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12 Products |
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17 Mechanisms of Action |
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756 Trials |
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- | Trial initiation date: Effect of Total Knee Arthroplasty on Sarcopenia in Patients With Osteoarthritis in the Knee (clinicaltrials.gov) - Jun 18, 2019
P=N/A, N=58, Not yet recruiting, Sponsor: Chinese University of Hong Kong
Initiation date: Apr 2019 --> Sep 2019
- | Trial initiation date: Investigating the Effectiveness of Vibration Therapy on Sarcopenia in Osteoarthritis Knee Patients (clinicaltrials.gov) - Jun 18, 2019
P=N/A, N=50, Not yet recruiting, Sponsor: Chinese University of Hong Kong
Initiation date: Apr 2019 --> Sep 2019 Initiation date: Apr 2019 --> Aug 2019
- | Enrollment open: n3 PUFA and Muscle-disuse Atrophy in Older Women (clinicaltrials.gov) - Jun 17, 2019
P=N/A, N=24, Recruiting, Sponsor: McMaster University
Initiation date: Apr 2019 --> Aug 2019 Not yet recruiting --> Recruiting
- | Preclinical, Journal: Phrenic Motor Neuron Loss in Aged Rats. (Pubmed Central) - Jun 17, 2019
The age-associated loss of PhMNs involved predominantly larger PhMNs. These results are consistent with an age-related denervation of larger more fatigable DIAm motor units, which are required primarily for high-force airway clearance behaviors.
- | Clinical, Journal: Low Skeletal Muscle Density Is Associated with Early Death in Patients with Perihilar Cholangiocarcinoma Regardless of Subsequent Treatment. (Pubmed Central) - Jun 17, 2019
A time-dependent effect of skeletal muscle density on OS was found in patients with PHC, regardless of subsequent treatment. Low skeletal muscle density may identify patients at risk for early death.
- | Clinical, Journal: Effects of a hybrid intervention combining exergaming and physical therapy among older adults in a long-term care facility. (Pubmed Central) - Jun 17, 2019
Further study is required to reduce physical inactivity. Geriatr Gerontol Int 2019; 19: 147-152.
- | Clinical, Observational data, Journal: Sarcopenia is associated with tongue pressure in older patients with type 2 diabetes: A cross-sectional study of the KAMOGAWA-DM cohort study. (Pubmed Central) - Jun 17, 2019
We should consider a decrease of swallowing function when examining patients with sarcopenia. Geriatr Gerontol Int 2019; 19: 153-158.
- | Review, Journal: Sarcopenia and dysphagia: Position paper by four professional organizations. (Pubmed Central) - Jun 17, 2019
Additionally, more discussion is required on issues such as the relationship between dysphagia and secondary sarcopenia, as well as the diagnostic criteria and means for diagnosing dysphagia caused by sarcopenia. Geriatr Gerontol Int 2019; ••: ••-••.
- || “This brief review provides an overview of the science underpinning why #dairy foods should be a point of nutritional emphasis for older persons.” https://t.co/nVGhJl3QZB #protein #sarcopenia #nutrition #aging @mackinprof (Twitter) - Jun 16, 2019
- || Does physical frailty #sarcopenia also lead to greater risk of delirium/cognitive impairment from surgery? (Twitter) - Jun 15, 2019
- | Journal: Molecular mechanism of sarcopenia (Pubmed Central) - Jun 15, 2019
Geriatr Gerontol Int 2019; ••: ••-••. No abstract available
- | Journal: Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study. (Pubmed Central) - Jun 15, 2019
Urinary AGT was related to sarcopenic indices and may be involved in the pathogenesis of sarcopenia. On the other hand, urinary Ald was not related to sarcopenic indices when considering other risk factors.
- | Clinical, Journal: The vitamin D receptor expression in skeletal muscle of women with distal radius fracture. (Pubmed Central) - Jun 15, 2019
This suggests that the VDR expression might be upregulated in the attempt to compensate for the decreasing muscle mass. Further studies are necessary to explore the role of VDR in the progression of sarcopenia.
- | abaloparatide (BA058) / Radius, Prolia (denosumab) / Amgen, Daiichi Sankyo, GSK, Evenity (romosozumab) / Astellas, Amgen, UCB
Review, Journal: Bone: best papers of the year 2017. (Pubmed Central) - Jun 15, 2019
Further studies are necessary to explore the role of VDR in the progression of sarcopenia. These papers offer a hopeful outlook for a better treatment and management of patients with osteoporosis and other metabolic bone diseases anno 2018.
- | Journal: Perspective: Protein Requirements and Optimal Intakes in Aging: Are We Ready to Recommend More Than the Recommended Daily Allowance? (Pubmed Central) - Jun 15, 2019
We propose that it should be recommended that older individuals consume ≥1.2 g protein · kg-1 · d-1 and that there should be an emphasis on the intake of the amino acid leucine, which plays a central role in stimulating skeletal muscle anabolism. Critically, the often-cited potential negative effects of consuming higher protein intakes on renal and bone health are without a scientific foundation in humans.
- | Clinical, Journal: Clinical usefulness of psoas muscle thickness for the diagnosis of sarcopenia in patients with liver cirrhosis. (Pubmed Central) - Jun 15, 2019
PMTH was well correlated with SMI in cirrhotic patients. SsPMTH-sarcopenia was an independent predictor of mortality in these patients and more accurately predicted mortality compared to SnPMTH-sarcopenia.
- | Clinical, Journal: Association between Increases in Normalized Protein Catabolic Rate and Increases in Creatinine Generation Rate in Dialysis Patients. (Pubmed Central) - Jun 15, 2019
This was the first study to demonstrate that an increase in dietary protein intake might increase the muscle mass, but this study had certain limitations. Future interventional studies will be needed to investigate whether increases in protein intake have a beneficial effect on sarcopenia, protein-energy wasting, and frailty.
- | Clinical, Journal: Analysis of security by vitamin D of the elderly people. (Pubmed Central) - Jun 15, 2019
Arterial hypertension, obesity of varying degrees, sarcopenia increased the risk of vitamin D deficiency in 1,15-1,17-1,2 (р<0,05-0,01) times, respectively. Oncological diseases in the anamnesis were accompanied by low parameters of vitamin 25(OH)D in blood serum (p=0,084).
- | Journal: Influence of the severity of knee osteoarthritis on the association between leg muscle mass and quadriceps strength: the SPSS-OK study. (Pubmed Central) - Jun 15, 2019
A 1-Nm increase in quadriceps strength per leg was associated with both a 0.14 point increase in KSS movement score and a 0.05 s decrease in TUG, regardless of knee OA severity (P for interaction 0.430 and 0.323). Severe knee OA may reduce efficiency in the exertion of quadriceps strength by leg muscle mass even when the amount of muscle mass remains unchanged.
- | Clinical, Journal: Psoas muscle area and quality are independent predictors of survival in patients treated for abdominal aortic aneurysms. (Pubmed Central) - Jun 15, 2019
L2-L3 PMD and LPMA are reliable, feasible, and independent predictors of mortality in patients treated for AAA. For every standard deviation increase in these standardized z-score muscle parameters, there was a 22%-26% decrease in the probability of death during follow-up.
- || 85M with mini-mental 30/30 and sarcopenia unable to do chair rise evaluated for CABG. When the 🧠 is all-there but the 💪 is in bad shape, cognitive and physical #frailty pull in opposite directions. Toughest (shared) decisions to make imo. (Twitter) - Jun 15, 2019
- | Biomarker, Journal: Sarcopenia as a severe organ failure, its diagnosing and present therapeutic possibilities. (Pubmed Central) - Jun 15, 2019
Physicians should be aware of clinical symptoms and diagnostic algorithm and target treatment according to sarcopenia leading causes. Key words: clinical diagnosis and treatment - muscle failure - muscle mass, strength and function - sarcopenia.
- | Journal: Pitfalls in the measurement of muscle mass: a need for a reference standard. (Pubmed Central) - Jun 15, 2019
Key words: clinical diagnosis and treatment - muscle failure - muscle mass, strength and function - sarcopenia. No abstract available
- || So, how do we do this high velocity power thing? Could you throw in a couple of examples for us sarcopenia warriors - thank you (Twitter) - Jun 15, 2019
- | Clinical, Journal: Effect of acceleration on the rate of power development and neural activity of the leg extensors across the adult life span. (Pubmed Central) - Jun 15, 2019
No abstract available These findings highlight the inability of aged individuals to quickly respond to abrupt changes in movement velocity, which requires more focus in training and prevention programs.
- | Biomarker, Journal: CoreSlicer: a web toolkit for analytic morphomics. (Pubmed Central) - Jun 15, 2019
CoreSlicer enables extraction of morphomic markers from CT images by non-technically skilled clinicians. Measurements were reproducible and accurate in relation to reference software.
- | Biomarker, Clinical, Retrospective data, Journal: Sarcopenia is a prognostic factor for overall survival in elderly patients with head-and-neck cancer. (Pubmed Central) - Jun 15, 2019
Sarcopenia is associated with impaired OS in elderly HNSCC patients. Sarcopenia, defined as the combination of low SMM and low MF, appears to be a better predictor of OS than low SMM or low MF separately.
- | Journal: Potential Cellular and Biochemical Mechanisms of Exercise and Physical Activity on the Ageing Process. (Pubmed Central) - Jun 15, 2019
Specifically, exercise improves cardiovascular, musculoskeletal, and metabolic health through reductions in oxidative stress, chronic low-grade inflammation and modulating cellular processes within a variety of tissues. In this this chapter we will discuss the effects of acute and chronic exercise on these processes and conditions in an ageing population, and how physical activity affects our vasculature, skeletal muscle function, our immune system, and cardiometabolic risk in older adults.
- | Journal: Osteoporosis and the Ageing Skeleton. (Pubmed Central) - Jun 15, 2019
Evidence associating nutritional factors, particularly calcium and vitamin D are reviewed as are the association of falls risk with fracture and the potential for interventions to prevent falls. Finally, the assessment of frailty in the oldest old, associated sarcopenia and multi-morbidity are considered in the evaluation of fall and fracture risk and the management of osteoporosis in the ninth decade of life and beyond.
- | Retrospective data, Review, Journal: Usefulness of skeletal muscle area detected by computed tomography to predict mortality in patients undergoing transcatheter aortic valve replacement: a meta-analysis study. (Pubmed Central) - Jun 14, 2019
CT-derived SMA provides value in predicting post-TAVR long-term outcomes for patients undergoing TAVR. This is a simple risk assessment tool that may help in making treatment decisions and help identifying and targeting high-risk patients with interventions to improve muscle mass prior to and following the procedures.
- | Journal: Classifying sarcopenia: using median value or cut-off values? (Pubmed Central) - Jun 14, 2019
This is a simple risk assessment tool that may help in making treatment decisions and help identifying and targeting high-risk patients with interventions to improve muscle mass prior to and following the procedures. No abstract available
- | Clinical, Journal: SARCOPENIA, OBESITY AND SARCOPENIC OBESITY IN LIVER TRANSPLANTATION: A BODY COMPOSITION PROSPECTIVE STUDY. (Pubmed Central) - Jun 14, 2019
The fat increased over the years after surgery and the lean mass decreased, although not significantly. Sarcopenia and obesity were present after transplantation; however, sarcopenic obesity was not a reality observed in these patients.
- | Retrospective data, Review, Journal: Efficacy of Xianling Gubao capsule in treating sarco-osteopenia: Protocol for a systematic review and meta-analysis. (Pubmed Central) - Jun 14, 2019
Sarcopenia and obesity were present after transplantation; however, sarcopenic obesity was not a reality observed in these patients. The conclusion of this study will provide evidence to judge the effectiveness and safety of XLGBC on SOP.
- || Clinical: Risk factors for #sarcopenia in #rheumatoid arthritis 👉🏼Male 👉🏼Old age 👉🏼Glucocorticoid 👉🏼Increased MMP3 👉🏼Increased HAQ #EULAR2019 THU0159 #muscle #RheumatoidArthritis (Twitter) - Jun 14, 2019
- | Enrollment open: SarcObeNDS: Sarcopenic Obesity in Neurodisabilities (clinicaltrials.gov) - Jun 12, 2019
P=N/A, N=150, Enrolling by invitation, Sponsor: Dionyssiotis, Yannis, M.D.
The conclusion of this study will provide evidence to judge the effectiveness and safety of XLGBC on SOP. Not yet recruiting --> Enrolling by invitation
- | New trial: Muscle Capillarization and Sarcopenia (clinicaltrials.gov) - Jun 12, 2019
P=N/A, N=40, Not yet recruiting, Sponsor: Baltimore VA Medical Center
- || Translational research on bears. Obesity, thrombosis, sarcopenia, osteoporosis- hibernating bears avoid it @lundbeckfonden @Foghsgaard @YndigegnY @PeterGodsk @novonordiskfond @AllanFlyvbjerg @DLBHATTMD @MGtberg (Twitter) - Jun 12, 2019
- | New trial: ICU Sarcopenia Rates by Abdominal CT: Sepsis vs. Trauma (clinicaltrials.gov) - Jun 11, 2019
P, N=146, Not yet recruiting, Sponsor: University of Calgary
- | Review, Journal: The Impact of Step Reduction on Muscle Health in Aging: Protein and Exercise as Countermeasures. (Pubmed Central) - Jun 11, 2019
Periodic activity, even in small quantities, and protein supplementation may serve as effective strategies to offset the loss of muscle mass with aging, specifically during periods of inactivity. The aim of this review is to examine the recent literature encompassing SR, as a model of inactivity, and to explore the capacity of nutrition and exercise interventions to mitigate adverse physiological changes as a result of SR.
- | Journal: Identification of human skeletal muscle miRNA related to strength by high-throughput sequencing. (Pubmed Central) - Jun 9, 2019
Muscle radiographic density, which is inversely proportional to myofiber lipid content Muscle attenuation was negatively correlated to let-7f-5p, miR-30d-5p and miR-125b-5p expression. In-silico analysis implicates miRNAs related to strength and muscle size in the regulation of mammalian target of rapamycin, whist whilst miRNAs related to muscle radiographic densityattenuation may have potential roles regulating the transforming growth factor- β/SMAD3 pathway.
- | Review, Journal: Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview. (Pubmed Central) - Jun 9, 2019
One miRNA that has become of interest recently is miRNA 141. The purpose of this article is to review the current literature available on miRNA 141 and how it could play a role in osteoporosis, osteoarthritis and musculoskeletal pathology overall.
- ||| Clinical: I'd like to see it. I enjoy traditional powerlifting but on vacation I'll do BW exercise and am trying to get my kids to do it too. I'm trying to learn more BW as well to help w my patients who many will not go to the gym. #beatingsarcopenia (Twitter) - Jun 8, 2019
- | Clinical, Journal: Low bone mineral density in middle-aged women: a red flag for sarcopenia. (Pubmed Central) - Jun 7, 2019
A BMD T-score below -1.5 suggests low muscle mass in middle-aged women, which is a central element in the diagnosis of sarcopenia. Early diagnosis provides the opportunity to introduce preventive and therapeutic options.
- | Journal: Nutrition, dietary intake, and eating behavior after liver transplantation. (Pubmed Central) - Jun 7, 2019
Early diagnosis provides the opportunity to introduce preventive and therapeutic options. Understanding eating behavior after liver transplantation could be key knowledge regarding dietary intake and its impact on nutritional modifications occurring after liver transplantation.
- | Journal: Bioelectrical impedance analysis in the assessment of sarcopenia. (Pubmed Central) - Jun 7, 2019
The lack of standardization of BIA use for assessing muscularity results in a wide range of sarcopenia prevalence rates among studies, even when conducted in the same population. As BIA equations and cut-off values are population and device-specific, results should be interpreted with caution when data from different devices are applied in equations or using cut-off values from a different population.
- | Journal: Vitamin D - a geriatric point of view (Pubmed Central) - Jun 7, 2019
Treatment of vitamin D deficiency should be intensive and last for several months. Although the doses are high, no adverse effects were observed.
- | Clinical, Journal: Quantifying Sarcopenia Reference Values Using Lumbar and Thoracic Muscle Areas in a Healthy Population. (Pubmed Central) - Jun 7, 2019
We defined the effect of IV contrast and different HU ranges for muscle. Combined, these results facilitate the extraction of clinically valuable data from the large numbers of existing scans performed for medical indications.