Sarcopenia
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  • ||||||||||  Clinical, Journal:  Sarcopenic Factors May Have No Impact on Outcomes in Ovarian Cancer Patients. (Pubmed Central) -  Dec 8, 2019   
    Low SMI and high IMAC were not significantly associated with disease-free survival (p = 0.329 and p = 0.3370, respectively) or poor overall survival (p = 0.921 and p = 0.988, respectively). Neither preoperative low muscle volume nor low muscle quality was a poor prognostic factor in ovarian cancer.
  • ||||||||||  Clinical, Journal:  Quality of meal protein determines anabolic response in older adults. (Pubmed Central) -  Dec 6, 2019   
    Highlighting that composition of EAA, in particular the presence of leucine rather than amount is most crucial for anabolism. We conclude that in the context of mixed meals, quality of protein affects NB through changes in protein breakdown and affects protein turnover following subsequent meal intake.
  • ||||||||||  Review, Journal:  Citrulline in health and disease. Review on human studies. (Pubmed Central) -  Dec 6, 2019   
    It appears that CIT is an anabolic pharmaconutrient that can be safely administered even in critically ill patients. Promising results in cardiovascular diseases and in disease-related malnutrition can now be considered sufficient to justify formal clinical exploration in these areas and in sarcopenia in general.
  • ||||||||||  Journal:  Sarcopenic obesity: Time to meet the challenge. (Pubmed Central) -  Dec 6, 2019   
    ESPEN and EASO therefore call for coordinated action aimed at reaching consensus on its definition, diagnostic criteria and optimal treatment with particular regard to nutritional therapy. We are convinced that achievement of these goals has strong potential to reduce the burden of morbidity and mortality in the rapidly increasing obese patient population.
  • ||||||||||  Clinical, Review, Journal:  The Aging Vestibular System: Dizziness and Imbalance in the Elderly. (Pubmed Central) -  Dec 6, 2019   
    If a specific cause for dizziness and imbalance can be identified, treatment is often successful even in advanced age. The common causes can be revealed by systematic clinical examination and selective laboratory testing.
  • ||||||||||  Clinical, Journal:  Decreased Appetite is Associated with Sarcopenia-Related Outcomes in Acute Hospitalized Older Adults. (Pubmed Central) -  Dec 6, 2019   
    In conclusion, decreased appetite was highly prevalent among acute hospitalized older adults and remained prevalent, although less, after discharge. Decreased appetite was significantly associated with negative sarcopenia-related outcomes, which underlines the need for assessment and monitoring of decreased appetite during and post hospitalization.
  • ||||||||||  Review, Journal:  Mitochondrial Activity and Skeletal Muscle Insulin Resistance in Kidney Disease. (Pubmed Central) -  Dec 6, 2019   
    In this mini review, we evaluate how mitochondrial activity of different renal cell types changes during DKD progression, and discuss the controversial role of oxidative stress and mitochondrial reactive oxygen species in DKD. We also compare the involvement of skeletal muscle mitochondria in uraemic and obesity-related muscle insulin resistance.
  • ||||||||||  Journal:  Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality. (Pubmed Central) -  Dec 2, 2019   
    Estimation of sarcopenia may identify patients eligible or not eligible for emergency surgery among elderly patients. Regulating pathways involved in protein synthesis and degradation, mitochondrial biogenesis, mitochondrial fusion/fission, autophagy, and mitochondria-dependent apoptosis by oligonol contributes to positive protein turnover and mitochondrial quality, thus increasing muscle mass and strength in SAMP8 mice.
  • ||||||||||  Trial completion, Trial completion date, Trial primary completion date:  Prevalence of Sarcopenia in Geriatric Patients (clinicaltrials.gov) -  Dec 1, 2019   
    P=N/A,  N=350, Completed, 
    Recruiting --> Active, not recruiting Recruiting --> Completed | Trial completion date: Jul 2020 --> Oct 2019 | Trial primary completion date: Apr 2020 --> Oct 2019
  • ||||||||||  Clinical, Review, Journal:  Frailty and Sarcopenia in Older Patients Receiving Kidney Transplantation. (Pubmed Central) -  Nov 30, 2019   
    Frail patients respond well to multiprofessional interventions that focus on the patients' positive frailty criteria, while physical rehabilitation and oral supplementation may improve sarcopenia. Prospective studies are still needed to evaluate the utility of formally measuring frailty and sarcopenia in the older candidates to renal transplantation as part of the transplant evaluation process.
  • ||||||||||  Clinical, Retrospective data, Journal:  Clinical Significance of Sarcopenia among Patients with Advanced Oropharyngeal Cancer. (Pubmed Central) -  Nov 30, 2019   
    Sarcopenia was not statistically significant in survival models; however, it was associated with increased mortality and recurrence. Conclusion Sarcopenia is a prognostic factor affecting OS independent of HPV status in advanced oropharyngeal cancer.
  • ||||||||||  Biomarker, Clinical, Journal:  Maximum Occlusal Force and Incident Functional Disability in Older Adults: The Tsurugaya Project. (Pubmed Central) -  Nov 29, 2019   
    Particularly in older adults, occlusal force is reduced by several factors other than tooth loss, such as the absence of a dental prostheses, sarcopenia in the masticatory muscle, poor periodontal condition, and orofacial pain. Our findings suggest that maximum occlusal force may be a useful biomarker associated with diverse parameters aside from the number of remaining teeth.