Sarcopenia
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  • ||||||||||  NN1213 / Novo Nordisk
    Enrollment closed, Enrollment change:  A Physical Activity Program in End-state Liver Disease (clinicaltrials.gov) -  May 2, 2019   
    P=N/A,  N=20, Active, not recruiting, 
    The preservation of skeletal muscle mass is important to protect patients with T2DM from increased mortality risk. Enrolling by invitation --> Active, not recruiting | N=50 --> 20
  • ||||||||||  Journal:  Frailty and Primary Sarcopenia: A Review. (Pubmed Central) -  May 1, 2019   
    Both conditions are characterized by decreased energy reserves and resistance to external and internal stressors, resulting in susceptibility to fatigue, comorbidity, sedentary life style, functional decline, hospitalization, quality of life, and even death. The estimated prevalence of frailty with sarcopenia is relatively low; however, the condition requires early detection and careful management.
  • ||||||||||  Clinical, Review, Journal:  Metabolic changes in patients with prostate cancer during androgen deprivation therapy. (Pubmed Central) -  May 1, 2019   
    Third, education and instruction, such as diet or exercise, to decrease metabolic changes before initiating androgen deprivation therapy is important, because metabolic changes are likely to occur in the early androgen deprivation therapy period. Fourth, routine monitoring of weight, laboratory data or bone mineral density during androgen deprivation therapy are required to avoid unfavorable events.
  • ||||||||||  Biomarker, Clinical, Journal:  Proteomics and frailty: a clinical overview. (Pubmed Central) -  Apr 30, 2019   
    Larger prospective studies are needed for confirming these findings and enabling their replication in real life scenarios. Albeit proteomic research in the field of age-dependent biologic impairment is in embryo, proteomics holds the greatest potential in frailty diagnostics.
  • ||||||||||  Retrospective data, Review, Journal:  Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis. (Pubmed Central) -  Apr 28, 2019   
    This study provides novel evidence on the prevalence of low protein intake, diurnal protein intake patterns and food group contributors to protein intake in the very old. Sarcopenia is a significant predictor of hospitalization among older individuals, and the association may not be significantly affected by the characteristics of the population or the definition of sarcopenia.
  • ||||||||||  Clinical, Observational data, Journal:  A pilot observational study measuring acute sarcopenia in older colorectal surgery patients. (Pubmed Central) -  Apr 28, 2019   
    Baseline hsCRP correlated with change in BATT (τb = 0.73, p = 0.04) and baseline DHEA-S correlated with change in gait speed (τb = 0.87, p = 0.02). This pilot study has assisted to refine the protocol for our larger study, which will further characterise these changes.
  • ||||||||||  Journal:  Comprehensive Geriatric Assessment and Nutrition-Related Assessment: A Cross-Sectional Survey for Health Professionals. (Pubmed Central) -  Apr 27, 2019   
    Multivariate logistic regression analyses for the CGA usage revealed that using ICF (P < 0.001), assessing sarcopenia (P = 0.001), sarcopenic dysphagia (P = 0.022), and cachexia (P = 0.039), and defining nutritional goals (P = 0.001) were statistically significant after adjusting for confounders. (4) There are correlations between the use of CGA and evaluation of sarcopenia, sarcopenic dysphagia, and cachexia and nutritional goals.
  • ||||||||||  Journal:  Repetitive TLR-3 activation in the lung induces skeletal muscle adaptations and cachexia. (Pubmed Central) -  Apr 26, 2019   
    Changes of note when comparing poly(I:C)-treated mice to PBS-treated controls include reductions in fiber cross-sectional area (-27% gastrocnemius, -25% soleus, -16% diaphragm), contractile dysfunction (soleus peak tetanic force, -26%), muscle mass (gastrocnemius -19%, soleus -23%), physical function (grip test -34%), body mass (-20%); and altered oxidative capacity (140% increase in succinate dehydrogenase activity in the diaphragm, but 66% lower in the gastrocnemius). Our data is supportive of a new model of cachexia/sarcopenia that has potential for future research into the mechanisms underlying muscle wasting.
  • ||||||||||  Journal:  Human neuromuscular aging: Sex differences revealed at the myocellular level. (Pubmed Central) -  Apr 26, 2019   
    These findings suggest the predominant mechanisms leading to whole muscle atrophy differ between aging males and females: myofiber atrophy in females vs. myofiber loss in males. Future studies will be important to better understand the mechanisms underlying sex differences in myocellular aging and optimize exercise prescriptions and adjunctive treatments to mitigate or reverse age-related changes.
  • ||||||||||  Journal:  An evaluation of common markers of muscle denervation in denervated young-adult and old rat gastrocnemius muscle. (Pubmed Central) -  Apr 26, 2019   
    NaV1.5 expression decreased after 1 and 2 weeks of denervation in NaV1.5 in young muscle fibres before returning to control levels, whereas old muscle fibres displayed a transient increase after 1 week followed by a decrease and a return to control levels after 2 and 4 weeks respectively. In conclusion, NCAM and NaV1.5 are not unequivocally elevated with denervation and consequently are not adequate markers of fibre denervation.
  • ||||||||||  Clinical, Journal, Video:  Dysphagia Onset in Older Adults during Unrelated Hospital Admission: Quantitative Videofluoroscopic Measures. (Pubmed Central) -  Apr 25, 2019   
    Alongside multimorbidity and polypharmacy, a combination of factors during hospitalization, such as fatigue, low levels of alertness, delirium, reduced respiratory support and disuse atrophy, may tip the balance of age-related swallowing adaptations and compensation toward dysfunctional swallowing. To optimize swallowing assessment and management for our aging population, care must be taken not to oversimplify dysphagia complaints as a characteristic of aging.
  • ||||||||||  Clinical, Journal:  Overweight in the Elderly Induces a Switch in Energy Metabolism that Undermines Muscle Integrity. (Pubmed Central) -  Apr 25, 2019   
    This ATP depletion induced early signs of impaired contractile function and a decline in skeletal muscle structural integrity, evidenced by lower levels of filamin C. Our findings reveal the main effector pathways at an early stage of obesity and highlight the importance of mitochondrial metabolism in overweight and obese individuals. Exploiting mitochondrial profiles for therapeutic purposes in humans is an ambitious strategy for treating muscle impairment diseases.
  • ||||||||||  Enrollment closed, Enrollment change, Trial primary completion date:  Roles of Uremic Toxins in Uremic Sacropenia (clinicaltrials.gov) -  Apr 23, 2019   
    P=N/A,  N=111, Active, not recruiting, 
    Therefore, evaluating patients for both pain and sarcopenia may be useful for risk assessment and treatment. Recruiting --> Active, not recruiting | N=300 --> 111 | Trial primary completion date: Jan 2020 --> Dec 2018
  • ||||||||||  Trial completion:  NUTRIMAL: Novel Nutrition Solutions for Sarcopenia (clinicaltrials.gov) -  Apr 18, 2019   
    P=N/A,  N=108, Completed, 
    Further research is needed to validate the clinical biomarkers involved in ICI responders. Recruiting --> Completed
  • ||||||||||  Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  DCE-Sarcopenia: Identification of Critical Outcomes in Sarcopenia (clinicaltrials.gov) -  Apr 18, 2019   
    P=N/A,  N=40, Completed, 
    Recruiting --> Completed Not yet recruiting --> Completed | N=280 --> 40 | Trial completion date: May 2019 --> Dec 2018 | Trial primary completion date: May 2019 --> Dec 2018
  • ||||||||||  Prolia (denosumab) / Amgen, Daiichi Sankyo, GSK
    Clinical, Review, Journal:  Antibodies as treatment option in older adults (Pubmed Central) -  Apr 17, 2019   
    Particularly, with respect to sarcopenia the transition to "doping for older adults" seems to be fluent. The present review provides an overview on the newest developments and prospective options.
  • ||||||||||  Biomarker, Clinical, Journal:  Sarcopenia in Children With End-Stage Liver Disease. (Pubmed Central) -  Apr 17, 2019   
    In this retrospective pilot study, PMSA was significantly lower in children with ESLD compared with healthy age- and gender-matched controls. Because this finding was independent of growth in ESLD subjects, PMSA may represent a novel objective nutritional biomarker in children with advanced liver disease.
  • ||||||||||  Review, Journal:  A role for nutritional intervention in addressing the aging neuromuscular junction. (Pubmed Central) -  Apr 17, 2019   
    However, current evidence seldom directly assesses neuromuscular outcomes and is not always in the context of aging. Additional clinical research studies are needed to confirm the benefits of dietary supplements on neuromuscular function, as well as to define the appropriate population, dosage, and duration for intervention.