Sarcopenia
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  • ||||||||||  Clinical, Review, Journal:  Staging the Host: Personalizing Risk Assessment for Radical Cystectomy Patients. (Pubmed Central) -  Oct 24, 2019   
    The use of standardized multidimensional instruments should be encouraged for patients undergoing consideration for RC to identify potentially modifiable risk factors that can be targeted with prehabilitation interventions. Future work is needed to validate the performance of these metrics with respect to predicting perioperative complications and oncologic outcomes and to define and assess the effectiveness of specific prehabilitation interventions to optimize patients before surgery.
  • ||||||||||  Journal:  Research advances in the relationship between nonalcoholic fatty fiver disease and sarcopenia (Pubmed Central) -  Oct 24, 2019   
    Recent studies have shown that the occurrence and development of NAFLD and sarcopenia are related, and there is a common base for the pathogenesis between the two, which may promote each other for mutual risk factors. This article reviews the current research progress of this field in order to clinically further understand the pathogenesis and intrinsic links between the two to look for appropriate interventions.
  • ||||||||||  Trial completion date, Trial primary completion date:  Microbiome and Sarcopenia in Patients With Liver Cirrhosis (clinicaltrials.gov) -  Oct 24, 2019   
    P=N/A,  N=120, Recruiting, 
    This article reviews the current research progress of this field in order to clinically further understand the pathogenesis and intrinsic links between the two to look for appropriate interventions. Trial completion date: Dec 2019 --> Dec 2021 | Trial primary completion date: Jul 2019 --> Jul 2021
  • ||||||||||  Dynapenia, Muscle Mass, and Fracture Risk in CKD (Stages 1-5 ND) () -  Oct 23, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_5584;    
    Results Age 70.17±10.49 years, 60.7% women.Frequencies of CKD stage(S) were:S1 6.1%,S2 18%;S3 56.1%;S4 15.6% and S5 4.2%.Pts with dynapenia were significantly older.The glomerular filtration rate and the risk of osteoporotic fracture were significantly higher in the dynapenic subjects (p ≤0.05).However, the risk of hip fracture was only significant in the dynapenic women (Table).Interstitial fluid measured did not show statistical significance. Conclusion Dynapenia is a related risk of vertebral fractures in both sexes.Hip fracture risk is higher in women.In both cases muscle mass is normal.The promotion of physical exercise in order to: increase the traction on the bone, stimuli the muscle and increase the bone structure is relevant in these patients.Dynamometry evaluation should be included as a routine tool in clinical practice Descriptive & ANOVA ( n=880)Date are mean(SD)FundingOther NIH Support
  • ||||||||||  Adiponectin Influences Skeletal Muscle Mass in Renal Transplant Recipients () -  Oct 23, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_5541;    
    Conclusion In renal transplant recipients, sarcopenia judged by the mass and quality of psoas muscles after RTX may be associated with the alteration of serum HMW-ADPN levels and PTDM. Funding Government Support - Non-U.S.
  • ||||||||||  Clinical, Journal:  Frailty and Sarcopenia as a Geriatric Syndrome in Community-Dwelling Older Adults. (Pubmed Central) -  Oct 23, 2019   
    These dietary changes may assist in offsetting sarcopenia and the chronic inflammation associated with aging in senior-adult cats. Geriatric syndrome refers to a series of symptoms and observations caused by a variety of factors associated with aging, where the older adults show the treatment consciously or otherwise, and long-term care becomes important at the same time [...].
  • ||||||||||  Trial initiation date:  Resistance Exercise or Vibration With HMB for Sarcopenia (clinicaltrials.gov) -  Oct 21, 2019   
    P=N/A,  N=141, Recruiting, 
    Slower Timed Up and Go test speed is associated with increased risk of developing myocardial infarction, congestive heart failure, and mortality in older adults. Initiation date: Mar 2019 --> Sep 2019
  • ||||||||||  Clinical, Journal:  Prognosis and Interplay of Cognitive Impairment and Sarcopenia in Older Adults Discharged from Acute Care Hospitals. (Pubmed Central) -  Oct 18, 2019   
    Such association was also confirmed after excluding patients with dementia (HR = 2.13, 95% CI = 1.06-4.17), underweight (HR = 2.18, 95% CI = 1.03-3.91), high comorbidity burden (HR = 2.63, 95% CI = 1.09-6.32), and severe disability (HR = 2.88, 95% CI = 1.10-5.73). The co-occurrence of sarcopenia and cognitive impairment may predict 1-year mortality in older patients discharged from acute care hospitals.
  • ||||||||||  Journal:  Assessment of sarcopenia in virally suppressed HIV-infected Asians receiving treatment. (Pubmed Central) -  Oct 18, 2019   
    Sarcopenia is more prevalent in HIV-infected at least 50 years old compared with matched controls. Our findings highlight associations between sarcopenia with loss of independence and greater healthcare burden among treated HIV-infected individuals necessitating early recognition and intervention.
  • ||||||||||  Clinical, Journal:  The Association between Red Blood Cell Distribution Width and Sarcopenia in U.S. Adults. (Pubmed Central) -  Oct 18, 2019   
    Further, in a model stratified by obesity, an elevated RDW was associated with sarcopenia in the overweight and obese group, but not in the normal weight group. Our study shows that elevated RDW is associated with sarcopenia, and this association is particularly strong in people who are overweight and obese.
  • ||||||||||  Clinical, Journal:  Emerging Interventions for the Elderly - The Promise of Regenerative Medicine. (Pubmed Central) -  Oct 18, 2019   
    Two major approaches are being pursued: The first targets specific organs that are adversely affected by senescence; the second targets senescence pathways themselves, with the goal of favorably altering the affected physiology. This review will highlight a few examples of recent applications of both of these approaches in order to illustrate the potential of the application of a regenerative medicine approach to improve the quality of life and independence in older adults.
  • ||||||||||  Review, Journal:  Recent Issues on Body Composition Imaging for Sarcopenia Evaluation. (Pubmed Central) -  Oct 17, 2019   
    We review current knowledge about sarcopenia, its pathophysiological impact, and advantages and disadvantages of methods for evaluation of sarcopenia focusing on body composition imaging modalities such as whole-body dual-energy X-ray absorptiometry, CT, and MRI. Controversial issues are discussed, including the lack of consensus and standardization of the disease definition, imaging modality, measurement methods, and diagnostic cutoff points.
  • ||||||||||  Clinical, Journal:  Prognostic value of low psoas muscle mass in patients with cervical spine metastasis. (Pubmed Central) -  Oct 17, 2019   
    In conclusion, a psoas muscle mass in the lowest quartile was independently associated with shorter survival among patients with cervical spine metastases. Although the poor prognostic predictive value was associated with surgical treatment, the overall survival was not different between patients who did or did not undergo surgery.
  • ||||||||||  Review, Journal:  Obesity Paradox in Chronic Liver Diseases: Product of Bias or a Real Thing? (Pubmed Central) -  Oct 15, 2019   
    Still, we should be aware that the obesity paradox might be true, especially in severe and end-stage illness. This suggests focusing our efforts toward preserving or building up fat-free mass and decreasing inflammatory activity responsible for catabolism and sarcopenia, and implying that the underlaying cause should be treated.
  • ||||||||||  Trial completion:  Leucine Supplementation in Sarcopenic Older Individuals (clinicaltrials.gov) -  Oct 15, 2019   
    P1,  N=59, Completed, 
    This suggests focusing our efforts toward preserving or building up fat-free mass and decreasing inflammatory activity responsible for catabolism and sarcopenia, and implying that the underlaying cause should be treated. Active, not recruiting --> Completed
  • ||||||||||  Diversity of Nutritional Status in Patients with Cancer and CKD (Exhibit Hall, Walter E. Washington Convention Center) -  Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_4574;    
    FU pcts presented higher BMI (27.1 [24.2 – 30.20] vs 25.10 [22.2 – 28.7], P=0.330 and higher prevalence of well-nourished status by PG-SGA (93.3 vs 76.7%, P=0.015). Conclusion The nutritional status in cancer pts with CKD is diverse, ranging from significant malnutrition to expressive overweight both for AT and FU pts.
  • ||||||||||  Pleuroperitoneal Leak in Peritoneal Dialysis Patients: Experience of a Single Center (Exhibit Hall, Walter E. Washington Convention Center) -  Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_2777;    
    In 4 of the 5 patients an attempt was made to return to peritoneal dialysis (PD), but PPL recurred in all.The prognosis is discouraging due to the high recurrence rate.We included biompedance data, none of the patients had sarcopenia, ruling out this condition as a risk factor to develop diafragmatic defect, the only biochemical association was with hypoalbuminemia. Characteristics of all patients
  • ||||||||||  Natural Killer Cell Activity Contributes to Development of Sarcopenia in Hemodialysis Patients (Exhibit Hall, Walter E. Washington Convention Center) -  Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_1907;    
    Low NK cell activity had a very significant correlation with sarcopenia, and the statistical significance was maintained even after adjustment for age, sex, BMI, ALM in multivariate regression analysis [Exp(B) 0.104(0.033, 0.324), P<0.001]. Conclusion Our results show that the NK cell activity of sarcopenic HD patients is significantly decreased and such low NK cell activity may contribute to development of sarcopenia in HD patients.
  • ||||||||||  Oxidative Stress Is Associated with Overhydration and Sarcopenia in Hemodialysis Patients (Exhibit Hall, Walter E. Washington Convention Center) -  Oct 14, 2019 - Abstract #KIDNEYWEEK2019KIDNEY_WEEK_1833;    
    Multivariate analysis showed that the serum levels of protein carbonyl, albumin, prealbumin, overhydration and sarcopenia were independent determinants of all-cause and cardiovascular mortality. (Figure 1.) Conclusion Serum protein carbonyl was significantly associated with overhydration, nutritional status and sarcopenia and could be an important predictor of long-term outcomes in patients undergoing HD