Sarcopenia
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  • ||||||||||  [VIRTUAL] Sarcopenia Predicts Worse Outcomes in Pediatric Liver Transplant Patients (Virtual) -  May 29, 2020 - Abstract #ATC2020ATC_1582;    
    Commonly accepted indicators of nutritional status such as skin fold measurements did correlate with measures of sarcopenia; however, PMSA may provide a more robust functional marker of overall health. Pediatric LT candidates with lower PMSA had more complicated post-transplant courses and were more likely to die.
  • ||||||||||  Clinical, Journal:  Lower-Extremity Torque Capacity and Physical Function in Mobility-Limited Older Adults. (Pubmed Central) -  May 29, 2020   
    Skeletal muscle torque capacity, a composite of strength and fatigue, may be a proximal determinant of physical function in mobility-limited older individuals. To more closely replicate the musculoskeletal demands of real-life tasks, future studies are encouraged to consider the combined interaction of distinct skeletal muscle faculties to overall functional ability in older adults.
  • ||||||||||  etoposide IV / Generic mfg.
    Journal:  Diet Modulation Restores Autophagic Flux in Damaged Skeletal Muscle Cells. (Pubmed Central) -  May 29, 2020   
    Interestingly, both dietary approaches were able to rescue myofiber from etoposide-induced damage. Glutamine supplementation, in particular, seemed to be a good strategy to preserve cell ultrastructure and functionality, by preventing the autophagic impairment and partially restoring the normal lysosomal activity, thus maintaining skeletal muscle homeostasis.
  • ||||||||||  Clinical, Journal:  Depression Severity as a Risk Factor of Sarcopenic Obesity in Morbidly Obese Patients. (Pubmed Central) -  May 29, 2020   
    Glutamine supplementation, in particular, seemed to be a good strategy to preserve cell ultrastructure and functionality, by preventing the autophagic impairment and partially restoring the normal lysosomal activity, thus maintaining skeletal muscle homeostasis. Depression is associated with a reduction of muscle function in severe obesity in relation to its severity and to changes in fat to fat-free mass, suggesting that screening and prevention of sarcopenic obesity should be considered in adult obese patients with depression.
  • ||||||||||  Journal:  Preoperative Diaphragm Function Is Associated With Postoperative Pulmonary Complications After Cardiac Surgery. (Pubmed Central) -  May 29, 2020   
    Depression is associated with a reduction of muscle function in severe obesity in relation to its severity and to changes in fat to fat-free mass, suggesting that screening and prevention of sarcopenic obesity should be considered in adult obese patients with depression. A low preoperative TFdi,max can help to identify patients at increased risk of postoperative pulmonary complications after cardiac surgery.
  • ||||||||||  Journal:  Associations of nutritional status and muscle size with mortality after open aortic aneurysm repair. (Pubmed Central) -  May 29, 2020   
    These results may be useful for identifying and optimizing treatment of high-risk patients who will not benefit from OSR so that endovascular aneurysm repair or no intervention can be recommended. Consideration of nutritional status and sarcopenia may therefore support the development of a more personalized, cost-effective treatment strategy.
  • ||||||||||  Clinical, Journal:  Clinical correlates of sarcopenia and falls in Parkinson's disease. (Pubmed Central) -  May 28, 2020   
    Sarcopenia and PD share common pathways and may affect each other's prognosis and patients' quality of life. Since sarcopenia is associated with lower quality of life and increased risk of falls, active case finding, diagnosis and proper management of sarcopenia in PD patients is essential.
  • ||||||||||  Journal:  The acute transcriptional response to resistance exercise: impact of age and contraction mode. (Pubmed Central) -  May 27, 2020   
    Following CON, 15 DE genes were young muscle-specific, whereas older muscle uniquely expressed 147 up-regulated genes enriched for cell adhesion and blood vessel development, and 28 down-regulated genes involved in mitochondrial respiration, amino acid and lipid metabolism. Thus, older age is associated with contraction-specific regulation often without clear functional relevance, perhaps reflecting a degree of stochastic age-related dysregulation.