Sarcopenia
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  • ||||||||||  Review, Journal:  Nutrition and Muscle Strength, As the Key Component of Sarcopenia: An Overview of Current Evidence. (Pubmed Central) -  Jul 2, 2020   
    These include the need for (i) better understanding of individual differences in responsiveness to dietary change, and the need for targeted nutritional support; (ii) clearer distinction between protective and therapeutic actions of diet; and (iii) definition of the role of dietary patterns and their influence on muscle strength, to allow effects of changes in food consumption to be evaluated-particularly when combined with physical activity. Development of this evidence is needed to enable translation into appropriate dietary recommendations for older populations.
  • ||||||||||  Review, Journal:  The effect of ageing on the resolution of inflammation. (Pubmed Central) -  Jul 2, 2020   
    Development of this evidence is needed to enable translation into appropriate dietary recommendations for older populations. No abstract available
  • ||||||||||  Biomarker, Clinical, Journal:  Pre-sarcopenia is the prognostic factor of overall survival in early-stage hepatoma patients undergoing radiofrequency ablation. (Pubmed Central) -  Jul 1, 2020   
    Multivariate analysis showed pre-sarcopenia (HR: 2.110 (1.092-4.078); P = .026) was the only factor significantly associated with overall survival (OS); however, there were no factors associated with HCC recurrence.For patients without and with pre-sarcopenia, the 1-, 3-, and 5-year OS rates were 92.0%, 77.6%, 68.9%, and 81.8%, 54.5%, 44.1% respectively (P = .007). For early-stage HCC patients undergoing RFA, pre-sarcopenia is the prognostic factor of OS, but not of recurrence, with a worse 5-year OS rate of 44.1%.
  • ||||||||||  Clinical, Journal:  Clinical and Anthropometric Characteristics of Non-obese NAFLD Subjects in Japan. (Pubmed Central) -  Jul 1, 2020   
    In patients with non-obese NAFLD, a sex difference was observed in the clinical features. In addition to the increased visceral fat, the decreased muscle mass and muscle strength, muscle atrophy (presarcopenia) and impaired glucose tolerance were considered to be important pathophysiological factors.
  • ||||||||||  Clinical, Journal:  Changes in Strength, Mobility, and Body Composition Following Self-Selected Exercise in Older Adults. (Pubmed Central) -  Jul 1, 2020   
    The 12 weeks of self-selected, self-paced exercise intensities improved resting heart rate, fat-free mass, percent body fat, handgrip strength, bench press strength, leg press strength, and all mobility measurements (p < .05) in males and females despite supplementation status. This suggests that additional protein in well-fed healthy older adults does not enhance the benefit of exercise.
  • ||||||||||  Journal:  Fibroblast growth factor 21 controls mitophagy and muscle mass. (Pubmed Central) -  Jun 30, 2020   
    A skeletal muscle mass evaluation among older adults should include an assessment of the total skeletal muscle mass and its asymmetry. FGF21 is a novel player in the regulation of muscle mass that requires the mitophagy protein Bnip3.
  • ||||||||||  Trial completion:  Evaluation of Sarcopenia in Patients With Stroke (clinicaltrials.gov) -  Jun 29, 2020   
    P=N/A,  N=81, Completed, 
    FGF21 is a novel player in the regulation of muscle mass that requires the mitophagy protein Bnip3. Enrolling by invitation --> Completed
  • ||||||||||  Journal:  Age-dependent skeletal muscle transcriptome response to bed rest-induced atrophy. (Pubmed Central) -  Jun 29, 2020   
    In summary, skeletal muscle dysregulation during bed rest in the old may be driven by alterations in molecules related to fibrosis, inflammation, and cell adhesion. This information may aide in the development of mechanistic-based therapies to combat muscle atrophy during short-term disuse.
  • ||||||||||  Review, Journal:  Cell therapy to improve regeneration of skeletal muscle injuries. (Pubmed Central) -  Jun 29, 2020   
    Recent improvements in our understanding of cell behaviour and the mechanistic basis for their modes of action have led to a new paradigm in cell therapies where physical, chemical, and signalling cues presented through biomaterials can instruct cells and enhance their regenerative capacity. Altogether, these studies and experiences provide a positive outlook on future opportunities towards innovative cell-based solutions for treating traumatic muscle injuries-a so far unmet clinical need.
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    Preclinical, Journal:  4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia. (Pubmed Central) -  Jun 29, 2020   
    Taken together, these findings demonstrate that deletion of 4E-BPs is associated with perturbed energy metabolism in skeletal muscle and could have beneficial effects on skeletal muscle mass and function in aging mice. They also identify 4E-BPs as potential targets for the treatment of sarcopenia.
  • ||||||||||  Journal:  Effects of IGF-1 isoforms on muscle growth and sarcopenia. (Pubmed Central) -  Jun 29, 2020   
    Moreover, morphological integrity of neuromuscular junctions was maintained and preserved in both MLC/IGF-1Ea and MLC/IGF-1Eb mice during aging. These data suggest that IGF-1 is a promising therapeutic agent in staving off advancing muscle weakness.
  • ||||||||||  Journal:  Kidney cachexia or protein-energy wasting in chronic kidney disease: facts and numbers. (Pubmed Central) -  Jun 29, 2020   
    The recent understanding of cachexia physiopathology during CKD progression suggests that PEW and cachexia are closely related and that PEW corresponds to the initial state of a continuous process that leads to cachexia, implicating the same metabolic pathways as in other chronic diseases. Despite the success of the definition of PEW, using a more uniform term such as 'kidney disease cachexia' could be more helpful to design future research through collaborative groups of researchers with focus on cachexia.
  • ||||||||||  Clinical, Journal:  Circulating miR-203 derived from metastatic tissues promotes myopenia in colorectal cancer patients. (Pubmed Central) -  Jun 29, 2020   
    The positive association between sarcopenia with falls and fractures in older adults strengthens the need to invest in sarcopenia prevention and interventions to evaluate its effect on falls and fractures. Assessment of serum miR-203 expression could be used for risk assessment of myopenia, and miR-203 might be a novel therapeutic target for inhibition of myopenia in CRC.
  • ||||||||||  Clinical, Journal:  Protein Valuation in Food Choice Is Positively Associated with Lean Mass in Older Adults. (Pubmed Central) -  Jun 29, 2020   
    Assessment of serum miR-203 expression could be used for risk assessment of myopenia, and miR-203 might be a novel therapeutic target for inhibition of myopenia in CRC. Together, these findings demonstrate that adult humans value calories derived from protein, carbohydrate, and fat differently, and that the tendency to value protein is associated with greater lean mass in older adults.
  • ||||||||||  Clinical, Journal:  Influence of sarcopenia on bone health parameters in a group of eumenorrheic obese premenopausal women. (Pubmed Central) -  Jun 28, 2020   
    The present findings provide evidence of the pressing need for integrated rehabilitation management in fragility fracture care to improve functional recovery in patients with sarcopenia. The present study suggests that sarcopenia negatively influences bone mineral density and hip geometry parameters before menopause in eumenorrheic obese women.
  • ||||||||||  Review, Journal:  Measurement and Interpretation of Handgrip Strength for Research on Sarcopenia and Osteoporosis. (Pubmed Central) -  Jun 28, 2020   
    As the measurement of HGS is widely used in clinical practice as well as in research, its accurate measurement and interpretation are becoming more crucial. This review describes how to use different types of dynamometers accurately, the impact of body and arm positions and anthropometric parameters on HGS, the current reference values of HGS for sarcopenia research, and the updates on the relationship between HGS and BMD and osteoporotic fractures.
  • ||||||||||  Preclinical, Review, Journal:  Rodent Model of Muscular Atrophy for Sarcopenia Study. (Pubmed Central) -  Jun 28, 2020   
    The rodent models that can be applied to the sarcopenia research are diverse, but a simple and fast method that can cause atrophy or aging is preferred. Therefore, we will introduce various methods of inducing muscular atrophy in rodent models to be applied to the study of sarcopenia.
  • ||||||||||  Review, Journal:  Financial impact of sarcopenia or low muscle mass - A short review. (Pubmed Central) -  Jun 27, 2020   
    Considering the demographic change, which will lead to an increasing number of patients with sarcopenia, every effort should be made to identify and treat patients with sarcopenia. The use of a unified definition and diagnostic criteria would allow a better comparison of data.
  • ||||||||||  Clinical, Journal:  Obesity Does Not Influence Management of Advanced Breast Cancer in the Elderly. (Pubmed Central) -  Jun 26, 2020   
    Breast cancer providers should turn to other patient and clinical factors when deciding treatment plans in this patient population. Further investigation is needed to examine how obesity influences tumor biology, diagnosis, and treatment decisions.
  • ||||||||||  Journal:  Nutritional interventions to prevent and treat frailty. (Pubmed Central) -  Jun 26, 2020   
    Public health recommendations to eat an optimal diet with the right amount of energy and proteins should be moved to the public domain. Whenever frailty is present, nutrition has a role in reverting it and avoiding adverse outcomes, but high-quality research is still needed in this area.
  • ||||||||||  Journal:  Sarcopenic obesity in fatty liver. (Pubmed Central) -  Jun 26, 2020   
    Management is not standardized, but dietary counseling and physical training have been proposed as promising strategies. Bariatric surgery may be considered in patients with severe 'resistant' obesity.