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|||||||||| Journal: Iron status and sarcopenia-related traits: a bi-directional Mendelian randomization study. (Pubmed Central) - Apr 29, 2024
Our study revealed a causal association between serum iron status and sarcopenia, with ferritin playing a key role in this relationship. These findings contribute to our understanding of the complex interplay between iron metabolism and muscle health.

|||||||||| doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal: Doxorubicin causes cachexia, sarcopenia, and frailty characteristics in mice. (Pubmed Central) - Apr 29, 2024
Importantly, all mice subjected to doxorubicin treatment were considered frail based on the evaluation of their overall condition and functional impairments. The proposed model holds significant characteristics of human chemotherapy treatment and can be useful to understand the intricate relationship between chemotherapy, cachexia, sarcopenia, and frailty.

|||||||||| Journal: Frailty, Sarcopenia, and Nutrition in Patients With Cirrhosis. (Pubmed Central) - Apr 29, 2024
The proposed model holds significant characteristics of human chemotherapy treatment and can be useful to understand the intricate relationship between chemotherapy, cachexia, sarcopenia, and frailty. No abstract available

|||||||||| Journal: Prevalence and outcome of sarcopenia in non-alcoholic fatty liver disease. (Pubmed Central) - Apr 29, 2024
The variability in study designs and assessment methods for sarcopenia and liver fibrosis may account for the inconsistent findings. This review demonstrates the multidimensional impact of sarcopenia on NAFLD, indicating its importance beyond liver-related events to include cardiovascular risks, mortality, and metabolic complications.

|||||||||| Review, Journal: Hepatocellular carcinoma and musculoskeletal system: A narrative literature review. (Pubmed Central) - Apr 29, 2024
Taken together, contemporary literature suggests that a multidisciplinary approach is essential for early recognition and clinical management of HCC-associated musculoskeletal alterations to improve patient prognosis. Further research into the mechanisms and treatment options for musculoskeletal complications is warranted to enhance our understanding and clinical management of this aspect of HCC.

|||||||||| Journal: Sarcopenia as a Predictor of Feeding Tube Placement in Individuals with Oropharyngeal Cancer. (Pubmed Central) - Apr 29, 2024
SMM measured at T4 may represent a novel and practical biomarker for sarcopenia detection that is associated with the need for FT placement. These findings suggest that the detection of baseline sarcopenia could guide decision-making related to the need for nutritional support in OPSCC patients undergoing RT/CRT.

|||||||||| Journal: Associations of serum albumin and dietary protein intake with all-cause mortality in community-dwelling older adults at risk of sarcopenia. (Pubmed Central) - Apr 29, 2024
Serum albumin levels are inversely associated with all-cause mortality in community-based older adults at risk of sarcopenia. Sufficient dietary protein consumption may attenuate the effect of low serum albumin on increased mortality and potential mechanisms for the interaction warrant further exploration.

|||||||||| Journal: Prevalence of Sarcopenia and Its Defining Components in Non-alcoholic Fatty Liver Disease Varies According to the Method of Assessment and Adjustment: Findings from the UK Biobank. (Pubmed Central) - Apr 28, 2024
In middle-aged and older adults, NAFLD was not associated with a higher prevalence of low muscle strength or sarcopenia but was associated with an increased risk of impaired physical function and low muscle mass when adjusted for BMI. These findings support the use of adiposity-based adjustments when assessing low muscle mass and the assessment of physical function in NAFLD.

|||||||||| Journal: Sarcopenic Obesity Promotes Recurrence in Patients Undergoing Resection for Colorectal Liver Metastases (CRLM). (Pubmed Central) - Apr 28, 2024
These findings support the use of adiposity-based adjustments when assessing low muscle mass and the assessment of physical function in NAFLD. There seems to be a benefit in merging data on mutational status and muscle wasting in patients with CRLM to facilitate an individual, patient-tailored approach.

|||||||||| Journal: Exploring the role of body mass index-adjusted calf circumference within the SARC-CalF screening tool among older patients with cancer. (Pubmed Central) - Apr 28, 2024
There seems to be a benefit in merging data on mutational status and muscle wasting in patients with CRLM to facilitate an individual, patient-tailored approach. BMI-adjusted SARC-CalF may be a promising strategy to enhance the detection of older patients with cancer and excess weight at risk of sarcopenia, and it may serve a dual role as a prognostic tool, as it was independently associated with prolonged LOS and mortality.

|||||||||| sirolimus / Generic mfg.
Journal: PGC-1? participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway. (Pubmed Central) - Apr 28, 2024
This research demonstrates that PGC-1? participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway.

|||||||||| Journal: Association between Triglyceride-glucose index and sarcopenia in China: A nationally representative cohort study. (Pubmed Central) - Apr 28, 2024
BMI mediated the relationship between sarcopenia and TyG index among older Chinese population. Future study should validate our findings in a larger population.

|||||||||| Journal: Ultrasonographically Measured Rectus Femoris Cross-sectional Area might Predict Osteosarcopenia. (Pubmed Central) - Apr 28, 2024
This has been the first study investigating the relationship between UMPs and body phenotypes. Multi-center and large-scale studies are, however, needed.

|||||||||| Journal: The geriatric assessment and sarcopenia to assess frailty in older patients with cancer. (Pubmed Central) - Apr 28, 2024
Multi-center and large-scale studies are, however, needed. No abstract available

|||||||||| Retrospective data, Review: Prevalence of sarcopenic obesity in the older non-hospitalized population: a systematic review and meta-analysis. (Pubmed Central) - Apr 27, 2024
SO prevalence is high among non-hospitalized older adults, especially those with functional and cognitive impairments. Thus, SO is a potential problem for the aging population; implementation of planned interventions in the community is needed to reduce the prevalence and adverse outcomes of SO.

|||||||||| Journal: Using Sequence Analyses to Quantitatively Measure Oropharyngeal Swallowing Temporality in Point-of-Care Ultrasound Examinations: A Pilot Study. (Pubmed Central) - Apr 27, 2024
They also helped lay the groundwork for future AI-assisted dysphagia assessment and outcome measures using POCUSs. Arguably, the proposed conceptualization and analyses are also modality-independent measures that can potentially be generalized for other instrumental swallowing assessment modalities.

|||||||||| Verquvo (vericiguat) / Bayer, Merck (MSD)
Journal: The sGCa Vericiguat Exhibit Cardioprotective and Anti-Sarcopenic Effects through NLRP-3 Pathways: Potential Benefits for Anthracycline-Treated Cancer Patients. (Pubmed Central) - Apr 27, 2024
GCa vericiguat reduces cytokines and chemokines involved in heart failure and sarcopenia. The findings that emerged from this study could provide the rationale for further preclinical and clinical investigations aimed at reducing anthracycline cardiotoxicity and sarcopenia in cancer patients.

|||||||||| Review, Journal: Restoring Mitochondrial Function and Muscle Satellite Cell Signaling: Remedies against Age-Related Sarcopenia. (Pubmed Central) - Apr 27, 2024
Indeed, the systemic delivery of mitochondria promotes muscle regeneration and restores muscle mass and function while reducing fibrosis during recovery after an injury. In this review, we discuss the contribution of altered MSC function to sarcopenia and illustrate the prospect of harnessing mitochondrial delivery and restoration of MSCs as a therapeutic strategy against age-related sarcopenia.

|||||||||| Review, Journal: Irisin and Its Role in Postmenopausal Osteoporosis and Sarcopenia. (Pubmed Central) - Apr 27, 2024
Therefore, irisin could represent a new therapeutic strategy for the treatment of osteoporosis and also serve as a new biomarker of sarcopenia, thus facilitating diagnosis and pharmacological intervention. The purpose of this review is to provide an updated summary of what we know about the role of irisin in postmenopausal osteoporosis and sarcopenia.

|||||||||| Journal: Association of the sarcopenia index with cognitive impairment in a middle-aged to older patients with acute ischemic stroke or transient ischemic attack: A multicenter cohort study. (Pubmed Central) - Apr 27, 2024
This study demonstrated that a lower sarcopenia index was positively associated with a higher prevalence of PSCI. Monitoring the SI index in stroke patients and early identification and treatment of individuals with low SI level may be helpful to reduce the risk of cognitive impairment.

|||||||||| Journal: Proposal and validation of an equation to identify sarcopenia using bioelectrical impedance analysis-derived parameters. (Pubmed Central) - Apr 27, 2024
Monitoring the SI index in stroke patients and early identification and treatment of individuals with low SI level may be helpful to reduce the risk of cognitive impairment. The study demonstrated that a simple formula using bioelectrical parameters at 50 kHz proved useful in identifying sarcopenia in the older adult population.

|||||||||| Retrospective data, Review, Journal: Effect of Different Exercise Interventions on Grip Strength, Knee Extensor Strength, Appendicular Skeletal Muscle Index, and Skeletal Muscle Index Strength in Patients with Sarcopenia: A Meta-Analysis of Randomized Controlled Trials. (Pubmed Central) - Apr 26, 2024
For example, age group and exercise duration were not considered. Future studies should further explore benefits in age groups as well as other relevant outcome indicators.

|||||||||| Retrospective data, Review, Journal: A commentary on "impact of sarcopenia on outcomes in surgical patients: A systematic review and meta-analysis". (Pubmed Central) - Apr 26, 2024
Future studies should further explore benefits in age groups as well as other relevant outcome indicators. No abstract available

|||||||||| Journal, HEOR: Influences of trans-theoretical model-based diet nursing intervention on sarcopenia and quality of life in maintenance hemodialysis patients. (Pubmed Central) - Apr 26, 2024
No abstract available a TTM-based diet nursing intervention can help improve the dietary management behavior of MHD patients, prevent malnutrition, reduce the incidence of sarcopenia, and improve their quality of life and survival rate.

|||||||||| Journal: Causal effect of sarcopenia-related traits on the occurrence and prognosis of breast cancer - A bidirectional and multivariable Mendelian randomization study. (Pubmed Central) - Apr 26, 2024
several sarcopenia-related traits were genetically associated with the occurrence and prognosis of breast cancer. It is crucial for elderly women to increase their strength and muscle mass to help prevent breast cancer.

|||||||||| Retrospective data, Journal, Metastases: Creatinine-to-cystatin C ratio and body composition predict response to PD-1 inhibitors-based combination treatment in metastatic gastric cancer. (Pubmed Central) - Apr 26, 2024
A nomogram based on CCR and BC-parameters showed a good performance in predicting the 12- and 16-month OS, with a concordance index of 0.756 (95% CI, 0.722-0.789). Low pre-treatment CCR and SATI were independently associated with lower response rates and worse survival in patients with metastatic GC receiving PD-1 inhibitors-based combination therapy.

|||||||||| Review, Journal: Effects of Exercise Training on Muscle Mass and Physical Function in Patients with Hepatocellular Carcinoma After Diagnosis: A Systematic Review. (Pubmed Central) - Apr 25, 2024
Low pre-treatment CCR and SATI were independently associated with lower response rates and worse survival in patients with metastatic GC receiving PD-1 inhibitors-based combination therapy. Together, the results suggest that patients may benefit from physical exercise training after treatment to improve muscle mass and physical function.

|||||||||| SARCOPENIA AFFECTS SURVIVAL WITH NATIVE LIVER IN CHILDREN WITH CHRONIC LIVER DISEASE (Station 05) - Apr 25, 2024 - Abstract #ESPGHAN2024ESPGHAN_708;

|||||||||| EFFECT OF BRANCH CHAIN AMINO ACID SUPPLEMENTATION ON SARCOPENIA IN CHILDREN WITH CHRONIC LIVER DISEASE -A DOUBLE BLIND PLACEBO CONTROLLED RANDOMIZED CONTROLLED TRIAL (Amber 3+4) - Apr 25, 2024 - Abstract #ESPGHAN2024ESPGHAN_172;

|||||||||| Body composition and its response to intradialytic exercise in kidney failure: a combined analysis of the PEDAL and CYCLE-HD randomised controlled trials (Pentland Auditorium) - Apr 25, 2024 - Abstract #UKKW2024UKKW_187;
Only a minority of patients had both LTI and FTI within the range associated with best survival. The majority of patients had hidden sarcopenia with nearly 75% with normal BMI being sarcopenic.

|||||||||| Piqray (alpelisib) / Novartis
Body composition measures as a determinant of alpelisib-related toxicity. () - Apr 24, 2024 - Abstract #ASCO2024ASCO_6162;
Body composition measures, specifically SMD and VAT may provide an opportunity to identify patients at higher risk for severe alpelisib related hyperglycemia, and cutaneous toxicity. These findings suggest the potential use of body composition assessment to predict toxicity, allowing for personalized therapeutic observation and intervention.

|||||||||| Correlation of plasma GDF15 with aging, organ disfunction, sarcopenia, and postoperative infectious complication in patients with esophageal cancer. () - Apr 24, 2024 - Abstract #ASCO2024ASCO_5472;
This study showed GDF15 is potentially suggesting deterioration of general condition, which came from aging, organ disfunction, and decreasing muscle mass, which may lead to cachexia in EC patients. In addition, higher GDF15 patients have risk of postoperative infectious complication.

|||||||||| Effect of malnutrition on cirrhotic patients with hepatocellular carcinoma: A nationwide study. () - Apr 24, 2024 - Abstract #ASCO2024ASCO_5372;
If identified, it can be treated efficiently. In this study, cirrhotic HCC patients with malnutrition had an increased chance of mortality.

|||||||||| 5-fluorouracil / Generic mfg., leucovorin calcium / Generic mfg., irinotecan / Generic mfg.
Identification of markers associated with toxicity of FOLFIRINOX in patients over 70 years with digestive cancers. () - Apr 24, 2024 - Abstract #ASCO2024ASCO_5305;
However, alternative regimens/strategies should be developed to enhance efficacy and reduce AEs. Particular attention to vulnerabilities detected using G8 and managed through MGA is of importance to reduce toxicity.

|||||||||| Verquvo (vericiguat) / Bayer, Merck (MSD)
Soluble guanylate cyclase activator vericiguat prevents anthracycline-mediated cardiotoxicity and sarcopenia through cGMP-NLRP3-cytokine pathway: Potential application in patients with cancer. () - Apr 24, 2024 - Abstract #ASCO2024ASCO_4856;
Particular attention to vulnerabilities detected using G8 and managed through MGA is of importance to reduce toxicity. Human cardiomyocytes (AC-16 cells) and Primary Skeletal Muscle Cells (HSkMC cells) were exposed for 24h h to doxorubicin (DOXO) at 0,3 and 1

|||||||||| Implementing a mutidisciplinary approach for older adults with cancer: Challenges and achievements in a geriatric oncology program in Sao Paulo, Brazil. () - Apr 24, 2024 - Abstract #ASCO2024ASCO_4283;
Geriatric conditions such as functional impairment are common and frequently unrecognized or inadequately addressed in older adults with cancer. Identifying geriatric conditions by performing a GA can help the health team to manage these conditions and provide better oncology care.

|||||||||| Mobile health (Hall A; Poster Bd #: 505) - Apr 24, 2024 - Abstract #ASCO2024ASCO_3716;
CIMmH significantly enhances short-term physical fitness in EC patients post-esophagectomy. These findings suggest the need for further refinement and optimization of the intervention to maximize its long-term effectiveness and impact on QOL.

|||||||||| xevinapant (Debio 1143) / EMD Serono
Xevinapant with radiation and concurrent carboplatin and paclitaxel in patients ineligible for cisplatin with locoregionally advanced squamous cell carcinoma of the head and neck (EXtRaCT study) (Hall A; Poster Bd #: 435b) - Apr 24, 2024 - Abstract #ASCO2024ASCO_3576;
P1
Exploratory aims: in-clinic geriatric evaluations (Katz ADL, Lawton iADL, MMSE), QoL surveys, symptom tracking via smartphone, and wearable-derived steps and sarcopenia assessment. Recruitment began 02/2024.

|||||||||| tagitanlimab (HBM9167) / Harbour BioMed
Characterizing the impact of sarcopenia on treatment response and survival in previously treated recurrent or metastatic nasopharyngeal carcinoma: Insights from a secondary analysis of the KL-A167 randomized trial. (Hall A; Poster Bd #: 362) - Apr 24, 2024 - Abstract #ASCO2024ASCO_3497;
Sarcopenia significantly correlates with poor treatment response and survival outcomes in patients with R/M NPC receiving immunotherapy. Targeting fibrinogen may offer a novel strategy to mitigate the negative impact of sarcopenia on patient survival.

|||||||||| Risk of low bone mineral density in young pediatric cancer survivors with sarcopenia. (Hall A; Poster Bd #: 437) - Apr 24, 2024 - Abstract #ASCO2024ASCO_3440;
Over one-third of young paediatric cancer survivors presented sarcopenia confirmed with higher risk of low aBMD. These findings suggest that interventions to mitigate osteosarcopenia in this population should be implemented at early stages after treatment completion.

|||||||||| The influence of sarcopenia and myosteatosis on severe laboratory toxicity and overall mortality in older adults with cancer receiving chemotherapy. (Hall A; Poster Bd #: 260) - Apr 24, 2024 - Abstract #ASCO2024ASCO_2878;
Pre-treatment myosteatosis defined by low SMD predicts overall mortality in the same cohort. Optimization of skeletal muscle health through targeted exercise and nutritional interventions may improve patient quality of life and clinical outcomes in older adults with cancer receiving chemotherapy.

|||||||||| Association of lung cancer-associated cachexia with the metastatic spread to pleura. (Hall A; Poster Bd #: 224) - Apr 24, 2024 - Abstract #ASCO2024ASCO_2843;
NSCLC relapse to the pleura after surgical treatment of the primary tumor, appears to be associated with a decrease in the skeletal muscle compartment. This finding may inform the design of the future studies aiming to investigate molecular correlates of sarcopenia and cancer-associated cachexia.

|||||||||| Debunking the frailty-sarcopenia-ADT axis in metastatic prostate cancer with multicomponent exercise: The FIERCE trial. (Hall A; Poster Bd #: 521b) - Apr 24, 2024 - Abstract #ASCO2024ASCO_2306;
P=N/A
To date, eight out of planned 80 patients have been enrolled. This trial is registered in clinicaltrials.gov (NCT06040125).

|||||||||| Systematic review of frailty assessment in ovarian cancer studies. (Hall A; Poster Bd #: 435) - Apr 24, 2024 - Abstract #ASCO2024ASCO_1877;
Most studies do not adhere to the ASCO vulnerability assessment guidelines. An association between frailty and poor outcomes was detected in surgical and systemic therapy studies.

|||||||||| Prospective nutritional status and body mass composition assessment in patients with advanced NSCLC treated with immune checkpoint inhibitors. (Hall A; Poster Bd #: 448) - Apr 24, 2024 - Abstract #ASCO2024ASCO_1459;
Baseline good nutritional status and skeletal muscle mass are valuable predictors of improved clinical outcomes in advanced NSCLC pts receiving ICIs. The study is still recruiting and underlines the need to improve pts assessment in terms of nutritional and BC phenotypes before ICIs start.

|||||||||| Impact of protein energy malnutrition on hospitalized patients with lung cancer: A United States population-based cohort study. (Hall A; Poster Bd #: 355) - Apr 24, 2024 - Abstract #ASCO2024ASCO_1089;
Efforts should be made to promote nutritional assessment and screening mechanisms with the aim to initiate early nutritional support as indicated. Further prospective studies are warranted to better understand these associations and guide management.

|||||||||| Tevimbra (tislelizumab) / BeiGene, cisplatin / Generic mfg., gemcitabine / Generic mfg.
Journal, PD(L)-1 Biomarker: Sarcopenia is associated with leukopenia in urothelial carcinoma patients who receive tislelizumab combined with gemcitabine and cisplatin therapy. (Pubmed Central) - Apr 24, 2024
There were no notable alterations observed in relation to anemia or thrombocytopenia. No significant difference was found between the sarcopenia group and non-sarcopenia group in terms of tumor response and grade 3-4 hematological toxicity.

|||||||||| Journal, Metastases: Visceral obesity and sarcopenia as predictors of efficacy and hematological toxicity in patients with metastatic breast cancer treated with CDK 4/6 inhibitors. (Pubmed Central) - Apr 24, 2024
No significant difference was found between the sarcopenia group and non-sarcopenia group in terms of tumor response and grade 3-4 hematological toxicity. The present study supported the significance of sarcopenia and low visceral adipose tissue as potential early indicators of poor PFS in patients treated with CDK 4/6 inhibitors.

|||||||||| Firmagon (degarelix) / Astellas, Ferring
Clinical Trial,Phase IV, Journal: Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study. (Pubmed Central) - Apr 24, 2024
P4
All patients underwent administration of the luteinizing hormone-releasing hormone antagonist degarelix...The funder had no role in design and conduct of the study, collection, management, analysis, and interpretation of the data and in preparation, review, or approval of the manuscript. clinicalTrials.gov NCT03202381, EudraCT Number 2016-004210-10.

|||||||||| Clinical, Journal: Effect of whole-body vibration stimulation on plasma soluble TNF receptors in elderly with sarcopenia: a randomized controlled trial. (Pubmed Central) - Apr 24, 2024
This suggested that WBV had a more pronounced impact on sTNFr2 in those with loss of muscle strength and/or physical performance. Additionally, WBV is gaining recognition as an efficient strategy for those with persistent health issues.



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