Sarcopenia
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  • ||||||||||  SARCOPENIA IS ASSOCIATED WITH WORSE OUTCOMES IN ACUTE PANCREATITIS () -  May 4, 2020 - Abstract #DDW2020DDW_6925;    
    Handgrip strength assessments should be performed as a part of screening of CLD for predicting a high risk of falling as well as sarcopenia Acute pancreatitis patients with sarcopenia have significantly worse outcomes when compared with the patients without sarcopenia, including a severe form of pancreatitis, prolonged hospital stay, and higher ICU admissions
  • ||||||||||  FACTORS ASSOCIATED WITH SARCOPENIA OF ACTUAL 5-YEAR SURVIVORS WHO UNDERWENT PANCREATECTOMY () -  May 4, 2020 - Abstract #DDW2020DDW_5878;    
    Multivariate analysis revealed that body mass index <18.5 (p<0.001), Low serum cholesterol (p=0.013) were independently associated with sarcopenia. [Conclusions] Body mass index and serum cholesterol, but not serum albumin, were associated with low skeletal muscle index (sarcopenia) of actual 5-year survivors who underwent pancreatectomy.
  • ||||||||||  PREOPERATIVE SARCOPENIA IS A RISK FACTOR FOR INFECTIOUS COMPLICATIONS AND PROLONGED STAY IN CROHN’S DISEASE PATIENTS UNDERGOING INTESTINAL RESECTION. () -  May 4, 2020 - Abstract #DDW2020DDW_4116;    
    On univariate analysis, a history of smoking and sarcopenia were associated with postoperative infectious complications. On multivariate analysis, sarcopenia continued to be strongly associated with postoperative infectious complications (odds ratio [OR]: 4.61, 95%; confidence interval [CI]: 1.39-15.28) Conclusion In CD patients undergoing intestinal resection, radiographic sarcopenia was found to be associated with prolonged postoperative length of stay and significantly higher odds of developing infectious complications within the first 30 days postoperatively.
  • ||||||||||  CAN BASELINE FRAILTY METRICS PREDICT OUTCOMES IN NECROTIZING PANCREATITIS? () -  May 4, 2020 - Abstract #DDW2020DDW_3768;    
    Prehabilitation during NAT is a potential preventative measure to counteract sarcopenia that warrants further exploration. Baseline malnutrition and lower psoas muscle density are components of frailty that portend worse outcomes in NP.
  • ||||||||||  Review, Journal:  Osteoporosis in Older Persons: Old and New Players. (Pubmed Central) -  May 2, 2020   
    This review provides updated information on new discoveries on the combined pathophysiology of osteoporosis and sarcopenia that have led to the development of novel therapeutic approaches. New recommendations for the use of risk calculators and densitometry are also presented in this review as well as evidence on current and upcoming pharmacologic treatments to prevent falls and fractures in older persons.
  • ||||||||||  Clinical, Journal:  Glomerular filtration rate: when to measure and in which patients? (Pubmed Central) -  May 1, 2020   
    The recent standardization of mGFRs is a step in the right direction and may help in treating the individual patient with CKD with a lower risk of complications and a better quality of life. We call for research in these subgroups of patients where it is clinically felt that mGFR is useful for clinical decision-making.
  • ||||||||||  Journal:  Top-down Mass Spectrometry of Sarcomeric Protein Post-translational Modifications from Non-human Primate Skeletal Muscle. (Pubmed Central) -  May 1, 2020   
    Most PTM sites were localized, including Asn13 deamidation on MLC-2S; His73 methylation on αactin; N-terminal acetylation on most identified proteins; N-terminal tri-methylation on MLC-1S, MLC-1F, MLC-2S, and MLC-2F; Ser14 phosphorylation on MLC-2S; and Ser15 and Ser16 phosphorylation on MLC-2F. In summary, a comprehensive characterization of sarcomeric proteins including multiple isoforms and PTMs in NHP skeletal muscle was achieved by analyzing intact proteins in the top-down MS approach.
  • ||||||||||  Journal:  Nonalcoholic Fatty Liver Disease Is Associated With Low Skeletal Muscle Mass in Overweight/Obese Youths. (Pubmed Central) -  May 1, 2020   
    This is the first study to establish an independent association between low muscle mass and NAFLD/NASH in overweight/obese youths. Considering the worldwide increase of pediatric obesity, measurements of muscle mass may serve as useful method of identifying among obese children those at high metabolic risk who may need intensive lifestyle interventions to prevent NAFLD and its progression.
  • ||||||||||  Review, Journal:  Multiple MuSK signaling pathways and the aging neuromuscular junction. (Pubmed Central) -  May 1, 2020   
    However, elucidating the function of this receptor in this range of settings is challenging since MuSK participates in at least three signaling pathways: as a tyrosine kinase-dependent receptor for agrin-LRP4 and Wnts; and, as a kinase-independent BMP co-receptor. Here we focus on NMJ stability during aging and discuss open questions regarding the molecular mechanisms that govern active maintenance of the NMJ, with emphasis on MuSK and the potential role of its multiple signaling contexts.
  • ||||||||||  Preclinical, Journal:  Diaphragm Neuromuscular Transmission Failure in Aged Rats. (Pubmed Central) -  Apr 30, 2020   
    Here we focus on NMJ stability during aging and discuss open questions regarding the molecular mechanisms that govern active maintenance of the NMJ, with emphasis on MuSK and the potential role of its multiple signaling contexts. Since type IIx and/or IIb DIAm fibres (type FInt and/or FF motor units) display greater susceptibility to neuromuscular transmission failure at higher frequencies of stimulation, these data suggest that the age-related loss of larger phrenic motor neurons impacts nerve conduction to muscle at higher frequencies and may contribute to DIAm sarcopenia in old rats.
  • ||||||||||  Journal:  Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing. (Pubmed Central) -  Apr 30, 2020   
    Moreover, we demonstrated that miR-21 could inhibit myogenesis in vitro via regulating IL6R, PTEN and FOXO3 signalling. In summary, upregulation of miR-21 in satellite cells and muscle during ageing may occur in response to elevated levels of TNFα and IL6, within satellite cells or myofibrillar environment contributing to skeletal muscle ageing and potentially a disease-related decline in potential for muscle regeneration.
  • ||||||||||  Clinical, Review, Journal:  Common Musculoskeletal Disorders in the Elderly: The Star Triad. (Pubmed Central) -  Apr 30, 2020   
    Their pathophysiological common denominator is represented by progressive loss of (focal or generalized) neuromuscular performance with a risk of adverse outcomes such as pain, mobility disorders, increased risk of falls and fractures, and impaired ability or disability to perform activities of daily living. The precise management of these disorders requires not only the use of available tools and recently proposed operational definitions, but also the development of new tools and approaches for prediction, diagnosis, monitoring, and prognosis of the three disorders and their combination.
  • ||||||||||  Herceptin (trastuzumab) / Roche
    [VIRTUAL] Pectoralis muscle wasting during chemotherapy. () -  Apr 29, 2020 - Abstract #ASCO2020ASCO_5987;    
    More data is needed to understand the course of sarcopenia in terms of recovery and survivorship. Research Funding: None