Sarcopenia
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  • ||||||||||  Clinical, Journal, HEOR:  Quality of life in cognitively impaired older adults. (Pubmed Central) -  Mar 13, 2020   
    For caregivers, however, the most relevant factor negatively affecting QOL was basic activities of daily living. Geriatr Gerontol Int 2019; 19: 999-1005.
  • ||||||||||  Review, Journal:  Updated concept of sarcopenia based on muscle-bone relationship. (Pubmed Central) -  Mar 13, 2020   
    Although many factors are supposed to be involved in the pathology and development of sarcopenia, precise mechanisms remain to be elucidated. Recent studies have also focused on the crosstalk between muscles and bones, including functional involvement of myokines and osteokines.
  • ||||||||||  Clinical, Review, Journal:  Controversies in Diagnosing Sarcopenia in Cirrhosis-Moving from Research to Clinical Practice. (Pubmed Central) -  Mar 13, 2020   
    Difficulties in diagnosis are partly driven by our ongoing limited understanding of the pathophysiology of sarcopenia in cirrhosis, the mechanisms by which it impacts on patient outcomes, the heterogeneity of patient populations, and the accuracy, availability and cost of assessments of muscle mass and function. This review discusses the currently studied diagnostic methods for sarcopenia in cirrhosis, and outlines why reaching a consensus on sarcopenia diagnosis is important and suggests potential ways to improve diagnostic criteria to allow us to translate sarcopenia research into improvements in clinical care.
  • ||||||||||  Journal:  Targeting Fundamental Aging Mechanisms to Treat Osteoporosis. (Pubmed Central) -  Mar 13, 2020   
    Bone anabolics seem to be the most appropriate therapeutic approach to osteoporosis in older persons. Considering that bone and muscle mass synchronically decline with aging thus predisposing older persons to falls and fractures, combined therapeutic approaches to osteosarcopenia with a dual anabolic effect on muscle and bone will be a major advance in the treatment of these devastating conditions in the future.
  • ||||||||||  Review, Journal:  Evidence-Based Role of Nutrients and Antioxidants for Chronic Pain Management in Musculoskeletal Frailty and Sarcopenia in Aging. (Pubmed Central) -  Mar 13, 2020   
    The review found the efficiency of the following topics: (a) accession of the patient to a dietary counselling (e.g., daily recommended amount of protein-equivalent to at least of 1 g of protein per kilogram of body weight); (b) intake of glutamic acid-rich such as soy, egg, and cod and tryptophan-rich foods such as milk and peanuts-or taking quick-acting, free-form supplements; (c) supplementation of vitamin D and magnesium, if lacking; (d) weekly consumption of fish or supplements of omega-3 fatty acids; and (e) availability of botanicals, in particular curcumin and gingerol. These non-pharmacological interventions can help the pain therapist to create a personalized medicine (precision medicine), acting with the maximum efficacy and safety, and also reducing the dosage of analgesic drugs needed.
  • ||||||||||  Journal:  Corticospinal Control of Human Locomotion as a New Determinant of Age-Related Sarcopenia: An Exploratory Study. (Pubmed Central) -  Mar 13, 2020   
    The novelty of this exploratory investigation is the hint toward a novel possible determinant of age-related sarcopenia, derived from corticospinal control of locomotion and shown by the observed large differences in CMC when sarcopenic and non-sarcopenic older adults are compared. This, in turn, might represent in future a potential treatment target to counteract sarcopenia as well as a parameter to monitor the progression of the disease and/or the potential recovery following other treatment interventions.
  • ||||||||||  Clinical, Journal:  The influence of trunk muscle strength on walking velocity in elderly people with sarcopenia. (Pubmed Central) -  Mar 13, 2020   
    In addition, the hip joint maximum flexion moment, ankle joint maximum plantar flexion moment, and walking velocity of participants in the sarcopenia group were significantly lower than those in the non-sarcopenia group. [Conclusion] This study revealed that weakness of the trunk muscle strength causes a decrease in walking velocity in elderly people with sarcopenia.
  • ||||||||||  Clinical, Journal:  Relationship between Sarcopenia and Mortality in Elderly Inpatients. (Pubmed Central) -  Mar 13, 2020   
    Sarcopenia in geriatric inpatients increased the length of hospital stay and mortality. Our findings may guide future studies examining the relationship between sarcopenia and mortality among elderly inpatients in other hospitals.
  • ||||||||||  Clinical, Journal:  Trunk fat mass correlates with balance and physical performance in a community-dwelling elderly population: Results from the Korean Frailty and aging cohort study. (Pubmed Central) -  Mar 12, 2020   
    In our study, we tried to check the correlation of tFMI with balance and physical performance and to determine the factors associated with tFMI.The tFMI was positively correlated with mean values of 4 m gait speed, repeat chair stand time in SPPB, TUG, and SARC-F and negatively correlated with hand grip, IADL, total balance test score in SPPB, total SPPB score, and age. The results of the multiple generalized linear model analysis that assessed the factors associated with balance and physical performance indicated that tFMI had a significant correlation with repeat chair stand time in SPPB (seconds) (Beta estimate [B]: 0.252), TUG (seconds) (B: 0.25), 4 m gait speed (seconds) (B: 0.055), and total balance score in SPPB (B: -0.035).Higher tFMI using DEXA was correlated with low physical performance and balance, indicating that trunk fat mass was associated with balance and physical performance in community-dwelling older people.
  • ||||||||||  Trial initiation date:  EFFORTcombo: The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Randomized Trial (clinicaltrials.gov) -  Mar 12, 2020   
    P3,  N=142, Not yet recruiting, 
    The results of the multiple generalized linear model analysis that assessed the factors associated with balance and physical performance indicated that tFMI had a significant correlation with repeat chair stand time in SPPB (seconds) (Beta estimate [B]: 0.252), TUG (seconds) (B: 0.25), 4 m gait speed (seconds) (B: 0.055), and total balance score in SPPB (B: -0.035).Higher tFMI using DEXA was correlated with low physical performance and balance, indicating that trunk fat mass was associated with balance and physical performance in community-dwelling older people. Initiation date: Jan 2020 --> Jun 2020
  • ||||||||||  Trial completion:  Roles of Uremic Toxins in Uremic Sacropenia (clinicaltrials.gov) -  Mar 11, 2020   
    P=N/A,  N=111, Completed, 
    Clinicaltrials.gov NCT03201926 Registered June 28, 2017, retrospectively registered. Active, not recruiting --> Completed
  • ||||||||||  Clinical, Review, Journal:  Promoting mobility and healthy aging in men: a narrative review. (Pubmed Central) -  Mar 10, 2020   
    Incorporating lifestyle interventions involving exercise and nutrition at a younger age can help prevent the age-related, progressive deterioration in bones, muscles, and joints that can reduce mobility in later life. Established barriers to physical activities (e.g., poor health, social isolation) in men are important to consider for optimizing outcomes.
  • ||||||||||  Clinical, Journal:  Sarcoscore: A Novel Approach for Assessing Sarcopenia and Functional Disability in Older Adults. (Pubmed Central) -  Mar 10, 2020   
    The adjusted HRs for IADL and BADL disabilities were reduced by 4% and 8% per point increase in the sarcoscore, respectively. The sarcoscore assessed the degree of sarcopenia and had a satisfactory performance for predicting functional disabilities in older Japanese adults, suggesting its usefulness as a complementary composite marker for clinical diagnosis.
  • ||||||||||  Clinical, Journal:  Sarcopenia in male patients with head and neck cancer receiving chemoradiotherapy: a longitudinal pilot study. (Pubmed Central) -  Mar 10, 2020   
    Patients with HNC undergoing 7 weeks of CRT showed clinically significant increases in the incidence of probable sarcopenia based on their total SARC-F score as well as clinically significant declines in handgrip strength, skeletal muscle mass and Timed Up and Go performance. Due to the relationship between sarcopenia and a host of adverse events related to CRT in HNC patients, these results suggest that oncologists and their allied health teams should routinely monitor these patients during CRT and provide the relevant exercise therapy and nutritional support to those patients in need.
  • ||||||||||  NN1213 / Novo Nordisk
    Trial completion date, Trial primary completion date:  Muscle Insulin Resistance in Aging (Mirage) (clinicaltrials.gov) -  Mar 10, 2020   
    P=N/A,  N=200, Active, not recruiting, 
    No abstract available Trial completion date: Nov 2019 --> Dec 2020 | Trial primary completion date: Nov 2019 --> Dec 2020
  • ||||||||||  Journal:  Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise. (Pubmed Central) -  Mar 9, 2020   
    Improvements in mitochondrial health and plasticity may mediate several beneficial effects of exercise in muscle. A greater understanding of the molecular changes that occur in the aged muscle following exercise and how they impact mitochondrial homeostasis is necessary for the exploration of potential targets that are amenable for interventions.
  • ||||||||||  Clinical, Journal:  Perioperative nutritional supplementation and skeletal muscle mass in older hip-fracture patients. (Pubmed Central) -  Mar 9, 2020   
    However, the effect of perioperative nutritional interventions on outcomes in elderly hip-fracture patients remains controversial. In this narrative review, an overview is presented of the existing literature on nutritional status and sarcopenia in elderly hip-fracture patients, clinical outcomes, and the effects of nutritional intervention on outcome and rehabilitation in this patient group.