Sarcopenia
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  • ||||||||||  Preclinical, Journal:  Aerobic exercise alleviates skeletal muscle aging in male rats by inhibiting apoptosis via regulation of the Trx system. (Pubmed Central) -  Jul 28, 2024   
    It was shown that aerobic exercise in senescent rats resulted in increased gastrocnemius index, decreased body weight, increased endurance, decreased skeletal muscle cell apoptosis, increased activity and protein expression of the Trx system, and decreased expression of p38 and ASK1. Based on these findings, we conclude that 10?weeks of aerobic exercise may enhance the anti-apoptotic effect of Trx by up-regulating Trx and Trx reductase (TR) protein expression, which in turn increases Trx activity in rat skeletal muscle, and ultimately alleviates apoptosis in senescent skeletal muscle cells.
  • ||||||||||  Review, Journal:  Nutrition for the older adult - Current concepts. Report from an ESPEN symposium. (Pubmed Central) -  Jul 28, 2024   
    In the future, even more individualised approaches like precision nutrition may enable better nutritional care. Meanwhile all stakeholders should focus on a better implementation of currently available strategies and work closely together to improve nutritional care for older adults.
  • ||||||||||  Review, Journal:  Insights into the epitranscriptomic role of N6-methyladenosine on aging skeletal muscle. (Pubmed Central) -  Jul 28, 2024   
    The inability of aged muscles to regenerate and repair after injury poses a great challenge to the geriatric populace. This review seeks to explore the m6A epigenetic regulation in the myogenesis and regeneration processes in skeletal muscle as well as the progress made on the m6A epigenetic regulation of aging skeletal muscles.
  • ||||||||||  Clinical data, Review, Journal:  Diagnostic criteria, prevalence, and clinical outcomes of pediatric sarcopenia: A scoping review. (Pubmed Central) -  Jul 28, 2024   
    Pediatric sarcopenia diagnosis primarily relies on skeletal muscle mass, with identified links to future clinical outcomes in specific conditions. The lack of standardized cutoffs for sarcopenia indicators underscores the necessity for age, gender, and race-specific cutoff values derived from studies establishing reference values for muscle mass and strength across diverse pediatric populations.
  • ||||||||||  Journal:  Measurement of muscle mass for diagnosing sarcopenia: Is it enough? (Pubmed Central) -  Jul 28, 2024   
    The lack of standardized cutoffs for sarcopenia indicators underscores the necessity for age, gender, and race-specific cutoff values derived from studies establishing reference values for muscle mass and strength across diverse pediatric populations. No abstract available
  • ||||||||||  Review, Journal:  SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets. (Pubmed Central) -  Jul 28, 2024   
    Currently, several SIRT1-mediated interventions on sarcopenia have been preliminarily developed, such as SIRT1 activator polyphenolic compounds, exercising and calorie restriction. In this review, we summarized the predominant mechanisms of SIRT1 involved in sarcopenia and therapeutic modalities targeting the SIRT1 signaling pathways for the prevention and prognosis of sarcopenia.
  • ||||||||||  Journal, Metastases:  Prevalence and survival implications of malnutrition and sarcopenia in (Pubmed Central) -  Jul 28, 2024   
    Notably, solitary malnutrition emerged as a prognostic factor for overall survival, whereas no significant association was observed for solitary sarcopenia or malnutrition with or without sarcopenia. This highlights the critical need for early identification of patients at risk of malnutrition and the importance of timely intervention.
  • ||||||||||  Journal:  Low dietary vitamin C intake is associated with low muscle strength among elderly Korean women. (Pubmed Central) -  Jul 28, 2024   
    Among older women ?65 y, those in the lowest quartile of dietary vitamin C intake had a higher risk of low muscle strength compared to those in the highest quartile after adjustment of confounding factors (odds ratio, 2.16; 95% confidence interval, 1.49-3.15). These results imply that adequate dietary vitamin C intake may reduce the risk of sarcopenia in older Korean women.
  • ||||||||||  Biomarker, Journal:  Autophagy markers LC3 and p62 in aging lumbar motor neurons. (Pubmed Central) -  Jul 28, 2024   
    No effect of sex or MN pool was observed in LC3 and p62 expression in MNs. Overall, these data suggest autophagy impairment during elongation (increased LC3) and degradation (increased p62) phases with aging in lumbar MNs.
  • ||||||||||  Journal:  The Double-Edged Sword of ROS in Muscle Wasting and COPD: Insights from Aging-Related Sarcopenia. (Pubmed Central) -  Jul 27, 2024   
    This duality of ROS suggests that the mere use of a broad-acting antioxidant is destined to fail in alleviating skeletal muscle wasting in COPD because it will also be influencing critical physiological ROS-dependent processes. Here, we take a close look at this duality of ROS in skeletal muscle physiology and pathophysiology pertaining to COPD and will aim to gain critical insights from other skeletal muscle wasting conditions due to aging such as sarcopenia.
  • ||||||||||  Journal:  Sarcopenia-related traits and 10 digestive system disorders: insight from genetic correlation and Mendelian randomization. (Pubmed Central) -  Jul 26, 2024   
    For non-alcoholic fatty liver, the intermediary impact is 0.0150 (95% CI, 0.0050, 0.0270), representing 19.7808% (95% CI, 6.5936, 35.6055%) of the total effect. The findings posit that augmenting muscle mass may serve as a preventative strategy against gastroesophageal reflux disease and non-alcoholic fatty liver, highlighting the critical role of metabolic disorder management in reducing the risks of these sarcopenia-related conditions.
  • ||||||||||  Journal, HEOR:  Quality of life in postmenopausal women and its association with sarcopenia. (Pubmed Central) -  Jul 26, 2024   
    Despite no significant association between quality of life and sarcopenia in postmenopausal women, somatic symptoms were significant in women with sarcopenia. The greater menopausal duration was associated significantly with sarcopenia.
  • ||||||||||  Review, Journal:  Ferroptosis and aerobic training in ageing: A review. (Pubmed Central) -  Jul 26, 2024   
    Physical activity could affect lipid, amino acid, and iron metabolism to modulate ferroptosis. The aim of this study is to showcase the current understanding of the molecular mechanisms leading to ferroptosis and discuss the role of aging and physical activity in this phenomenon.
  • ||||||||||  Daytime sleepiness in urological patients (Hall D / Level 0) -  Jul 26, 2024 - Abstract #DGU2024DGU_376;    
    The aim of this study is to showcase the current understanding of the molecular mechanisms leading to ferroptosis and discuss the role of aging and physical activity in this phenomenon. Irrespective of frailty, daytime sleepiness should be considered a risk factor for elderly and urological patients.
  • ||||||||||  Trial completion, Enrollment change, Trial primary completion date:  The Effect of Culinary Medicine to Enhance Protein Intake on Muscle Quality in Older Adults (clinicaltrials.gov) -  Jul 24, 2024   
    P=N/A,  N=28, Completed, 
    Irrespective of frailty, daytime sleepiness should be considered a risk factor for elderly and urological patients. Recruiting --> Completed | N=46 --> 28 | Trial primary completion date: Jan 2024 --> Apr 2024
  • ||||||||||  Journal:  Computed tomography cannot see "Sarcopenic Obesity". (Pubmed Central) -  Jul 23, 2024   
    A comprehensive analysis of body composition (visceral adipose index:VAI and skeletal muscle index: SMD) and inflammation index (SII)may contribute to prognostic stratification of patients with advance NSCLC receiving chemo-immunotherapy as first-line. No abstract available