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|||||||||| THE TREATMENT WITH AMINO ACIDS OF RAMIFIED CHAINS IMPROVES THE MUSCULAR MASS OF CIRCUTIC PATIENTS WITH SARCOPENIA () - Jan 27, 2020 - Abstract #AEEH2020AEEH_104;

|||||||||| Enrollment closed, Trial completion date, Trial primary completion date: Effects of Resistance Training With High vs. Light-moderate Loads on Muscle-tendon Function in the Elderly (clinicaltrials.gov) - Jan 27, 2020
P=N/A, N=55, Active, not recruiting, Sponsor: University of Castilla-La Mancha
Recruiting --> Active, not recruiting | Trial completion date: Sep 2019 --> Jul 2020 | Trial primary completion date: Feb 2019 --> Apr 2020

|||||||||| Journal: MRI Quantitation of Abdominal Skeletal Muscle Correlates with CT-Based Analysis: Implications for Sarcopenia Measurement. (Pubmed Central) - Jan 27, 2020
T2w MRI can be used interchangeably with CT for assessment of SMA and sarcopenia. This finding has important clinical implications.

|||||||||| Preclinical, Journal: Non-invasive Assessment of Dorsiflexor Muscle Function in Mice. (Pubmed Central) - Jan 27, 2020
Here, we describe an in vivo, non-invasive technique involving a helpful and easy assessment of force frequency-curve (FFC) in mice that can be performed on the same animal over time. This permits monitoring of disease progression and/or efficacy of a potential therapeutic treatment.

|||||||||| New trial: MASS_LC: Muscle Ageing Sarcopenia Study Lifecourse (MASS Lifecourse) (clinicaltrials.gov) - Jan 27, 2020
P, N=160, Recruiting, Sponsor: Newcastle-upon-Tyne Hospitals NHS Trust

|||||||||| Clinical, Journal: Sarcopenia and AFP Level in Patients With Hepatocellular Carcinoma Undergoing Liver Transplantation. (Pubmed Central) - Jan 27, 2020
This permits monitoring of disease progression and/or efficacy of a potential therapeutic treatment. No abstract available

|||||||||| Clinical, Journal: Sarcopenia and Alpha-fetoprotein Level in Patients With Hepatocellular Carcinoma Undergoing Liver Transplantation: In Response. (Pubmed Central) - Jan 27, 2020
No abstract available No abstract available

|||||||||| Clinical, Journal: Clinical Implications of Estimating Glomerular Filtration Rate with Three Different Equations Among Older People. Preliminary Results of the Project "Screening for Chronic Kidney Disease among Older People across Europe (SCOPE)". (Pubmed Central) - Jan 26, 2020
In conclusion, CKD-EPI and BIS/FAS equations are not interchangeable to assess eGFR among older people. Muscle mass may represent a relevant source of discrepancy among eGFR equations.

|||||||||| Journal: Pre-Disease and Pre-Surgery BMI, Weight Loss and Sarcopenia Impact Survival of Resected Lung Cancer Independently of Tumor Stage. (Pubmed Central) - Jan 26, 2020
Body reserves assessed by simple clinical markers impact survival of surgically treated NSCLC. Strategies improving body fat and muscular mass before surgery should be considered.

|||||||||| Sarcopenia assessments as predictors of overall survival in patients with metastatic renal cell carcinoma. (In front of the Helsinki rooms) - Jan 25, 2020 - Abstract #DKK2020DKK_2481;

|||||||||| Impact of Sarcopenia (SMI(+)) In Patients (PTS) with Advanced or Metastatic Soft Tissue Sarcoma (A/MSTS) during Multimodal Therapy (MT) as Risk Parameter (Room A2) - Jan 25, 2020 - Abstract #DKK2020DKK_2254;
A trend of inferior PFS and an independent risk for reduced OS was identified in SMI(+) pts. However, this analysis is limited due to its sample size.

|||||||||| Are visceral obesity and sarcopenia postoperative risk factors for patients undergoing hepatic resections for synchronous colorectal liver metastases? (Room A2) - Jan 25, 2020 - Abstract #DKK2020DKK_2046;

|||||||||| Clinical, Journal: Sarcopenia defined by a computed tomography estimate of the psoas muscle area does not predict frailty in geriatric trauma patients. (Pubmed Central) - Jan 25, 2020
Sarcopenia as an individual marker might not be an effective screening tool for risk assessment in geriatric-trauma patients. Frailty assessment should be a part of risk assessment and prognostication.

|||||||||| Clinical, Journal: Effects of a leucine-enriched amino acid supplement on muscle mass, muscle strength, and physical function in post-stroke patients with sarcopenia: A randomized controlled trial. (Pubmed Central) - Jan 25, 2020
Frailty assessment should be a part of risk assessment and prognostication. We demonstrated that an eight-wk intervention consisting of a leucine-enriched amino acid supplementation and low-intensity resistance training increased muscle mass, strength, and physical function in post-stroke patients with sarcopenia.

|||||||||| Clinical, Journal: Impact of preoperative cachexia on postoperative length of stay in elderly patients with gastrointestinal cancer. (Pubmed Central) - Jan 25, 2020
We demonstrated that an eight-wk intervention consisting of a leucine-enriched amino acid supplementation and low-intensity resistance training increased muscle mass, strength, and physical function in post-stroke patients with sarcopenia. Our results suggested that preoperative cachexia prolongs postoperative LOS in elderly patients with gastrointestinal cancer, implying that cachexia should be assessed and treated before surgery.

|||||||||| Clinical, Journal: Sarcopenia in Brazilian rural and urban elderly women: Is there any difference? (Pubmed Central) - Jan 25, 2020
Our results suggested that preoperative cachexia prolongs postoperative LOS in elderly patients with gastrointestinal cancer, implying that cachexia should be assessed and treated before surgery. Urban elderly women are more vulnerable to sarcopenia than rural elderly women.

|||||||||| Biomarker, Journal: Inter-muscular adipose tissue is associated with adipose tissue inflammation and poorer functional performance in central adiposity. (Pubmed Central) - Jan 25, 2020
Urban elderly women are more vulnerable to sarcopenia than rural elderly women. Our results suggest the possible role of IMAT as a candidate imaging biomarker for adipose tissue inflammation and associated poorer functional outcomes in SO.

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Clinical, Journal: Clinical Impact of Highly Purified, Whey Proteins in Patients Affected With Colorectal Cancer Undergoing Chemotherapy: Preliminary Results of a Placebo-Controlled Study. (Pubmed Central) - Jan 24, 2020
We have conducted a study to evaluate the effects of whey protein in colorectal cancer patients, undergoing 5-fluorouracil-based chemotherapy...At univariate analysis, a condition of malnutrition risk according to MUST (relative risk [RR] = 7.5, P = .02) or MNA (RR = 1.45, P = .02) and ProLYOtin intake (RR = 0.12, P = .01) were found to be significantly predictive of chemotherapy toxicity. At present, our study shows how whey protein could be an important therapeutic option to improve nutritional status, and particularly to prevent severe toxicity during chemotherapy.

|||||||||| Biomarker, Clinical, Journal: Soluble Intercellular Adhesion Molecule-1 (sICAM-1) as a Biomarker of Vascular Cognitive Impairment in Older Adults. (Pubmed Central) - Jan 24, 2020
High concentrations of sICAM-1 are independently associated with VCI group membership. Efforts to further characterize the relationship between indices of endothelial dysfunction and pathological changes to the aging brain should be further pursued.

|||||||||| Clinical, Review, Journal: Bone Diseases in Patients with Chronic Liver Disease. (Pubmed Central) - Jan 24, 2020
Due to increased life expectancy and therapeutic advances in chronic liver disease, the importance of managing osteoporosis and other bone diseases in patients with chronic liver disease is expected to increase. Consequently, specific guidelines need to be established in the near future.

|||||||||| Journal: SARCOPENIA AND SEVERITY OF NON-ALCOHOLIC FATTY LIVER DISEASE. (Pubmed Central) - Jan 24, 2020
In the present study, an association was found between the sarcopenic index and non-alcoholic hepatic steatosis, with an inversely proportional relation between this index and the severity of fatty infiltration. This finding offers further evidence of the metabolic interaction of the liver, adipose tissue and muscle.

|||||||||| Journal: Choosing coaching frameworks for promoting diet modifications. (Pubmed Central) - Jan 24, 2020
The condensed version includes synthesis preparation, synthesis (comparison of converging and diverging components), synthesis refinement (conceptual connection), and a concluding discussion of all three theories related to nursing practice. This synthesis will inform the focus of interventions that aim to promote dietary changes in adults at risk of developing sarcopenia.

|||||||||| Clinical, Journal: Associations between Brain Structural Damage and Core Muscle Loss in Patients with Parkinson's Disease. (Pubmed Central) - Jan 24, 2020
Patients with PD experience core muscle loss in the thigh, associated with default mode network (DMN) degeneration, longer disease duration, and female gender. Identification of risk factors associated with lean muscle mass loss may assist in early prevention of comorbidities such as sarcopenia.

|||||||||| Journal: Sarcopenia in heart failure with reduced ejection fraction. (Pubmed Central) - Jan 24, 2020
Despite having higher lean mass, women with HFrEF were weaker. Low gait speed was associated with biventricular systolic dysfunction.

|||||||||| Journal: A comparison of two different software packages for the analysis of body composition using computed tomography images. (Pubmed Central) - Jan 23, 2020
All four body composition measures were statistically significantly different by the software package used for analysis; however, the clinical significance of these differences is doubtful. Nevertheless, the same software package should be used if serial measurements are being performed.

|||||||||| Clinical, Journal: The association of medical and demographic characteristics with sarcopenia and low muscle radiodensity in patients with nonmetastatic colorectal cancer. (Pubmed Central) - Jan 23, 2020
Muscle abnormalities were common in patients with nonmetastatic CRC, with great variability in muscle mass and SMD across age, TAT, and race/ethnicity. Factors associated with muscle abnormalities may be used to facilitate risk stratification and the guidance of targeted strategies to counteract these abnormalities.

|||||||||| Clinical, Journal: Dietary protein intake is not associated with 5-y change in mid-thigh muscle cross-sectional area by computed tomography in older adults: the Health, Aging, and Body Composition (Health ABC) Study. (Pubmed Central) - Jan 23, 2020
This conclusion contradicts some, but not all, previous research. This trial was registered at www.trialregister.nl as NTR6930.

|||||||||| Trial completion date, Trial primary completion date: SAMPHYR: SArcopenia, Mobility, PHYsical Activity and Post-operative Risk of Bladder Carcinoma in the Elderly (clinicaltrials.gov) - Jan 23, 2020
P=N/A, N=69, Recruiting, Sponsor: University Hospital, Caen
This trial was registered at www.trialregister.nl as NTR6930. Trial completion date: Dec 2019 --> Oct 2020 | Trial primary completion date: Aug 2019 --> Mar 2020

|||||||||| New trial: MIDAS: Muscle Multi-parametric NMR Imaging Development in Aged People With Sarcopenia or Frailty Syndrome; CLINical Study (clinicaltrials.gov) - Jan 22, 2020
P=N/A, N=60, Recruiting, Sponsor: University Hospital, Bordeaux

|||||||||| Journal: Alpha-Casein and Beta-Lactoglobulin from Cow Milk Exhibit Antioxidant Activity: A Plausible Link to Antiaging Effects. (Pubmed Central) - Jan 22, 2020
PRACTICAL APPLICATION: Our results provide that antioxidant effects of milk proteins containing α-caseins, β-caseins, and β-lactoglobulin can mitigate aging-related damage induced by oxidative stress through showing inhibition of cellular senescence and increase of differentiation and maturation of myoblast. Therefore, we suggest that milk proteins could be potent health supplements to prevent aging-associated diseases, especially sarcopenia.

|||||||||| Clinical, Journal: Impact of sarcopenia on long-term mortality and cardiovascular events in patients undergoing hemodialysis. (Pubmed Central) - Jan 21, 2020
Sarcopenia was strongly associated with long-term mortality and cardiovascular events in HD patients. Assessment of muscle strength and muscle mass may provide additional prognostic information to survival in patients with end-stage renal disease.

|||||||||| Review, Journal: Sarcopenia, frailty and their prevention by exercise. (Pubmed Central) - Jan 21, 2020
We also discuss the importance of malnutrition and physical inactivity in these geriatric syndromes. Finally, we propose multimodal interventions, including exercise programs and nutritional supplementation, as the strategies to prevent and treat both sarcopenia and frailty.

|||||||||| Review, Journal: Mitochondria and cellular senescence: Implications for musculoskeletal ageing. (Pubmed Central) - Jan 21, 2020
Mitochondrial dysfunction has been shown to contribute to senescence and the SASP. Here we review the role of cellular senescence in musculoskeletal ageing as well as the potential mechanisms by which mitochondrial dysfunction may impact on the induction and development of the senescent phenotype.

|||||||||| Preclinical, Review, Journal: Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice. (Pubmed Central) - Jan 21, 2020
Sarcopenia is initiated in motor neurons leading to a disruption of neuromuscular junctions that results in mitochondrial dysfunction and increased generation of reactive oxygen species (ROS) in skeletal muscle. The mitochondrial ROS generated in muscle feedback on the neuromuscular junctions propagating more disruption of neuromuscular junctions and more ROS production by muscle resulting in a vicious cycle that eventually leads to disaggregation of neuromuscular junctions, denervation, and loss of muscle fibers.

|||||||||| Biomarker, Clinical, Journal: The effect of ageing on shear wave elastography muscle stiffness in adults. (Pubmed Central) - Jan 21, 2020
Ageing was associated with a decline in skeletal muscle stiffness which positively correlates with muscle weakness. Further research is needed to evaluate the promising role of SWE as a biomarker for sarcopenia assessment and potential falls risk prediction in elderly individuals.

|||||||||| Clinical, Journal: Prognostic significance of sarcopenia in patients undergoing esophagectomy for superficial esophageal squamous cell carcinoma. (Pubmed Central) - Jan 21, 2020
Patients with sarcopenia and lymph node metastasis (n = 18) had a worse outcome than the other patients (P < 0.001). This study suggests that the alleviation of sarcopenia through nutritional support and rehabilitation in SESCC patients scheduled to undergo surgery might help to prevent postoperative pulmonary complications and to improve the long-term outcome.

|||||||||| Clinical, Journal: A comparison between an ICT tool and a traditional physical measure for frailty evaluation in older adults. (Pubmed Central) - Jan 21, 2020
ADAMO system seems to be a suitable time tracking that allows to measure mobility levels in a non-intrusive way providing wider information on individual health status and specifically on frailty. For the frail individuals with an important loss of resources in physical domain, this innovative device may represent a considerable help in preventing physical consequences and in monitoring functional status.

|||||||||| Journal: Myosteatosis predicts prognosis after radical gastrectomy for gastric cancer: A propensity score-matched analysis from a large-scale cohort. (Pubmed Central) - Jan 21, 2020
Myosteatosis in gastric cancer is associated with poor prognosis. Classifying the skeletal muscle into subranges of radio density is a promising strategy to understand the impact of skeletal muscle on unfavorable surgical outcomes in gastric cancer patients.

|||||||||| Clinical, Review, Journal: Effect of Milk and Other Dairy Products on the Risk of Frailty, Sarcopenia, and Cognitive Performance Decline in the Elderly: A Systematic Review. (Pubmed Central) - Jan 21, 2020
The consumption of dairy products by older people may reduce the risk of frailty, especially with high consumption of low-fat milk and yogurt, and may also reduce the risk of sarcopenia by improving skeletal muscle mass through the addition of nutrient-rich dairy proteins (ricotta cheese) to the habitual diet. Despite the scarcity of evidence on the topic, our systematic review shows that there are some positive effects of dairy products on frailty and sarcopenia, whereas studies concerning cognitive decline have contradictory findings.

|||||||||| Biomarker, Review, Journal: Introduction and Executive Summary of the Supplement, Role of Milk and Dairy Products in Health and Prevention of Noncommunicable Chronic Diseases: A Series of Systematic Reviews. (Pubmed Central) - Jan 21, 2020
Finally, consumption of milk or dairy products did not show a proinflammatory effect on healthy subjects, overweight/obese individuals, or individuals with other metabolic abnormalities, and fortification of dairy products with phytosterols and ω-3 fatty acids seems to be a good approach to improve cardiometabolic risk biomarkers. In conclusion, the systematic reviews and meta-analyses of the present supplement support adequate milk consumption at various stages of life and in the prevention/control of various noncommunicable chronic diseases.

|||||||||| Clinical, Review, Journal: The Role of Muscle Mass Gain Following Protein Supplementation Plus Exercise Therapy in Older Adults with Sarcopenia and Frailty Risks: A Systematic Review and Meta-Regression Analysis of Randomized Trials. (Pubmed Central) - Jan 21, 2020
Meta-regression analyses showed that changes in appendicular LM were significantly associated with the effect sizes of leg strength (β = 0.08; p = 0.003) and walking capability (β = 0.17; p = 0.04), respectively. Our findings suggest that LM gain after PS + MSE significantly contributes to the efficacy of the intervention in terms of muscle strength and physical mobility in elderly patients with a high risk of sarcopenia or frailty.

|||||||||| Clinical, Journal: Quantification of muscle mass in the legs of patients with peripheral arterial occlusive disease: associations between volumetric and cross-sectional single-slice measurements for identification of atrophy and focal sarcopenia. (Pubmed Central) - Jan 21, 2020
In the current study, LESMI was lower in patients with Fontaine class IV PAOD compared to patients with Fontaine class IIb PAOD. Future studies should assess the predictive value of the LESMI on clinical outcomes in PAOD patients.

|||||||||| Clinical, Journal: The Impact of Sarcopenia on Postoperative Course following Pancreatoduodenectomy: Single-Center Experience of 110 Consecutive Cases. (Pubmed Central) - Jan 21, 2020
Future studies should assess the predictive value of the LESMI on clinical outcomes in PAOD patients. Sarcopenia represents a valid indicator of increased morbidity risk and may play a central role in preoperative risk stratification, allowing the selection of patients who may benefit from prehabilitation programs.

|||||||||| Trial completion, Enrollment change: VR-based Rehabilitation in the Treatment and Prevention of Sarcopenia of Older Residents (clinicaltrials.gov) - Jan 21, 2020
P=N/A, N=43, Completed, Sponsor: Cishan Hospital, Ministry of Health and Welfare
Sarcopenia represents a valid indicator of increased morbidity risk and may play a central role in preoperative risk stratification, allowing the selection of patients who may benefit from prehabilitation programs. Recruiting --> Completed | N=30 --> 43

|||||||||| Retrospective data, Journal: Comments on "Sarcopenia and Postoperative Complication Risk in Gastrointestinal Surgical Oncology: A Meta-analysis". (Pubmed Central) - Jan 19, 2020
Recruiting --> Completed | N=30 --> 43 No abstract available

|||||||||| Journal: The Influence of Sarcopenia on High-Risk Neuroblastoma. (Pubmed Central) - Jan 19, 2020
No abstract available A decrease in the skeletal muscle mass was suggested to be a significant prognostic factor for high-risk neuroblastoma.

|||||||||| Clinical, Journal: Sarcopenia predicts poor postoperative outcome in elderly patients with lung cancer. (Pubmed Central) - Jan 18, 2020
A decrease in the skeletal muscle mass was suggested to be a significant prognostic factor for high-risk neuroblastoma. In elderly lung cancer patients, sarcopenia was observed to be a high risk for morbidity and predicted poor prognosis.

|||||||||| Journal: Association of different bioimpedanciometry estimations of muscle mass with functional measures. (Pubmed Central) - Jan 18, 2020
These findings might be relevant for defining both sarcopenia and malnutrition. Geriatr Gerontol Int 2019; 19: 593-597.

|||||||||| Clinical, Journal: Validity of the Kihon Checklist for evaluating frailty status in Turkish older adults. (Pubmed Central) - Jan 18, 2020
We recommend its use by healthcare professionals in Turkey in order to identify frail older adults and direct them to relevant support. Geriatr Gerontol Int 2019; 19: 616-621.

|||||||||| Clinical, Journal: Nutrition, Physical Exercise, and the Prevalence of Sarcopenia in Elderly Residents in Nursing Homes in China. (Pubmed Central) - Jan 18, 2020
Increased BMI and a diet containing meat, eggs, and milk were protective factors. The findings from this study provide support that adequate dietary protein can prevent sarcopenia in the elderly.



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