Sarcopenia
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  • ||||||||||  Journal:  Management of pancreatic exocrine insufficiency. (Pubmed Central) -  May 27, 2020   
    Increasing evidence supports the relevance of PEI management by dietary advice and appropriate PERT. Well designed and powered randomized, placebo-controlled clinical trials are needed to further evaluate the clinical impact of PEI and its treatment in clinical practice.
  • ||||||||||  Enrollment closed, Enrollment change, Trial completion date:  Time Course Adaptations Using Deuterated Creatine (D3Cr) Method (clinicaltrials.gov) -  May 27, 2020   
    P=N/A,  N=21, Active, not recruiting, 
    No abstract available Recruiting --> Active, not recruiting | N=34 --> 21 | Trial completion date: Jul 2020 --> May 2021
  • ||||||||||  Clinical, Review, Journal:  Review article: impact of exercise on physical frailty in patients with chronic liver disease. (Pubmed Central) -  May 26, 2020   
    Exercise improves key components of physical frailty (functional/aerobic capacity, sarcopenia) and quality of life in chronic liver disease and after liver transplantation. Understanding the type, compliance, intensity and duration of exercise and its impact on hard clinical outcomes should be the focus of future large controlled clinical trials.
  • ||||||||||  Trial completion date, Trial primary completion date:  Exercise Effects on Sarco-Osteopenia in Older Men (clinicaltrials.gov) -  May 26, 2020   
    P=N/A,  N=43, Active, not recruiting, 
    Understanding the type, compliance, intensity and duration of exercise and its impact on hard clinical outcomes should be the focus of future large controlled clinical trials. Trial completion date: Apr 2020 --> Oct 2020 | Trial primary completion date: Dec 2019 --> Aug 2020
  • ||||||||||  Journal:  Effects of Hormone Replacement Therapy on Sarcopenia: Is It Real? (Pubmed Central) -  May 23, 2020   
    Thus, cognitive impairment, diabetic peripheral neuropathy, and high serum phosphorus concentrations are associated with hand grip weakness in elderly patients with type 2 DM. No abstract available
  • ||||||||||  Journal:  Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells. (Pubmed Central) -  May 23, 2020   
    A lentiviral vector system was used to overexpress miR-34a in C2C12 cells, and EVs isolated from these transfected cells were observed to home to bone in vivo and to induce senescence and decrease Sirt1 expression of primary bone marrow cells ex vivo. These findings suggest that aged skeletal muscle is a potential source of circulating, senescence-associated EVs that may directly impact stem cell populations in tissues such as bone via their microRNA cargo.
  • ||||||||||  Trial completion date, Trial primary completion date:  Exercise and Nutrition to Improve Pancreatic Cancer Outcomes (clinicaltrials.gov) -  May 22, 2020   
    P=N/A,  N=60, Recruiting, 
    SO was independently associated with decreased eGFR in postmenopausal Korean women. Trial completion date: Feb 2020 --> Aug 2020 | Trial primary completion date: Feb 2020 --> Jul 2020
  • ||||||||||  [VIRTUAL] SARCOPENIA AND RHEUMATOID ARTHRITIS () -  May 22, 2020 - Abstract #EULAR2020EULAR_4210;    
    Patients with rheumatoid arthritis had not only bone tissue, but also skeletal muscle tissue disorders, resulting in a significant deterioration of functional capacity and quality of life. Given the significant medical and social significance of the problem, further studies into the mechanisms of pathogenesis, development of diagnostic methods, prevention and treatment of sarcopenia in patients with rheumatoid arthritis are required.
  • ||||||||||  [VIRTUAL] BODY COMPOSITION IN PATIENTS WITH RHEUMATOID ARTHRITIS () -  May 22, 2020 - Abstract #EULAR2020EULAR_4022;    
    Given the significant medical and social significance of the problem, further studies into the mechanisms of pathogenesis, development of diagnostic methods, prevention and treatment of sarcopenia in patients with rheumatoid arthritis are required. About 97% women with RA had abnormal body composition phenotype: 16,5% - OP, 8.9% -osteosarcopenia, 16,5% - osteosarcopenic obesity and 54,4% - overfat.
  • ||||||||||  [VIRTUAL] SARC-F PERFORMANCE FOR SARCOPENIA SCREENING IN PATIENTS WITH SYSTEMIC SCLEROSIS (Poster View) -  May 22, 2020 - Abstract #EULAR2020EULAR_3631;    
    This is the first study to evaluate the performance of SARC-F questionnaire for sarcopenia screening in patients with SSc. Although it appropriately identifies severe cases of sarcopenia, the SARC-F alone may not be an adequate screening tool in high-risk populations, such as SSc, that may benefit from early intervention and treatment.
  • ||||||||||  [VIRTUAL] PSORIATIC DISEASE AND BODY COMPOSITION: A SYSTEMATIC REVIEW OF THE LITERATURE () -  May 22, 2020 - Abstract #EULAR2020EULAR_3048;    
    There is an increased prevalence of metabolic, anthropometric and internal body composition derangements in psoriatic patients compared with controls, and these changes seem to be independent of obesity and the customary metabolic syndrome, including higher overall body fat, visceral fat and sarcopenia. Our study highlights the applicability of several imaging techniques in the evaluation of body composition in psoriatic patients, including some novel automated systems, and future studies should focus on validation and standardization of assessment tools both in research and clinical practice.
  • ||||||||||  [VIRTUAL] SARCOPENIA AND HIP FRACTURE IN GERIATRIC POPULATION () -  May 22, 2020 - Abstract #EULAR2020EULAR_2597;    
    SSc patients with most severe microvascular damage show a significantly altered body composition and bone status suggesting a strong link between microvascular failure and associated muscle/bone sufference. The presence of sarcopenia indicates consequently reduced functionality and a degree of disability in patients with hip fractures, slows recovery and increases the need for mobility aids, thus extending hospital stay and patient recovery.
  • ||||||||||  [VIRTUAL] SARCOPENIA IN PATIENTS WITH RHEUMATOID ARTHRITIS (Poster View) -  May 22, 2020 - Abstract #EULAR2020EULAR_2402;    
    Longer disease duration and higher disease activity should lead to development of sarcopenia due to chronic inflammation. Sarcopenia potentially effects patients’ social lives and daily functions and conceive decrease quality of life.