Sarcopenia
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  • ||||||||||  Review, Journal:  Supplements with purported effects on muscle mass and strength. (Pubmed Central) -  Apr 29, 2020   
    Interventional strategies to reduce ADT-related sarcopenia and sexual dysfunction should assess whether targeting these muscle groups, including the pelvic floor improves clinical outcomes.  In summary, despite their popularity, there is little evidence supporting the use of most supplements, and some of them have been even proven ineffective or potentially associated with adverse effects.
  • ||||||||||  Clinical, Journal:  Urinary sex steroid and glucocorticoid hormones are associated with muscle mass and strength in healthy adults. (Pubmed Central) -  Apr 29, 2020   
    The associations with muscle strength appear to be independent of muscle mass. Steroid hormones exert age-specific anabolic effects on lean mass and handgrip strength: Deficits in physical performance of aged muscles may be attenuated by androgens, whereas glucocorticoids in a physiological range increase skeletal muscle mass at all ages, and muscle strength in particular in younger adults.
  • ||||||||||  Clinical, Review, Journal:  Impact of Endurance and Resistance Training on Skeletal Muscle Glucose Metabolism in Older Adults. (Pubmed Central) -  Apr 28, 2020   
    While both types of exercise generally increase insulin sensitivity in older adults, the metabolic pathways through which this occurs can differ and can be dependent on preexisting conditions including obesity and type 2 diabetes. In this review, we will first highlight age-related changes to skeletal muscle which can contribute to insulin resistance, followed by a comparison of endurance and resistance training adaptations to insulin-stimulated glucose metabolism in older adults.
  • ||||||||||  Adlumiz (anamorelin) / Helsinn, Ono Pharma
    Clinical, Review, Journal:  Sarcopenia in patients with colorectal cancer: A comprehensive review. (Pubmed Central) -  Apr 28, 2020   
    A multimodal approach including nutritional support (dietary intake, high energy, high protein, and omega-3 fatty acids), exercise programs and anabolic-orexigenic agents (ghrelin, anamorelin), could contribute to muscle mass preservation. Addition of sarcopenia screening to the established clinical-pathological scores for patients undergoing oncological treatment (chemotherapy, radiotherapy or surgery) seems to be the next step for the best of care of CRC patients.
  • ||||||||||  Trial suspension:  DART: Dual-benefits of Aerobic and Resistance Training (clinicaltrials.gov) -  Apr 27, 2020   
    P=N/A,  N=30, Suspended, 
    Addition of sarcopenia screening to the established clinical-pathological scores for patients undergoing oncological treatment (chemotherapy, radiotherapy or surgery) seems to be the next step for the best of care of CRC patients. Recruiting --> Suspended
  • ||||||||||  Is Frailty Associated with Sarcopenia and Dynapenia in Lung Transplant Candidates? () -  Apr 26, 2020 - Abstract #ISHLT2020ISHLT_990;    
    Quadriceps muscle strength and power were associated with muscle CSA (r=0.44 and 0.47, respectively; p< 0.002) and echogenicity (r= -0.38 and -0.58, respectively; p< 0.008). Conclusion Mobility limitations appear to overlap with the frailty phenotype in lung transplant candidates, however the presence of sarcopenia and dynapenia may be distinct from frailty.
  • ||||||||||  Sarcopenia is Associated with Frailty in Lung Transplant Candidates () -  Apr 26, 2020 - Abstract #ISHLT2020ISHLT_964;    
    Conclusion Sarcopenia is associated with frailty in LT candidates by EWGSOP and ASM mass index lowest quartile definitions. Future studies should optimize sarcopenia definitions and determine if reducing sarcopenia improves LT outcomes.
  • ||||||||||  Journal:  Diagnosis and prevalence of sarcopenia in long-term care homes: EWGSOP2 versus EWGSOP1 (Pubmed Central) -  Apr 26, 2020   
    the prevalence of sarcopenia in institutionalized older adults is high, being remarkable that the majority of the participants had low muscle strength and low physical performance. The utilization of the methodology proposed by the EWGSOP2 did not have influence in the results of prevalence of sarcopenia obtained when the EWGSOP1 recommendations were applied.
  • ||||||||||  Clinical, Journal:  Sarcopenia assessment: from investigation to clinical practice (Pubmed Central) -  Apr 26, 2020   
    The utilization of the methodology proposed by the EWGSOP2 did not have influence in the results of prevalence of sarcopenia obtained when the EWGSOP1 recommendations were applied. No abstract available
  • ||||||||||  Clinical, Journal:  Muscle Weakness in Adults: Evaluation and Differential Diagnosis. (Pubmed Central) -  Apr 26, 2020   
    Electromyography is indicated when certain diagnoses are being considered, such as amyotrophic lateral sclerosis, myasthenia gravis, neuropathy, and radiculopathy, and may also guide biopsy. If the etiology remains unclear, specialist consultation or muscle biopsy may be necessary to reach a diagnosis.
  • ||||||||||  Clinical, Observational data, Journal:  Body Composition in Individuals with Obesity According to Age and Sex: A Cross-Sectional Study. (Pubmed Central) -  Apr 25, 2020   
    This study demonstrated that even though the WBLTM and FM are relatively constant with age, individuals with obesity present a localized redistribution of these two components. This body composition change leads to a decrease of the ALMI with age, one of the criteria included in the sarcopenia definition.
  • ||||||||||  Clinical, Reimbursement, Journal, Medicare:  Opportunistic Measurement of Skeletal Muscle Size and Muscle Attenuation on Computed Tomography Predicts One-year Mortality in Medicare Patients. (Pubmed Central) -  Apr 24, 2020   
    A one-unit standard deviation (SD) increase was associated with a HR=0.69 (95% CI=0.49, 0.96; p=0.03) for total muscle index, HR=0.67 (95% CI=0.49, 0.90; p<0.01) for psoas muscle index, HR=0.54 (95% CI=0.40, 0.74; p<0.01) for total muscle attenuation, and HR=0.79 (95% CI=0.66, 0.95; p=0.01) for psoas muscle attenuation. In older adults, higher skeletal muscle index and muscle attenuation on abdominopelvic CT examinations were associated with better survival, after adjusting for multiple risk factors.
  • ||||||||||  Biomarker, Journal:  MicroRNAs in skeletal muscle aging: Current issues and perspectives. (Pubmed Central) -  Apr 24, 2020   
    Over the years, miRNAs have emerged as promising candidates for biomarkers of sarcopenia and targets for interventions to slow muscle aging. Here we comprehensively review the current knowledge on the role of miRNAs in skeletal muscle aging and highlight their potential as biomarkers or therapeutic targets for skeletal muscle health.