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17 Mechanisms of Action |
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756 Trials |
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22406 News |
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- | Journal: Bioinformatics and systems biology approaches to identify potential common pathogeneses for sarcopenia and osteoarthritis. (Pubmed Central) - Jul 4, 2024
Finally, receiver operating characteristic (ROC) curves were plotted to verify the reliability of our results. Our findings provide a theoretical foundation for future research on the potential common pathogenesis and molecular mechanisms of sarcopenia and osteoarthritis.
- | Biomarker, Journal: Metabolic signatures and risk of sarcopenia in suburb-dwelling older individuals by LC-MS-based untargeted metabonomics. (Pubmed Central) - Jul 4, 2024
The current investigation elucidates the metabolic perturbations observed in individuals diagnosed with sarcopenia. The identified metabolites hold promise as potential biomarkers, offering avenues for exploring the underlying pathological mechanisms associated with sarcopenia.
- | Biomarker, Journal: BMP Signaling Is a Prognostic Marker in Patients With Colorectal Cancer and Associates With Frailty. (Pubmed Central) - Jul 4, 2024
Furthermore, high BMP-4 expression was significantly correlated with high C-reactive protein/Albumin ratio, sarcopenia, and osteopenia. BMP-4 is a significant prognostic factor in CRC, particularly in predicting death from other diseases, while also showing associations with inflammatory and nutritional statuses.
- | Journal: Association between sarcopenia and sleep disorders: a cross-sectional population based study. (Pubmed Central) - Jul 4, 2024
These findings suggest that maintaining optimal muscle mass may have a beneficial impact on sleep-related issues. In terms of exploring the mechanisms underlying the relationship between sarcopenia and sleep disorders, more in-depth research is warranted to ascertain the definitive causal relationship.
- | Journal, Metastases: Relationship between locomotive syndrome and advanced glycation end products measured by skin autofluorescence in community-dwelling patients: the Yakumo Study. (Pubmed Central) - Jul 4, 2024
High SAF values were identified as an independent risk factor for LS. AGEs could be a potential screening tool for people for LS.
- | Journal: Branched-chain amino acids and L-alanine supplementation ameliorate calcium dyshomeostasis in sarcopenia: New insights for nutritional interventions. (Pubmed Central) - Jul 4, 2024
BCAAs, particularly the formulation BCAAs+2-Ala, were able to ameliorate all these alterations. These results provide evidence that Ca2+ homeostasis dysfunction plays a role in the functional deficit observed in aged muscle and supports the interest of dietary BCAA supplementation in counteracting sarcopenia-related SOCE dysregulation.
- | Journal: The effects of whey, pea, and collagen protein supplementation beyond the recommended dietary allowance on integrated myofibrillar protein synthetic rates in older males: a randomized controlled trial. (Pubmed Central) - Jul 3, 2024
P=N/A
Our findings demonstrate that supplemental protein provided at breakfast and lunch over the current RDA enhanced anabolic signaling and integrated MPS in older males; however, the source of additional protein may be an important consideration in overcoming age-related anabolic resistance. This trial was registered clinicaltrials.gov as NCT04026607.
- | Journal: Association of Sarcopenia and Oxygen Uptake Efficiency Slope in Male Patients With Heart Failure. (Pubmed Central) - Jul 3, 2024
This trial was registered clinicaltrials.gov as NCT04026607. Our results suggest that sarcopenia is related to impaired ventilatory response during exercise in patients with HF.
- | Journal: Normative values of skeletal muscle mass, strength and performance in the Indian population. (Pubmed Central) - Jul 3, 2024
Interestingly, our population's muscle parameters were consistently lower compared to western literature benchmarks. These normative values will help to define sarcopenia parameters in our population, which have prognostic value in multiple ailments.
- || Review, Journal: Post-Radiotherapy Dysphagia in Head and Neck Cancer: Current Management by Speech-Language Pathologists. (Pubmed Central) - Jul 3, 2024
There is wide variation in treatment programmes, with a paucity of evidence to support optimal type, timing and intensity of treatment. We discuss the need for further research, including exploration of the impact of radiotherapy on the central nervous system (CNS), the link between sarcopenia and radiotherapy-induced dysphagia and the benefits of visual biofeedback in rehabilitation.
- || Review, Journal: Impact of malnutrition and nutritional support after gastrectomy in patients with gastric cancer. (Pubmed Central) - Jul 3, 2024
PN was also associated with benefits such as weight maintenance and QoL. This review explores the mechanisms, assessment, and clinical impact of malnutrition, emphasizing the importance of nutritional support in gastric cancer patients undergoing gastrectomy.
- | Journal: Kidney function and sarcopenia: A risk assessment. Author's reply. (Pubmed Central) - Jul 2, 2024
This review explores the mechanisms, assessment, and clinical impact of malnutrition, emphasizing the importance of nutritional support in gastric cancer patients undergoing gastrectomy. No abstract available
- | Journal: Kidney function and sarcopenia: A risk assessment. (Pubmed Central) - Jul 2, 2024
No abstract available No abstract available
- | Journal: The role of sarcopenic obesity for the prediction of prognosis of patients with gastrointestinal cancer. (Pubmed Central) - Jul 2, 2024
No abstract available Preoperative assessment of SO is useful not only for monitoring nutritional status but also for predicting 5-year OS in gastrointestinal cancer patients.
- | Journal: Sarcopenia and its components suppress the improvement of depression symptoms in patients with stroke. (Pubmed Central) - Jul 2, 2024
Sarcopenia and handgrip strength were significantly associated with improved depression symptoms in patients with stroke admitted to a convalescent rehabilitation ward. However, further prospective studies should investigate the association between sarcopenia and depression symptoms in patients with stroke.
- | Journal: Functional dependency as a marker for positive SARC-F screen among older persons at the emergency department. (Pubmed Central) - Jul 2, 2024
Functional dependency is strongly associated with positive SARC-F screen among older adults at the ED. This highlights the need for increased vigilance, especially in the presence of dependency in relevant domains such as managing finances, feeding, and stair-climbing.
- | Observational data, Journal: Correlation between phase angle and the number of medications in older inpatients: A cross-sectional study. (Pubmed Central) - Jul 2, 2024
Analyses were adjusted for age, BMI, sarcopenia, CRP, and hemoglobin levels. The number of medications at admission negatively impacted PhA in older inpatients, highlighting the importance of reviewing prescribed drugs and their interactions.
- || Clinical, Journal: "How difficult it is to change dietary behaviour" experience of older people with sarcopenic obesity: a qualitative study. (Pubmed Central) - Jul 2, 2024
The complication of food amount estimation and diary record, personal sacrifice for next generations, and previous living experience were barriers for implementing the intervention. Overall, the older people with sarcopenic obesity can accept the design of DBC intervention program and have great willing to join.
- || Observational data, Retrospective data, Review, Journal: Factors associated with sarcopenic obesity in Brazilian adults and older people: Systematic review and meta-analysis of observational studies. (Pubmed Central) - Jul 1, 2024
It is essential to direct attention to changes in prevalence rates in the coming years, given the rising obesity trends and the absolute increase in the elderly population. Geriatr Gerontol Int 2024; 24: 661-674.
- | Journal: Association between sarcopenia at discharge and functional outcomes 1?month and 6?months after discharge in patients in convalescent rehabilitation wards. (Pubmed Central) - Jul 1, 2024
Sarcopenia at the time of discharge from convalescent rehabilitation wards does not independently predict FIM 1?month or 6?months after discharge. Geriatr Gerontol Int 2024; 24: 715-721.
- | Journal: Evaluation of the Effectiveness of In-Hospital Exercise Rehabilitation in Middle-Aged and Elderly Patients with Type 2 Diabetes Mellitus Combined with Sarcopenia Effect of Lifestyle Management on Disease Status in Patients with Type 2 Diabetes Mellitus. (Pubmed Central) - Jul 1, 2024
After 12?weeks of intervention, the experimental group showed an increase in glycemic control from 33.3% to 73.3%, a significant decrease in body fat percentage and a significant increase in grip strength, lower limb extension and lower limb flexion strength and peak oxygen uptake. In-hospital exercise rehabilitation can effectively improve the glycemic and lipid profiles of patients with T2DM combined with sarcopenia and enhance their health fitness, with good clinical rehabilitation effects.
- | Journal: Digital health and medical technology for perioperative sarcopenia optimisation and prehabilitation - Where to go from here? (Pubmed Central) - Jul 1, 2024
The COVID-19 pandemic has led to the rapid adaptation of digital health and medical technology. Our perspective piece will review the current available evidence and propose innovative ways to incorporate technology into physical and nutritional prehabilitation.
- | Journal: Possible sarcopenia and risk of chronic kidney disease: a four-year follow-up study and Mendelian randomization analysis. (Pubmed Central) - Jul 1, 2024
All the sensitivity analyses supported the main findings. Possible sarcopenia is an independent risk factor for CKD and may serve as a predictor of CKD for early identification and intervention.
- | Preclinical, Journal: Fermented Yak-Kong using Bifidobacterium animalis derived from Korean infant intestine effectively relieves muscle atrophy in an aging mouse model. (Pubmed Central) - Jul 1, 2024
Furthermore, it mitigated age-related declines in skeletal muscle force production and functional limitation by enhancing exercise performance and grip strength. Taken together, the results suggest that FYK has the potential to be a new functional food material that can alleviate the loss of muscle mass and strength caused by aging and prevent sarcopenia.
- | Journal: Quantitative 3D-CT imaging of sarcopenia mitigation in elderly: evidence from a case report. (Pubmed Central) - Jul 1, 2024
Despite aging, the results of the scans performed at the beginning and end of the study period did not show significant changes in the patient's musculature, suggesting that a persistent Full-Body in-Bed Gym protocol ("Gym Bed" exercise routine) can effectively contribute to maintaining muscle mass and density in the elderly. These preliminary results highlight the potential of advanced imaging techniques not only to diagnose but also to quantify the effectiveness of non-pharmacological interventions against sarcopenia.
- | Journal: Sarcopenia and metabolic dysfunction associated steatotic liver disease: Time to address both. (Pubmed Central) - Jul 1, 2024
Future studies are needed to reach a consensus and reduce diagnostic variation. With similar pathophysiology and shared risk factors between the two diseases, future research may also identify potential therapeutic targets along the liver-muscle axis that would benefit both sarcopenia and MASLD in order to maximize their outcomes.
- || Review, Journal: Nexus Between Sarcopenia and Microbiome Research: A Bibliometric Exploration. (Pubmed Central) - Jul 1, 2024
Malnutrition, dietary fiber, signaling pathways, frailty, and intestinal microbes are currently research hotspots. Furthermore, the visual atlas analysis of research on microbes and sarcopenia helps to track the knowledge structure in research fields related to sarcopenia and microbes, providing direction for future research.
- || Review, Journal: Sarcopenic obesity in patients awaiting liver transplant: Unique challenges for nutritional recommendations. (Pubmed Central) - Jul 1, 2024
While these nutrition guidelines have been established in non-cirrhotic patients, established guidelines for liver transplant candidates with sarcopenic obesity are lacking. In this paper, we review existing literature on sarcopenic obesity in patients with chronic liver disease and address opportunities to improve nutritional counseling in patients awaiting liver transplantation.
- || Review, Journal: Role of Nutrition in the Management of Patients with Chronic Musculoskeletal Pain. (Pubmed Central) - Jul 1, 2024
Beyond mere analgesia, comprehensive patient care for CMP requires acknowledgment of the complex and multifactorial nature of pain and its foundational elements. Embracing an integrative treatment model allows healthcare practitioners to promise better patient prognoses, enriched life quality, and a decrease in the sustained healthcare costs associated with CMP.
- | Journal: Importance of Assessing Sarcopenia in Patients with Type 2 Diabetes Mellitus Based on Body Fat Percentage Measured by Dual-Energy X-Ray Absorptiometry in Different Genders. (Pubmed Central) - Jul 1, 2024
This correlation was generally consistent, as demonstrated in further subgroup analyses. High BFP was significantly associated with sarcopenia risk, and this association was independent of gender, age, and BMI.
- | Journal: Lack of association between serum apelin levels and sarcopenia in elderly malnourished subjects. (Pubmed Central) - Jul 1, 2024
High BFP was significantly associated with sarcopenia risk, and this association was independent of gender, age, and BMI. Our study shows a lack of association between apelin and sarcopenia in elderly malnourished patients.
- | Journal: Low muscle quality on a procedural computed tomography scan assessed with deep learning as a practical useful predictor of mortality in patients with severe aortic valve stenosis. (Pubmed Central) - Jun 30, 2024
Our study shows a lack of association between apelin and sarcopenia in elderly malnourished patients. Our findings suggest that deep learning-assessed low muscle quality, as indicated by fat infiltration in muscle tissue, is a practical, useful and independent predictor of mortality after TAVI.
- || Review, Journal: Geriatric syndromes: the importance of the problem, controversial issues of terminology. (Pubmed Central) - Jun 30, 2024
The main purpose of the presented review is precisely to try to answer these questions. In addition, it has not yet been determined whether geriatric syndromes should be included in the diagnosis (the only exception is sarcopenia syndrome, which was officially included in the 10th International Classification of Diseases in 2016).
- | Journal: Utilizing a novel MRI technique to identify adverse muscle composition in end-stage liver disease: A pilot study. (Pubmed Central) - Jun 29, 2024
In addition, it has not yet been determined whether geriatric syndromes should be included in the diagnosis (the only exception is sarcopenia syndrome, which was officially included in the 10th International Classification of Diseases in 2016). The AMRA
- | Journal: Musculoskeletal morbidity in adults with spinal cord injuries: A nationwide cohort study. (Pubmed Central) - Jun 29, 2024
SCI increases the risk of MSK morbidity. Lumbar SCI is associated with a higher incidence and risk of MSK morbidity than are cervical or thoracic SCIs.
- | Journal: Association of muscle disorders in late postmenopausal women according to the type of experienced menopause. (Pubmed Central) - Jun 28, 2024
Women experiencing surgical PM have a higher likelihood of developing muscle disorders. This underscores the potential significance of hormonal levels in influencing musculoskeletal health during postmenopause.
- Observational data, Journal: Prevalence of sarcopenia and association with HIV infection in China elderly: An observational study. (Pubmed Central) - Jun 28, 2024
HIV infection was a risk factor for sarcopenia. It is urgent to establish a prevention and treatment system for sarcopenia in the elderly population, especially for elderly HIV-infected male.
- | Journal, Surgery: Sarcopenic obesity predicts short- and long-term outcomes after neoadjuvant chemotherapy and surgery for gastric cancer. (Pubmed Central) - Jun 28, 2024
It is urgent to establish a prevention and treatment system for sarcopenia in the elderly population, especially for elderly HIV-infected male. Pre-NAC SO was an independent prognostic factor in patients with LAGC undergoing NAC; post-NAC SO independently predicted postoperative morbidity.
- || Trial completion date, Trial primary completion date: ENHANce: Exercise and Nutrition for Healthy AgeiNg (clinicaltrials.gov) - Jun 28, 2024
P=N/A, N=180, Recruiting, Sponsor: Universitaire Ziekenhuizen KU Leuven
Pre-NAC SO was an independent prognostic factor in patients with LAGC undergoing NAC; post-NAC SO independently predicted postoperative morbidity. Trial completion date: Jun 2024 --> Jun 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
- | sirolimus / Generic mfg.
New P2 trial: Rapamycin impact on muscle strength and endurance in older adults (EUDRACT) - Jun 28, 2024
P2, N=40, Not yet recruiting, Sponsor: Dr Brad Stanfield Ltd
- | Trial completion date, Trial primary completion date: TEMPUS-FUGIT: Trial in Elderly With Musculoskeletal Problems Due to Underlying Sarcopenia - Faeces to Unravel Gut and Inflammation Translationally (clinicaltrials.gov) - Jun 28, 2024
P=N/A, N=110, Recruiting, Sponsor: Universitaire Ziekenhuizen KU Leuven
Trial completion date: Jun 2024 --> Jun 2025 | Trial primary completion date: Dec 2023 --> Dec 2024 Trial completion date: Jan 2024 --> Nov 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
- | New trial: C4M: Effect of Exercise Type on Muscle Quality in Patients With OA, SARC and RA: an Explorative Study (clinicaltrials.gov) - Jun 27, 2024
P=N/A, N=69, Not yet recruiting, Sponsor: Amsterdam UMC, location VUmc
- | Journal: Telomere Length is Associated with the Prevalence, Persistence, and Incidence of Sarcopenia. (Pubmed Central) - Jun 27, 2024
Implementation of interventions to delay the decline of TL in older adults is warranted. Further translational studies are needed to elucidate the effects of exercise or diet on DNA repair in the telomeric region and their associations with sarcopenia.
- | metformin / Generic mfg.
Journal, HEOR: Metformin Improves Sarcopenia-Related Quality of Life in Geriatric Adults: A Randomized Controlled Trial. (Pubmed Central) - Jun 27, 2024
Overall, metformin improved HGS and SarQoL by repairing intestinal leakage. Our data have clinical relevance for improving the quality of life in older adults with sarcopenia.
- || Biomarker, Review, Journal: Biomarkers of Cellular Senescence and Aging: Current State-of-the-Art, Challenges and Future Perspectives. (Pubmed Central) - Jun 27, 2024
Further, technologies from the current decade including multi-omics and computational methods used in the fields of senescence and aging are also discussed in this review. Understanding aging-associated biological processes by using cellular senescence biomarkers can enable therapeutic innovation and interventions to improve the quality of life of older adults.
- || Review, Journal: Physical rehabilitation in sarcopenia: modern approaches. (A literature review) (Pubmed Central) - Jun 27, 2024
This article describes the parameters of exercises that are most effective in terms of muscle strength and mass increase and safe for patients. The compilation and further study of this complex in practice are needed.
- | Journal: The Relationship Between Body Composition and Pathological Response to Neoadjuvant Chemotherapy in Breast Cancer Patients. (Pubmed Central) - Jun 27, 2024
Addressing these conditions through tailored interventions, such as nutritional support, exercise programs, and careful monitoring of body composition, could improve treatment outcomes. Further research with larger patient populations and comprehensive body measurements is essential to fully understand these relationships and develop effective strategies to mitigate their impact.
- | Preclinical, Journal: Aster glehni Extract, Including Caffeoylquinic Acids as the Main Constituents, Induces PPAR ?/?-Dependent Muscle-Type Change and Myogenesis in Apolipoprotein E Knockout Mice. (Pubmed Central) - Jun 27, 2024
AG extract can contribute to the amelioration of skeletal muscle inactivity and sarcopenia through myogenesis in skeletal muscle tissues from ApoE KO mice, and function of AG extract may be dependent on PPAR?/?, and the main functional constituents of AG are trans-5-O-caffeoylquinic acid and 3,5-O-dicaffeoylquinic acid. In addition, in skeletal muscle, AG has potent efficacies against dyslipidemia and obesity through the increase of the type 1 muscle fiber content to produce more ATP by oxidative phosphorylation in skeletal muscle tissues from ApoE KO mice.
- | Retrospective data, Journal: The adverse impact of perioperative body composition abnormalities on outcomes after split liver transplantation: a multi-center retrospective cohort study. (Pubmed Central) - Jun 27, 2024
Sarcopenia, myosteatosis, and their progression negatively affect outcomes including early allograft dysfunction, early complications, ICU stay and survival after SLT. Systemic evaluation and dynamic monitoring of body composition are valuable.
- || Review, Journal: Osteoporosis e-learning courses: A systematic review to develop a comprehensive virtual course for General Practitioners. (Pubmed Central) - Jun 27, 2024
Through a systematic approach, we developed modules for e-learning of osteoporosis management, which can be used to improve knowledge and skills of GPs in their practice in our setting. The online version contains supplementary material available at 10.1007/s40200-023-01361-8.