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12 Products |
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17 Mechanisms of Action |
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756 Trials |
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22406 News |
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- | Clinical, Journal: The malnourished surgery patient: a silent epidemic in perioperative outcomes? (Pubmed Central) - Aug 30, 2019
The recent publication of new surgical nutrition guidelines, the PONS score, and use of LBM assessments will allow better identification and earlier intervention on perioperative malnutrition. It is essential that in the future no patient undergoes elective surgery without nutrition screening and nutrition intervention when malnutrition risk is identified.
- | Journal: Race and socioeconomic effect on sarcopenia and sarcopenic obesity in the Louisiana Osteoporosis Study (LOS). (Pubmed Central) - Aug 30, 2019
Under one diagnostic definition, the prevalence of sarcopenia and sarcopenic obesity is highest among Asians and lowest amongst blacks. Income and education had significant associations with sarcopenia and sarcopenic obesity, in males and females, respectively.
- ||| Clinical: Michelle Mei worked with @mackinprof investigating the impact of milk intake on #sarcopenia in older women. If the study finds that milk supports muscle retention, this work will support an affordable, accessible dietary intervention for muscle loss. (Twitter) - Aug 30, 2019
- | Journal: Response to the letter of Dr Ayubi, "Sarcopenia based on the Asian working Group for Sarcopenia criteria and all-cause mortality risk in older Japanese adults: Methodological issues". (Pubmed Central) - Aug 30, 2019
Income and education had significant associations with sarcopenia and sarcopenic obesity, in males and females, respectively. No abstract available
- | Journal: The contributions of fibre atrophy, fibre loss, in situ specific force and voluntary activation to weakness in sarcopenia. (Pubmed Central) - Aug 30, 2019
No abstract available in situ specific force declines relatively early in older age and reduced voluntary activation occurs later, but the overall weakness in sarcopenia is mainly related to loss of both type I and II fibres and type II fibre atrophy.
- | Journal: The Protective Effect of Melatonin Against Age-Associated Sarcopenia-Dependent Tubular Aggregates Formation, Lactate Depletion and Mitochondrial Changes. (Pubmed Central) - Aug 30, 2019
Oral melatonin administration conserved the normal muscular architecture, weight, muscle fibers number, and activity in the old age; it stimulated lactate production, prevented mitochondrial damage and tubular aggregates, and reduced the percentage of apoptotic nuclei in aged muscles. Altogether, gastrocnemius muscle showed age-mediated signs of sarcopenia that were reduced by melatonin treatment.
- | Preclinical, Journal: Impaired Mitochondrial Energetics Characterize Poor Early Recovery Of Muscle Mass Following Hind Limb Unloading In Old Mice. (Pubmed Central) - Aug 30, 2019
Importantly, this is linked to more severe whole-body insulin resistance, as determined by insulin tolerance test. The findings suggest that muscle fuel metabolism and mitochondrial energetics could be a focus for mining therapeutic targets to improve recovery of muscle mass following periods of disuse in older animals.
- | Journal: Preoperative Sarcopenia Portends Worse Outcomes after Descending Thoracic Aortic Aneurysm Repair. (Pubmed Central) - Aug 30, 2019
Preoperative sarcopenia significantly correlated with postoperative adverse events and long-term mortality following DTAA repair. If anatomically feasible, TEVAR should be considered in sarcopenic patients.
- | Xience (everolimus-eluting stent) / Abbott
Clinical, Journal, HEOR: Effect, process, and economic evaluation of a combined resistance exercise and diet intervention (ProMuscle in Practice) for community-dwelling older adults: design and methods of a randomised controlled trial. (Pubmed Central) - Aug 30, 2019
If anatomically feasible, TEVAR should be considered in sarcopenic patients. Evaluating the effects, implementation, and costs of this combined intervention provides valuable insight into the feasibility of this intervention for community-dwelling older adults and into the intervention's ability to improve or to maintain physical functioning and quality of life.
- | Review, Journal: Musculoskeletal health of Indigenous Australians. (Pubmed Central) - Aug 30, 2019
Evaluating the effects, implementation, and costs of this combined intervention provides valuable insight into the feasibility of this intervention for community-dwelling older adults and into the intervention's ability to improve or to maintain physical functioning and quality of life. Data on more detailed musculoskeletal health outcomes are required in Indigenous Australians to better understand fracture risk and to formulate evidence-based strategies for fracture prevention and to minimise the risk of falls.
- | Journal: Albumin Is Predictive of 1-Year Mortality After Transcatheter Aortic Valve Replacement. (Pubmed Central) - Aug 30, 2019
Albumin was the only frailty marker that was associated with higher mortality. Future studies should investigate whether optimization of nutritional status can improve outcomes following TAVR.
- | Review, Journal: Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. (Pubmed Central) - Aug 30, 2019
The hypothesis that inflammation affects CVD, multimorbidity, and frailty by inhibiting growth factors, increasing catabolism, and interfering with homeostatic signalling is supported by mechanistic studies but requires confirmation in humans. Whether early modulation of inflammageing prevents or delays the onset of cardiovascular frailty should be tested in clinical trials.
- | Clinical, Journal: Dysmobility syndrome is associated with prevalent morphometric vertebral fracture in older adults: the Korean Urban-Rural Elderly (KURE) study. (Pubmed Central) - Aug 30, 2019
Whether early modulation of inflammageing prevents or delays the onset of cardiovascular frailty should be tested in clinical trials. Dysmobility syndrome was associated with elevated odds of morphometric VF in community-dwelling older adults, independent of age and covariates.
- | Clinical, Journal: Prevalence and associated risk factors for osteoporosis in Korean men. (Pubmed Central) - Aug 30, 2019
Low socioeconomic status, unhealthy lifestyle, insufficient nutrition, and chronic kidney disease increased the risk of osteoporosis in Korean men. Men who have the abovementioned risk factors even at a young age need to undergo bone mineral density evaluation, and proper interventions should be reinforced to prevent and manage osteoporosis.
- | Clinical, Journal: Editorial: putting more muscle into treating our chronic hepatitis B patients-the importance of assessing sarcopenia. (Pubmed Central) - Aug 30, 2019
Men who have the abovementioned risk factors even at a young age need to undergo bone mineral density evaluation, and proper interventions should be reinforced to prevent and manage osteoporosis. No abstract available
- | Journal: The malnutrition overlap syndromes of cachexia and sarcopenia: a malnutrition conundrum. (Pubmed Central) - Aug 30, 2019
No abstract available No abstract available
- | Clinical, Observational data, Journal: Investigating Risk of Suboptimal Macro and Micronutrient Intake and Their Determinants in Older Danish Adults with Specific Focus on Protein Intake-A Cross-Sectional Study. (Pubmed Central) - Aug 30, 2019
Total energy intake and attitude regarding healthy eating were associated with lower nutrient intake. The current study illustrates that there is room for improvements in the dietary quality of community dwelling older Danish adults.
- | Journal: Prevention of disoders of activity which associated with the risk of dynapenia and sarcopenia by combined aerobic-anaerobic training. (Pubmed Central) - Aug 30, 2019
It was found that the best results of the increase in total activity, improved gait and stability, as well as increased muscle strength were achieved in the 3rd group of patients. Such, combined aerobic-anaerobic exercise can be recommended as a program of geriatric prevention of disorders associated with the risk of dynapenia and sarcopenia.
- | Biomarker, Review, Journal: The Biological Foundations of Sarcopenia: Established and Promising Markers. (Pubmed Central) - Aug 29, 2019
Interestingly, mice studies have shown that SNAP25 affects the neuromuscular function. SNARE complex and, in particular, SNAP25 may represent a promising pathway to explore the molecular and cellular mechanisms regulating muscular homeostasis and concur at profiling the sarcopenia biological background.
- | New trial: Characterization of the Nutritional Status in the Patient With Liver Cirrhosis (clinicaltrials.gov) - Aug 29, 2019
P=N/A, N=32, Completed, Sponsor: Puerta de Hierro University Hospital
- | Clinical, Journal: Feasibility of systematic handgrip strength testing in digestive cancer patients treated with chemotherapy: The FIGHTDIGO study. (Pubmed Central) - Aug 28, 2019
HGS testing is routinely feasible, inexpensive, and well accepted by patients and medical teams in an ambulatory digestive cancer unit. Cancer 2017.
- | Journal: Associations of sarcopenia definitions, and their components, with the incidence of recurrent falling and fractures; the Longitudinal Aging Study Amsterdam. (Pubmed Central) - Aug 28, 2019
When examining the individual components, only a low grip strength was independently associated with recurrent falling. No associations between sarcopenia with incidence of fractures were found.
- ||| Clinical: @GrantWilliamsMD presenting on geriatric assessment in older adults and sarcopenia. Check out his impressive work! https://t.co/Iif15kQAR3 @uabmedicine #hpm #hapc #pallonc #Gerionc (Twitter) - Aug 28, 2019
- | Journal: Insulin Resistance is a Significant Determinant of Sarcopenia in Advanced Kidney Disease. (Pubmed Central) - Aug 28, 2019
Human SM biopsy showed positive correlation between glucose and leucine disposal rates and P-AKT to AKT ratio and muscle mitochondrial markers in controls but not in MHD patients. Diminished response to anabolic actions of insulin in the stimulated setting could lead to muscle wasting in MHD patients.
- | Clinical, Journal, HEOR: The RESTORE Randomized Controlled Trial: Impact of a Multidisciplinary Rehabilitative Program on Cardiorespiratory Fitness in Esophagogastric cancer Survivorship. (Pubmed Central) - Aug 28, 2019
P=N/A
The RESTORE program significantly improved cardiorespiratory fitness of disease-free patients after esophagogastric cancer surgery, without compromise to body composition. This randomized controlled trial provides proof of principle for rehabilitation programs in esophagogastric cancer.
- | NN1213 / Novo Nordisk
Trial completion: Effect Study of Marine Protein Hydrolysates to Prevent Loss of Muscle Mass and Physical Function in Frail Elderly (clinicaltrials.gov) - Aug 28, 2019
P=N/A, N=92, Completed, Sponsor: Molde University College
This randomized controlled trial provides proof of principle for rehabilitation programs in esophagogastric cancer. Active, not recruiting --> Completed
- | Trial completion date, Trial primary completion date: Investigating the Effectiveness of Vibration Therapy on Sarcopenia in Osteoarthritis Knee Patients (clinicaltrials.gov) - Aug 28, 2019
P=N/A, N=50, Not yet recruiting, Sponsor: Chinese University of Hong Kong
Active, not recruiting --> Completed Trial completion date: Dec 2021 --> Sep 2021 | Trial primary completion date: Mar 2021 --> Sep 2021
- | Journal: Highlights from the 2019 International Congress on Frailty and Sarcopenia Research. (Pubmed Central) - Aug 27, 2019
Trial completion date: Dec 2021 --> Sep 2021 | Trial primary completion date: Mar 2021 --> Sep 2021 No abstract available
- | Journal: Development of Pharmacotherapies for the Treatment of Sarcopenia. (Pubmed Central) - Aug 27, 2019
We provide a review of the leading programs and approaches and available findings from recent studies. In addition, we briefly discuss several related issues needed to facilitate the development of a safe and efficacious pharmacotherapeutic that could be used as part of a treatment plan for older men and women with sarcopenia.
- | Journal: Serum Vitamin D and Age-Related Muscle Loss in Afro-Caribbean Men: The Importance of Age and Diabetic Status. (Pubmed Central) - Aug 27, 2019
Higher endogenous vitamin D concentrations are associated with less lean mass loss with aging among older and prediabetic Afro-Caribbean men independent of potential confounders. Our findings raise a possibility that maintaining high serum vitamin D level might be important for musculoskeletal health in elderly and prediabetic African ancestry men.
- | Clinical, Journal: Adherence to a Mediterranean Diet Is Not Associated with Risk of Sarcopenic Symptomology: A Cross-Sectional Analysis of Overweight and Obese Older Adults in Australia. (Pubmed Central) - Aug 27, 2019
Adherence to a MedDiet was not associated with a decreased risk of sarcopenic symptomology (SPPB: OR = 0.20; 95% CI: 0.01-3.1; P = 0.234; Muscle strength: OR = 1.81; 95% CI: 0.32-10.15; P = 0.499; Gait speed: OR = 0.58; 95% CI: 0.13-2.50; P = 0.468). Future research should investigate whether a Mediterranean-style intervention can prevent or improve sarcopenic symptomology, including in non-Mediterranean populations.
- | Journal: Relationship between Grip Strength and Nonalcoholic Fatty Liver Disease in Men Living with HIV Referred to a Metabolic Clinic. (Pubmed Central) - Aug 27, 2019
GS has an inverse association with NAFLD prevalence in HIV-infected men. Specific mechanisms through which muscle weakness and NAFLD are related require further exploration but are not accounted for merely by the burden of comorbid illness, HIV disease stage, or ART exposure.
- | Egrifta (tesamorelin acetate) / Theratechnologies
Clinical, Journal: The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV. (Pubmed Central) - Aug 27, 2019
Among those with clinically significant decrease in visceral adipose tissue on treatment, tesamorelin was effective in increasing skeletal muscle area and density. Long term effectiveness of tesamorelin among people with and without HIV, and the impact of these changes in daily life should be further studied.
- | Review, Journal: Variables Influencing the Effectiveness of Creatine Supplementation as a Therapeutic Intervention for Sarcopenia. (Pubmed Central) - Aug 27, 2019
However, research is inconsistent regarding the effectiveness of creatine on aging muscle. The purpose of this perspective paper is to: (1) propose possible reasons for the inconsistent responsiveness to creatine in aging adults, (2) discuss the potential mechanistic actions of creatine on muscle biology, (3) determine whether the timing of creatine supplementation influences aging muscle, (4) evaluate the evidence investigating the effects of creatine with other compounds (protein, conjugated linoleic acid) in aging adults, and (5) provide insight regarding the safety of creatine for aging adults.
- Care strategies for nutritional care of dementia cases in hospital () - Aug 27, 2019 - Abstract #AEC2019AEC_656;
Nutrition problems of most cases were protein-energy inadequate, and difficulty to swallowing was the second nutritional diagnosis. So, we designed additional strategies for further care, include of 1) increase calories density from diet; 2) designed thick liquid diet for dysphagia population; 3) supplied habitual foods and board games about foods for patients and their caregivers.in group activities weekly for modified eating environment.
- Care strategies for nutritional care of dementia cases in hospital () - Aug 27, 2019 - Abstract #AEC2019AEC_484;
Nutrition problems of most cases were protein-energy inadequate, and difficulty to swallowing was the second nutritional diagnosis. So, we designed additional strategies for further care, include of 1) increase calories density from diet; 2) designed thick liquid diet for dysphagia population; 3) supplied habitual foods and board games about foods for patients and their caregivers.in group activities weekly for modified eating environment.
- | Journal: High Concentration of Serum Aspartate Aminotransferase in Older Underweight People: Results of the Kanagawa Investigation of the Total Check-Up Data from the National Database-2 (KITCHEN-2). (Pubmed Central) - Aug 26, 2019
So, we designed additional strategies for further care, include of 1) increase calories density from diet; 2) designed thick liquid diet for dysphagia population; 3) supplied habitual foods and board games about foods for patients and their caregivers.in group activities weekly for modified eating environment. High serum AST but normal serum ALT is highly prevalent in older underweight people and might reflect skeletal muscle pathology.
- | Clinical, Journal: Effect of Resistance Exercise on Depression in Mild Alzheimer Disease Patients With Sarcopenia. (Pubmed Central) - Aug 26, 2019
High serum AST but normal serum ALT is highly prevalent in older underweight people and might reflect skeletal muscle pathology. No abstract available
- Inspiratory muscle training associated with whole body vibration improves diaphragm thickness and mobility but does not affect serum BDNF and peripheral muscle in pre-frail older: a randomized double-blind clinical trial (TP-47) - Aug 26, 2019 - Abstract #ERS2019ERS_5090;
After the intervention, FR, VI, QA and lean mass did not change between groups. The IMT+WBV increases the thickness and DM, but does not improves BDNF, RF, VI, QA and lean mass in pre-frail older.
- Impact of Sarcopenia and Malnutrition on disease severity, nutritional variables and inflammatory parameters in COPD patients (TP-20) - Aug 26, 2019 - Abstract #ERS2019ERS_4539;
Conclusions In COPD, sarcopenia and malnutrition may be associated with greater airway obstruction, worse gas exchange and functional status and greater symptoms. Levels of vitamin D may also be affected, but further studies are needed.
- Main predictors and correlations of COPD-induced sarcopenia. (TP-20) - Aug 26, 2019 - Abstract #ERS2019ERS_4533;
Sarcopenia is associated with COPD duration, long smoking history. It was more common in patients with severe symptoms, emphysematous phenotype and low FEV1.
- Role of Parkin in the pathogenesis of COPD-related sarcopenia (TP-07) - Aug 26, 2019 - Abstract #ERS2019ERS_4274;
It was more common in patients with severe symptoms, emphysematous phenotype and low FEV1. These results suggest that Parkin-mediated mitophagy may have a regulatory role in myogenesis during CS exposure as a part of sarcopenia pathogenesis in COPD.
- Prevalence of the latent sarcopenia in overweight or obese COPD patients (TP-02) - Aug 26, 2019 - Abstract #ERS2019ERS_4189;
The prevalence of this pathological condition is significantly higher among overweight patients - reaches more than third of the contingent (37.1%). Among obese COPD patients sarcopenia occurs only in 8.1%.
- Relationship between sarcopenia and malnutrition in patients with stable COPD in JAPAN (TP-02) - Aug 26, 2019 - Abstract #ERS2019ERS_4188;
Japanese COPD patients with sarcopenia and malnutrition showed a significant decrease in FEV1 and 6MWT and showed an increase in CAT and mMRC. That suggests the importance of intervention inboth exercise and nutrition.
- DEFICIENT MUSCLE REGENERATION POTENTIAL IN SARCOPENIC COPD PATIENTS: ROLE OF SATELLITE CELLS (RETIRO) - Aug 26, 2019 - Abstract #ERS2019ERS_4157;
TUNEL-positive cell counts were greater in VL of all patient groups than in the controls. A differential profile of muscle damage and regeneration potential was observed in the lower limb muscles between sarcopenic COPD patients and those with normal body composition.
- Elevated circulating activin A levels in malignant pleural mesothelioma patients are related to cancer cachexia and poor response to platinum-based chemotherapy (6F) - Aug 26, 2019 - Abstract #ERS2019ERS_4014;
A differential profile of muscle damage and regeneration potential was observed in the lower limb muscles between sarcopenic COPD patients and those with normal body composition. Activin A could be used as a biomarker in MPM and presents a treatable pathway to reverse cancer cachexia and improve chemotherapy response.
- The association among severity of sarcopenia, salivation and salivary oxidative stress marker in stable COPD (N103) - Aug 26, 2019 - Abstract #ERS2019ERS_3500;
The amount of salivation was correlated positively with the grip strength, saliva 8-OHdG level showed a negative correlation with muscle mass and grip strength. Measurement of salivation and salivary oxidative stress in COPD may be useful for prediction of sarcopenia and mastication ability.
- Risk factors for the decline of pulmonary function among bronchiectasis patients in Japan (TP-22) - Aug 26, 2019 - Abstract #ERS2019ERS_2838;
Bronchiectasis contributed to the decline of pulmonary function test, especially in female in Japan. In this study, bacterial colonization, macrolide use, laboratory data, and severity of bronchiectasis rather than sarcopenia might not affect the decline of FEV1.
- Early rehabilitation is associated with reduced in-hospital mortality from sepsis in patients with sarcopenia (6B) - Aug 26, 2019 - Abstract #ERS2019ERS_2321;
ICU rehabilitation could be more beneficial in sarcopenic patients. In particular, it could be more effective in the non-elderly.