Sarcopenia News - LARVOL Sigma

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|||||||||| Trial primary completion date: ReFit: Reducing Falls With Progressive Resistance Training for the Oldest Old Adults With Sarcopenia (clinicaltrials.gov) - Mar 7, 2024
P=N/A, N=240, Enrolling by invitation, Sponsor: Norwegian University of Science and Technology
Trial primary completion date: Mar 2025 --> Dec 2025

|||||||||| New trial: PREFISAR: Evaluation of Physical Performance in Old Adults With Sarcopenic Obesity (clinicaltrials.gov) - Mar 6, 2024
P=N/A, N=80, Active, not recruiting, Sponsor: Istituto Auxologico Italiano

|||||||||| Review, Journal: Fat malabsorption in pancreatic cancer: Pathophysiology and management. (Pubmed Central) - Mar 6, 2024
Medical nutrition therapies may also be applicable and may include fat-soluble vitamin replacement, medium-chain triglycerides, and, in some cases, enteral nutrition. Optimizing nutrition status is an important adjunct treatment approach to improve quality of life and may also improve overall survival.

|||||||||| Retrospective data, Review, Journal: Potential protective effects of increased serum uric acid concentration in sarcopenia: A meta-analysis and systematic review. (Pubmed Central) - Mar 6, 2024
A notable correlation between serum UA concentration and sarcopenia was observed. Hence, monitoring UA levels could aid in the early detection and treatment of sarcopenia, enabling timely intervention to preserve muscle mass and strength.

|||||||||| Journal: Agreement and diagnostic differences among three definitions of sarcopenia in patients with chronic hepatitis C. (Pubmed Central) - Mar 6, 2024
In patients without cirrhosis or with compensated cirrhosis, and with chronic hepatitis C, the agreement between EWGSOP1 and EWGSOP2 classifications was substantial for sarcopenia diagnosis. Concerning EWGSOP and FNIH criteria, a fair agreement and limited overlap were found in these patients.

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Clinical data, Journal: Body composition measurements and clinical outcomes in patients with resectable pancreatic adenocarcinoma - analysis from SWOG S1505. (Pubmed Central) - Mar 6, 2024
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Visceral adipose tissue was associated with survival; however, there was no association between OS and sarcopenia or sarcopenic obesity. Further studies should evaluate these findings in more detail.

|||||||||| Review, Journal: Making the invisible visible: imaging techniques for assessing muscle mass and muscle quality in chronic kidney disease. (Pubmed Central) - Mar 6, 2024
In the field of CKD and end-stage kidney disease (ESKD), imaging techniques are gaining attention for evaluating muscle quantity and more recently muscle fat infiltration. This review describes the potential of these techniques in CKD and ESKD settings for muscle assessment beyond that of muscle quantity.

|||||||||| Journal: The identification of an optimal body size parameter to adjust skeletal muscle area on chest CT in COVID-19 patients. (Pubmed Central) - Mar 6, 2024
Gender and estimated VBA from simple linear measurements at T5 level on CT images can be utilized for adjustment of SMA without the need for height. Validation of these findings in larger cohorts of critically ill patients is now needed.

|||||||||| Review, Journal, Adherence: A systematic review of Behaviour Change Interventions to improve exercise self-efficacy and adherence in people with Parkinson's disease using the Theoretical Domains Framework. (Pubmed Central) - Mar 6, 2024
The most effective domains appear to be Behavioural regulation, Belief about Capabilities, Social influences, Reinforcement and Goals. Future research should examine multi-component BC interventions encompassing the five most effective TDF domains.

|||||||||| Journal: Sarcopenia and Hip Fractures. (Pubmed Central) - Mar 6, 2024
Future research should examine multi-component BC interventions encompassing the five most effective TDF domains. No abstract available

|||||||||| Journal: 3D Topographical Scanning for the Detection of Osteoporosis. (Pubmed Central) - Mar 6, 2024
Mobile device-based 3D scanning may hold promise as an adjunct screening tool for osteoporosis when DEXA scanning is not available or feasible for patients, although further studies are needed to elucidate the full potential of its clinical utility. At a minimum, identifying a patient as high risk may promote earlier diagnostic DEXA scanning.

|||||||||| Journal: The SHARE Frailty Instrument for Primary Care was Associated with Sarcopenia, as Measured by Bioelectrical Impedance, in Falls Clinic Attendees. (Pubmed Central) - Mar 6, 2024
At a minimum, identifying a patient as high risk may promote earlier diagnostic DEXA scanning. Among the 118 patients who underwent BIA, ASMM was independently associated with pre-frail/frail status, but there was no significant association between abnormal MNA

|||||||||| Journal: Relation Between Ultrasonographic Measurements of the Biceps Brachii and Total Muscle Mass in Older Hospitalized Persons: A Pilot Study. (Pubmed Central) - Mar 6, 2024
Biceps brachii looks like a very good muscle measuring tool: easy, comfortable, fast, good correlated with total body muscle mass. This muscle could effectively be used for the assessment of muscle mass in the diagnosis of sarcopenia since it reflects muscle mass precisely, however more studies are needed to provide reference values in all age cohorts.

|||||||||| Retrospective data, Journal, Surgery: Impact of Frailty in Patients Undergoing Minimally Invasive Mitral Valve Surgery. (Pubmed Central) - Mar 6, 2024
Contrary to other cardiac operations, for patients undergoing isolated minimally invasive mitral valve surgery, sarcopenia was not associated with increased perioperative risk except for higher readmission rates. Minimally invasive surgical approaches should be strongly considered as the approach of choice in frail patients.

|||||||||| Journal, HEOR: A path analysis investigation into menopausal osteoporosis, sarcopenia risk, and their impact on sleep quality, depressive symptoms and quality of life. (Pubmed Central) - Mar 6, 2024
Further, individuals with osteoporosis had lower pain levels, less sarcopenia risk, and higher engaged in exercise presentation improved physical and mental QOL. Future longitudinal research holds the promise of providing deeper insights into these complex relationships.

|||||||||| New trial: The Krill Ageing Muscle Mechanisms (KAMM) Study (clinicaltrials.gov) - Mar 6, 2024
P=N/A, N=80, Not yet recruiting, Sponsor: University of Glasgow

|||||||||| Journal, Adverse events: Commentary to: Pectoralis Muscle Area Measured at T4 Level is Closely Associated With Adverse COVID-19 Outcomes in Hospitalized Patients. (Pubmed Central) - Mar 5, 2024
Future longitudinal research holds the promise of providing deeper insights into these complex relationships. No abstract available

|||||||||| Retrospective data, Review, Journal: The prognostic utility of temporalis muscle thickness measured on magnetic resonance scans in patients with intra-axial malignant brain tumours: A systematic review and meta-analysis. (Pubmed Central) - Mar 5, 2024
TMT has significant prognostic potential in intra-axial malignant neoplasms, showing a moderate to high certainty for its association with outcomes following GRADE evaluation. This will enable shared decision making between patients and clinicians.

|||||||||| Journal: Higher ultra processed foods intake is associated with low muscle mass in young to middle-aged adults: a cross-sectional NHANES study. (Pubmed Central) - Mar 5, 2024
Our study underscores a significant linear association between higher UPFs consumption and an elevated risk of low muscle mass in adults. These findings emphasize the potential adverse impact of UPFs on muscle health and emphasize the need to address UPFs consumption as a modifiable risk factor in the context of sarcopenia.

|||||||||| Journal: Prevalence and co-incidence of geriatric syndromes according to the ECOG performance status in older cancer patients. (Pubmed Central) - Mar 5, 2024
Geriatric syndromes and their co-incidence were common in older cancer patients, even in normal performance status. Oncologists should incorporate geriatric syndromes into the decision-making process of cancer treatment to maximize the impact on clinical outcomes in older patients with cancer.

|||||||||| New trial, HEOR: WBV: Whole- Body Vibration Among Egyptian Elderly With Sarcopenia (clinicaltrials.gov) - Mar 5, 2024
P=N/A, N=84, Active, not recruiting, Sponsor: Cairo University

|||||||||| Journal: Low hemoglobin levels are associated with compromised muscle health: Insights from a post-stroke rehabilitation cohort. (Pubmed Central) - Mar 5, 2024
Evaluating anemia at the outset serves as a crucial prognostic indicator. Geriatr Gerontol Int 2024; 24: 305-311.

|||||||||| Journal: Coincidence of sarcopenia and body weight loss. (Pubmed Central) - Mar 5, 2024
Geriatr Gerontol Int 2024; 24: 305-311. No abstract available

|||||||||| Journal: Sensitivity and specificity of Yubi-wakka (finger-ring) screening method for sarcopenia among older Thai adults. (Pubmed Central) - Mar 5, 2024
The Yubi-wakka test is a practical way of identifying the risk of sarcopenia among the elderly; it exhibits promising sensitivity and specificity. Geriatr Gerontol Int 2024; 24: 263-268.

|||||||||| Observational data, Journal, Machine learning: Influence of hand grip strength test and short physical performance battery on FRAX in post-menopausal women: a machine learning cross-sectional study. (Pubmed Central) - Mar 5, 2024
In light of the major findings, this cross-sectional study using a machine learning model related SPPB and HGS to FRAX. Therefore, a precise assessment including muscle strength and physical performance might be considered in the multidisciplinary assessment of fracture risk in post-menopausal women.

|||||||||| Journal: Explanatory sequential mixed-methods approach to understand how registered dietitians implemented computed tomography skeletal muscle assessments in clinical practice. (Pubmed Central) - Mar 5, 2024
Preliminary results suggest RDs found CT SM assessments positively contributed to their nutrition care practice, particularly in completing nutrition assessments and in planning, advocating for, and implementing nutrition interventions. Use of CT SM assessments in clinical practice requires innovative IT solutions and strategies to support skill development and use in clinical nutrition care.

|||||||||| Journal: Effect of intradialytic weight resistance training exercise in sarcopenic hemodialysis patients: A randomized controlled trial. (Pubmed Central) - Mar 5, 2024
Over a 12-week follow-up, resistance exercise improved muscle strength in sarcopenic ESKD patients. Muscle mass and physical performance showed no significant change, but there is still a trend demonstrating to improve.

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Cirrhosis Care: Emerging Changes () - Mar 5, 2024 - Abstract #APASL2024APASL_3083;
The patients with cirrhosis and MELD score ? 15 should be evaluated for liver transplantation.

|||||||||| Effects of Exercise on Physical Function and Prognosis of Patients with Liver Cirrhosis and HCC () - Mar 5, 2024 - Abstract #APASL2024APASL_3040;
Moreover, in patients with HCC, exercise had beneficial effects on the prognosis with no worsening of liver function. These findings suggest that exercise therapy should be considered a fundamental therapy for patients with both liver cirrhosis and HCC.

|||||||||| NAFLD/NASH and sarcopenia - usefulness of nutritional and exercise therapy - () - Mar 5, 2024 - Abstract #APASL2024APASL_2999;
In cirrhosis resulting from NASH, the progression of fibrosis and the dynamics of amino acids, including BCAA, should be evaluated and BCAA replacement therapy should be considered. In conclusion, it is critical to develop safe and appropriate liver rehabilitation to improve the prognosis and quality of life of NAFLD/NASH patients with sarcopenia.

|||||||||| Etiology and Usefulness of MAFLD in the Asian-Pacific region () - Mar 5, 2024 - Abstract #APASL2024APASL_2970;
In this session, I will introduce the etiology of Asian-Pacific MAFLD according to the APASL guidelines. I also mention the impact of MAFLD on the identification of patients at risk of hepatic events as well as extra-hepatic events in the Asia

|||||||||| Trial completion: High Intensity Resistance Training and Possible Sarcopenia (clinicaltrials.gov) - Mar 4, 2024
P=N/A, N=32, Completed, Sponsor: Riphah International University
I also mention the impact of MAFLD on the identification of patients at risk of hepatic events as well as extra-hepatic events in the Asia Recruiting --> Completed

|||||||||| Journal: Low physical activity is a risk factor for sarcopenia: a cross-sectional analysis of two exercise trials on community-dwelling older adults. (Pubmed Central) - Mar 4, 2024
Probable sarcopenia is common among community-dwelling older adults not meeting the PA guidelines and very common among individuals recovering from HF who are able to be involved in exercise interventions. In addition, since low PA is associated with higher probable sarcopenia and sarcopenia risk, it is recommended to screen for sarcopenia and promote regular physical activity to prevent sarcopenia in these populations.

|||||||||| Journal, Surgery: MRI-based central sarcopenia negatively impacts the therapeutic effectiveness of single-segment lumbar fusion surgery in the elderly. (Pubmed Central) - Mar 4, 2024
There were no significant differences between the groups in terms of leg pain VAS scores at each time point and the fusion status at 12 months postoperatively. MRI-based central sarcopenia has a negative impact on the therapeutic effectiveness following single-segment lumbar fusion surgery in elderly patients.

|||||||||| Journal: Preoperative Myosteatosis and Prognostic Nutritional Index Predict Survival in Older Patients With Resected Biliary Tract Cancer. (Pubmed Central) - Mar 4, 2024
These factors may be useful for risk stratification and clinical decision-making. Early interventions, such as nutritional support and physical exercise, may improve outcomes after resection of biliary tract cancer.

|||||||||| Journal: Prognostic Significance of Sarcopenia and Eicosapentaenoic Acid (EPA) Levels in Patients With Unresectable Pancreatic or Biliary Tract Cancer. (Pubmed Central) - Mar 4, 2024
In patients administered with enteral nutrition containing omega-3 fatty acids, both EPA concentration and lumbar muscle volume were significantly higher than those prior to intervention, indicating sarcopenia improvement due to the intervention. In patients with recurrent non-resected pancreatic and biliary tract cancer, low blood EPA levels before chemotherapy are associated with sarcopenia and poor prognosis.

|||||||||| Retrospective data, Journal: Impact of Sarcopenia on Prognosis in Primary Hepatocellular Carcinoma Patients Treated with Transcatheter Arterial Chemoembolization: A Single Center Retrospective Study. (Pubmed Central) - Mar 4, 2024
200 ng/mL and maximal tumor diameter were also independent risk factors for a poor prognosis. The prognostic risk grading system based on sarcopenia, AFP, and maximal tumor diameter had good guiding value for the prognosis of patients.

|||||||||| Review, Journal: Fat infiltration in skeletal muscle: Influential triggers and regulatory mechanism. (Pubmed Central) - Mar 4, 2024
Furthermore, we reviewed the molecular regulatory mechanism, detection methods, and intervention strategies of fat infiltration in skeletal muscle. Based on the current findings, our review will provide new insight into regulating function and lipid metabolism of skeletal muscle and treating muscle-related diseases.

|||||||||| Retrospective data, Review, Journal: The Effect of Vitamin D Supplementation to Parameter of Sarcopenia in Elderly People: a Systematic Review and Meta-Analysis. (Pubmed Central) - Mar 4, 2024
Vitamin D supplementation had minimal effect on sarcopenia-related parameters. Further research into understanding the role of Vitamin D in preventing the progressivity of sarcopenia still needs to be explored.

|||||||||| Biomarker, Retrospective data, Journal: Integrated assessment of computed tomography density in pectoralis and erector spinae muscles as a prognostic biomarker for coronavirus disease 2019. (Pubmed Central) - Mar 4, 2024
Muscle density, rather than muscle area, predicts the clinical outcomes of COVID-19. Integrated assessment of pectoralis and erector spinae muscle densities demonstrated higher accuracy in predicting the clinical course of COVID-19 than individual assessments.

|||||||||| Journal: Associations between sarcopenic obesity and risk of cardiovascular disease: A population-based cohort study among middle-aged and older adults using the CHARLS. (Pubmed Central) - Mar 4, 2024
Sarcopenic obesity and possibly sarcopenic obesity are positively associated with the development of CVD. The middle-aged and elderly population should prevent obesity and maintain muscle mass through some interventions such as weight control and moderate exercise, which may reduce the CVD risk.

|||||||||| Journal: Novel equations incorporating the sarcopenia index based on serum creatinine and cystatin C to predict appendicular skeletal muscle mass in patients with nondialysis CKD. (Pubmed Central) - Mar 4, 2024
The middle-aged and elderly population should prevent obesity and maintain muscle mass through some interventions such as weight control and moderate exercise, which may reduce the CVD risk. Novel ASM equations offer a simple method for predicting skeletal muscle mass and can provide valuable prognostic information regarding patients with nondialysis CKD.

|||||||||| Journal: Sarcopenia and poor nutritional status in older adults. (Pubmed Central) - Mar 4, 2024
Novel ASM equations offer a simple method for predicting skeletal muscle mass and can provide valuable prognostic information regarding patients with nondialysis CKD. In this study, the prevalence of sarcopenia ranged from 12.6 to 44.9

|||||||||| Journal: Specific bioelectrical vectors pattern in individuals with sarcopenic obesity. (Pubmed Central) - Mar 4, 2024
In this study, the prevalence of sarcopenia ranged from 12.6 to 44.9 Specific BIVA detects body composition peculiarities of individuals with sarcopenic obesity, thus allowing their diagnosis when associated with low handgrip strength values.

|||||||||| Journal, Surgery: Relevance of sarcopenia in elderly patients undergoing surgery for oral squamous cell carcinoma. (Pubmed Central) - Mar 4, 2024
This study shows that sarcopenia negatively influences surgical outcomes in elderly patients. Routine measurement of SMI could be an indication for a comprehensive geriatric assessment (CGA).

|||||||||| Journal: Skeletal muscle mass and function are affected by pancreatic atrophy, pancreatic exocrine insufficiency and poor nutritional status in patients with chronic pancreatitis. (Pubmed Central) - Mar 4, 2024
Routine measurement of SMI could be an indication for a comprehensive geriatric assessment (CGA). SM loss was associated with pancreatic exocrine insufficiency, low nutritional status, and pancreatic imaging findings such as parenchymal atrophy and main pancreatic duct dilatation, whereas older age and low nutritional status led to additional reduced GS.

|||||||||| Journal: Clinical Impact of improvement in sarcopenia Through cardiac Rehabilitation in patients With Heart Failure. (Pubmed Central) - Mar 4, 2024
No improvement in sarcopenia status in patients with HF undergoing outpatient CR was associated with a higher risk of all-cause death. Sarcopenia may be an important target to improve the prognosis of patients with HF.

|||||||||| Review, Journal: Prevalence of sarcopenia and depressive symptoms among older adults: a scoping review. (Pubmed Central) - Mar 4, 2024
Appropriate nutritional assessments and interventions should be taken to manage these two geriatric conditions. Further studies should be planned, considering multidomain intervention strategies to improve sarcopenia and older people's mental health.

|||||||||| Journal: Sarcopenia and sleep status in older female patients with mild to moderate Alzheimer's disease: a risk assessment. (Pubmed Central) - Mar 4, 2024
Further studies should be planned, considering multidomain intervention strategies to improve sarcopenia and older people's mental health. No abstract available

|||||||||| Journal, Adverse events, Machine learning: Machine learning-based detection of sarcopenic obesity and association with adverse outcomes in patients undergoing surgical treatment for spinal metastases. (Pubmed Central) - Mar 4, 2024
The SO phenotype was associated with increased odds of nonhome discharge, readmission, and postoperative mortality. This study suggests that SO may be an important prognostic factor to consider when developing care plans for patients with spinal metastases.



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