Sarcopenia
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  • ||||||||||  Enrollment open:  Sarcopenia and Outcomes of Neuroplasty in Lumbar Spinal Stenosis (clinicaltrials.gov) -  May 21, 2020   
    P=N/A,  N=79, Recruiting, 
    The probability of major osteoporotic fracture and hip fracture was significantly higher in patients with RA and SP compared with patients without SP. Not yet recruiting --> Recruiting
  • ||||||||||  Journal:  The inter-relationship between marginal vitamin D deficiency and muscle. (Pubmed Central) -  May 21, 2020   
    Large-scale clinical trials with well defined cohorts and outcomes are needed to provide clinically meaningful insights into this area. Care should be taken to stratify participants by vitamin D status at baseline and over follow-up in addition to observing a range of measures of muscle function.
  • ||||||||||  PREOPERATIVE SARCOPENIA IS A RISK FACTOR FOR INFECTIOUS COMPLICATIONS AND PROLONGED STAY IN CROHN’S DISEASE PATIENTS UNDERGOING INTESTINAL RESECTION. (S105d) -  May 19, 2020 - Abstract #SSAT2020SSAT_284;    
    On univariate analysis, a history of smoking and sarcopenia were associated with postoperative infectious complications. On multivariate analysis, sarcopenia continued to be strongly associated with postoperative infectious complications (odds ratio [OR]: 4.61, 95%; confidence interval [CI]: 1.39-15.28)ConclusionIn CD patients undergoing intestinal resection, radiographic sarcopenia was found to be associated with prolonged postoperative length of stay and significantly higher odds of developing infectious complications within the first 30 days postoperatively.Psoas muscle measurementsPrimary outcomes analysis
  • ||||||||||  CAN BASELINE FRAILTY METRICS PREDICT OUTCOMES IN NECROTIZING PANCREATITIS? (S105d) -  May 19, 2020 - Abstract #SSAT2020SSAT_50;    
    On multivariate analysis, sarcopenia continued to be strongly associated with postoperative infectious complications (odds ratio [OR]: 4.61, 95%; confidence interval [CI]: 1.39-15.28)ConclusionIn CD patients undergoing intestinal resection, radiographic sarcopenia was found to be associated with prolonged postoperative length of stay and significantly higher odds of developing infectious complications within the first 30 days postoperatively.Psoas muscle measurementsPrimary outcomes analysis Baseline malnutrition and lower psoas muscle density are components of frailty that portend worse outcomes in NP.
  • ||||||||||  Clinical, Journal:  Musculoskeletal Factors and Geriatric Syndromes Related to the Absence of Musculoskeletal Degenerative Disease in Elderly People Aged over 70 Years. (Pubmed Central) -  May 19, 2020   
    There was no significant difference in age or gender between group N (n = 54) and group D (n = 225). Lower BMI and pain, including neuropathic pain; greater back muscle strength, physical ability, and balance with eyes closed; larger lumbar lordosis, sacral inclination, and lumbar ROM; and smaller spinal inclination were found in group N. The rates of LS and sarcopenia were significantly lower and QOL was significantly higher in group N. This study firstly revealed the significant musculoskeletal factors and geriatric syndromes related to an absence of MSD, which may form the basis of interventions to improve QOL in elderly people ≥70 years old.
  • ||||||||||  Clinical, Journal:  Evaluation of nutritional risk factors in hematopoietic stem cell transplantation-eligible patients. (Pubmed Central) -  May 19, 2020   
    Most patients in this sample were overweight and sarcopenic. Lean mass depletion was associated with risk of cardiovascular disease, reduced muscle strength, food intake changes, reduced functional capacity, self-reported well-nourished status and inadequate intake of vitamin B6 and manganese, but not with oxidative stress.
  • ||||||||||  Retrospective data, Review, Journal:  Skeletal Muscle Mass Change During Chemotherapy: A Systematic Review and Meta-analysis. (Pubmed Central) -  May 19, 2020   
    Lean mass depletion was associated with risk of cardiovascular disease, reduced muscle strength, food intake changes, reduced functional capacity, self-reported well-nourished status and inadequate intake of vitamin B6 and manganese, but not with oxidative stress. Oncologists should recognize sex-specific differences in skeletal muscle mass loss during chemotherapy and consider adjusting treatment accordingly.
  • ||||||||||  Journal:  Bone Mineral Density and Muscle Mass in Masters Olympic Weightlifters and Runners. (Pubmed Central) -  May 19, 2020   
    Lean mass was greater in OWLs versus RUNs (β = 0.29, p < .01), but did not relate to total body BMD (r = .15; p = .08). Greater total and regional BMD and lean mass in OWLs compared with RUNs may reduce risk for developing osteoporosis and/or sarcopenia and associated downstream health outcomes.
  • ||||||||||  Trial completion date, Trial primary completion date:  Prevalence of Sarcopenia and Undernutrition in Patients With Cirrhosis and Abdominal Hernia (clinicaltrials.gov) -  May 19, 2020   
    P=N/A,  N=140, Recruiting, 
    Greater total and regional BMD and lean mass in OWLs compared with RUNs may reduce risk for developing osteoporosis and/or sarcopenia and associated downstream health outcomes. Trial completion date: Apr 2020 --> Jun 2021 | Trial primary completion date: Jul 2019 --> Mar 2021
  • ||||||||||  Journal:  Extra-articular Manifestations and Comorbidity in Rheumatoid Arthritis: Potential Impact of Pre-Rheumatoid Arthritis Prevention. (Pubmed Central) -  May 17, 2020   
    A larger proportion of patients with RA have atherosclerosis, myocardial dysfunction, interstitial lung disease, and sarcopenia that is subclinical in the preclinical and earliest clinical phases of RA, emphasizing the importance of targeting the pre-RA phase for the prevention of comorbidities that are often poorly responsive to treatment once they develop. Herein, we review the potential impact of pre-RA prevention on the incidence and burden of extra-articular manifestations and nonarticular comorbidities.
  • ||||||||||  Clinical, Review, Clinical Trial,Phase I, Clinical Trial,Phase II, Journal:  Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis. (Pubmed Central) -  May 17, 2020   
    Administration of specialized, inflammation pro-resolving mediators has been shown to ameliorate the inflammatory manifestations. Considering all these findings, we hypothesize that sarcopenia, OBSP, CHF and dysbiosis are inflammaging-oriented disorders, whereby inflammaging is common and most probably the causative mechanism driving their pathogenesis.
  • ||||||||||  Review, Journal:  A ”Neuromuscular Look” to sarcopenia: Is it a movement disorder? (Pubmed Central) -  May 15, 2020   
    Treatments targeting muscle mass only would be insufficient unless we address the impairment of neurocognitive functions. It is essential that prescribing life-long exercise is important for healthy aging including the preservation of muscle mass/strength, physical and cognitive functioning, and independent living.