Sarcopenia
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  • ||||||||||  Clinical, Review, Journal:  Attenuation of frailty in older adults with mesenchymal stem cells. (Pubmed Central) -  Jun 26, 2020   
    These studies have formed the basis for larger ongoing trials. Here we review the pathobiology of frailty, and the potential for developing biological strategies to treat this important syndrome.
  • ||||||||||  Journal:  Prognostic networks for unraveling the biological mechanisms of Sarcopenia. (Pubmed Central) -  Jun 26, 2020   
    Additionally, we applied logistic regression analysis to propose the interplay among the most discriminative biological variables of Sarcopenia: anthropometry, body composition, functional performance of lower limbs, systemic oxidative stress, presence of depression and medication for the digestive system based on proton-pump inhibitors. Our data also demonstrate that besides a loss of muscle mass, impairments on functional performance of lower limbs are more relevant for develop Sarcopenia than those affecting the muscle strength.
  • ||||||||||  Clinical, Journal:  Evaluation of the impact of sarcopenia in patients with acute mesenteric ischemia. (Pubmed Central) -  Jun 25, 2020   
    It is also and possibly more importantly, a systemic disorder requiring a special awareness, a multidisciplinary approach and a multidimensional vision. Further studies on longer follow-up period would be of interest to fully understand the prognostic value of sarcopenia in patients with acute mesenteric ischemia.
  • ||||||||||  Clinical, Journal:  Predictive value of serum creatinine/cystatin C in neurocritically ill patients. (Pubmed Central) -  Jun 25, 2020   
    Further studies on longer follow-up period would be of interest to fully understand the prognostic value of sarcopenia in patients with acute mesenteric ischemia. Serum Cr/CysC ratio at admission could be used as a predictor of long-term poor prognosis in neurocritically ill patients.
  • ||||||||||  Review, Journal:  COVID-19 and Older People in Asia: AWGS Calls to Actions. (Pubmed Central) -  Jun 25, 2020   
    Thus, the Asian Working Group for Sarcopenia summarized the considerations of Asian countries focusing on responses and difficulties in each country, impacts of health inequity related to COVID-19 pandemic and proposed recommendations for older people which are germane to the Asian context. More innovative services should be developed to address the increasing demands for new approaches to deliver health care in the difficult times and to establish resilient health care systems for older people.
  • ||||||||||  Biomarker, Trial completion date, Trial primary completion date:  Effect of Fermented Oyster Extract on Musculoskeletal Biomarkers in Relative Sarcopenia Adults (clinicaltrials.gov) -  Jun 23, 2020   
    P=N/A,  N=54, Recruiting, 
    More innovative services should be developed to address the increasing demands for new approaches to deliver health care in the difficult times and to establish resilient health care systems for older people. Trial completion date: May 2020 --> Dec 2020 | Trial primary completion date: Apr 2020 --> Dec 2020
  • ||||||||||  Journal:  Impact of Sarcopenia on Early Postoperative Complications in Early-Stage Non-Small-Cell Lung Cancer. (Pubmed Central) -  Jun 23, 2020   
    The predictors of overall complications were low PVI (odds ratio [OR], 2.18; 95% confidence interval [CI], 1.07-4.09; p=0.03), low hemoglobin level (OR, 0.686; 95% CI, 0.54-0.87; p=0.002), and smoking history (OR, 3.93; 95% CI, 2.03-7.58; p<0.001). Low PVI was associated with a higher rate of early postoperative complications in patients with early-stage NSCLC.
  • ||||||||||  Review, Journal:  Sarcopenic obesity: a new challenge in the practical clinic. (Pubmed Central) -  Jun 23, 2020   
    Although there is no clear consensus on its definition and diagnostic methods, there is a growing interest in finding biomarkers useful for the detection and monitoring. Regarding the treatment, a multimodal approach is recomended, based on dietary recommendations, exercise and eventually bariatric surgery.
  • ||||||||||  [VIRTUAL] Diabetes Risk for Non-Obese Subjects in a Japanese Population () -  Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_1053;    
    Increased risk of developing diabetes was observed among non-obese individuals with suspected sarcopenia. This study suggests that maintenance of muscle mass may be an effective countermeasure to reduce the risk of developing diabetes.
  • ||||||||||  [VIRTUAL] The Impact of Micronutrients on Cellular Metabolism and Healthy Aging () -  Jun 20, 2020 - Abstract #ENDOI2020ENDO-I_641;    
    Micronutrients are involved in nearly all cellular processes, inadequacies or deficiencies may accelerate cellular aging and increase risk for chronic diseases later in life.1 Optimizing micronutrient intake may help reduce the risk for developing certain age-related conditions/diseases, including osteopenia/osteoporosis,2 sarcopenia,3 falls,4 mild cognitive impairment,5 immunosenescence,6 impaired resilience,7 hypertension,8 cataracts,9 and age-related macular degeneration.10 The importance of calcium and vitamin D for maintaining bone health has been established,2 but these micronutrients may also be involved with muscle health and reducing the risk for falls and consequent bone fractures in later life.11 Vitamin D may also be involved in stress management and resilience.12 Vitamins C, D, and E, zinc, selenium, and other micronutrients are necessary for healthy immune system function,13,14 and vitamin E is important for cognition,15 immune competence,16 and eye health.10 Although these micronutrients are individually involved with these processes by acting as antioxidants, hormonal regulators of gene expression, or cofactors in enzymatic reactions, there are also important interactions between micronutrients to consider (eg, calcium/vitamin D in musculoskeletal health). Importantly, a significant proportion of the aging population does not meet the recommended intake of many micronutrients.17 Clinical trials on the benefits of micronutrient supplementation have not been conclusive, but adequate intake should be considered an essential component of comprehensive healthcare for older adults.
  • ||||||||||  Journal:  Association of sarcopenia with performance in multiple cognitive domains: results from the ELSA-Brasil study. (Pubmed Central) -  Jun 19, 2020   
    The study demonstrates that in healthy elderly subjects an EAA-based multi-ingredient nutritional supplementation of 12 weeks is not effective to change myoelectric manifestation of fatigue and TtT failure but can positively affect muscle mass, muscle strength, muscle power and VAT, counterbalancing more than one year of age-related loss of muscle mass and strength. Sarcopenia was associated with poorer performance on the verbal fluency test and low muscle strength was associated with poorer performance in all cognitive tests in middle-aged and older adults.
  • ||||||||||  Journal:  The role of the microcirculation in muscle function and plasticity. (Pubmed Central) -  Jun 19, 2020   
    If so, stimulation of angiogenesis by for instance endurance training before a hypertrophic stimulus may enhance the hypertrophic response. The microcirculation may thus well be a little-explored target to improve muscle function and the success of rehabilitation programmes during ageing and chronic diseases.
  • ||||||||||  Clinical, Journal:  Association between Sarcopenia and Overactive Bladder in Elderly Diabetic Patients. (Pubmed Central) -  Jun 19, 2020   
    This study found that sarcopenia was significantly associated with OAB in elderly diabetic male patients based on SARC-F-J. Moreover, the possibility of the development of OAB should be considered during the medical examinations of elderly diabetic male patients with sarcopenia.
  • ||||||||||  Clinical, Journal:  Come in from the Cold: Are Older Adults Who Live in Colder Climates at Greater Risk for Sarcopenia? (Pubmed Central) -  Jun 19, 2020   
    Ultrasound measurement in the aging muscle might be promising, and further studies should validate its application in the context of dynapenia. The operational definition of "sarcopenia", an age-related skeletal muscle disease resulting from adverse changes that accrue across the lifetime, was recently updated by the European Working Group on Sarcopenia in Older People (EWGSOP) [...].
  • ||||||||||  Clinical, Journal:  Sarcopenia Is Related to Mortality in the Acutely Hospitalized Geriatric Patient. (Pubmed Central) -  Jun 18, 2020   
    Among older Chinese inpatients in the present study, prealbumin levels were negatively correlated with sarcopenia incidence, when prealbumin levels were below 265.9mg/L. Sarcopenia is prevalent in acutely hospitalized geriatric patients and is associated with significantly higher 2-year mortality according the EWGSOP and FNIH criteria.
  • ||||||||||  Review, Journal:  Genetics of Bone and Muscle Interactions in Humans. (Pubmed Central) -  Jun 18, 2020   
    It is clear that the study of pleiotropy may provide novel insights into disease pathophysiology potentially leading to the identification of new treatment strategies that simultaneously prevent or treat both osteoporosis and sarcopenia. However, the role of muscle factors (myokines) that stimulate bone metabolism, as well as osteokines that affect muscles, is in its earliest stage of understanding.
  • ||||||||||  Clinical, Journal:  Reduced Mitochondrial Content, Elevated ROS, and Modulation by Denervation in Skeletal Muscle of Pre-frail/Frail Elderly Women. (Pubmed Central) -  Jun 18, 2020   
    Consistent with a significant accumulation of neural cell adhesion molecule positive muscle fibers in FE (indicative of denervation), a 50% reduction in ROS production after pharmacologically inhibiting the denervation-mediated ROS response in FE women suggests a significant modulation of mitochondrial function by denervation. In conclusion, our data support the hypothesis that denervation plays a modulating role on skeletal muscle mitochondrial function in FE women, suggesting therapeutic strategies in advanced age should focus on the causes and treatment of denervation.