Sarcopenia
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  • ||||||||||  Clinical, Journal:  A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women. (Pubmed Central) -  Dec 21, 2019   
    The pathway analysis showed the amino acid metabolism pathways (aspartic acid and glutamic acid) might play important roles in the regulation of muscle mass and strength. In conclusion, our study identified novel metabolites associated with sarcopenia-related traits, suggesting novel metabolic pathways for muscle regulation.
  • ||||||||||  Clinical, Journal:  Osteosarcopenia increases hip fracture risk: A case-controlled study in the elderly. (Pubmed Central) -  Dec 21, 2019   
    The risk of hip fracture should not be assessed by only examining bone density in patients over 65 years of age. The clinical relevance is that increasing the gluteal muscle volume above cut-off value in elderly individuals may help to reduce hip fracture risk.
  • ||||||||||  Journal:  How much frailty is important in cardiology? (Pubmed Central) -  Dec 20, 2019   
    Therefore, physicians should be aware that age by itself is probably not the best criterion to rely on for challenging clinical decision-making in this setting. In this clinical context, it becomes mandatory that, beyond age-based decisions or an "eyeballing" perception of "frailty" or "vulnerability", standardized and valid measures aimed at selecting those patients who may potentially derive the greatest benefit from medical or interventional procedures are made available for daily clinical use.
  • ||||||||||  cisplatin / Generic mfg.
    Journal:  Ninjin-yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia. (Pubmed Central) -  Dec 20, 2019   
    These results demonstrate that Ninjin-yoeito directly targets both ghrelin-responsive and unresponsive NPY neurons in ARC and preserves food intake and body weight in cisplatin-treated anorectic mice. Ninjin-yoeito's signaling through ghrelin-responsive and ghrelin-unresponsive NPY pathways may provide strong mechanistic basis for this medicine for treating anorectic conditions associated with cancer, depression, heart failure, sarcopenia, frailty and aging.
  • ||||||||||  Journal:  Tetra-linoleoyl cardiolipin depletion plays a major role in the pathogenesis of sarcopenia. (Pubmed Central) -  Dec 20, 2019   
    Together, these findings from the literature prompt the hypothesis that depletion of the cardiolipin (18:2) species may be at the root of mitochondrial dysfunction with aging, in turn leading to sarcopenia. Corroboration of the tetra-linoleoyl cardiolipin depletion hypothesis suggests new leads for the prevention and treatment of sarcopenia by enhancing the biosynthesis, accretion, and integrity of tetra-linoleoyl cardiolipin.
  • ||||||||||  Clinical, Journal:  Sarcopenia as a potential cause of chronic hyponatremia in the elderly. (Pubmed Central) -  Dec 20, 2019   
    Since muscle mass is the main potassium body store, this condition usually represents a reduced body potassium content. In the present article it is hypothesized that sarcopenia, as a cause of low potassium body content, could induce or co-induce hyponatremia, particularly in elderly individuals suffering from frailty phenotype.
  • ||||||||||  Review, Journal:  Frailty, Cognitive Decline, Neurodegenerative Diseases and Nutrition Interventions. (Pubmed Central) -  Dec 20, 2019   
    Additionally, nutritional factors that may influence vascular risk factors will potentially have an effect on dementia decline among patients with cognitive frailty. This review aims to describe the nutritional factors that have been researched so far which may lead to the development of frailty, and especially cognitive decline.
  • ||||||||||  Review, Journal, IO Biomarker:  Multiple Modes of Vitamin K Actions in Aging-Related Musculoskeletal Disorders. (Pubmed Central) -  Dec 20, 2019   
    However, the basic studies explaining the effects of vitamin K on muscular tissue are limited. Further research on vitamin K will clarify new biological mechanisms which contribute to human longevity and health through the prevention and treatment of aging-related musculoskeletal disorders.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date, Trial primary completion date:  MUSFAT: Muscle Loss and Fatigue as a Consequence of Radiotherapy (clinicaltrials.gov) -  Dec 20, 2019   
    P=N/A,  N=20, Active, not recruiting, 
    Further research on vitamin K will clarify new biological mechanisms which contribute to human longevity and health through the prevention and treatment of aging-related musculoskeletal disorders. Trial completion date: Nov 2019 --> Dec 2021 | Trial primary completion date: Oct 2019 --> Dec 2020
  • ||||||||||  Trial completion date, Trial primary completion date:  Exercise Effects on Sarco-Osteopenia in Older Men (clinicaltrials.gov) -  Dec 20, 2019   
    P=N/A,  N=43, Active, not recruiting, 
    ALM/BMI may be more accurate for the evaluation of muscle mass in middle-aged obese, PDM and DM subjects. Trial completion date: Dec 2020 --> Apr 2020 | Trial primary completion date: Jul 2020 --> Dec 2019
  • ||||||||||  Clinical, Journal:  Resistance Training for Older Adults: Position Statement From the National Strength and Conditioning Association. (Pubmed Central) -  Dec 19, 2019   
    This Position Statement provides evidence to support recommendations for successful resistance training in older adults related to 4 parts: (a) program design variables, (b) physiological adaptations, (c) functional benefits, and (d) considerations for frailty, sarcopenia, and other chronic conditions. The goal of this Position Statement is to a) help foster a more unified and holistic approach to resistance training for older adults, b) promote the health and functional benefits of resistance training for older adults, and c) prevent or minimize fears and other barriers to implementation of resistance training programs for older adults.
  • ||||||||||  Journal:  Sarcopenia associated with gastric cancer. (Pubmed Central) -  Dec 19, 2019   
    The goal of this Position Statement is to a) help foster a more unified and holistic approach to resistance training for older adults, b) promote the health and functional benefits of resistance training for older adults, and c) prevent or minimize fears and other barriers to implementation of resistance training programs for older adults. No abstract available
  • ||||||||||  Journal:  Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens. (Pubmed Central) -  Dec 19, 2019   
    Similar results were obtained with relative HGS (OR, 0.40; 95% CI, 0.36-0.45; P<0.0001), but standard HGS had better model fitting (quasi-likelihood under independence model criteria=33,890). HGS may be considered an index for the diagnosis of sarcopenia and may also affect self-rated health, which is a multidimensional indicator of an individual's health status and can identify patients who may require special attention.
  • ||||||||||  Trial completion date:  Identifying Therapeutic Targets of Accelerated Sarcopenia (clinicaltrials.gov) -  Dec 19, 2019   
    P=N/A,  N=102, Recruiting, 
    HGS may be considered an index for the diagnosis of sarcopenia and may also affect self-rated health, which is a multidimensional indicator of an individual's health status and can identify patients who may require special attention. Trial completion date: Dec 2022 --> Dec 2025
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date:  Screening for Age-Related Skeletal Muscle Dysfunction (clinicaltrials.gov) -  Dec 19, 2019   
    P=N/A,  N=30, Active, not recruiting, 
    Trial completion date: Dec 2022 --> Dec 2025 Trial completion date: Nov 2019 --> Aug 2020
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion, Enrollment change:  Exercise Intervention in Liver Transplant Patients (clinicaltrials.gov) -  Dec 17, 2019   
    P=N/A,  N=83, Completed, 
    Thus, spine surgery can be safely performed in elderly patients 80 years of age or older. Recruiting --> Completed | N=500 --> 83
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date, Trial primary completion date:  PRIMe: Protein Recommendation to Increase Muscle (clinicaltrials.gov) -  Dec 16, 2019   
    P=N/A,  N=40, Recruiting, 
    Initiation date: Sep 2019 --> Jan 2020 Trial completion date: Dec 2020 --> Dec 2022 | Trial primary completion date: Dec 2019 --> Dec 2021
  • ||||||||||  Transcriptional Networks and Epigenomic Mechanisms Regulating human Mesenchymal Stem Cell Differentiation (Room 153) -  Dec 14, 2019 - Abstract #ENDO2020ENDO_689;    
    We show that dynamic enhancer-enhancerinteractions play a key role in regulation of enhancer function, and that highlyconnected enhancers are important for both signal integration andcompartmentalization of the genome. Lineage-selective genes are associated withhighly connected enhancer communities, and in response to differentiation cues,these communities are further activated, leading to looping of additionalenhancers into the 3-D hubs as well as increased looping to promoters.
  • ||||||||||  S22. Assessing and Optimizing Musculoskeletal Health in the Elderly (Room 207) -  Dec 14, 2019 - Abstract #ENDO2020ENDO_380;    
    Sarcopenia and frailty also contribute to the risk of fall and fracture. Finally, nutrition is another important factor in such patients, especially in the setting of weight loss and nutritional deficiencies such as hypovitaminosis D. Treating osteoporosis in this population often involves measures beyond traditional osteoporosis medications.
  • ||||||||||  Review, Journal:  Frailty Screening in Chronic Kidney Disease: Current Perspectives. (Pubmed Central) -  Dec 13, 2019   
    This review highlights the value of frailty screening in CKD by summarizing the outcomes associated with frailty and exploring proposed changes to the management of frail patients with CKD. Finally, we will propose a framework for how to implement frailty screening into standard nephrology care.