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17 Mechanisms of Action |
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- | Journal: The Mood-Muscle Meta Bridge (Brain Muscle Axis). (Pubmed Central) - Apr 13, 2024
In this brief communication we describe the bidirectional association between muscle function and mood (psychological health), explore the various pathways that link these aspects of health, and underscore their clinical implications. This paper emphasizes the importance of maintaining good mental health through exercise and vice a versa.
- | Journal, Surgery: The Impact of Sarcopenia in the Long-Term Survival of Patients following Complex Endovascular Aortic Surgery for Thoracoabdominal Aortic Aneurysms. (Pubmed Central) - Apr 13, 2024
This paper emphasizes the importance of maintaining good mental health through exercise and vice a versa. Using SMI and TPMI, sarcopenia was not associated with reduced long-term survival in patients undergoing complex endovascular repair for thoracoabdominal aortic aneurysms.
- || Retrospective data, Review, Journal: Impact of Frailty and Sarcopenia on Thirty-Day and Long-Term Mortality in Patients Undergoing Elective Endovascular Aortic Aneurysm Repair: A Systematic Review and Meta-Analysis. (Pubmed Central) - Apr 13, 2024
Patients with sarcopenia or frailty have a significantly increased risk of mortality following elective EVAR. Prospective studies validating the use of frailty and sarcopenia for risk prediction after EVAR are needed before these tools can be used to support decision making.
- || Review, Journal: The Impact of Geriatric Conditions in Elderly Patients with Coronary Heart Disease: A State-of-the-Art Review. (Pubmed Central) - Apr 13, 2024
In this review, we aim to summarize the available evidence on the treatment of acute coronary syndrome in the elderly. Additionally, we contextualize frailty, comorbidity, sarcopenia, and cognitive impairment, common in these patients, within the realm of coronary artery disease, proposing strategies for each case that may assist in therapeutic approaches.
- | Journal: Low ALT Is Associated with IBD and Disease Activity: Results from a Nationwide Study. (Pubmed Central) - Apr 13, 2024
These findings remained consistent following multivariate regression and in a propensity score-matched cohort. Low ALT is more common in patients with IBD and is associated with biochemical disease activity indices.
- | Observational data, Journal: Allergic Phenotypes and Sarcopenia: Evidence from Observational Studies and Mendelian Randomization Analysis. (Pubmed Central) - Apr 12, 2024
The findings of our study will raise the awareness of preventing aging-related disorders or geriatric syndromes among allergic populations. The online version contains supplementary material available at 10.1007/s43657-023-00110-4.
- | Journal: Ambient air pollution exposure and the risk of probable sarcopenia: A prospective cohort study. (Pubmed Central) - Apr 12, 2024
Air pollution exposure elevated the risk of developing sarcopenia and related manifestations in a dose-dependent manner, while physical activity maintained protective under this circumstance. Efforts should be made to control air pollution and emphasize the importance of physical activity for skeletal muscle health under this circumstance.
- | Trial completion: Effect of potassium bicarbonate supplementation on muscle protein synthesis in older women (EUDRACT) - Apr 12, 2024
P=N/A, N=20, Completed, Sponsor: Dr Caoileann Murphy
Efforts should be made to control air pollution and emphasize the importance of physical activity for skeletal muscle health under this circumstance. Recruiting --> Completed
- | New trial: The Foods & Oil to Repair, Correct and Enhance Strength (FORCES) Study (clinicaltrials.gov) - Apr 12, 2024
P=N/A, N=66, Not yet recruiting, Sponsor: Ohio State University
- | New trial: Pilot Study of the Human Metagenome in Metabolic Diseases (clinicaltrials.gov) - Apr 12, 2024
P=N/A, N=600, Recruiting, Sponsor: Sengkang General Hospital
- | New trial: A Personalized Video-based Exercise Program for Fall Prevention in Frail and Pre-frail Older Adult (clinicaltrials.gov) - Apr 12, 2024
P=N/A, N=100, Not yet recruiting, Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
- Feasibility and Utility of Introducing Handgrip Strength Measurement (for Sarcopenia Assessment) for Outpatients Living with Parkinson's Disease (In-Person; LOBBYBAR AREA) - Apr 12, 2024 - Abstract #NDS2024NDS_29;
Handgrip strength could be used to monitor the effect of lifestyle change in individuals. Limitations include self-reporting bias about which activities classifies as exercise.
- | Journal: Increased serum adipokines are associated with sarcopenia in non-obese women with rheumatoid arthritis. (Pubmed Central) - Apr 11, 2024
Taken together, our study reveals that secondary sarcopenia of RA females may be an imbalance of RA-related, but not obesity-related, increase in adipokine production; additionally, the reduced leptin/adiponectin ratio could be a better indicator in monitoring sarcopenia in non-obese RA females. Moreover, adipokine imbalance may promote muscle atrophy through inducing autophagy.
- | Journal: Sarcopenia as a robust predictor of readmission within six months among individuals experiencing acute stroke. (Pubmed Central) - Apr 11, 2024
Sarcopenia was negatively associated with readmission within 6 months of stroke onset in patients in Japan who had experienced an acute stroke. These findings suggest that the identification of sarcopenia may facilitate prognostic prediction from the acute stage and intervention(s) to prevent rehospitalization.
- | Observational data, Journal: Pain characteristics and progression to sarcopenia in Chinese middle-aged and older adults: a 4-year longitudinal study. (Pubmed Central) - Apr 11, 2024
These findings suggest that the identification of sarcopenia may facilitate prognostic prediction from the acute stage and intervention(s) to prevent rehospitalization. Our study showed that pain, especially pain persistence, was closely correlated to the increased risk of progression to sarcopenia in Chinese middle-aged and older adults.
- | New trial: Effects of the EatWelLog App on Diet Management for Older Adults With Sarcopenic Obesity (clinicaltrials.gov) - Apr 11, 2024
P=N/A, N=40, Not yet recruiting, Sponsor: The Hong Kong Polytechnic University
- | Journal: Lean body mass in living kidney donors impacts postoperative renal function. (Pubmed Central) - Apr 10, 2024
Our study showed that pain, especially pain persistence, was closely correlated to the increased risk of progression to sarcopenia in Chinese middle-aged and older adults. When selecting donors, this study highlights that patients with low skeletal mass are unlikely to underperform in terms of recovery of their renal function postoperatively at one year when compared to patients with normal muscle mass and should not be a barrier to kidney donation.
- | Journal: The association of appendicular lean mass and grip strength with low-density lipoprotein, very low-density lipoprotein, and high-density lipoprotein particle diameter: a Mendelian randomization study of the UK Biobank cohort. (Pubmed Central) - Apr 10, 2024
There were potentially causal associations between both increasing ALM and HGS and increasing HDL particle size and decreasing VLDL particle size. These causal associations may offer possibilities for interventions aimed at improving cardiovascular disease risk profile.
- | Journal: Assessing paraspinal muscle atrophy with electrical impedance myography: Limitations and insights. (Pubmed Central) - Apr 10, 2024
With the current methodology, paraspinal EIM is not a valid alternative to MRI assessment of muscle quality, as it is strongly influenced by the dermal and subcutaneous layers. Further studies are required for refining the methodology and confirming our results.
- | Retrospective data, Journal: Predictive Value of a New Muscle Parameter in Patients with Resectable Gastric Cancer: A Pooled Analysis of Three Prospective Trials. (Pubmed Central) - Apr 10, 2024
The prospective large sample data showed that the new muscle parameter, SMG, can effectively predict the short-term outcome and long-term prognosis of patients with resectable gastric cancer. As a new muscle parameter index, SMG is worthy of further study.
- | Journal: Impact of low skeletal muscle mass in oropharyngeal cancer patients treated with radical chemo-radiotherapy: A mono-institutional experience. (Pubmed Central) - Apr 10, 2024
In our setting, SMI demonstrated a crucial impact on overall survival. Further investigation with larger samples is necessary to confirm our results to improve patient outcomes.
- | Journal: Association of Performance on Multiple Cognitive Domains with Sarcopenia Among Middle-aged and Older Adults. (Pubmed Central) - Apr 9, 2024
Further investigation with larger samples is necessary to confirm our results to improve patient outcomes. Better cognitive function especially episodic memory and visuospatial ability was negatively associated with incident sarcopenia among community middle-aged and older adults.
- || metformin / Generic mfg.
Review, Journal: From liver to hormones: The endocrine consequences of cirrhosis. (Pubmed Central) - Apr 9, 2024
Established standards are followed for managing hypoglycemia, and hormone replacement therapy is often necessary for other endocrine dysfunctions. Liver transplantation can address some of these problems.
- || Review, Journal: Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies. (Pubmed Central) - Apr 9, 2024
The ongoing research aims to develop more effective strategies in the future. Our review of research on disease mechanisms and drug development will be a valuable contribution to future research endeavors.
- | Observational data, Journal: Relationship between Pulse Pressure and Handgrip Strength in the Korean Population: A Nationwide Cross-Sectional Study. (Pubmed Central) - Apr 9, 2024
Elevated PP was significantly associated with a higher prevalence of weak muscle strength. Thus, PP monitoring may be used to identify individuals at risk of sarcopenia and is helpful in improving health outcomes.
- | Journal: Total Muscle Area and Visceral Adipose Tissue Measurements for Frailty Assessment in TAVR Patients. (Pubmed Central) - Apr 9, 2024
Thus, PP monitoring may be used to identify individuals at risk of sarcopenia and is helpful in improving health outcomes. The effect of nTMA on 5-year, all-cause mortality was gender dependent: the protective effect of higher nTMA was found in male patients (pinteraction: sex
- || Review, Journal: Effects of High-Intensity Interval Training on Muscle Strength for the Prevention and Treatment of Sarcopenia in Older Adults: A Systematic Review of the Literature. (Pubmed Central) - Apr 9, 2024
HIIT training shows improvements in body composition and functional and cardiorespiratory capacity, has benefits on muscle strength, increases muscle quality and architecture, and is associated with muscle hypertrophy in healthy older adults. Nonetheless, given the shortcomings affecting primary research in terms of the limited number of studies and the high risk of bias, further research is warranted.
- | Journal: Myosteatosis is associated with coronary artery calcification in patients with type 2 diabetes. (Pubmed Central) - Apr 9, 2024
Nonetheless, given the shortcomings affecting primary research in terms of the limited number of studies and the high risk of bias, further research is warranted. Myosteatosis is a novel risk factor for atherosclerosis in patients with T2DM, especially in the population with younger ages and fewer traditional risk factors.
- | Journal: Associations between Geriatric Nutrition Risk Index, bone mineral density and body composition in type 2 diabetes patients. (Pubmed Central) - Apr 9, 2024
Poor nutrition, as indicated by a low GNRI, was associated with low levels of ASMI and BMD at all bone sites in T2DM patients. Using the GNRI to evaluate nutritional status and using DXA to investigate body composition in patients with T2DM is of value in assessing bone health and physical performance.
- | Journal: Sarcopenia in peripheral arterial disease: Establishing and validating a predictive nomogram based on clinical and computed tomography angiography indicators. (Pubmed Central) - Apr 9, 2024
A simple nomogram based on five independent factors, namely age, BMI, history of CHD, WBC count, and the severity of luminal stenosis, was developed to assist clinicians in estimating sarcopenia risk among PAD patients. This tool boasts impressive predictive capabilities and broad utility, significantly aiding clinicians in identifying high-risk individuals and enhancing the prognosis of PAD patients.
- | Preclinical, Journal: Endurance exercise has a negative impact on the onset of SOD1-G93A ALS in female mice and affects the entire skeletal muscle-motor neuron axis. (Pubmed Central) - Apr 9, 2024
Our findings show the potentiality of skeletal muscle as a target for both prognostic and therapeutic strategies; the preservation of skeletal muscle health by specific intervention could counteract the dying-back process and protect motor neurons from death. The physiological characteristics and accessibility of skeletal muscle further enhance its appeal as a therapeutic target.
- | Journal: The relationship between sarcopenic obesity and changes in quadriceps muscle thickness and echo intensity in patients with stroke. (Pubmed Central) - Apr 9, 2024
-0.37, p?<?0.001) and significantly positively associated with QEI (paretic side ??=?0.21, p?=?0.034; non-paretic side: ??=?0.20, p?=?0.029). Post-stroke sarcopenic obesity was independently associated with quantitative and qualitative changes in skeletal muscles on both the paretic and non-paretic sides.
- ||| Trial completion: To Investigate Effects of Amway Bundle Combination of Products on Osteoarthritis & Sarcopenia (clinicaltrials.gov) - Apr 8, 2024
P=N/A, N=240, Completed, Sponsor: Amway (China) R&D Center
Post-stroke sarcopenic obesity was independently associated with quantitative and qualitative changes in skeletal muscles on both the paretic and non-paretic sides. Recruiting --> Completed
- | New trial: Practical Ultrasonographic Detection of Sarcopenia in Patients With Long-term Gastrectomy (clinicaltrials.gov) - Apr 8, 2024
P=N/A, N=90, Completed, Sponsor: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
- | Journal: Cutoff value of the geniohyoid muscle mass to identify sarcopenic dysphagia by ultrasonography. (Pubmed Central) - Apr 8, 2024
Recruiting --> Completed We found that the cut-off value of the ultrasonographic cross-sectional area of the geniohyoid muscle was 172.5
- | Observational data, Retrospective data, Journal: Abnormal sleep duration is associated with sarcopenia in older Chinese people: A large retrospective cross-sectional study. (Pubmed Central) - Apr 8, 2024
A non-linear relationship (U-shaped) between sarcopenia risk and sleep duration was found (p for non-linear = 0.009). Our findings highlight the importance of sleep duration in the onset of sarcopenia and might assist older persons to maintain good sleeping habits.
- | Journal: Correlation between Instrumental Activities of Daily Living and muscle mass in older adults: impact of comorbidities. (Pubmed Central) - Apr 8, 2024
Among different parameters studies, a statistical correlation was found in a stratified regression analysis between the Lawton index score and muscle mass in patients who were overweight (p value:0.001 ;beta coefficient: 0.08), obese (p value: 0.001 ; beta coefficient: 0.05), had diabetes (p value: 0.012 ;beta coefficient: 0.03), and had COPD (p value:0.001 ;beta coefficient:0.03). The correlation between muscle mass and instrumental activities of daily living should be evaluated individually according to the needs of each participant and according to their comorbidities, promoting patient-centered geriatric medicine.
- | Journal: Overlap between Osteosarcopenia and Frailty and their association with poor health conditions: The Bushehr Elderly Health (BEH) Program. (Pubmed Central) - Apr 8, 2024
Combined osteosarcopenia and frailty were not associated with poor health. These findings indicate the importance of diagnosing osteosarcopenia and frailty as separate entities to provide appropriate interventions and treatment.
- | Journal: How to detect non-institutionalized older patients at risk of malnutrition during their hospitalization? Comparison of 8 screening tools for malnutrition or nutritional risk. (Pubmed Central) - Apr 8, 2024
Nutritional risk tools could be effective at this stage. In a second step, malnutrition should be confirmed according to established criteria such as GLIM.
- | Journal: Bidirectional effect of uric acid on C2C12 myotubes and its partial mechanism. (Pubmed Central) - Apr 8, 2024
Inhibiting cGAS-Sting signaling attenuated HUA-induced C2C12 myotube autophagy and atrophy. Geriatr Gerontol Int 2024; 24: 430-439.
- | Journal, Surgery: Sarcopenia and its effects on outcome of lumbar spine surgeries. (Pubmed Central) - Apr 8, 2024
The management can be revolutionised by predicting those who are at high risk of developing post-operative complications and poor surgical outcomes by mere diagnosis of sarcopenia. This knowledge will benefit both the patients and the surgeons.
- | Journal: Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting. (Pubmed Central) - Apr 8, 2024
Importantly, CSP-7 was associated with a muscle wasting phenotype in mice in vivo. Overall, our findings provide new mechanistic insights in the pathophysiology of muscle inflammation and wasting.
- | Retrospective data, Journal: Impact of possible sarcopenia on functional prognosis in patients with acute stroke with premorbid disability. (Pubmed Central) - Apr 8, 2024
The results of this study demonstrated that a high rate of possible sarcopenia was observed in patients with stroke with premorbid disability; however, this did not affect functional prognosis. Geriatr Gerontol Int 2024; 24: 359-363.
- || Clinical data, Journal: The diagnostic performance of Cr/CysC for sarcopenia and its predictive value on clinical outcomes in hospitalized older patients: a prospective cohort study. (Pubmed Central) - Apr 8, 2024
Cr/CysC has satisfactory diagnostic accuracy for sarcopenia diagnosis and predictive value for poor outcomes in hospitalized older patients. The combination of Cr/CysC and SARC-CalF may provide a more accurate screening for sarcopenia and the Ishii score may be the most accurate clinical method for detecting sarcopenia.
- || Review, Journal: Control of muscle satellite cell function by specific exercise-induced cytokines and their applications in muscle maintenance. (Pubmed Central) - Apr 8, 2024
Emerging evidence reveals that exercise regulates muscle function largely via the exercise-induced cytokines that govern SC potential, but this phenomenon is complicated and confusing. This review provides a comprehensive integrative overview of the identified exercise-induced cytokines and the roles of these cytokines in SC function, providing a more complete picture regarding the mechanism of SC homeostasis and rejuvenation therapies for skeletal muscle.
- || Review, Journal: Nutritional interventions during treatment for ovarian cancer: A narrative review and recommendations for future research. (Pubmed Central) - Apr 8, 2024
A key finding from this review is that, despite the high prevalence of malnutrition and muscle loss in women with ovarian cancer and the critical importance of addressing these modifiable prognostic factors, nutrition intervention studies are limited. Prospective studies with samples large enough to provide adequate power to evaluate intervention effectiveness are urgently required to inform optimal management.
- | Journal: Are we underestimating the potential of neuroactive drugs to augment neuromotor function in sarcopenia? (Pubmed Central) - Apr 8, 2024
Prospective studies with samples large enough to provide adequate power to evaluate intervention effectiveness are urgently required to inform optimal management. No abstract available
- | Journal: The optimal cut-off value of five-time chair stand test for assessing sarcopenia among Chinese community-dwelling older adults. (Pubmed Central) - Apr 8, 2024
We determined the optimal cut-off value of the 5CST for assessing older adults with sarcopenia in the Chinese community, and this cut-off can significantly improve the detection rate of sarcopenia. The cut-off determined in our study will help community workers detect more people with sarcopenia and benefit from early intervention and management of sarcopenia in practice.
- | Journal: Effects of resistance training associated with a verbal fluency task on physical performance and cognitive function in frail nursing home residents. (Pubmed Central) - Apr 8, 2024
The present investigation was based on a small sample of nursing home residents. Larger and more structured studies are necessary to confirm our results.
- | Journal: Longitudinal association between muscle and bone loss: Results of US and Japanese cohort studies. (Pubmed Central) - Apr 8, 2024
Larger and more structured studies are necessary to confirm our results. Muscle loss co-occurred with bone loss in both cohorts, but the association in the NILS-LSA tended to be stronger than in the BLSA, and the association was higher in women than in men, implying that the association may differ by sex and country.