Sarcopenia
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  • ||||||||||  Journal:  The Differential Effect of Excess Aldosterone on Skeletal Muscle Mass by Sex. (Pubmed Central) -  Apr 16, 2019   
    The odds of HA-ASM in subjects with PA were 10.63-fold (95% CI: 0.83-135.50) higher, with marginal significance (P = 0.069) than in those with NFAI. Skeletal muscle mass in women with PA was lower than that in women with NFAI; suggesting that excess aldosterone has adverse effects on skeletal muscle metabolism.
  • ||||||||||  Journal:  Detection and Monitoring of Repetitions Using an mHealth-Enabled Resistance Band. (Pubmed Central) -  Apr 16, 2019   
    There were 16.6 repetitions per exercise across reviewers, with an intraclass correlation of 0.912 (95%CI: 0.853-0.953, p<0.001) between reviewers and the algorithm. Using this novel resistance band, we feasibly detected repetition of exercises in older adults.
  • ||||||||||  Review, Journal:  Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation. (Pubmed Central) -  Apr 15, 2019   
    Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral. Therefore, the purpose of this review is to: (1) summarize the effects of creatine supplementation, with and without resistance training, in aging adults and discuss possible mechanisms of action, (2) examine the effects of creatine on bone biology and risk of falls, (3) evaluate the potential anti-inflammatory effects of creatine and (4) determine the safety of creatine supplementation in aging adults.
  • ||||||||||  Clinical, Journal:  Comorbidities, age, and other patient-related predictors of allogeneic hematopoietic cell transplantation outcomes. (Pubmed Central) -  Apr 12, 2019   
    Domains covering functional, physical, mental, social, nutritional, bone, and other health statuses should be evaluated and considered. Expert commentary: In this review we merge the current assessment tools with the potential approaches to objectify functional resources, as well as with possible methods to improve these resources in older or otherwise medically unfit patients prior to allogeneic HCT.
  • ||||||||||  Clinical, Journal:  Gait speed has comparable prognostic capability to six-minute walk distance in older patients with cardiovascular disease. (Pubmed Central) -  Apr 11, 2019   
    There was no significant difference in prognostic capability between gait speed and six-minute walk distance (c-index: 0.64 (95% confidence interval: 0.60-0.69) and 0.66 (95% confidence interval: 0.61-0.70), respectively, p = 0.357). Conclusions Gait speed and six-minute walk distance showed similar prognostic predictive ability for all-cause mortality in older cardiovascular disease patients, indicating the potential utility of gait speed as a simple risk stratification tool in older cardiovascular disease patients.
  • ||||||||||  NN1213 / Novo Nordisk
    Biomarker, Trial completion:  A Prospective Study Of Biomarkers Of Skeletal Muscle Atrophy (clinicaltrials.gov) -  Apr 11, 2019   
    P=N/A,  N=30, Completed, 
    MMP3 might be a useful marker for sarcopenia in patients with RA. Active, not recruiting --> Completed
  • ||||||||||  Clinical, Journal:  A High Serum Cortisol/DHEA-S Ratio Is a Risk Factor for Sarcopenia in Elderly Diabetic Patients. (Pubmed Central) -  Apr 10, 2019   
    The concentrations of cortisol and DHEA-S, as well as the cortisol/DHEA-S ratio, changed in accordance with the severity of sarcopenia. A relative increase in cortisol may reflect the presence of stress and stimulate muscle catabolism, whereas a relative decrease in DHEA-S may cause a decrease in the anabolic action of DHEA on muscle; the combination of these factors may lead to sarcopenia.
  • ||||||||||  Enrollment open:  Distribution of Nutrient Derived Amino Acids (clinicaltrials.gov) -  Apr 10, 2019   
    P=N/A,  N=24, Recruiting, 
    A relative increase in cortisol may reflect the presence of stress and stimulate muscle catabolism, whereas a relative decrease in DHEA-S may cause a decrease in the anabolic action of DHEA on muscle; the combination of these factors may lead to sarcopenia. Not yet recruiting --> Recruiting
  • ||||||||||  Review, Journal:  Potential roles of vitamin E in age-related changes in skeletal muscle health. (Pubmed Central) -  Apr 10, 2019   
    Several factors, including difficulties in validating vitamin E intake and deficiency, variations in muscle-protective activity and metabolism of diverse forms of vitamin E, and lack of understanding of the mechanisms of action, preclude randomized clinical trials of vitamin E in people with sarcopenia. Future research should consider long-term clinical trials of with adequate sample size, advanced imaging technology and omics approaches to investigate underlying mechanisms and assess clinically meaningful parameters such as muscle strength, physical performance, and muscle mass in sarcopenia prevention and/or treatment.
  • ||||||||||  Journal:  The Psychology of Nutrition with Advancing Age: Focus on Food Neophobia. (Pubmed Central) -  Apr 9, 2019   
    However, when demographic characteristics were also considered, food neophobia scores were no longer related to denture wearing (Beta = 0.069, p = 0.226) but instead were related to a higher age, living alone, and a shorter education (smallest Beta = -0.104, p = 0.048). Food neophobia may thus act as a barrier to the consumption of novel foods/products in those who are of higher age, are living alone, and have a shorter education.