2024 | Trial primary completion date: Dec 2025 --> Apr 2026
- | Ozempic (semaglutide SC once-weekly) / Novo Nordisk
Trial completion date, Trial initiation date, Trial primary completion date: SEMASEARCH, Retrospective/Prospective Cohort Nested at ATUc/AP2 WEGOVY (clinicaltrials.gov) - Mar 2, 2024
P=N/A, N=1000, Not yet recruiting, Sponsor: Hospices Civils de Lyon
Trial completion date: Jun 2026 --> Jun 2027 | Initiation date: Jan 2024 --> Apr 2024 | Trial primary completion date: Dec 2025 --> Apr 2026 Trial completion date: Sep 2025 --> Apr 2026 | Initiation date: Sep 2023 --> Apr 2024 | Trial primary completion date: Sep 2025 --> Apr 2026
- | Trial completion date, Trial primary completion date: SARCOBEAGING: Sarcopenic Obesity as a Risk of Premature Aging (clinicaltrials.gov) - Mar 2, 2024
P=N/A, N=75, Active, not recruiting, Sponsor: Hospital de Leon
Trial completion date: Sep 2025 --> Apr 2026 | Initiation date: Sep 2023 --> Apr 2024 | Trial primary completion date: Sep 2025 --> Apr 2026 Trial completion date: Mar 2024 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024
- | Trial completion date, Trial primary completion date: FITFOOD: The Effect of a Combined Personalized Nutritional Intervention and a Personalized Graded Activity Functional Training Program on Physical Performance in Hospitalized Older Patients, Compared to Usual Care (clinicaltrials.gov) - Mar 2, 2024
P=N/A, N=136, Active, not recruiting, Sponsor: Radboud University Medical Center
Trial completion date: Mar 2024 --> Dec 2024 | Trial primary completion date: Dec 2023 --> Dec 2024 Trial completion date: Jul 2025 --> Jan 2026 | Trial primary completion date: Nov 2024 --> Nov 2025
- || Review, Journal, Surgery, Bariatric surgery: A multifaceted and inclusive methodology for the detection of sarcopenia in patients undergoing bariatric surgery: an in-depth analysis of current evidence. (Pubmed Central) - Mar 1, 2024
Therefore, this review aimed to define the concept of sarcopenia applicable to patients undergoing bariatric surgery, based on the consensus reached for sarcopenia in the general population. We also discuss the methods and significance of measuring muscle mass, quality, and strength, which are key variables requiring a comprehensive assessment.
- || Review, Journal: Obstacles to the Early Diagnosis and Management of Sarcopenia: Current Perspectives. (Pubmed Central) - Mar 1, 2024
In this article, we summarize current obstacles to early diagnosis and management of sarcopenia in clinical practice, and make recommendations to how these might be overcome. This includes our recommendation of incorporation of handgrip strength measurement into standard care, to enable dynamic assessment and identification of early declines in handgrip strength, so that interventions can be implemented to prevent disability.
- | Journal: Research progress of relationship in long-novel coronavirus syndrome and sarcopenia (Pubmed Central) - Mar 1, 2024
However, at present, the scholars have not paid enough attention to the skeletal muscle weakness caused by the novel coronavirus. Therefore, this paper focuses on the long-novel coronavirus syndrome and sarcopenia to explore the pathological mechanism of skeletal muscle attenuation caused by the SARS-CoV-2 mediated "cytokine storm", mitochondrial damage, hypoxia state and other links,so as to raise the attention of clinical and academic researchers and improve the clinical strategy of frailty and sarcopenia after novel coronavirus infection.
- || Review, Journal: Approaching the Sarcopenic Patient with Nonalcoholic Steatohepatitis-related Cirrhosis. (Pubmed Central) - Mar 1, 2024
This can be achieved by properly designed diets integrated with specific nutritional supplementations and accompanied by adequate physical exercise. Future studies aiming to add to the knowledge of the correct assessment and approach to sarcopenia in the context of NAFLD-related CLD are eagerly awaited.
- | Biomarker, Journal: Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer. (Pubmed Central) - Mar 1, 2024
As a nutritional indicator, the CONUT score could predict long-term outcomes after radical surgery for colorectal cancer, and its predictive ability was superior to other indexes. The correlation between the CONUT score and skeletal muscle may be one of the factors that play a predictive role.
- || Retrospective data, Review, Journal: Impact of sarcopenia on outcomes of bladder cancer undergoing radical cystectomy: A systematic review and meta-analysis. (Pubmed Central) - Mar 1, 2024
The correlation between the CONUT score and skeletal muscle may be one of the factors that play a predictive role. Sarcopenia among patients with bladder cancer and managed using RC is associated with adverse survival outcomes and an increased risk of postoperative complications.
- | Journal: Nutrition Management in Geriatric Patients with Chronic Kidney Disease. (Pubmed Central) - Mar 1, 2024
Prevention of protein and energy depletion and replenishing the already low nutritional reserves elderly patients with CKD should focus on conventional and innovative strategies. This review aims to provide an overview of the mainstay of nutritional therapy in this patient population such as intake of adequate amounts of protein and energy along with along with preserving fluid, electrolyte, and mineral balance and to discuss more innovative interventions to aid these approaches.
- | Retrospective data, Journal, Combination therapy: Resistance exercise in combination with aerobic exercise reduces the incidence of serious events in patients with liver cirrhosis: a meta-analysis of randomized controlled trials. (Pubmed Central) - Mar 1, 2024
Resistance exercise in combination with aerobic exercise reduces serious events in patients with liver cirrhosis. A combination of aerobic and resistance exercise may be beneficial to improve the prognosis of patients with liver cirrhosis.
- | New trial: The Efficacy of Aerobic Exercise Training on Autonomic Nervous System and Endothelial Function in Patients with Compensated Cirrhosis (clinicaltrials.gov) - Mar 1, 2024
P=N/A, N=70, Not yet recruiting, Sponsor: King Chulalongkorn Memorial Hospital
- | New trial: GTAW: Effect of Green Tea Supplementation in Older Adult Women (clinicaltrials.gov) - Mar 1, 2024
P=N/A, N=120, Recruiting, Sponsor: University of Valladolid
- | New trial: Efficacy of Structured Exercise-Nutritional Intervention on Sarcopenia in Patients With Osteoporosis (clinicaltrials.gov) - Feb 29, 2024
P=N/A, N=20, Active, not recruiting, Sponsor: Kowloon Hospital, Hong Kong
- || Review, Journal: Sarcopenic Obesity as a Risk Factor for Cardiovascular Disease: An Underrecognized Clinical Entity. (Pubmed Central) - Feb 29, 2024
However, numerous drugs and the role of bariatric surgery are still under trial, and have great scope for further research. This article covers the available literature regarding the definition, diagnostic criteria, and prevalence of SO, with available evidence linking it to CVD, metabolic disease and mortality, and an overview of current directives on management.
- || Retrospective data, Review, Journal: Impact of Chinese herbal medicine on sarcopenia in enhancing muscle mass, strength, and function: A systematic review and meta-analysis of randomized controlled trials. (Pubmed Central) - Feb 29, 2024
The funnel plot and Egger's test indicated publication bias. To confirm our conclusions, further high-quality studies should be conducted.
- | Observational data, Journal: Household use of solid fuel and sarcopenia among middle-aged and older adults: The China Health and Retirement Longitudinal Study. (Pubmed Central) - Feb 29, 2024
Household use of solid fuel was significantly associated with a higher risk of sarcopenia, while ageing and smoking had synergetic effects with burning solid fuels on the risk of sarcopenia. Our results highlight the importance of taking multi-pronged measures with respect to both air pollution and healthy lifestyle to prevent sarcopenia and promote healthy ageing.
- | Journal: The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study. (Pubmed Central) - Feb 29, 2024
The odds ratios indicate the increased risk of the binary outcome variable (usual walking pace) per rheumatoid arthritis standard deviation increase. This study has demonstrated a negative causal effect of rheumatoid arthritis with five major sarcopenia-related features in a European population.
- | Journal: Popular diets and nutritional assessment in the management of irritable bowel syndrome in inflammatory bowel disease: an overview of current evidence. (Pubmed Central) - Feb 29, 2024
These diets include Low-FODMAP diet, Gluten-free diet as well as Mediterranean diet and plant-based diet. To date, current evidence does not conclusively establish the optimal diet for the topic of this review, suggesting that personalized dietary approaches may be the best strategy.
- || Review, Journal: Cerebrovascular adaptations to habitual resistance exercise with aging. (Pubmed Central) - Feb 29, 2024
The purpose of this narrative review is to synthesize literature pertaining to cerebrovascular adaptations to RT at different stages of the life span. This review also aims to identify gaps in current understanding of long-term impacts of RT on cerebral hemodynamics and provide mechanistic rationale for these adaptations as they relate to aging, the cerebrovasculature and overall brain health.
- | Journal: Highlighting the effect of reduced training volume on maintaining hormonal adaptations obtained from periodized resistance training in sarcopenic older women. (Pubmed Central) - Feb 29, 2024
During the volume reduction period, there were no significant differences between MT1 and MT2 groups, but both groups saw increases in IGF-1, Fstn, GH, and decreases in MSTN and Cort compared to the DT group. These findings suggest that performing at least one training session per week with the HIIRT protocol is crucial for maintaining hormonal adaptations in sarcopenic older women.
- | New P1 trial: Ankle Assistance and Resistance in Older Adults (clinicaltrials.gov) - Feb 29, 2024
P1, N=8, Recruiting, Sponsor: Northern Arizona University
- || Retrospective data, Review, Journal: Creatine supplementation for optimization of physical function in the patient at risk of functional disability: A systematic review and meta-analysis. (Pubmed Central) - Feb 28, 2024
Creatine supplementation improves sit-to-stand performance, muscle function, and lean tissue mass. It is crucial to conduct high-quality prospective RCTs to confirm these hypotheses (PROSPERO number, CRD42023354929).
- | Journal, Metastases: Sex Differences in Sarcopenia in Patients Undergoing Total Knee Arthroplasty for Advanced Knee Osteoarthritis. (Pubmed Central) - Feb 28, 2024
When compared with the propensity-matched female group, male patients had inferior PROMs up to 12 months postoperatively. Alcohol consumption, current smoker status, and higher mCCI were predisposing factors for sarcopenia in male patients with advanced knee OA.
- | Journal: Nutrient Intake and Its Association with Appendicular Total Lean Mass and Muscle Function and Strength in Older Adults: A Population-Based Study. (Pubmed Central) - Feb 28, 2024
Findings of positive correlations for some nutrients with lean mass suggest a role for these nutrients in maintaining muscle volume. These results can be used to inform clinical trials to expand the preventive strategies and treatment options for individuals at risk of muscle loss and sarcopenia.
- | Journal: Is ChatGPT an Effective Tool for Providing Dietary Advice? (Pubmed Central) - Feb 28, 2024
However, when the chatbot handled overlapping conditions, limitations emerged, resulting in some contradictory or inappropriate advice. In conclusion, although ChatGPT exhibited a reasonable accuracy in providing general dietary advice for NCDs, its efficacy decreased in complex situations necessitating customized strategies; therefore, the chatbot is currently unable to replace a healthcare professional's consultation.
- || Review, Journal: Immunogenetic Aspects of Sarcopenic Obesity. (Pubmed Central) - Feb 28, 2024
The lack of anti-inflammatory cytokine (e.g., IL-15) can increase SO risk, but further studies are needed to evaluate the exact mechanisms of implications of various cytokines in SO individuals. This manuscript analyses various immunogenetic and non-genetic factors and summarizes the recent findings on immunogenetics potentially impacting SO development.
- | Preclinical, Journal: The Effects of Aging on Sarcoplasmic Reticulum-Related Factors in the Skeletal Muscle of Mice. (Pubmed Central) - Feb 28, 2024
Furthermore, JPH1 and JPH2 co-localized with matrix metalloproteinase (MMP) 2 around the TA. These results suggest that sarcoplasmic reticulum-related factors are localized in or around TAs that occur in fast-twitch muscle with aging, but some of them might be degraded by MMP2.
- || sirolimus / Generic mfg.
Review, Journal: Mitochondrial Quantity and Quality in Age-Related Sarcopenia. (Pubmed Central) - Feb 28, 2024
Several systems have been implicated in the regulation of muscle plasticity and trophism such as the fine-tuned and complex regulation between the stimulator of protein synthesis, mechanistic target of rapamycin (mTOR), and the inhibitor of mTOR, AMP-activated protein kinase (AMPK), that promotes muscle catabolism...We also discuss lifestyle interventions (i.e., physical exercise and nutrition) that may be exploited to preserve mitochondrial function in the aged muscle. Finally, we illustrate the emerging possibility of rescuing muscle tissue homeostasis through mitochondrial transplantation.
- | Retrospective data, Journal: Dyslipidemia is associated with sarcopenia of the elderly: a meta-analysis. (Pubmed Central) - Feb 28, 2024
Finally, we illustrate the emerging possibility of rescuing muscle tissue homeostasis through mitochondrial transplantation. Dyslipidemia was associated with sarcopenia in the elderly, which was affected by sex, region and age.
- | Journal: Protein digestibility and ACE inhibitory activity of fermented flours in older adults and standard gastrointestinal simulation. (Pubmed Central) - Feb 28, 2024
However, the ACE inhibitory activity increased in SSF-dried samples, in part because of melanoidins generated during drying. Finally, lower values of protein digestibility and thus smaller peptides, amino acid profile, and ACE inhibitory activity of fermented flours were found in the older adult digestion model.
- | New trial: Presence and Comparison of Sarcopenia in Early Rheumatoid Arthritis and Rheumatoid Arthritis (clinicaltrials.gov) - Feb 28, 2024
P=N/A, N=48, Recruiting, Sponsor: Kayseri City Hospital
- | Journal: Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases. (Pubmed Central) - Feb 28, 2024
Furthermore, the metabolite-gene interaction networks were constructed. Our research suggested new evidence of the relationship between identified metabolites and 6 age-related diseases, which may hold promise as valuable biomarkers.
- | New trial: ESPAI-F: Effectiveness of Intervention in Prevention of Sarcopenia, Frailty and Functional Decline in Pre-frail Community Elderly (clinicaltrials.gov) - Feb 28, 2024
P=N/A, N=232, Active, not recruiting, Sponsor: Consorci Sanitari del Maresme
- | Journal: Impact of electrical muscle stimulation on serum myostatin level and maintenance of skeletal muscle mass in patients undergoing living-donor liver transplantation: Single-center controlled trial. (Pubmed Central) - Feb 28, 2024
Our research suggested new evidence of the relationship between identified metabolites and 6 age-related diseases, which may hold promise as valuable biomarkers. Stimulation of muscles by EMS decreases the serum myostatin and helps to maintain skeletal muscle in patients who have undergone LDLT.
- | Enrollment open: Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial (clinicaltrials.gov) - Feb 28, 2024
P=N/A, N=80, Recruiting, Sponsor: Dana-Farber Cancer Institute
Stimulation of muscles by EMS decreases the serum myostatin and helps to maintain skeletal muscle in patients who have undergone LDLT. Not yet recruiting --> Recruiting
- | New trial: Sarcopenia in Chronic Lung Diseases (clinicaltrials.gov) - Feb 28, 2024
P=N/A, N=300, Recruiting, Sponsor: Taichung Veterans General Hospital