Sarcopenia
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  • ||||||||||  Journal:  Identification of risk factors and development of a predictive nomogram for sarcopenia in Alzheimer's disease. (Pubmed Central) -  Jan 12, 2025   
    Serum albumin and Frailty Rating Scale (FRS) scores are significantly associated with both sarcopenia and cognitive assessment indicators in AD patients with sarcopenia (ADSA). The combined sarcopenia nomogram model with indexes of age at diagnosis, creatinine/cystatin C ratio (CCR), FRS score, and albumin levels can aid in effectively identifying and personalizing interventions for sarcopenia in the AD population.
  • ||||||||||  Review, Journal:  Periodic paralysis across the life course: age-related phenotype transition and sarcopenia overlap. (Pubmed Central) -  Jan 12, 2025   
    Understanding the interaction between ageing physiology and disease phenotype will provide a window into the healthy ageing process but also help understand how, and why PP phenotype changes with age. Understanding the mechanism underlying PP phenotype-transition and its link with ageing physiology, not only has the potential to identify the first disease modifying therapies for PP, but also to identify novel and potentially tractable mechanisms that contribute to sarcopenia, the pathological loss of muscle mass and function with age.
  • ||||||||||  Journal:  Predictive models of sarcopenia based on inflammation and pyroptosis-related genes. (Pubmed Central) -  Jan 12, 2025   
    qRT-PCR results indicated that the expression trends of these six IPRGs aligned with those observed in the database. Six biomarkers-BTG2, FOXO3, AQP9, GPC3, CYCS, and SCN1B-were identified alongside a diagnostic model that offers a novel approach for early diagnosis of sarcopenia.
  • ||||||||||  Review, Journal:  Skeletal Muscle Stem Cells and the Microenvironment Regulation in Sarcopenia:A Review. (Pubmed Central) -  Jan 12, 2025   
    This study highlights TF as a potential auxiliary measure, but further research with larger sample sizes and additional parameters is needed to confirm its clinical utility. Sarcopenia is an age-related degenerative skeletal muscle disorder characterized by the loss of skeletal muscle mass and function during aging.Sarcopenia can impair the elderly's ability to perform daily activities and is associated with high risks of falls,fractures,and hospitalization.It seriously affects the quality of life of the elderly and becomes one of the major health problems in the aging society.Skeletal muscle stem cells,also known as muscle satellite cells,play a key role in supporting muscle regeneration and homeostasis maintenance.Studies have suggested that muscle satellite cell functions are tightly regulated by microenvironment signals in the skeletal muscle.Of note,skeletal muscle fibers,serving as an immediate niche of muscle satellite cells,regulate their activation,proliferation,and self-renewal.This article reviews the research progress in the regulatory roles of skeletal muscle stem cells and their microenvironment in sarcopenia during aging,providing theoretical support for potential treatment of sarcopenia via modifying skeletal muscle microenvironment and regulating muscle satellite cell functions.
  • ||||||||||  Journal:  Feasibility within-subject RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during period of Immobility (IMMI). (Pubmed Central) -  Jan 12, 2025   
    Sarcopenia is an age-related degenerative skeletal muscle disorder characterized by the loss of skeletal muscle mass and function during aging.Sarcopenia can impair the elderly's ability to perform daily activities and is associated with high risks of falls,fractures,and hospitalization.It seriously affects the quality of life of the elderly and becomes one of the major health problems in the aging society.Skeletal muscle stem cells,also known as muscle satellite cells,play a key role in supporting muscle regeneration and homeostasis maintenance.Studies have suggested that muscle satellite cell functions are tightly regulated by microenvironment signals in the skeletal muscle.Of note,skeletal muscle fibers,serving as an immediate niche of muscle satellite cells,regulate their activation,proliferation,and self-renewal.This article reviews the research progress in the regulatory roles of skeletal muscle stem cells and their microenvironment in sarcopenia during aging,providing theoretical support for potential treatment of sarcopenia via modifying skeletal muscle microenvironment and regulating muscle satellite cell functions. Although it would be feasible to evaluate the specific effect of NMES in fragility fracture patients in a multi-centre trial using home-based NMES, this would be possible only in a minority of mildly frail fragility fracture patients with little premorbid disability.
  • ||||||||||  Review, Journal:  The role of glucagon-like peptides in osteosarcopenia. (Pubmed Central) -  Jan 11, 2025   
    Beyond their well-known anti-diabetic and anti-obesity effects, GLP-1 agonists can enhance muscle mass and bone density, making them valuable in addressing conditions like sarcopenia and osteoporosis. This review focuses on the effects of GLP-1 analogs on musculoskeletal health, by critically assessing the underlying signaling mechanisms in order to understand their translational potential for the treatment of osteo-sarcopenia.
  • ||||||||||  Review, Journal:  Dysphagia development in heart failure patients: A scoping review. (Pubmed Central) -  Jan 9, 2025   
    Key risk factors include older age, high inflammation, low activities of daily living, and sarcopenia, which is suggested as a pathogenic mechanism in dysphagia. Future research should focus on diverse samples, investigate the impact of sarcopenia and cachexia, and objectively assess swallowing function.
  • ||||||||||  Journal:  Abdominal aortic calcification volume as a preoperative prognostic predictor for pancreatic cancer. (Pubmed Central) -  Jan 9, 2025   
    These measurements, in addition to patient (ECOG performance status, smoking status) and surgical (robotic approach, continent diversion) characteristics can then be utilized to individualize patient counseling and facilitate triage of nutritional and rehabilitation efforts. The AAC volume may serve as a preoperative prognostic indicator for patients with pancreatic cancer.
  • ||||||||||  Journal:  A descriptive analysis of sarcopenia markers in young adults with down syndrome. (Pubmed Central) -  Jan 8, 2025   
    An alarming number of young adults with DS had sarcopenia, and low HGS and ASM when using the EWGSOP2 definition. Health professionals are encouraged to screen for sarcopenia in young adulthood rather than deferring it to a later stage in life for individuals with DS.
  • ||||||||||  Preclinical, Journal:  Arginase-II gene deficiency reduces skeletal muscle aging in mice. (Pubmed Central) -  Jan 6, 2025   
    Finally, we demonstrate an increased arg-ii gene expression level in aging skeletal muscle and found Arg-II protein expression in endothelial cells and fibroblasts, but not in skeletal muscle fibers, macrophages, and satellite cells. Our results suggest that increased Arg-II in non-skeletal muscle cells promotes age-associated sarcopenia, particularly in male mice.
  • ||||||||||  Journal:  A Perspective on Frailty and its Predisposing Factors among People Living with HIV. (Pubmed Central) -  Jan 6, 2025   
    Addressing these factors is crucial to preventing functional decline and improving the quality of life of PLHIV, though more research is necessary. The aim of this article was to identify and conduct a narrative review of these factors in a pragmatic way in order to facilitate the clinicians.
  • ||||||||||  Journal:  Cumulative effects of H+ and Pi on force and power of skeletal muscle fibres from young and older adults. (Pubmed Central) -  Jan 6, 2025   
    We also found peak absolute power did not differ in slow fibres from young and older adults but it was ?33% lower in older adult fast fibres, which was explained entirely by age differences in fibre size. These data suggest that fast fibre atrophy is a major factor contributing to the loss in power of older men and women, but that the age-related increase in fatigability cannot be explained by an increased sensitivity of the cross-bridge to H+ and Pi.