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46 Companies |
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12 Products |
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12 Products |
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17 Mechanisms of Action |
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756 Trials |
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22406 News |
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- | NN1213 / Novo Nordisk
Trial completion: The Physical Fitness Cohort Study in the Community-dwelling Elderly in the WanHwa Area. (clinicaltrials.gov) - Jun 11, 2020
P=N/A, N=66, Completed, Sponsor: National Taiwan University Hospital
Recruiting --> Completed
- | Journal: Response: Sarcopenia Is Significantly Associated with Presence and Severity of Nonalcoholic Fatty Liver Disease (J Obes Metab Syndr 2019;28:129-38). (Pubmed Central) - Jun 11, 2020
Recruiting --> Completed No abstract available
- ||| Grand rounds: Grand Rounds Part 2, @bilenma reviews recent research in GU oncology, risk stratification, inflammation, sarcopenia #kidneycancer #medonc @SES_AUA https://t.co/Y52jjb1Lqj (Twitter) - Jun 10, 2020
- | Biomarker, Journal: Sarcopenia is an effective prognostic indicator of postoperative outcomes in laparoscopic-assisted gastrectomy. (Pubmed Central) - Jun 10, 2020
No abstract available Sarcopenia is an independent clinical predictor of short-term postoperative complications after laparoscopic-assisted gastrectomy.
- | Clinical, Journal: Decreased total psoas muscle area after neoadjuvant therapy is a predictor of increased mortality in patients undergoing oesophageal cancer resection. (Pubmed Central) - Jun 10, 2020
A decrease in TPA of >4% is associated with a significantly higher risk of post-operative mortality in patients undergoing neoadjuvant therapy followed by oesophagectomy. Measuring the loss of TPA during neoadjuvant treatment could be a novel aid to preoperative risk assessment.
- ||| Preclinical: #COVID19: a major cause of #cachexia and #sarcopenia? Animal studies have shown that #coronavirus‐2 causes #weightloss in animals associated with an increase in inflammatory #cytokines. In humans, COVID‐19 causes #anorexia, weight loss and low #albumin. https://t.co/Dx0cl8aTK1 (Twitter) - Jun 10, 2020
- | Journal: Editorial: Screening for Sarcopenia. (Pubmed Central) - Jun 9, 2020
Measuring the loss of TPA during neoadjuvant treatment could be a novel aid to preoperative risk assessment. No abstract available
- | Clinical, Clinical guideline, Journal: Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management. (Pubmed Central) - Jun 9, 2020
No recommendation was given for systematic additional therapies such as cognitive therapy, problem-solving therapy, vitamin D supplementation, and hormone-based treatment. Pharmacological treatment as presently available is not recommended therapy for the treatment of frailty.
- | Clinical, Journal: Effect of a Resistance Training Program on Sarcopenia and Functionality of the Older Adults Living in a Nursing Home. (Pubmed Central) - Jun 9, 2020
Pharmacological treatment as presently available is not recommended therapy for the treatment of frailty. The resistance training program improves the functionality (muscle strength and physical performance), with the benefit of the decrease in severe sarcopenia.
- | Journal: Development and Validation of a Tool to Screen for Cognitive Frailty among Community-Dwelling Elders. (Pubmed Central) - Jun 9, 2020
The resistance training program improves the functionality (muscle strength and physical performance), with the benefit of the decrease in severe sarcopenia. A CFR score based on simple history-taking and anthropometric measurements integrates age, sex, cardiometabolic risk, memory deficits, sarcopenia, and nutrition, with validated predictive accuracy, and could be performed easily in community settings to identify seniors with cognitive frailty for appropriate interventions.
- | Clinical, Journal: Reduction of Resting Energy Expenditure and Sarcopenic Obesity in Adults with Overweight and Obesity: A Brief Report. (Pubmed Central) - Jun 9, 2020
SO appears to be present in a high proportion of treatment-seeking adults with overweight or obesity of both genders, and it seems to be associated with a reduced REE, compared with those without SO. Future studies are needed to clarify whether this may influence clinical outcomes.
- | Preclinical, Journal: Promotion of oxidative stress is associated with mitochondrial dysfunction and muscle atrophy in aging mice. (Pubmed Central) - Jun 9, 2020
These findings have important implications for the mechanisms that underlie sarcopenia and frailty processes. Geriatr Gerontol Int 2020; 20: 78-84.
- || Review, Journal: Association between sarcopenia and pneumonia in older people. (Pubmed Central) - Jun 9, 2020
Evaluation and management of sarcopenia could potentially become a new strategy to prevent and treat pneumonia in older patients, and research has only recently been launched. Geriatr Gerontol Int 2019; ••: ••-••.
- || Clinical, Journal: Intervention with erythropoietin in sarcopenic patients with femoral intertrochanteric fracture and its potential effects on postoperative rehabilitation. (Pubmed Central) - Jun 9, 2020
Therefore, postoperative administration of EPO might potentially promote rapid postoperative rehabilitation. Geriatr Gerontol Int 2020; 20: 150-155.
- | Review, Journal: Skeletal Muscle Aging Atrophy: Assessment and Exercise-Based Treatment. (Pubmed Central) - Jun 9, 2020
Some researchers have highlighted the efficacy of the combination of the mentioned strategies. In this chapter, we will focus only on physical exercise as a strategy to reduce skeletal muscle loss during aging.
- | Review, Journal: The Role of Nutrition in Attenuating Age-Related Skeletal Muscle Atrophy. (Pubmed Central) - Jun 9, 2020
Supplemental, hormonal, and pharmacological approaches have been attempted to attenuate sarcopenia but these have not achieved outstanding results. In this review, we summarize the current knowledge of nutrition-based therapies for counteracting sarcopenia.
- || Review, Journal: Metabolic Impacts of Confinement during the COVID-19 Pandemic Due to Modified Diet and Physical Activity Habits. (Pubmed Central) - Jun 9, 2020
Moreover, hypertension, diabetes, and cardiovascular disease have been identified as potential risk factors for more severely ill patients with COVID-19. Thus, adequate control of metabolic disorders could be important to reduce the risk of severe COVID-19.
- | Journal: Sarcopenia in Hemiplegia. (Pubmed Central) - Jun 9, 2020
Suggestions have been made concerning general treatment and management of sarcopenia, associated with exercise, diet and the use of medical preparations, lacking though disease-specific guidelines for management, treatment and possibly prevention of stroke-related sarcopenia. Nowadays, it is considered of major importance that the medical community should be properly informed and to raise awareness on this particular issue aiming to a better and holistic management of the patients after a cerebrovascular accident, in order to reduce morbidity and disability that both are sequelae that reduce quality of life.
- || No slides etc. as we never presented it (costs a little too high for conference). Full abstract here: https://t.co/ZSOK3QfFdU Paper draft done with full analysis including predictors of sarcopenia, and risk of dialysis (Twitter) - Jun 9, 2020
- | New trial: Preventing Bed-rest Induced Muscle Loss in the Elderly (clinicaltrials.gov) - Jun 8, 2020
P=N/A, N=20, Completed, Sponsor: University of Birmingham
- || Clinical, Retrospective data, Journal: The IMPACT study: early loss of skeletal muscle mass in advanced pancreatic cancer patients. (Pubmed Central) - Jun 8, 2020
Early LSMM ≥ 10% has a negative prognostic role in advanced PC patients. Further prospective investigations are needed to confirm these preliminary data.
- | Journal: Relative sarcopenia and mortality and the modifying effects of chronic kidney disease and adiposity. (Pubmed Central) - Jun 8, 2020
Relative sarcopenia is nearly three-fold more prevalent amplifying its associated mortality risk at the population level. The association between relative sarcopenia and mortality is attenuated in persons with higher FMI.
- || Clinical, Journal: Easy surveillance of muscle volume decline in chronic liver disease patients using finger-circle (yubi-wakka) test. (Pubmed Central) - Jun 8, 2020
The association between relative sarcopenia and mortality is attenuated in persons with higher FMI. The finger-circle test is an easy to perform and effective screening method for predicting earlier stage of MA in CLD patients without the need for special equipment.
- | Review, Journal: Cachexia and advanced dementia. (Pubmed Central) - Jun 8, 2020
The present narrative review is aimed at presenting recent insights concerning the pathophysiology of weight loss and wasting syndrome in dementia, the putative mechanisms involved in the dysregulation of energy balance, and the interplay among the chronic clinical conditions of sarcopenia, malnutrition, and frailty in the elderly. We discuss the clinical implications of these new insights, with particular attention to the challenging question of nutritional needs in advanced dementia and the utility of tube feeding in order to optimize the management of end-stage dementia.
- | Journal: Assessment of renal function in cirrhosis: Sarcopenia, gender and ethnicity matter. (Pubmed Central) - Jun 8, 2020
We discuss the clinical implications of these new insights, with particular attention to the challenging question of nutritional needs in advanced dementia and the utility of tube feeding in order to optimize the management of end-stage dementia. No abstract available
- || Clinical, Journal: Is cachexia associated with chemotherapy toxicities in gastrointestinal cancer patients? A prospective study. (Pubmed Central) - Jun 8, 2020
No abstract available Cachexia and ECOG score may identify patients with an increased risk for developing severe toxicity events during chemotherapy treatment for gastrointestinal cancer.
- | Journal: Sarcopenia: Ammonia metabolism and hepatic encephalopathy. (Pubmed Central) - Jun 8, 2020
Besides other factors, hyperammonemia has recently gained attention and increase sarcopenia by various mechanisms including increased expression of myostatin, increased phosphorylation of eukaryotic initiation factor 2a, cataplerosis of α ketoglutarate, mitochondrial dysfunction, increased reactive oxygen species that decrease protein synthesis and increased autophagy-mediated proteolysis. Sarcopenia contributes to frailty and increases the risk of minimal and overt hepatic encephalopathy.
- | Observational data, Retrospective data, Journal: The association between six month intra-dialytic resistance training and muscle strength or physical performance in patients with maintenance hemodialysis: a multicenter retrospective observational study. (Pubmed Central) - Jun 8, 2020
Sarcopenia contributes to frailty and increases the risk of minimal and overt hepatic encephalopathy. Six-month resistance training was associated with improved muscle strength and physical performance in patients with MHD.
- | Clinical, Journal: Effects of photobiomodulation on muscle strength in post-menopausal women submitted to a resistance training program. (Pubmed Central) - Jun 8, 2020
Quality of life (p = 0.015) and balance (p = 0.006) increased only in the RTG. The results suggest that PBM were not able for inducing additional benefits to RT to improve muscle strength in post-menopausal women.
- || Clinical, Review, Journal: Clinical relevance of skeletal muscle abnormalities in patients with cirrhosis. (Pubmed Central) - Jun 8, 2020
Moreover, inclusion of these muscle abnormalities within the current organ allocation policies might lead to a better mortality risk assessment in patients awaiting liver transplant and even to a decrease in the rates of futile liver transplants. This review summarizes the current knowledge regarding the modalities to evaluate skeletal muscle abnormalities in cirrhosis, the incidence and clinical impact of these abnormalities in cirrhosis; existing and potential novel therapeutic strategies are also discussed.
- | Journal: Malnutrition, sarcopenia, and refractory ascites in end stage liver diseases: is there a way to climb back up? (Pubmed Central) - Jun 8, 2020
This review summarizes the current knowledge regarding the modalities to evaluate skeletal muscle abnormalities in cirrhosis, the incidence and clinical impact of these abnormalities in cirrhosis; existing and potential novel therapeutic strategies are also discussed. No abstract available
- || Clinical, Journal: Protein supplementation combined with low-intensity resistance training in geriatric medical patients during and after hospitalization: a randomized, double-blind, multicenter trial. (Pubmed Central) - Jun 8, 2020
Participants were randomly allocated (1:1) to receive PrS (totally 27.5 g whey protein/day, ≈2000 kJ/day) or iso-energetic placebo-products (0.05). In conclusion, PrS increasing total protein intake by 0.4 and 0.2 g/kg/d during hospitalization and after discharge, respectively, does not seem to increase the adaptive response to low intensity/volume RT in geriatric medical patients.
- | Journal: Muscle psoas indices measured by ultrasound in cirrhosis - Preliminary evaluation of sarcopenia assessment and prediction of liver decompensation and mortality. (Pubmed Central) - Jun 8, 2020
In conclusion, PrS increasing total protein intake by 0.4 and 0.2 g/kg/d during hospitalization and after discharge, respectively, does not seem to increase the adaptive response to low intensity/volume RT in geriatric medical patients. Ultrasound measurement of psoas muscle diameter and its derived indices is applicable and associated with hospitalization and mortality in patients with decompensated liver cirrhosis.
- | Journal: The additive value of sarcopenia, myosteatosis and hepatic encephalopathy in the predictivity of model for end-stage liver disease. (Pubmed Central) - Jun 8, 2020
The accuracy of MELD in predicting 3- and 6-months mortality may be improved by considering the muscle alterations. A model considering the above parameters may classify more accurately over 30% of the patients.
- | metformin / Generic mfg.
Preclinical, Journal: Long-Term Moderate Exercise Combined with Metformin Treatment Induces an Hormetic Response That Prevents Strength and Muscle Mass Loss in Old Female Wistar Rats. (Pubmed Central) - Jun 8, 2020
Our results suggest- that the MTF administration, both in the sedentary and the exercise groups, might activate a mechanism that is directly related to the induction of the hormetic response through the redox state modulation. MTF treatment does not eliminate the beneficial effects of exercise throughout life, and although MTF does not increase muscle mass, it increases longevity.
- | Journal: Preventing endothelial cell-mediated muscle satellite cell dysfunction: A new hot topic? (Pubmed Central) - Jun 8, 2020
MTF treatment does not eliminate the beneficial effects of exercise throughout life, and although MTF does not increase muscle mass, it increases longevity. No abstract available
- || Clinical, Journal: What Factors Affect Changes in Body Composition and Swallowing Function in Patients Hospitalized for Oral Cancer Surgery? (Pubmed Central) - Jun 8, 2020
Postoperative chemoradiotherapy is a risk factor for weight loss, muscle mass loss, and dysphagia at discharge, and chemoradiotherapy may affect rather than an invasion of surgery. After surgery, besides follow-ups for cancer, oral cancer patients should be followed up to assess dysphagia, undernutrition, and sarcopenia.
- || Clinical, Review, Journal: Management of The Elderly Cancer Patients Complexity: The Radiation Oncology Potential. (Pubmed Central) - Jun 7, 2020
However, though widely used, there are limited clinical trials strictly designed for the elderly. This paper will review the key points in the assessment and treatment of elderly cancer patient including quality of life, active life expectancy, cognitive performance, frailty, sarcopenia and how the new technologies can help to reach the key goal of maintaining autonomy and independence for the elderly cancer patient.
- || Review, Journal: Sarcopenia: Current treatments and new regenerative therapeutic approaches. (Pubmed Central) - Jun 6, 2020
Translational potential: This review summarizes the causes underlying sarcopenia from the perspective of mitochondria dysfunction and age-associated inflammation, and the progress of clinical trials for the treatment of sarcopenia. We also propose therapeutic potential of stem cell therapy and bioactive secretome for sarcopenia.
- || Clinical, Journal: Study of the Older Adults' Motivators and Barriers Engaging in a Nutrition and Resistance Exercise Intervention for Sarcopenia: An Embedded Qualitative Project in the MIlkMAN Pilot Study. (Pubmed Central) - Jun 6, 2020
Barriers to maintenance included affordability, environmental factors, and concerns over negative health outcomes. Nutrition and RE interventions for sarcopenia should focus on knowledge acquisition about their health benefits, being enjoyable, and offering social opportunities that have the potential to last beyond the study duration to promote and maintain positive health behaviors.
- | Journal: Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing's Disease. (Pubmed Central) - Jun 6, 2020
Circulating irisin levels tend to be lower in patients with active CD compared to those with controlled CD and controls. They are strongly associated with osteosarcopenia and central obesity in CD and therefore may be a possible marker of diagnosis.
- | Preclinical, Journal: Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development. (Pubmed Central) - Jun 6, 2020
Future use of molecules based on a similar mode of action to promote muscle growth should be carefully profiled for adverse side-effects on the testis. However the effectiveness of sActRIIB as a modulator of Activin function provides a possible therapeutic strategy to alleviate testicular seminoma development.
- | Journal: Thirty years of translational research in Mobility Medicine: Collection of abstracts of the 2020 Padua Muscle Days. (Pubmed Central) - Jun 6, 2020
The excellent contents of this Collection of Abstracts reflect the high scientific caliber of researchers and clinicians who are eager to present their results at the PaduaMuscleDays. A series of EJTM Communications will also add to this preliminary evidence.
- || Clinical, Journal: Leisure-time physical activity at moderate and high intensity is associated with parameters of body composition, muscle strength and sarcopenia in aged adults with obesity and metabolic syndrome from the PREDIMED-Plus study. (Pubmed Central) - Jun 5, 2020
Total-PA and PA at moderate and high intensities may protect against the prevalence of sarcopenia, have a beneficial role on body composition and prevent loss of muscle strength. SB, particularly TV-viewing, may have detrimental effects on body composition in older adults at high cardiovascular risk.
- | Retrospective data, Journal: Validation of the sarcopenia index to assess muscle mass in the critically ill: A novel application of kidney function markers. (Pubmed Central) - Jun 5, 2020
A low SI was associated with longer hospital length of stay and frailty. Future studies could explore whether the use of SI assists with identifying patients likely to benefit from pharmacotherapy-, nutrition-, or physical therapy-based interventions.
- | Journal: The effect of acute oral phosphatidic acid ingestion on myofibrillar protein synthesis and intracellular signaling in older males. (Pubmed Central) - Jun 5, 2020
P=N/A
Acute oral phosphatidic acid ingestion appears to interfere with resistance exercise-induced intramuscular anabolic signaling and MyoPS in older males and, therefore, may not be a viable treatment to counteract sarcopenia. Clinicaltials.gov registration no: NCT03446924.
- | Journal: Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner. (Pubmed Central) - Jun 5, 2020
Clinicaltials.gov registration no: NCT03446924. Nrf2 deficiency exacerbated frailty and sarcopenia during aging, at least partially by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner.
- || Clinical, Journal: Sarcopenia-related parameters in adults with Down syndrome: A cross-sectional exploratory study. (Pubmed Central) - Jun 5, 2020
Findings from this exploratory study indicate that adults with DS show muscle mass indexes and physical performance levels similar to or lower than older adults with sarcopenia. The assessment of muscle mass and functional status should therefore be included in the routine evaluation of this population starting at young age.
- | Preclinical, Journal: A follistatin-based molecule increases muscle and bone mass without affecting the red blood cell count in mice. (Pubmed Central) - Jun 5, 2020
In both ovariectomized and naive mice, FST-mFc therapy did not influence red blood cell count or hematocrit or hemoglobin levels. If the results are reproduced, a human FST-mFc version could be applicable in patients with musculoskeletal conditions irrespective of hematocrit status.-Lodberg, A., van der Eerden, B. C. J., Boers-Sijmons, B., Thomsen, J. S., Brüel, A., van Leeuwen, J. P. T. M., Eijken, M. A follistatin-based molecule increases muscle and bone mass without affecting the red blood cell count in mice.
- || Biomarker, Clinical, Journal, HEOR: Body Composition, Serum Biomarkers of Inflammation and Quality of Life in Clinically Stable Women with Estrogen Receptor Positive Metastatic Breast Cancer. (Pubmed Central) - Jun 5, 2020
The abPGSGA did not differentiate women with sarcopenia. Future interventions should test if improvements in body composition are associated with better outcomes for this vulnerable, emerging population.