Sarcopenia
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  • ||||||||||  Clinical, Journal:  Sarcopenia and frailty in older patients with rheumatism (Pubmed Central) -  Sep 11, 2019   
    Currently, many interventional strategies are being tested, including exercise regimens, nutrition programs, hormone replacement and pharmacological strategies involving anabolic principles. According to the current data, training programs and medications have a high potential.
  • ||||||||||  Review, Journal:  Becoming older with axial spondyloarthritis (Pubmed Central) -  Sep 11, 2019   
    Although the standardized assessment of cardiovascular risk factors in patients with inflammatory rheumatic diseases (independent of age) has been recommended for years, it is rarely done in clinical practice. Overall, data on comorbidities and risk factors are only available for AS patients and are lacking for other forms of spondyloarthritides.
  • ||||||||||  Journal:  Osteosarcopenia. (Pubmed Central) -  Sep 11, 2019   
    Improved understanding of the interactions between muscle and bone could facilitate the development of new therapeutic agents which target muscle and bone as one. Together with existing pharmacological, nutritional and exercise-based therapies, this should enable a more holistic approach to osteosarcopenia in the future.
  • ||||||||||  Journal:  The Aging Brain & the Dorsal Basal Ganglia: Implications for Age-Related Limitations of Mobility. (Pubmed Central) -  Sep 10, 2019   
    This knowledge gap has hampered the development of effective interventions for mobility limitations and the subsequent reduction of major functional disability for older adults. Here, we discuss the potential role of the motor control circuit of the dorsal basal ganglia as well as dopaminergic function in age-related reductions in mobility.
  • ||||||||||  Journal:  The pulmonary rehabilitation regimen: a treatment for frailty and 'inflammaging'? (Pubmed Central) -  Sep 8, 2019   
    Exercise, including pulmonary rehabilitation, has an anti-inflammatory effect on innate immune chemistry, and improves outcomes in a variety of conditions, although for most diagnostic groups there is no consistent structured programme similar to pulmonary rehabilitation. The authors contend that the pulmonary rehabilitation model could be used generically to treat other chronic and post-acute inflammatory states and thereby reduce the risk of frailty and other adverse outcomes.
  • ||||||||||  Journal:  Skeletal muscle mitochondrial remodeling in exercise and diseases. (Pubmed Central) -  Sep 8, 2019   
    In addition, increasing evidence suggests that mitochondria also serve to "communicate" with the nucleus and mediate adaptive genomic re-programming. Here we review the current state of knowledge relevant to the dynamic remodeling of skeletal muscle mitochondria in response to exercise and in disease states.
  • ||||||||||  Review, Journal:  Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review. (Pubmed Central) -  Sep 8, 2019   
    The development of a tool that encompasses consensus definition criteria and directs clinicians toward the underlying diagnosis would be optimal to target treatment and improve outcomes. We propose that tool should incorporate a stepwise assessment of nutritional status, oral intake, disease status, age, muscle mass and function, and metabolic derangement.
  • ||||||||||  Review, Journal:  Roles of folate in skeletal muscle cell development and functions. (Pubmed Central) -  Sep 8, 2019   
    However, the precise effects of folate in skeletal muscle development are still poorly understood. Thus, this review provides an updated discussion of the roles of folate in skeletal muscle cell development and the effects of folic acid supplementation on the functions of skeletal muscle cells.
  • ||||||||||  Retrospective data, Journal:  Sarcopenia and Postoperative Complication Risk in Gastrointestinal Surgical Oncology: A Meta-analysis. (Pubmed Central) -  Sep 7, 2019   
    Sarcopenia was associated with an increased risk of complications after gastrointestinal tumor resection, but lack of methodological consensus hampers the interpretation and clinical utilization of these findings. Combining assessment of muscle mass with measures of physical function may increase the prognostic value and accuracy in preoperative risk stratification.
  • ||||||||||  Preclinical, Journal:  Impact of aging on diaphragm muscle function in male and female Fischer 344 rats. (Pubmed Central) -  Sep 7, 2019   
    Importantly, in both males and females, Pdi generated during ventilatory behaviors was unimpaired by sarcopenia, even during more forceful ventilatory efforts induced via airway occlusion. Although ventilatory behaviors were preserved with aging, there was a ~20% reduction in Pdi , which likely impairs the ability of the DIAm to generate higher-force expulsive airway clearance behaviors necessary to maintain airway patency.
  • ||||||||||  Journal:  Sarcopenic Obesity: Time to Meet the Challenge. (Pubmed Central) -  Sep 7, 2019   
    ESPEN and EASO therefore call for coordinated action aimed at reaching consensus on its definition, diagnostic criteria, and optimal treatment with particular regard to nutritional therapy. We are convinced that achievement of these goals has a strong potential to reduce the burden of morbidity and mortality in the rapidly increasing obese patient population.
  • ||||||||||  Clinical, Journal:  Trabecular bone score in adults with cerebral palsy. (Pubmed Central) -  Sep 6, 2019   
    TBS correlated with both areal BMD and appendicular lean mass. Maintaining muscle function is likely to be important for bone health in young adults with CP and needs to be confirmed in further studies.
  • ||||||||||  Journal:  Defining sarcopenia in terms of skeletal health. (Pubmed Central) -  Sep 6, 2019   
    In men, low ALM/height or grip strength played a role in fragility fractures. In women, only the combination of low ALM/BMI and grip strength had discriminatory power for fragility fractures.
  • ||||||||||  Biomarker, Journal:  What's next in using CT scans to better understand cachexia? (Pubmed Central) -  Sep 6, 2019   
    SMM loss may be a key element in defining early protein disorders occurring before weight loss and could be used as a trigger for initiating early nutritional support. Changes in SMM and body composition during follow-up are useful tools for exploring CAX mechanisms in terms of intrinsic factors or tumor evolution.
  • ||||||||||  Biomarker, Journal:  Sarcopenia predicts poor outcomes in urgent exploratory laparotomy. (Pubmed Central) -  Sep 6, 2019   
    Sarcopenia is measured from CT scans, making it an accessible outcome predictor. In urgent laparotomies, sarcopenia was associated with higher morbidity, mortality, length of stay, and worse discharge destination.
  • ||||||||||  Clinical, Journal:  Bridging the gap between the laboratory and the clinic for patients with sarcopenia. (Pubmed Central) -  Sep 6, 2019   
    Such pleiotropic interventions may be the only way to avoid the perils of polypharmacy and drug interactions that bedevil care for many older people. Maximising the potential for scientific discoveries in the biology of ageing muscle to improve health requires that discovery scientists, translational clinical scientists and clinicians come together to exchange findings and shape each others ideas within a shared culture.
  • ||||||||||  Biomarker, Clinical, Journal:  Urinary creatinine excretion is related to short-term and long-term mortality in critically ill patients. (Pubmed Central) -  Sep 4, 2019   
    These findings suggest that a failure to expand the motor unit size distinguishes sarcopenic from pre-sarcopenic muscles. In ICU patients without severe renal dysfunction, low urinary creatinine excretion is associated with short-term and long-term mortality, independent of age, sex, renal function and disease characteristics, underscoring the role of muscle mass as risk factor for mortality and UCE as relevant biomarker.
  • ||||||||||  Journal:  Hormones and Mobility (Pubmed Central) -  Sep 3, 2019   
    On the other hand, the endocrine system plays an important role in the development of (osteo)sarcopenia, the meaning of which is increasingly recognized in the prognosis of various diseases. Conversely, lack of physical activity is crucial in the development of metabolic diseases, which are associated with serious individual and socio-economic consequences.
  • ||||||||||  Trial completion date, Trial primary completion date:  Exercise and Nutrition to Improve Pancreatic Cancer Outcomes (clinicaltrials.gov) -  Sep 3, 2019   
    P=N/A,  N=60, Recruiting, 
    Conversely, lack of physical activity is crucial in the development of metabolic diseases, which are associated with serious individual and socio-economic consequences. Trial completion date: Sep 2019 --> Feb 2020 | Trial primary completion date: Sep 2019 --> Feb 2020
  • ||||||||||  Journal:  Identifying Sarcopenia in Female Long-Term Care Residents: A Comparison of Current Guidelines. (Pubmed Central) -  Sep 1, 2019   
    Current consensus criteria from the EWGSOP and FNIH Sarcopenia Project do not agree and have little overlap in older female long-term care residents. The SARC-F questionnaire is a simple tool that could be implemented in long-term care, but it has low sensitivity compared with current consensus guidelines in the identification of sarcopenic individuals.
  • ||||||||||  Preclinical, Journal:  Aging affects the in vivo regenerative potential of human mesoangioblasts. (Pubmed Central) -  Sep 1, 2019   
    In addition, elderly MABs proliferated less, but yet retained other multilineage capabilities. Overall, our results indicate that aging negatively impacted on the regenerative potential of MABs and this should be carefully considered for potential therapeutic applications of MABs.
  • ||||||||||  Clinical, Journal:  Change of skeletal muscle mass in patients with pheochromocytoma. (Pubmed Central) -  Sep 1, 2019   
    The odds ratio for low skeletal muscle mass in the presence of pheochromocytoma was 10.33 (95% confidence interval, 2.65-40.22). Our results indicate that patients with pheochromocytoma have a reduced skeletal muscle mass and suggest that catecholamine excess has adverse effects on skeletal muscle metabolism.