Sarcopenia
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  • ||||||||||  Review, Journal:  Irisin and Bone: From Preclinical Studies to the Evaluation of Its Circulating Levels in Different Populations of Human Subjects. (Pubmed Central) -  May 17, 2019   
    Additionally, our in vitro studies suggest the existence of a negative interplay between PTH and irisin biology and these results were also supported by the observation that post-menopausal women with primary hyperparathyroidism have lower levels of irisin compared to matched controls. In this review, we will focus on recent findings about circulating level of irisin in different populations of human subjects and its correlation with their bone status.
  • ||||||||||  Journal:  Body weight and bone/calcium metabolism. Sarcopenia and its relationship with bone and calcium metabolism. (Pubmed Central) -  May 17, 2019   
    Sarcopenia is characterized by age-related loss of skeletal muscle mass, strength and function, and its diagnostic criteria as well as the practical guideline have been established. Although underlying mechanisms of sarcopenia remains to be fully elucidated, recent progress in research has suggested the concept of muscle bone connection including the association between sarcopenia and osteoporosis.
  • ||||||||||  Clinical, Review, Journal:  Elderly Obesity: Is It Harmful or Beneficial? (Pubmed Central) -  May 16, 2019   
    This review summarizes the epidemiology of obesity in Korea, the clinical implications of elderly obesity, and considerations regarding weight management. Understanding the complexity of elderly obesity could facilitate the design of preventative and therapeutic strategies that would have a positive impact on the overall health of the Korean population.
  • ||||||||||  Clinical, Journal:  Prevalence of sarcopenia and associated factors in climacteric women of the Colombian Caribbean. (Pubmed Central) -  May 15, 2019   
    Our nomogram was a simple and practical instrument to quantify the individual risk of IAI and could be used to identify patients at a high risk. Sarcopenia was present in this middle-aged female Colombian Caribbean sample and associated with various factors such as ethnicity, age, and menopausal symptoms and status.
  • ||||||||||  Journal:  Association between CT-Measured Abdominal Skeletal Muscle Mass and Pulmonary Function. (Pubmed Central) -  May 15, 2019   
    The β regression coefficients for FVC and FEV1 significantly increased as the SMI quartiles increased after adjusting for other confounding variables (p for trend < 0.05). This study showed that abdominal muscle mass, which was precisely measured by CT, independently affected lung function proportionally after adjusting for confounding factors in relatively healthy adults.
  • ||||||||||  Journal:  Potential Application of Centrifuges to Protect the CNS in Space and on Earth. (Pubmed Central) -  May 15, 2019   
    Moreover, it is possible that hypergravity may counteract the neurodegeneration in hippocampus induced by the microgravity conditions and psychiatric diseases. Collectively, further investigations are warranted to demonstrate that centrifuge-induced hypergravity may be beneficial for the therapy of the CNS disorders.
  • ||||||||||  Journal:  The exerkine apelin reverses age-associated sarcopenia. (Pubmed Central) -  May 15, 2019   
    Various strategies that restored apelin signaling during aging further demonstrated that this peptide considerably enhanced muscle function by triggering mitochondriogenesis, autophagy and anti-inflammatory pathways in myofibers as well as enhancing the regenerative capacity by targeting muscle stem cells. Taken together, these findings revealed positive regulatory feedback between physical activity, apelin and muscle function and identified apelin both as a tool for diagnosis of early sarcopenia and as the target of an innovative pharmacological strategy to prevent age-associated muscle weakness and restore physical autonomy.
  • ||||||||||  Journal:  Aging-related frailty and sarcopenia. The concepts and diagnostic criteria of frailty. (Pubmed Central) -  May 15, 2019   
    Furthermore besides physical frailty, psychological frailty, which encompasses cognitive and mood components, and social frailty, which includes the lack of participation in social networks and perceived lack of contacts and support, have been proposed, although there is no consensus regarding the definition as well as criteria of these frailty. In super-aged society, Japan, from the viewpoint of healthy life expectancy, the concept of phenotype model of frailty is important.
  • ||||||||||  Journal:  Aging-related frailty and sarcopenia. Concept and diagnosis of sarcopenia. (Pubmed Central) -  May 15, 2019   
    Those criteria include muscle weakness or muscle function or both of them in addition to low muscle mass because longitudinal studies indicated that muscle mass correlated with muscle strength less than expected before, and that muscle weakness progressed with advancing age more rapidly and influenced more on incident dependency than loss of muscle mass. It is important how we implement the diagnosis of sarcopenia into daily practice and how we manage it based on the diagnosis.
  • ||||||||||  Clinical, Journal:  Aging-related frailty and sarcopenia. Epidemiology of Frailty and Sarcopenia. (Pubmed Central) -  May 15, 2019   
    Further, the prevalence of frailty with comorbidity of sarcopenia was 21.6% and 52.2% in men and women, respectively, and the prevalence of sarcopenia with comorbidity of frailty was 28.6% and 34.4% in men and women, respectively. The estimated number of prevalent cases of frailty, pre-frailty, and sarcopenia in Japanese older adults was approximately 3,090,000, 17,950,000, and 2,710,000, respectively.
  • ||||||||||  Biomarker, Journal:  Aging-related frailty and sarcopenia. Frailty - Sarcopenia and biomarker. (Pubmed Central) -  May 15, 2019   
    However, the diagnosis of frailty is not necessarily unified, the molecular mechanism underlying the onset of sarcopenia is not clear, and clinical treatment strategy has not been established. Therefore, the searching and identifying of the biomarkers of the frailty and sarcopenia is very important for the prevention as well as the treatment of the muscle disease, and the further studies will be needed to investigate these issues.
  • ||||||||||  Journal:  Aging-related frailty and sarcopenia. Frailty/sarcopenia and insulin/IGF-1 signaling. (Pubmed Central) -  May 15, 2019   
    It is also known that sarcopenia is associated with the development of frailty, one of the phenomena of systemic aging. Actually insulin/IGF-1 signaling is known to affect longevity in lower organisms, but in humans, little is known about roles of the signaling in the development of frailty, and further investigation is needed.
  • ||||||||||  Journal:  Aging-related frailty and sarcopenia. Frailty, sarcopenia and dysphagia. (Pubmed Central) -  May 15, 2019   
    Rehabilitation nutrition can be practiced by using the rehabilitation nutrition care process, which is a systematic problem-solving method. It consists of five steps:rehabilitation nutrition assessment and diagnostic reasoning, rehabilitation nutrition diagnosis, rehabilitation nutrition goal setting, rehabilitation nutrition intervention, and rehabilitation nutrition monitoring.
  • ||||||||||  Biomarker, Journal:  Aging-related frailty and sarcopenia. Frailty and sarcopenia in the centenarians. (Pubmed Central) -  May 15, 2019   
    Recent studies have demonstrated pathogenic roles of age-related inflammatory activation(inflammaging), and some of circulation biomarkers for frailty are developed. It is important to prevent frailty and sarcopenia by caring a lifestyle from the earlier ages in life, preparing for the aging society with healthy status.
  • ||||||||||  Journal:  Aging-related frailty and sarcopenia. Kampo medicine for frailty and sarcopenia. (Pubmed Central) -  May 15, 2019   
    In this guideline, traditional herbal medicines, which are suggested to be useful for the elderly, have been taken up, and the evidence of which is being accumulated. We regarded frailty and sarcopenia as 'kidney-Qi' deficiency, a concept that represents aging phenomenon in Kampo medicine and clarified the anti-sarcopenic effects of Go-sha-jinki-gan, a 'kidney-Qi'-tonifying medicine, using animal experimental models.
  • ||||||||||  Journal:  Indoxyl sulfate induces myotube atrophy by ROS-ERK and JNK-MAFbx cascades. (Pubmed Central) -  May 14, 2019   
    Besides, the inhibition of p-JNK was capable to attenuate IS-induced upward change in MAFbx protein expression. These findings indicated that IS-mediated myotube atrophy may manipulate through ROS-ERK axis and JNK-MAFbx regulation in C2C12 cells.
  • ||||||||||  Journal:  Sarcopenia: revised European consensus on definition and diagnosis. (Pubmed Central) -  May 14, 2019   
    Our results suggest that PIC protects skeletal muscles from oxidative stress by activating antioxidant enzymes such as HO-1 and SOD1 and can therefore help prevent oxidative stress-induced muscle dysfunction such as muscle fatigue and sarcopenia. No abstract available
  • ||||||||||  Review, Journal:  Interleukin-6: a molecule with complex biological impact in cancer. (Pubmed Central) -  May 13, 2019   
    IL-6 supports tumour growth and metastasising in terminal patients, and it significantly engages in cancer cachexia (including anorexia) and depression associated with malignancy. The pharmacological treatment impairing IL-6 signalling represents a potential mechanism of anti-tumour therapy targeting cancer growth, metastatic spread, metabolic deterioration and terminal cachexia in patients.