Sarcopenia
Welcome,         Profile    Billing    Logout  
 46 Companies   12 Products   12 Products   17 Mechanisms of Action   756 Trials   22406 News 


«12...365366367368369370371372373374375...401402»
  • ||||||||||  Review, Journal:  Diagnosis and therapy of sarcopenia-an update (Pubmed Central) -  Sep 28, 2019   
    In general, it has to be stated that there are still only few intervention studies available that focused specifically on sarcopenia in older individuals. More studies in this rapidly increasing population are urgently needed.
  • ||||||||||  sirolimus / generics
    Review, Journal:  The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle. (Pubmed Central) -  Sep 27, 2019   
    Therefore, our review aims to describe and summarize the differences seen in older muscle in this pathway in response to resistance exercise (RE) and describe approaches that researchers have sought out to maximize the response in muscle. Furthermore, this review will present the hypothesis that inositol hexakisphosphate kinase 1 (IP6K1) may be implicated in IGF-1 signaling and thus sarcopenia, based on recent evidence that IGF-1 and insulin share some intracellular bound signaling events and that IP6K1 has been implicated in skeletal muscle insulin resistance.
  • ||||||||||  Clinical, Review, Journal:  Nutritional Strategies to Combat Type 2 Diabetes in Aging Adults: The Importance of Protein. (Pubmed Central) -  Sep 27, 2019   
    The consumption of dairy specific protein consumption has also been shown to improve insulin sensitivity by improving body composition, enhancing insulin release, accelerating fat oxidation, and stimulating rates of muscle protein synthesis (MPS) in older adults. Exercise, specifically resistance training, also works synergistically to attenuate the progression of PD and T2D by further stimulating rates of MPS thereby increasing muscle mass and inducing favorable changes in glycemic control independent of lean body mass increases.
  • ||||||||||  Enrollment open, Trial completion date, Trial primary completion date:  Effects of Variable Load Exercise on Aging Atrophy (clinicaltrials.gov) -  Sep 25, 2019   
    P=N/A,  N=30, Recruiting, 
    The decrease in SMI after surgery might be a negative prognostic factor for OS in patients who underwent RC to treat UBC. Not yet recruiting --> Recruiting | Trial completion date: Mar 2020 --> Jul 2020 | Trial primary completion date: Dec 2019 --> Mar 2020
  • ||||||||||  BONE AND MUSCLE LOSS IN PATIENTS WITH END-STAGE LUNG DISEASE (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 2) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_3716;    
    Bone density is associated with lung function and muscle area.Clinical Implications:Loss of bone density and muscle mass are associated with obstructive but not restrictive lung disease. A better understanding of the mechanisms underlying these changes may help to prevent bone and muscle loss in patients with obstructive lung disease.
  • ||||||||||  SARCOPENIA: A PROGNOSTIC FACTOR IN PATIENTS WITH SEVERE ACUTE REPIRATORY FAILURE APPLYING ECMO THERAPY (Ernest N. Morial Convention Center - Exhibit Hall - Poster Area 5) -  Sep 25, 2019 - Abstract #CHEST2019CHEST_2429;    
    A better understanding of the mechanisms underlying these changes may help to prevent bone and muscle loss in patients with obstructive lung disease. Sarcopenia predicted worse 1-year mortality in patients who underwent respiratory ECMO.Clinical Implications:This is the first study to demonstrate that measuring muscle area using CT in patients undergoing ECMO is as predictor of long-term outcome.
  • ||||||||||  Surgical Resection after Neoadjuvant Chemoradiation in Patients with Sarcopenia and Pancreatic Cancer (ASTRO Innovation Hub) -  Sep 24, 2019 - Abstract #ASTRO2019ASTRO_4315;    
    On multivariate analysis, SMI change was not associated with overall survival (HR 1.014, 95% CI 0.998-1.029, p = 0.083); surgical resection was associated overall survival (HR 3.312, 95% CI 1.421-7.718, p = 0.006).Conclusion Our analysis suggests that sarcopenia is common in the population undergoing definitive and neoadjuvant chemoradiation for PDAC. Contrary to previous reports, presence of sarcopenia is not necessarily associated with worse outcome, and even patients who have worsening sarcopenia may be candidates for surgical resection after chemoradiation.
  • ||||||||||  Effects of three different physical therapies in body composition of Parkinson’s disease (Les Muses Terrace, Level 3) -  Sep 24, 2019 - Abstract #MDSCongress2019MDS_1800;    
    Low SMG is associated with worse survival outcomes in men with p16-positive oropharyngeal cancers undergoing concurrent chemoradiation and may help identify patients who are at higher risk for poor outcomes. After the intervention period, most of body composition parameters presented difference in the three groups on time, showing that dance, deep water running and nordic walk are efficient to change these parameters in PD.
  • ||||||||||  Trial initiation date:  ICU Sarcopenia Rates by Abdominal CT: Sepsis vs. Trauma (clinicaltrials.gov) -  Sep 22, 2019   
    P=N/A,  N=146, Not yet recruiting, 
    After the intervention period, most of body composition parameters presented difference in the three groups on time, showing that dance, deep water running and nordic walk are efficient to change these parameters in PD. Initiation date: Aug 2019 --> Nov 2019
  • ||||||||||  Journal:  Exercise-induced myokines: a brief review of controversial issues of this decade. (Pubmed Central) -  Sep 22, 2019   
    However, among published reports, there is wide discrepancy in the quantification of myokines induced by exercise, which could be due to timing of sample collection, pre-analytic sample processing, analytical method, and calculation and other factors. Thus, these factors need to be considered in future studies on exercise induced myokines.
  • ||||||||||  Clinical, Review, Journal:  Optimization of perioperative management of proximal femoral fracture in the elderly. (Pubmed Central) -  Sep 20, 2019   
    The most comprehensive care plan involves team-work between emergency physicians, surgeons, orthopedic specialists, anesthesiologists, geriatricians, pharmacists, rehabilitation specialists and nursing staff, to reduce mortality and readmission and improve functional results. Post-fracture coordination seeks to prevent falls and further fractures and to treat bone demineralization.
  • ||||||||||  Biomarker, Journal:  Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies. (Pubmed Central) -  Sep 20, 2019   
    Further research is needed to understand why men apparently differ from women in the interrelationship between their myostatin levels and muscle mass. Serum proteomic analysis allowed to not only discriminate among DMD, BMD, and healthy subjects, but it enabled to detect significant associations with clinical function, dystrophin levels, and disease progression.
  • ||||||||||  RELATIONSHIP BETWEEN PRE-SARCOPENIA AND EVENT OCCURRENCE IN PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA () -  Sep 20, 2019 - Abstract #ILCA2019ILCA_173;    
    In patients with primary hepatocellular carcinoma, low skeletal muscle mass is an independent factor related to event occurrence. In the patients with JIS score 3 or more, there was no difference in the event rate regardless of pre-sarcopenia, whereas in patients with JIS score 2 points or less, the event rate was significantly higher in the pre-sarconia group than in the nonpre-sarconia group.
  • ||||||||||  Journal:  Electromyostimulation to fight atrophy and to build muscle: facts and numbers. (Pubmed Central) -  Sep 20, 2019   
    The effect of superimposing EMS on conventional exercise training to achieve more muscle mass and better function is still discussed controversially. Nevertheless, EMS should not be regarded as a replacement of exercise training per se, since the beneficial effect of exercise training is not just relying on building muscle mass but it also exerts positive effects on endothelial, myocardial, and cognitive function.
  • ||||||||||  Clinical, Journal:  Relationship between endothelial function and skeletal muscle strength in community dwelling elderly women. (Pubmed Central) -  Sep 20, 2019   
    Nevertheless, EMS should not be regarded as a replacement of exercise training per se, since the beneficial effect of exercise training is not just relying on building muscle mass but it also exerts positive effects on endothelial, myocardial, and cognitive function. Endothelial function and skeletal muscle strength had a significant correlation in elderly women, providing additional support for the relevant role of vascular system in sarcopenia.
  • ||||||||||  Clinical, Journal:  Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia. (Pubmed Central) -  Sep 20, 2019   
    We also demonstrated that conditioned media from young, but not old, bone marrow cells promoted myoblast proliferation in vitro, and we found that factors released by young bone marrow cells were more supportive of myotube differentiation in vitro. Together, our results demonstrate that aging of bone marrow cells promotes the age-related reduction of satellite cell number and function and contributes to sarcopenia.-Wang, Y., Wehling-Henricks, M., Welc, S. S., Fisher, A. L., Zuo, Q., Tidball, J. G. Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia.