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17 Mechanisms of Action |
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756 Trials |
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22406 News |
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- | Biomarker, Clinical, Review, Journal: Dental Functional Status as a Possible Risk Factor of Sarcopenia: A Computed Tomography-Based Study. (Pubmed Central) - Dec 28, 2024
This unique perspective of the study contributes to the existing knowledge regarding the role of tooth loss in sarcopenia, highlighting the importance of functional occlusion.
- || Clinical, Retrospective data, Review, Journal: Prevalence and risk factors of sarcopenia in patients with stroke: a systematic review and meta-analysis. (Pubmed Central) - Dec 27, 2024
Age, low albumin, low hemoglobin, stroke duration, length of hospital stay, and pneumonia history were the risk factors for sarcopenia in patients with stroke. This review will provide evidence for the screening and early identification of high-risk groups and the prevention of sarcopenia to improve the quality of life of stroke patients.
- | Journal: Long-Term Outcome of Elderly Patients with Severe Aortic Stenosis Undergoing a Tailored Interventional Treatment Using Frailty-Based Management: Beyond the Five-Year Horizon. (Pubmed Central) - Dec 27, 2024
We found a moderate increase of disability levels, malnutrition status, comorbidities, and number of drugs, but none of them self-reported advanced NYHA class III-IV heart failure. An accurate clinical-instrumental and functional geriatric evaluation in an elderly population with AS is required for a non-futile interventional treatment in terms of survival and functional status even in long-term follow-up.
- || Review, Journal: Spotlight on the Mechanism of Action of Semaglutide. (Pubmed Central) - Dec 27, 2024
Moreover, possible applications in protection from infections and anti-aging properties are discussed. Semaglutide enhancement of the core molecular mechanisms involved in the progress of obesity and diabetes, although mostly preclinical, may provide a framework for future research applications in human diseases overall.
- | Journal: Prevention of Muscle Atrophy by Low-Molecular-Weight Fraction from Hirsutella sinensis Mycelium. (Pubmed Central) - Dec 27, 2024
This comprehensive pilot study suggests that the low-molecular-weight fraction of H. sinensis mycelium exhibits considerable potential for muscle mass preservation and atrophy mitigation. As a result, it offers a promising direction for the development of supplements aimed at addressing fatigue and preventing muscle atrophy.
- || Review, Journal: Bridging the Gap: Supplements Strategies from Experimental Research to Clinical Applications in Sarcopenic Obesity. (Pubmed Central) - Dec 27, 2024
There have been many studies highlighting the potential of vitamin D in preventing age related sarcopenia; however, the effect of vitamin D supplementation in SO is under-researched and appears less promising. Future clinical trials using natural supplements hold promise, as these provide multiple beneficial components that may work synergistically to treat SO.
- | Journal: Wearable Fabric System for Sarcopenia Detection. (Pubmed Central) - Dec 27, 2024
Moreover, this fabric system can be seamlessly integrated into sole to track critical indicators of sarcopenia patients, such as walking speed and gait. Clinical evaluations have shown that this fabric system can effectively detect variations in indicators relevant to sarcopenia patients, proving that it offers a straightforward and promising approach for the diagnosis and assessment of sarcopenia.
- | carboplatin / Generic mfg.
Journal: Bioelectrical Impedance Analysis of Body Composition in Male Childhood Brain Tumor Survivors. (Pubmed Central) - Dec 27, 2024
Conclusion. A BIA allows for the detection of changes in body composition in survivors of childhood brain tumors, revealing either the presence of central obesity correlated with the risk of MetS or signs of sarcopenia that deserve early treatment.
- | Trial completion date, Trial primary completion date: M&M: Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer (clinicaltrials.gov) - Dec 27, 2024
P=N/A, N=300, Recruiting, Sponsor: Wake Forest University Health Sciences
A BIA allows for the detection of changes in body composition in survivors of childhood brain tumors, revealing either the presence of central obesity correlated with the risk of MetS or signs of sarcopenia that deserve early treatment. Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Dec 2025
- || Enrollment closed, Trial completion date, Trial primary completion date, HEOR: The Effect of Intradialytic Parenteral Nutrition on Nutritional Status and Quality of Life in Hemodialysis Patients (clinicaltrials.gov) - Dec 27, 2024
P4, N=166, Active, not recruiting, Sponsor: Erasmus Medical Center
Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2024 --> Dec 2025 Recruiting --> Active, not recruiting | Trial completion date: Sep 2023 --> Sep 2025 | Trial primary completion date: Sep 2023 --> Mar 2025
- | Journal: Development and validation of a predicative model for identifying sarcopenia in Chinese adults using nutrition indicators (AHLC). (Pubmed Central) - Dec 27, 2024
The AHLC model stands out for weight-independent evaluations. This novel approach could assess sarcopenia risk in the Chinese population, thereby enhancing aging and quality of life.
- | Journal: Prognostic Value of Sarcopenia Definitions and Outcomes Consortium Criteria in Older Patients With Heart Failure. (Pubmed Central) - Dec 26, 2024
This novel approach could assess sarcopenia risk in the Chinese population, thereby enhancing aging and quality of life. Among older patients with heart failure, the SDOC criteria for sarcopenia diagnosis are useful for risk stratification and provide prognostic capabilities equivalent to those of the AWGS 2019 criteria.
- | Journal: Risk of Sarcopenia Following Long-Term Statin Use in Community-Dwelling Middle-Aged and Older Adults in Japan. (Pubmed Central) - Dec 26, 2024
Among older patients with heart failure, the SDOC criteria for sarcopenia diagnosis are useful for risk stratification and provide prognostic capabilities equivalent to those of the AWGS 2019 criteria. Statin use was not associated with an elevated risk of sarcopenia or impaired muscle health among community-dwelling middle-aged and older adults in Japan.
- | Journal: Skeletal Muscle 31P MR Spectroscopy Surpasses CT in Predicting Patient Survival After Liver Transplantation. (Pubmed Central) - Dec 26, 2024
Abnormal 31P MRS results of calf muscles were superior to CT-based diagnosis of myosteatosis and sarcopenia in predicting perioperative complications and long-term survival after LT. Resting muscle metabolism normalized 1?year after LT in most recipients.
- | 5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg., irinotecan / Generic mfg.
Journal: Skeletal Muscle Index Changes on Locoregional Treatment Application After FOLFIRINOX and Survival in Pancreatic Cancer. (Pubmed Central) - Dec 26, 2024
Progressive sarcopenic deterioration after four cycles of chemotherapy was associated with poor survival outcomes in patients with BR or LAPC after FOLFIRINOX. We also investigated the optimal clinical setting for the early application LRTs using the ?SMI and post-chemotherapy CA 19-9.
- | Journal, Discordant: Concordance of Freehand 3D Ultrasound Muscle Measurements With Sarcopenia Parameters in a Geriatric Rehabilitation Ward. (Pubmed Central) - Dec 26, 2024
This study was the first to use 3D-US in a geriatric setting and develop a model to predict ASMM in very old hospitalized patients. MV measurements with 3D-US proved to be reliable and more concordant with appendicular muscle mass and strength than 2D parameters.
- | Journal: Examination of Gait Characteristics Related to Sarcopenia in Community-Dwelling Older Adults: A Study Focusing on Plantar Pressure. (Pubmed Central) - Dec 26, 2024
The sarcopenia, probable sarcopenia and nonsarcopenia groups differed concerning gait characteristics, including plantar pressure. It is thought that exercise instruction that takes into account walking characteristics is important for probable sarcopenia and sarcopenia.
- | Journal: Sarcopenia Seems to Be Common in Older Patients With Restless Legs Syndrome. (Pubmed Central) - Dec 26, 2024
This study demonstrated that sarcopenia is prevalent among older patients with RLS, which seems to be associated with low muscle strength and slow gait speed. Given the negative health outcomes related to sarcopenia, interventions aimed at preventing its development could be significantly beneficial for patients with RLS in older adults as well.
- | Journal: Metagenomic Analysis Identifies Sex-Related Gut Microbial Functions and Bacterial Taxa Associated With Skeletal Muscle Mass. (Pubmed Central) - Dec 26, 2024
This study highlights sex-specific differences in gut microbiota and functional pathways associated with SMI. These findings suggest that gut microbiota may play a role in muscle health and point toward microbiota-targeted strategies for maintaining muscle mass.
- | Journal: Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young. (Pubmed Central) - Dec 26, 2024
Maintained anabolic sensitivity with age appears to be a function of a compensatory increase in basal levels of proteins involved in anabolic signalling. Therefore, our results suggest that age per se does not appear to cause AR in human skeletal muscle.
- | Journal: Durable Muscle Extracellular Matrix Engineered with Adhesive Phenolic Moieties for Effective Skeletal Muscle Regeneration in Muscle Atrophy. (Pubmed Central) - Dec 26, 2024
Notably, these engineered MEM hydrogels, devoid of cells or drugs, induce tissue rejuvenation by promoting muscle protein synthesis and facilitating functional muscle recovery in mouse models of disuse- and age-induced atrophy. This study introduces cell-free, ECM-based therapeutics with translational potential for muscle atrophy by reversing muscle loss and restoring function.
- | Journal: Correlation between individual thigh muscle volume and grip strength in relation to sarcopenia with automated muscle segmentation. (Pubmed Central) - Dec 26, 2024
The findings indicate that stronger grip strength correlates with larger thigh muscles in males but not in females, with specific muscles like the Rectus femoris and Vastus lateralis linked to sarcopenia in men only. The study's small sample size calls for further research with more diverse and gender-balanced groups to verify these results.
- | Trial completion date, Trial primary completion date: The Effects of Eccentric Cycling Exercise Program in Chronic Kidney Disease Patients (clinicaltrials.gov) - Dec 26, 2024
P=N/A, N=90, Recruiting, Sponsor: National Cheng Kung University
The study's small sample size calls for further research with more diverse and gender-balanced groups to verify these results. Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Oct 2024 --> Jun 2026
- | Journal: Causal Associations with Arterial Stiffness and Sarcopenia: A Mendelian Randomization Analysis. (Pubmed Central) - Dec 26, 2024
The increased AS could reduce the motor ability slightly and the lower upper and lower limb strength could lead to the higher AS. This bidirectional causal relationship of the two may offer novel perspectives for advancing the understanding of the underlying mechanisms related to AS and muscle pathophysiology.
- | Observational data, Journal: Fasting Glycemia, Glycosylated Hemoglobin and Malnutrition Inflammation Are Associated With Sarcopenia in Older People With Chronic Kidney Disease Undergoing Hemodialysis Treatment: A Cross-Sectional Study. (Pubmed Central) - Dec 26, 2024
However, only fasting glycemia was found to be a significant predictor of sarcopenia. More studies are needed to determine the influence of glycemic control on sarcopenia in older people with CKD.
- | Journal: Systematic Exploration of the Association Between Vitamin A Intakes and Sarcopenia Prevalence in American Adults. (Pubmed Central) - Dec 26, 2024
There may be a gender- and race-specific relationship between dietary vitamin A intake and sarcopenia. Further prospective studies are imperative to elucidate the association between vitamin A intake and sarcopenia prevalence.
- | Journal: The Relationship Between Cr/CysC Levels and Short-Term Prognosis with Acute Ischemic Stroke: Findings from a Cohort Study. (Pubmed Central) - Dec 26, 2024
A linear relationship was identified between Cr/CysC and prognosis (P overall This study establishes a significant linear correlation between Cr/CysC levels and poor short-term prognosis in AIS patients. Encouraging muscle function exercises may enhance patient outcomes.
- || Retrospective data, Review, Journal: Sarcopenia and risk of postoperative pneumonia: a systematic review and meta-analysis. (Pubmed Central) - Dec 25, 2024
Our research findings indicate that preoperative sarcopenia significantly increases the risk of postoperative pneumonia. Future high-quality prospective studies and intervention studies are needed to validate the relationship between sarcopenia and postoperative pneumonia and improve patient outcomes.
- | Journal: Sarcopenia is associated with lower step count in patients with peripheral artery disease following endovascular treatment. (Pubmed Central) - Dec 24, 2024
After controlling for potential confounders, the Sarcopenia Group demonstrated significantly lower step counts than the Suspected-Sarcopenia Group (p?=?.016) and No-Sarcopenia Group (p?=?.009). Our findings indicate that patients with PAD and sarcopenia require rehabilitation strategies to enhance physical performance.
- || Review, Journal: Muscle mass, muscle strength and the renin-angiotensin system. (Pubmed Central) - Dec 24, 2024
This has led to a new understanding of the physiological function of the RAS in skeletal muscle. This review summarizes the diverse physiological functions of the RAS in skeletal muscle and considers the potential of future therapeutic strategies targeting the RAS to overcome problems such as sarcopenia and muscle weakness associated with chronic disease.
- | Journal: Body composition and nutritional status in nursing home residents during the COVID-19 lockdown: a 15-month follow-up. (Pubmed Central) - Dec 24, 2024
Our findings suggest that negative changes in body composition during the pandemic are owed to age rather than to changes in lifestyle caused by the pandemic. Regular monitoring of body composition in nursing homes may help to preserve the health of older people in general and particularly in cases of possible future lockdowns.
- || Retrospective data, Review, Journal: The relationship between muscle mass changes and protein or energy intake in critically ill children: A systematic review and meta-analysis. (Pubmed Central) - Dec 24, 2024
Using this cutoff, 92 (49.2%) children developed muscular atrophy during their PICU admission. Overall, muscle mass decreased by nearly 10% during a child's first week in PICU, with almost half of children developing muscular atrophy during their admission.
- || Clinical, Review, Journal: Association between muscular atrophy and mortality risk in patients with COPD: a systematic review. (Pubmed Central) - Dec 24, 2024
This systematic review protocol was prospectively registered with PROSPERO (No. CRD42024589435).
- | Journal: Predicting sarcopenia risk in stroke patients: a comprehensive nomogram incorporating demographic, anthropometric, and biochemical indicators. (Pubmed Central) - Dec 24, 2024
This study creates a new nomogram which can be used to predict pre-sarcopenia in stroke. The new screening device is accurate, precise, and cost-effective, enabling medical personnel to identify patients at an early stage and take action to prevent and treat illnesses.
- || Clinical, Journal: Effects of Blood Flow Restriction Combined with Aerobic Stepping Exercise in Sarcopenia: A Study Protocol for a Randomized Clinical Trial. (Pubmed Central) - Dec 24, 2024
The new screening device is accurate, precise, and cost-effective, enabling medical personnel to identify patients at an early stage and take action to prevent and treat illnesses. Outcomes will be assessed at one of or all the time points of baseline, 12 and 24
- || Clinical, Clinical protocol, Journal: The effect of Sarcomeal (Pubmed Central) - Dec 24, 2024
Outcomes will be assessed at one of or all the time points of baseline, 12 and 24 It is hypothesized that the Sarcomeal
- | Journal, Metastases: Textbook oncological outcome of locally advanced gastric cancer patients with preoperative sarcopenia: a multicenter clinical study. (Pubmed Central) - Dec 23, 2024
Preoperative sarcopenia was an independent predictor of TOO implementation. A prognostic prediction model that integrates preoperative sarcopenia and TOO, which outperforms the current staging system, can aid clinicians in effectively assessing the prognosis of patients with LAGC.
- | Journal: CT-Based Body Composition and Frailty as Predictors of Survival Among Older Adults With Gastrointestinal Malignancies. (Pubmed Central) - Dec 23, 2024
SMV is independently associated with OS among older adults with newly diagnosed gastrointestinal cancers. Capturing body composition measurements in oncology practice may provide additional prognostic information for older adults with cancer above and beyond what is captured in routine clinical assessment including frailty.
- | Journal: Relationship between hearing loss and Glasgow prognostic score in patients with cancer. (Pubmed Central) - Dec 22, 2024
The GPS was independently associated with elevated standard PTA thresholds in patients with cancer. These results suggest an association between malnutrition/chronic inflammation and hearing loss and provide new information for planning clinical research on hearing loss prevention.
- | Biomarker, Journal: Sarcopenia as a predictive factor for febrile neutropenia during induction chemotherapy in head and neck squamous cell cancer. (Pubmed Central) - Dec 22, 2024
Sarcopenia defined by CT imaging is associated with FN in patients with HNSCC treated with IC. The combination of sarcopenia and high CRP is a more significant risk factor, and it helps determine patients at risk of FN during IC.
- || Clinical, Review, Journal: Non-pharmacological treatment strategies for anthropometric, physical capacity and physiological indicators among sarcopenic obesity patients: a systematic review of rigorous randomized controlled trials. (Pubmed Central) - Dec 22, 2024
The effects of exercise and nutrition interventions on SO are limited individually, especially regarding muscle mass, but their combination can yield optimal results. Additionally, physical therapy also demonstrated some potential.
- || Review, Journal: Unlocking the therapeutic potential of WISP-1: A comprehensive exploration of its role in age-related musculoskeletal disorders. (Pubmed Central) - Dec 21, 2024
Regulating WISP-1 expression holds promise as a therapeutic strategy for improving musculoskeletal function, potentially offering new avenues for treating age-related musculoskeletal diseases in clinical practice. This review highlights the signaling pathways associated with WISP-1, its physiological roles within the musculoskeletal system, and its therapeutic potential in treating age-related musculoskeletal disorders.
- || Review, Journal: The prognostic value of pre-treatment sarcopenia in overall survival in head and neck cancer patients: a systematic review. (Pubmed Central) - Dec 21, 2024
Sarcopenia evaluation appears to be a good prognostic marker in the HNC population. Future nutritional interventional studies might focus on reversing the muscle loss and improving overall outcomes in identified sarcopenic individuals.
- || Review, Journal: Chaperone Proteins: The Rising Players in Muscle Atrophy. (Pubmed Central) - Dec 21, 2024
This highlights the therapeutic potential of targeting chaperones and confirms their crucial anti-atrophic functions. In this review, we summarize the most relevant data showing the modulation and the causative role of chaperone proteins in different types of skeletal muscle atrophies.
- | Journal: Lean diabetes: 20-year trends in its prevalence and clinical features among Korean adults. (Pubmed Central) - Dec 21, 2024
Patients with lean type 2 diabetes showed decreased beta-cell function and sarcopenia. These findings emphasize the need for tailored management strategies for lean type 2 diabetes given its characteristics and rising prevalence.
- | Journal: Clinical Implications of Functional Imaging in the Assessment of Bronchiectasis-Associated Sarcopenia. (Pubmed Central) - Dec 21, 2024
Non-invasive ultrasound and MRI techniques showed that features of muscle quality architecture and fat infiltration are hallmarks of bronchiectasis-associated sarcopenia. Functional radiological tools should be implemented in clinical settings to early diagnose and monitor sarcopenia in these patients.
- | Journal: The association between handgrip strength and metabolic syndrome: A large prospective Chinese cohort study. (Pubmed Central) - Dec 21, 2024
This large cohort study showed that higher relative handgrip strength, but not absolute handgrip strength, was associated with a lower risk of metabolic syndrome. Although handgrip strength may not be highly sensitive in screening for metabolic syndrome, it remains a valuable predictive tool due to its convenience, ease of measurement, and cost-effectiveness.
- | Observational data, Journal: Physical inactivity, depressive symptoms, and progression to sarcopenia in older adults: a 4-year longitudinal study. (Pubmed Central) - Dec 21, 2024
This study indicates that the coexistence of physical inactivity and depressive symptoms may contribute to the progression of sarcopenia. Addressing both physical and mental factors, rather than limiting the problem to a single factor, may be essential for preventing sarcopenia.
- | Preclinical, Journal: Differential effects of EPA and DHA on aging-related sarcopenia in mice and possible mechanisms involved. (Pubmed Central) - Dec 20, 2024
Moreover, EPA also revealed a better effect on inhibiting mitochondria- and endoplasmic reticulum stress-mediated apoptosis in aged skeletal muscle. Furthermore, EPA manifested a more pronounced effect on improving mitochondrial damage of aged skeletal muscle than DHA, and the reason might be due to its superior capability of regulating mitochondrial quality control, as clearly shown by enhancing mitochondrial biogenesis through the AMPK/PGC-1?-dependent pathway, restraining the loss of mitochondrial fusion and fission proteins including Opa1, Mfn2, and Fis1, and promoting mitophagy via the PINK1/Parkin-dependent pathway.
- || Retrospective data, Review, Journal: Comment on "Circulating irisin levels in patients with sarcopenia: a systematic review and meta-analysis". (Pubmed Central) - Dec 20, 2024
Furthermore, EPA manifested a more pronounced effect on improving mitochondrial damage of aged skeletal muscle than DHA, and the reason might be due to its superior capability of regulating mitochondrial quality control, as clearly shown by enhancing mitochondrial biogenesis through the AMPK/PGC-1?-dependent pathway, restraining the loss of mitochondrial fusion and fission proteins including Opa1, Mfn2, and Fis1, and promoting mitophagy via the PINK1/Parkin-dependent pathway. No abstract available