Sarcopenia
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  • ||||||||||  Clinical, Retrospective data, Journal:  Sarcopenia as a predictor of survival in patients undergoing bland transarterial embolization for unresectable hepatocellular carcinoma. (Pubmed Central) -  Aug 14, 2020   
    Sarcopenia, estimated by the L3SMI method, is an emerging prognostic factor in patients with HCC undergoing bland TAE therapy as it is associated with increased mortality, without impairing the safety of the locoregional treatment. Measures to ameliorate the SMI, such as nutritional support and physical exercise, should be evaluated in clinical trials for HCC patients receiving liver embolization to determine their impact on overall survival.
  • ||||||||||  Journal:  Total Dietary Antioxidant Capacity and Longitudinal Trajectories of Body Composition. (Pubmed Central) -  Aug 14, 2020   
    Additional adjustment for adherence to dietary guidelines and exclusion of individuals with comorbid disease at baseline did not change our results. In conclusion, dietary intake of antioxidants may positively affect the amount of lean mass and overall body composition among the middle-aged and elderly.
  • ||||||||||  Journal:  An Overview of the Beneficial Effects of Exercise on Health and Performance. (Pubmed Central) -  Aug 13, 2020   
    In contrast to medication, physical exercise has no negative side effects, costs very little, and targets many health issues at once. If the multitude of beneficial effects of regular exercise were to be combined in a single low-cost drug, it would be prescribed for almost all types of physical and mental health issues.
  • ||||||||||  Clinical, Journal, HEOR:  Effects of Exercise on the Immune Function, Quality of Life, and Mental Health in HIV/AIDS Individuals. (Pubmed Central) -  Aug 13, 2020   
    Moderate- to high-intensity aerobic exercise, progressive resistance exercise, or a combination of both is considered as a complementary part of medical care and treatment of HIV-infected individuals. In the present chapter, the results of recent investigations regarding the effects of physical activity on muscle strength and function, mental health, and immune system of HIV infected individuals will be discussed.
  • ||||||||||  Review, Journal:  Sarcopenia and Its Implications for Metabolic Health. (Pubmed Central) -  Aug 11, 2020   
    On the other hand, increased obesity, decreased quality of life, and reduced metabolic health also contribute to sarcopenia. The purpose of this mini-review is to discuss the implications sarcopenia has for the development of obesity and comorbidities that occur with aging.
  • ||||||||||  Clinical, Journal:  Sarcopenia is common in adults with complex congenital heart disease. (Pubmed Central) -  Aug 11, 2020   
    Contrary to men, the women had increased body fat and a higher BMI. Further research is required to assess the cause, possible adverse long-term effects and whether sarcopenia is preventable or treatable.
  • ||||||||||  Clinical, Journal:  Nutritional Considerations in Frail Older Patients with COVID-19. (Pubmed Central) -  Aug 11, 2020   
    Early nutritional support should be guaranteed in order to improve several malnutrition-related adverse outcomes. The evaluation of the nutritional status is today even more crucial than in normal times given the delicate status of older patients with COVID-19.
  • ||||||||||  Clinical, Journal:  What are the factors associated with sarcopenia-related variables in adult women with severe obesity? (Pubmed Central) -  Aug 11, 2020   
    In severely obese women, muscle mass and function were inversely associated with age, smoking status, endocrine parameters, hypercholesterolemia, and comorbidities such as diabetes. Thus, the results of this investigation are relevant in supporting the development of clinical interventions to aid in the prevention of sarcopenia in adult women with severe obesity.
  • ||||||||||  Journal:  Comment on article by Abe et al. (Pubmed Central) -  Aug 10, 2020   
    Thus, the results of this investigation are relevant in supporting the development of clinical interventions to aid in the prevention of sarcopenia in adult women with severe obesity. No abstract available
  • ||||||||||  Retrospective data, Review, Journal:  Exercise Programs for Muscle Mass, Muscle Strength and Physical Performance in Older Adults with Sarcopenia: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Aug 9, 2020   
    Muscle strength (grip strength [SMD 0.57, 95 % CI 0.42 to 0.73, P <0.00001] and timed five chair stands [SMD -0.56, 95 % CI -0.85 to -0.28, P < 0.0001]) and physical performance (gait speed [SMD 0.44, 95 % CI 0.26 to 0.61, P < 0.00001] and the timed up and go test [SMD -0.97, 95 % CI -1.22 to -0.72, P < 0.00001]) showed significant improvement following exercise treatment, while no differences in muscle mass (ASM [SMD 0.15, 95 % CI -0.05 to 0.36, P = 0.15] and ASM/height [SMD 0.21, 95 % CI -0.05 to 0.48, P = 0.12]) were detected. Exercise programs showed overall significant positive effects on muscle strength and physical performance but not on muscle mass in sarcopenic older adults.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion, Trial completion date:  Role of the Gut Microbiome on Lean Mass and Physical Function in Older Adults (clinicaltrials.gov) -  Aug 8, 2020   
    P=N/A,  N=29, Completed, 
    Exercise programs showed overall significant positive effects on muscle strength and physical performance but not on muscle mass in sarcopenic older adults. Active, not recruiting --> Completed | Trial completion date: Apr 2020 --> Nov 2019
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion:  A Physical Activity Program in End-state Liver Disease (clinicaltrials.gov) -  Aug 8, 2020   
    P=N/A,  N=20, Completed, 
    Active, not recruiting --> Completed | Trial completion date: Apr 2020 --> Nov 2019 Active, not recruiting --> Completed
  • ||||||||||  Journal:  Impact of sarcopenia on diaphragm muscle fatigue. (Pubmed Central) -  Aug 8, 2020   
    We conclude that ageing increases the relative contribution of type I and IIa fibres to DIAm force with decreased contributions of type IIx and/or IIb fibres. The residual force generated by the DIAm after repeated stimulation is sufficient to accomplish ventilatory behaviours, regardless of age.
  • ||||||||||  Trial completion, Trial completion date, Trial primary completion date, Surgery:  Analysis of Body Composition in Relation to Outcome After Surgery in a Cohort of Patients With Esophageal Cancer (clinicaltrials.gov) -  Aug 8, 2020   
    P=N/A,  N=76, Completed, 
    Inflammation may play a role in chemotherapy-induced sarcopenia in newly diagnosed non-metastatic patients. Active, not recruiting --> Completed | Trial completion date: Mar 2017 --> Jul 2020 | Trial primary completion date: Nov 2010 --> Jul 2020
  • ||||||||||  Enrollment change, Trial withdrawal:  Improvement of Sarcopenia in Patients Following Two Different Diets (clinicaltrials.gov) -  Aug 8, 2020   
    P=N/A,  N=0, Withdrawn, 
    Active, not recruiting --> Completed | Trial completion date: Mar 2017 --> Jul 2020 | Trial primary completion date: Nov 2010 --> Jul 2020 N=40 --> 0 | Not yet recruiting --> Withdrawn
  • ||||||||||  Enrollment open:  Dietary Nitrate and Muscle Power With Aging (clinicaltrials.gov) -  Aug 8, 2020   
    P1,  N=20, Recruiting, 
    No abstract available Suspended --> Recruiting
  • ||||||||||  Preclinical, Journal:  An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies. (Pubmed Central) -  Aug 7, 2020   
    It is vital that neurologists clearly understand the pathophysiology of NMJ aging and differentiate between physiological and pathological effects of aging. With the current knowledge of science, the changes in NMJ aging can be better prevented rather than cured.
  • ||||||||||  Clinical, Journal:  HoSAGE: Sarcopenia in Older Patients before and after Treatment with Androgen Deprivation Therapy and Radiotherapy for Prostate Cancer. (Pubmed Central) -  Aug 7, 2020   
    This preliminary study showed a high prevalence of muscle disorders before initiation of ADT in a population of elderly cancer prostate patients with intermediate frailty status, and an increased risk of falls at the end of ADT. This highlighted the importance of screening for sarcopenia before treatment initiation, to prevent the occurrence or aggravation of sarcopenia by possible adjustment of treatment, and implementation of appropriate exercise and nutrition interventions.
  • ||||||||||  Clinical, Journal:  The prevalence and factors associated with sarcopenia among community living elderly with type 2 diabetes mellitus in primary care clinics in Malaysia. (Pubmed Central) -  Aug 7, 2020   
    Those aged ≥70 years (β = 0.73;OR = 2.07; 95%CI = 1.24, 3.48; p = 0.006), men (β = 0.61; OR = 1.84; 95%CI = 1.12, 3.02; p = 0.017), with ≥10 years duration of diabetes (β = 0.62; OR = 1.85; 95%CI = 1.11, 3.09; p = 0.018), not using insulin sensitizers (β = -1.44; OR = 0.24; 95%CI = 0.08, 0.71; p = 0.010), using less than 5 medications (β = 0.68; OR = 1.98; 95%CI = 1.17, 3.36; p = 0.011), low body mass index (BMI) (β = -2.43; OR = 0.09; 95%CI = 0.05, 0.17; p<0.001), and engaging in low (β = 0.77; OR = 2.15; 95%CI = 1.07, 4.35; p = 0.032) and moderate physical activities (β = 0.80; OR = 2.23; 95%CI = 1.07, 4.66; p = 0.033) were associated with sarcopenia. Factors that predicts sarcopenia such as level of physical activity and body mass index were among the modifiable factors that could be used in developing future strategies to prevent or delay the progression of sarcopenia among elderly with T2DM to improve their health status.
  • ||||||||||  Journal:  Sarcopenia: hand grip dynamometers, the latest addition to the doctor's bag. (Pubmed Central) -  Aug 7, 2020   
    Factors that predicts sarcopenia such as level of physical activity and body mass index were among the modifiable factors that could be used in developing future strategies to prevent or delay the progression of sarcopenia among elderly with T2DM to improve their health status. No abstract available
  • ||||||||||  Lenvima (lenvatinib) / Eisai, Merck (MSD)
    Clinical, Journal:  Impact of Grip Strength in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib. (Pubmed Central) -  Aug 7, 2020   
    A multivariate Cox proportional hazards model showed that modified albumin-bilirubin-grade (mALBI) 2b (hazard ratio (HR) 4.39) and a decreased GS (HR 3.55) were independently associated with an increased risk of poor prognosis. In addition to the hepatic functional reserve, a decreased GS was a poor prognostic factor in lenvatinib-treated u-HCC patients.