Sarcopenia
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  • ||||||||||  Clinical, Journal:  Relative Handgrip Strength Diminishes the Negative Effects of Excess Adiposity on Dependence in Older Adults: A Moderation Analysis. (Pubmed Central) -  Apr 23, 2020   
    The present study demonstrated that (i) the adverse effect of having a higher WHtR level on dependence in ADL was moderated by relative HGS, and (ii) two moderation thresholds of relative HGS were estimated: 0.35, below which the adverse effect of WHtR levels on dependency is aggravated, and 0.62, above which the adverse effect of fat on dependency could be improved. Because muscular strength represents a critically important and modifiable predictor of ADL, and the increase in adiposity is inherent in aging, our results underscore the importance of an optimal level of relative HGS in the older adult population.
  • ||||||||||  Journal:  Prdx6 Plays a Main Role in the Crosstalk Between Aging and Metabolic Sarcopenia. (Pubmed Central) -  Apr 23, 2020   
    Muscle atrophy was also present in Prdx6 mice by the increase in Muscle RING finger 1 (MuRF1) levels and proteins ubiquitination associated to a reduction in muscle strength. The present study, innovatively, highlights a fundamental role of Prdx6, in the crosstalk between aging, sarcopenia, and DM.
  • ||||||||||  Clinical, Journal:  ESPEN guideline on clinical nutrition in liver disease. (Pubmed Central) -  Apr 22, 2020   
    A total of 85 recommendations were made for the nutritional and metabolic management of patients with acute liver failure, severe alcoholic steatohepatitis, non-alcoholic fatty liver disease, liver cirrhosis, liver surgery and transplantation as well as nutrition associated liver injury distinct from fatty liver disease. The recommendations are preceded by statements covering current knowledge of the underlying pathophysiology and pathobiochemistry as well as pertinent methods for the assessment of nutritional status and body composition.
  • ||||||||||  Clinical, Journal:  Reported Weight Change in Older Adults and Presence of Frailty. (Pubmed Central) -  Apr 21, 2020   
    The effectiveness of using executive function to serve as a prodromal marker of sarcopenia in PD patients should be evaluated in future studies. There is an association between frailty and reported weight loss over time while only weight gain in the last year has an association with frailty.
  • ||||||||||  Journal:  The Prevalence of Sarcopenia in Bipolar Disorder. (Pubmed Central) -  Apr 21, 2020   
    This is the first study that investigated SP in BD patients. Sarcopenia was found more frequently in BD patients than in the general population.
  • ||||||||||  Trial completion date, Trial suspension:  Dietary Nitrate and Muscle Power With Aging (clinicaltrials.gov) -  Apr 20, 2020   
    P1,  N=20, Suspended, 
    Recruiting --> Suspended Trial completion date: Aug 2020 --> Aug 2021 | Recruiting --> Suspended
  • ||||||||||  Journal:  Content of exercise programmes targeting older people with sarcopenia or frailty - findings from a UK survey. (Pubmed Central) -  Apr 18, 2020   
    Outcome measures suitable for assessing the effect of resistance training programmes were reported by fewer than half of respondents (hand grip: 13/119 [11%]; chair stands: 55/119 [46%]). Current UK exercise programmes offered to older people with sarcopenia or frailty lack the specificity, frequency or duration of exercise likely to improve outcomes for this patient group.
  • ||||||||||  Review, Journal:  Changes in the Paradigm of Traditional Exercise in Obesity Therapy and Application of a New Exercise Modality: A Narrative Review Article. (Pubmed Central) -  Apr 16, 2020   
    Hypoxic therapy has been reported to improve obesity and obesity-related diseases through appetite loss, reduced dietary intake, increased energy consumption, improved glycogen storage and fatty acid oxidation, angiogenesis and left ventricle remodeling, decreased mechanical load, and reduced sarcopenia progression due to aging. The new therapeutic exercise modalities, namely, high-intensity interval training, whole-body vibration training, and hypoxic therapy, are practical, useful, and effective for improving obesity and various metabolic and cardiovascular diseases induced by obesity.
  • ||||||||||  Clinical, Clinical data, Journal:  An interdisciplinary approach to the older transplant patient: strategies for improving clinical outcomes. (Pubmed Central) -  Apr 15, 2020   
    Prospective studies should confirm whether PMA or other body composition parameters should be extracted automatically from CT-scans to include in clinical decision making and outcome prediction for TAVI. As trends in the aging of the population continue to impact transplant and MCSD candidates and recipients, it is increasingly important for providers to be cognizant of the methods for assessment of aging-associated dysfunction including frailty and sarcopenia.
  • ||||||||||  Clinical, Journal:  Weight Cycling as a Risk Factor for Low Muscle Mass and Strength in a Population of Males and Females with Obesity. (Pubmed Central) -  Apr 15, 2020   
    As trends in the aging of the population continue to impact transplant and MCSD candidates and recipients, it is increasingly important for providers to be cognizant of the methods for assessment of aging-associated dysfunction including frailty and sarcopenia. In adults with obesity, weight cycling is associated with lower muscle mass and strength and a greater likelihood of developing sarcopenic obesity.