Sarcopenia
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  • ||||||||||  Clinical, Observational data, Journal:  Respiratory Muscle Strength as a Discriminator of Sarcopenia in Community-Dwelling Elderly: A Cross-Sectional Study. (Pubmed Central) -  Oct 10, 2019   
    Elderly patients with sarcopenia had lower MIP and MEP values when compared to non-sarcopenic individuals, and respiratory muscle strength was inversely associated with the diagnosis of sarcopenia and its indicators (HGS, gait speed and MMI). Furthermore, cut-off points for MIP and MEP can be used in clinical practice as discriminators of sarcopenia in community-dwelling elderly.
  • ||||||||||  Clinical, Review, Journal:  Handgrip Strength and Pulmonary Disease in the Elderly: What is the Link? (Pubmed Central) -  Oct 9, 2019   
    At present, early muscle reconditioning and optimal nutrition appear to be the most effective approaches to reduce the impact of CLDs and low muscle strength on the quality of life of these individuals. Nonetheless, larger in-depth studies are needed to evaluate the link between HGS and CLDs.
  • ||||||||||  Journal:  Sarcopenia in Liver Transplantation. (Pubmed Central) -  Oct 9, 2019   
    Supervised exercise programs should be encouraged for all ESLD patients. More advanced therapies require further clinical investigation before their widespread use.
  • ||||||||||  Review, Journal:  Musculoskeletal factors, sarcopenia and falls in old age (Pubmed Central) -  Oct 9, 2019   
    Structured physical exercise plays the key role in the prevention of falls and the management of functional decline caused by sarcopenia and frailty. The combined supplementation with proteins and vitamin D supports muscle protein synthesis in undersupplied persons and improves aspects of physical function.
  • ||||||||||  Journal:  Perioperative Nutritional Optimization in Spine Surgery. (Pubmed Central) -  Oct 9, 2019   
    Malnourished patients should be given balanced diets replenishing key nutrient deficits, glucose should be maintained with sliding scale insulin or continuous infusions and immunonutrition may be implemented. Postoperatively, patients should initiate a diet as soon as possible to decrease overall length of stay and complication rates, facilitating return to normal activities.
  • ||||||||||  Retrospective data, Review, Journal:  Predictive Value of Preoperative Sarcopenia in Patients with Gastric Cancer: a Meta-analysis and Systematic Review. (Pubmed Central) -  Oct 9, 2019   
    This meta-analysis reveals that preoperative sarcopenia may be used as a new indicator of poor pathological staging, impaired overall survival, and increased postoperative complications. Notably, patients with gastric cancer who are over 65 years old and from Asia should be routinely screened for sarcopenia before surgery to adequately assess the risk of postoperative complications in clinical practice.
  • ||||||||||  Journal:  Research advances of sarcopenia in chronic liver disease (Pubmed Central) -  Oct 8, 2019   
    In view of its impact in chronic liver disease, sarcopenia can be considered as a powerful prognostic factor and a useful additional tool in the global assessment of patients with advanced liver disease. Rational nutritional intervention, appropriate physical exercise, effective ammonia lowering strategies, hormone supplements and targeted molecular therapy (use of myostatin blockers), and liver transplantation, may improve sarcopenia, but still needs more studies for validation.
  • ||||||||||  Enrollment open:  ICU Associated Weakness and Bedside Ultrasound Assessment (clinicaltrials.gov) -  Oct 7, 2019   
    P=N/A,  N=30, Recruiting, 
    Rational nutritional intervention, appropriate physical exercise, effective ammonia lowering strategies, hormone supplements and targeted molecular therapy (use of myostatin blockers), and liver transplantation, may improve sarcopenia, but still needs more studies for validation. Not yet recruiting --> Recruiting
  • ||||||||||  Body Composition and Nailfold Videocapillaroscopy Patterns in a Cohort of Systemic Sclerosis Patients (Hall B5) -  Oct 7, 2019 - Abstract #ACRARHP2019ACR_3680;    
    This study demonstrates in SSc patients a relationship between a more severe microvascular damage ("Late" SSc pattern) and the body composition, characterized by lower weight, lower total lean mass, lower bone mineral content and sarcopenia, without any significant variation in total fat mass. These clinical conditions seem not to be associated with severity of skin involvement and/or disease duration
  • ||||||||||  Sarcopenia and the Likelihood of Incident Knee Osteoarthritis and Knee Pain Among Older Adults in the Health ABC Study (Hall B5) -  Oct 7, 2019 - Abstract #ACRARHP2019ACR_3142;    
    That those with low grip strength (compared to those without low grip strength) were not statistically more likely to develop incident knee pain suggests that published grip strength cut-points may be inadequate to identify older adults at increased risk of developing knee pain. Those with low ALM (compared to those without low ALM) were not statistically more likely to develop either incident knee OA or knee pain.
  • ||||||||||  Sarcopenia in Systemic Sclerosis (Hall B5) -  Oct 7, 2019 - Abstract #ACRARHP2019ACR_2704;    
    The recognition of this condition has important therapeutic implications, due to the impact on the quality of life, morbidity and mortality. Strategies should include a focus on the nutritional aspects, improving the protein-rich diet intake with physical training program that aims to increase muscle mass and improve strength and performance, maintaining an adequate control of the disease and associated comorbidities.
  • ||||||||||  Frailty and Sarcopenia in Women with Systemic Lupus Erythematosus (Hall B5) -  Oct 7, 2019 - Abstract #ACRARHP2019ACR_2488;    
    Frailty did not appear to be a proxy for comorbidity or fibromyalgia. Compared to pre-frail and non-frail women, frail women had poorer health-related quality of life and a higher proportion of sarcopenia.
  • ||||||||||  Frailty and Sarcopenia in Inflammatory Rheumatic Disease (Hall B5) -  Oct 7, 2019 - Abstract #ACRARHP2019ACR_1201;    
    Rheumatologists should make an early detection of signs of frailty. The screenig and early detection of frailty can spur reforms to make routine care less hazardous, can focus on outcomes most relevant to patients and can aid in understanding effectiveness of health care interventions, including at the population level.
  • ||||||||||  Sarconeos (BIO101) / Biophytis
    Trial completion date, Trial primary completion date:  A Double-blind, Placebo-controlled, Randomized INTerventional Clinical Trial (SARA-INT) (clinicaltrials.gov) -  Oct 6, 2019   
    P2,  N=334, Recruiting, 
    The screenig and early detection of frailty can spur reforms to make routine care less hazardous, can focus on outcomes most relevant to patients and can aid in understanding effectiveness of health care interventions, including at the population level. Trial completion date: Jun 2021 --> Dec 2020 | Trial primary completion date: Jun 2021 --> Dec 2020
  • ||||||||||  Review, Journal:  Advantage of Dairy for Improving Aging Muscle. (Pubmed Central) -  Oct 5, 2019   
    Dairy products are rich in these nutrients, which implicates that dairy products might be ideal for elderly population. This systematic review highlights the effects of dairy products on muscle mass, muscle strength and body performance in the elderly population in the perspective of Ca, P, vitamin D and protein.
  • ||||||||||  Enrollment open, Trial initiation date:  Resistance Exercise or Vibration With HMB for Sarcopenia (clinicaltrials.gov) -  Oct 3, 2019   
    P=N/A,  N=141, Recruiting, 
    This trial was registered at isrctn.org as ISRCTN16665940. Not yet recruiting --> Recruiting | Initiation date: Sep 2019 --> Mar 2019
  • ||||||||||  Clinical, Journal:  Body Composition in Patients with Atrial Fibrillation. (Pubmed Central) -  Oct 3, 2019   
    Body composition parameters were associated with the occurrence and form of AF in our study cohort. However, further studies are needed to clarify the relationships due to an imbalance in comorbidities.
  • ||||||||||  Trial completion date:  Leucine Supplementation in Sarcopenic Older Individuals (clinicaltrials.gov) -  Oct 2, 2019   
    P1,  N=59, Active, not recruiting, 
    Trial completion date: Dec 2019 --> Jun 2021 | Trial primary completion date: Jul 2019 --> Jun 2021 Trial completion date: Sep 2019 --> Nov 2019
  • ||||||||||  Preclinical, Journal:  Chronic vitamin D insufficiency impairs physical performance in C57BL/6J mice. (Pubmed Central) -  Oct 2, 2019   
    Additionally, microRNA sequencing revealed differential expression of mIR‑26a in muscle tissue of LOW mice. These data suggest chronic vitamin D insufficiency may be an important factor contributing to functional decline and sarcopenia.
  • ||||||||||  Trulicity (dulaglutide) / Eli Lilly
    Clinical, Journal:  The effect of dulaglutide on body composition in type 2 diabetes mellitus patients on hemodialysis. (Pubmed Central) -  Oct 2, 2019   
    Six months of dulaglutide treatment significantly reduced not only FM but also SMM, although changes in GA and insulin doses were comparable with those in the teneligliptin group. Dulaglutide may have the effect of promoting sarcopenia; therefore, it may be carefully used in T2DM patients on HD.