Sarcopenia
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  • ||||||||||  Clinical, Review, Journal:  Interactions of lean soft-tissue and chemotherapy toxicities in patients receiving anti-cancer treatments. (Pubmed Central) -  Jun 28, 2019   
    Beyond that, there is increasing interest in use of lean soft-tissue mass as a more accurate method for dosing chemotherapy, as compared to body surface area. In this review, we summarize the current evidence that supports interactions between skeletal muscle and chemotherapy, the role of lean soft tissue in predicting chemotherapy toxicities and potential use of an alternate method of chemotherapeutic dosing, all based on quantification of skeletal muscle mass by computed tomography.
  • ||||||||||  Clinical, Journal:  Bone Mineral Density as a Risk Factor for Patients Undergoing Surgery for Hepatocellular Carcinoma. (Pubmed Central) -  Jun 28, 2019   
    In this review, we summarize the current evidence that supports interactions between skeletal muscle and chemotherapy, the role of lean soft tissue in predicting chemotherapy toxicities and potential use of an alternate method of chemotherapeutic dosing, all based on quantification of skeletal muscle mass by computed tomography. Preoperative low BMD was an independent risk factor for cancer-specific mortality after hepatectomy for HCC.
  • ||||||||||  Clinical, Review, Journal:  Frailty assessment: from clinical to radiological tools. (Pubmed Central) -  Jun 25, 2019   
    Radiological modalities, such as computed tomography and ultrasonography, are widely performed before surgery, and are therefore available to be used opportunistically to objectively evaluate surrogate markers of frailty. This review presents the importance of frailty assessment by anaesthesiologists; lists common clinical tools that have been applied; and proposes that utilising radiological imaging as an objective surrogate measure of frailty is a novel, expanding approach for which anaesthesiologists can significantly contribute to broad implementation.
  • ||||||||||  Review, Journal:  Sarcopenia Associated with Chronic Obstructive Pulmonary Disease. (Pubmed Central) -  Jun 23, 2019   
    We are fascinated to be able to diagnose 2 diseases through similar physical performance tests and to improve both diseases using the same treatment such as exercise. Therefore, this review summarizes the clinical relevance and integrative management of the 2 diseases.
  • ||||||||||  Review, Journal:  Sarcopenia. (Pubmed Central) -  Jun 22, 2019   
    Treatment options for sarcopenia comprise an active lifestyle with physical activity and exercise training, modifications of nutritional intake, and pharmacological therapies. Strength training and an adequate nutritional intake form the basis of successful sarcopenia treatment.
  • ||||||||||  Journal:  Rickets/Osteomalacia. Non-skeletal effects of vitamin D. (Pubmed Central) -  Jun 22, 2019   
    However, vitamin D supplementation has not shown a therapeutic effect in any of these diseases, and a detailed cause-and-effect relationship remains elusive. Future studies should consider non-skeletal effects when investigating cutoff levels of serum 25(OH)D for therapeutic intervention in vitamin D insufficiency and deficiency, the required supplement dose, and the length of supplementation.
  • ||||||||||  Review, Journal:  The Link Between Inflammaging and Degenerative Joint Diseases. (Pubmed Central) -  Jun 22, 2019   
    In addition, systemic inflammaging can lead to cartilage destruction, pain, disability, and an impaired quality of life. The purpose of this review is to summarize the main mechanisms implicated in inflammaging and the connection it has with degenerative joint diseases.
  • ||||||||||  Clinical, Journal:  Inhibition of the Fission Machinery Mitigates OPA1 Impairment in Adult Skeletal Muscles. (Pubmed Central) -  Jun 22, 2019   
    However, the simultaneous inhibition of the fission protein Drp1 when Opa1 is absent alleviates FGF21 induction, oxidative stress, denervation, and inflammation rescuing the lethal phenotype of Opa1 knockout mice, despite the presence of any muscle weakness. Thus, the simultaneous inhibition of fusion and fission processes mitigates the detrimental effects of unbalanced mitochondrial fusion and prevents the secretion of pro-senescence factors.
  • ||||||||||  Journal:  Skeletal muscle-gut axis: emerging mechanisms of sarcopenia for intestinal and extra intestinal diseases. (Pubmed Central) -  Jun 20, 2019   
    The main emerging pathways implicated in the skeletal muscle-gut axis are: the myostatin/activin signaling pathway, the IGF1/PI3K/AKT/mTOR signaling pathway, which results suppressed, the NF-kB signaling pathway and the FOXO signaling pathway. Further researches in this field are necessary to better explain the linkage between gut microbiota and muscle wasting and the possible emerging therapies associated.
  • ||||||||||  Journal:  Muscle mass measurement by DXA and MRI in non-human primates (Pubmed Central) -  Jun 19, 2019   
    Furthermore, correlation analysis between the amount of excised muscle for measurement and the results from MRI and DXA showed a high correlation at all sites examined, with the correlation coefficient higher for MRI than for DXA. We expect that the establishment of a highly accurate method for measurement of muscle mass using MRI and DXA will give impetus to the development of drugs that target muscle mass.