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|||||||||| Clinical, HEOR: Sarcopenia and lower extremity peripheral arterial disease have musculoskeletal consequences that directly impair patients' quality of life and prognosis https://t.co/nIJ1noY4tQ #PAD (Twitter) - Jul 21, 2020

|||||||||| Trial completion: Effect of Protein Consumption and Resistance Training on Body Composition, Muscular Strength and Functional Capacity in the Elderly (clinicaltrials.gov) - Jul 20, 2020
P=N/A, N=38, Completed, Sponsor: Federal University of Health Science of Porto Alegre
Active, not recruiting --> Completed

|||||||||| Clinical: Could be a possibility. Patients can also develop macro/micronutrient deficiencies, suboptimal hydration and sarcopenia during a flare. All other potential contributors to fatigue. Once remission is achieved, How often are these elements routinely assessed? #MondayNightIBD (Twitter) - Jul 20, 2020

|||||||||| Journal: Parkin overexpression protects from aging-related loss of muscle mass and strength. (Pubmed Central) - Jul 19, 2020
Finally, our results show that Parkin overexpression protects against oxidative stress, fibrosis and apoptosis. These findings highlight that Parkin may be an attractive therapeutic target to attenuate sarcopenia and improve skeletal muscle health and performance.

|||||||||| Clinical, Review, Journal: Evaluation and Management of Osteoporosis and Sarcopenia in Patients with Distal Radius Fractures. (Pubmed Central) - Jul 19, 2020
Since DRFs typically occur earlier than vertebral or hip fractures, they reflect early changes of the bone and muscle frailty and provide physicians with an opportunity to prevent progression of frailty and secondary fractures. In this review, we will discuss the concept of DRFs as a medical condition that is at the start of the fragility fracture cascade, recent advances in the diagnosis of bone fragility including emerging importance of cortical porosity, fracture healing with osteoporosis medications, and recent progress in research on sarcopenia in patients with DRFs.

|||||||||| Journal: Higher Paraspinal Muscle Density Effect on Outcomes After Anterior Cervical Discectomy and Fusion. (Pubmed Central) - Jul 19, 2020
The present study is the first to assess the association between cervical paraspinal muscle Goutalier grade and patient-reported outcomes following ACDF. Based on our study, patients with worse cervical paraspinal degeneration may benefit from improved symptom relief in comparison to patients with a lesser degree of degeneration undergoing ACDF.

|||||||||| [VIRTUAL] New approaches to sarcopenia (Hall 5) - Jul 19, 2020 - Abstract #UEGW2020UEGW_5876;

|||||||||| [VIRTUAL] SARCOPENIA AS A PREDICTOR OF POSTOPERATIVE COMPLICATIONS AND PANCREATIC FISTULA AFTER PANCREATIC RESECTIONS IN PATIENTS WITH PANCREATIC CANCER (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_5141;
Based on our study, patients with worse cervical paraspinal degeneration may benefit from improved symptom relief in comparison to patients with a lesser degree of degeneration undergoing ACDF. This abstract will be published on October 11, 2020

|||||||||| [VIRTUAL] SARCOPENIA IN CHILDREN AND YOUNG ADULTS WITH PRIMARY SCLEROSING CHOLANGITIS AND IBD (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4982;
Additionally, sarcopenia correlates to the degree of liver fibrosis assessed by APRI score. Further larger studies are warranted in order to corroborate the importance of sarcopenia in patients with PSC.

|||||||||| [VIRTUAL] THE ASSOCIATION OF SARCOPENIA WITH MYOSTATIN, FOLLISTATIN AND IRISIN LEVELS IN CIRRHOTIC PATIENTS: A MULTICENTER CROSS-SECTIONAL STUDY (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4945;
Further larger studies are warranted in order to corroborate the importance of sarcopenia in patients with PSC. This abstract will be published on October 11, 2020

|||||||||| [VIRTUAL] RESISTANCE TRAINING EFFECTS ON QUALITY OF LIFE AND FATIGUE FOR COMPENSATED CIRRHOTIC PATIENTS: PRELIMINARY RESULTS FROM A RANDOMIZED CONTROLLED TRIAL (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4938;
RT for 24 weeks in compensated cirrhotic patients has been shown to improve quality of life and fatigue. This study is planned to be continued for another 18 months to include more patients.

|||||||||| [VIRTUAL] RESISTANCE TRAINING EFFECTS ON MUSCLE STRENGTH AND MUSCLE MASS IN COMPENSATED CIRRHOTIC PATIENTS: PRELIMINARY RESULTS FROM A RANDOMIZED CONTROLLED TRIAL (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4935;
Resistance training is likely to be an effective tool to enhance physical function and musculoskeletal system in compensated cirrhotic patients. Greater sample sizes will be necessary to determine the superiority of resistance training in future studies.

|||||||||| [VIRTUAL] SARCOPENIA IS A PREDICTOR FOR SEVERE DISEASE COURSE IN PEDIATRIC INFLAMMATORY BOWEL DISEASE (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4451;
Greater sample sizes will be necessary to determine the superiority of resistance training in future studies. This abstract will be published on October 11, 2020

|||||||||| [VIRTUAL] NUTRITIONAL EVALUATION AND MANAGEMENT IN PATIENTS WITH COVID-19 FOLLOWING HOSPITALIZATION IN INTENSIVE CARE UNITS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4335;
Critical illpatients with COVID 19 pneumonia are malnourished and have severe sarcopenia following ICU stay despite adequate nutrition management. Optimal nutrition therapy remains crucial during the rehabilitation period.

|||||||||| [VIRTUAL] SARCOPENIA AS A PREDICTOR OF POSTOPERATIVE COMPLICATIONS AND PANCREATIC FISTULA AFTER PANCREATIC RESECTIONS IN PATIENTS WITH PANCREATIC CANCER (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_3165;
Optimal nutrition therapy remains crucial during the rehabilitation period. This abstract will be published on October 11, 2020

|||||||||| [VIRTUAL] SARCOPENIA IN CHILDREN AND YOUNG ADULTS WITH PRIMARY SCLEROSING CHOLANGITIS AND IBD (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_3006;
Additionally, sarcopenia correlates to the degree of liver fibrosis assessed by APRI score. Further larger studies are warranted in order to corroborate the importance of sarcopenia in patients with PSC.

|||||||||| [VIRTUAL] THE ASSOCIATION OF SARCOPENIA WITH MYOSTATIN, FOLLISTATIN AND IRISIN LEVELS IN CIRRHOTIC PATIENTS: A MULTICENTER CROSS-SECTIONAL STUDY (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2969;
Further larger studies are warranted in order to corroborate the importance of sarcopenia in patients with PSC. This abstract will be published on October 11, 2020

|||||||||| [VIRTUAL] RESISTANCE TRAINING EFFECTS ON QUALITY OF LIFE AND FATIGUE FOR COMPENSATED CIRRHOTIC PATIENTS: PRELIMINARY RESULTS FROM A RANDOMIZED CONTROLLED TRIAL (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2962;
RT for 24 weeks in compensated cirrhotic patients has been shown to improve quality of life and fatigue. This study is planned to be continued for another 18 months to include more patients.

|||||||||| [VIRTUAL] RESISTANCE TRAINING EFFECTS ON MUSCLE STRENGTH AND MUSCLE MASS IN COMPENSATED CIRRHOTIC PATIENTS: PRELIMINARY RESULTS FROM A RANDOMIZED CONTROLLED TRIAL (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2959;
Resistance training is likely to be an effective tool to enhance physical function and musculoskeletal system in compensated cirrhotic patients. Greater sample sizes will be necessary to determine the superiority of resistance training in future studies.

|||||||||| [VIRTUAL] SARCOPENIA IS A PREDICTOR FOR SEVERE DISEASE COURSE IN PEDIATRIC INFLAMMATORY BOWEL DISEASE (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2475;
Greater sample sizes will be necessary to determine the superiority of resistance training in future studies. This abstract will be published on October 11, 2020

|||||||||| [VIRTUAL] NUTRITIONAL EVALUATION AND MANAGEMENT IN PATIENTS WITH COVID-19 FOLLOWING HOSPITALIZATION IN INTENSIVE CARE UNITS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2359;
Critical illpatients with COVID 19 pneumonia are malnourished and have severe sarcopenia following ICU stay despite adequate nutrition management. Optimal nutrition therapy remains crucial during the rehabilitation period.

|||||||||| [VIRTUAL] TRANSPLANT-FREE SURVIVAL IN PATIENTS WITH HEPATOCELLULAR CARCINOMA UNDERGOING LOCOREGIONAL THERAPY - THE IMPACT OF SARCOPENIA AND SARCOPENIC OBESITY (Hall 4) - Jul 19, 2020 - Abstract #UEGW2020UEGW_1953;
Both sarcopenia and obesity lower median TFS significantly (lowest with sarcopenia), independent of BCLC stages. Natural MELD-Na modified for sarcopenia (MELD-sarcopenia and MELD-SMI) have higher accuracy than natural MELD-Na and LRT prognostic scores for predicting TFS.

|||||||||| [VIRTUAL] SARCOPENIA AS A PREDICTOR OF POSTOPERATIVE COMPLICATIONS AND PANCREATIC FISTULA AFTER PANCREATIC RESECTIONS IN PATIENTS WITH PANCREATIC CANCER (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_1181;
Natural MELD-Na modified for sarcopenia (MELD-sarcopenia and MELD-SMI) have higher accuracy than natural MELD-Na and LRT prognostic scores for predicting TFS. This abstract will be published on October 11, 2020

|||||||||| [VIRTUAL] SARCOPENIA IN CHILDREN AND YOUNG ADULTS WITH PRIMARY SCLEROSING CHOLANGITIS AND IBD (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_1022;
Additionally, sarcopenia correlates to the degree of liver fibrosis assessed by APRI score. Further larger studies are warranted in order to corroborate the importance of sarcopenia in patients with PSC.

|||||||||| [VIRTUAL] THE ASSOCIATION OF SARCOPENIA WITH MYOSTATIN, FOLLISTATIN AND IRISIN LEVELS IN CIRRHOTIC PATIENTS: A MULTICENTER CROSS-SECTIONAL STUDY (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_985;
Further larger studies are warranted in order to corroborate the importance of sarcopenia in patients with PSC. This abstract will be published on October 11, 2020

|||||||||| [VIRTUAL] RESISTANCE TRAINING EFFECTS ON QUALITY OF LIFE AND FATIGUE FOR COMPENSATED CIRRHOTIC PATIENTS: PRELIMINARY RESULTS FROM A RANDOMIZED CONTROLLED TRIAL (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_978;
RT for 24 weeks in compensated cirrhotic patients has been shown to improve quality of life and fatigue. This study is planned to be continued for another 18 months to include more patients.

|||||||||| [VIRTUAL] RESISTANCE TRAINING EFFECTS ON MUSCLE STRENGTH AND MUSCLE MASS IN COMPENSATED CIRRHOTIC PATIENTS: PRELIMINARY RESULTS FROM A RANDOMIZED CONTROLLED TRIAL (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_975;
Resistance training is likely to be an effective tool to enhance physical function and musculoskeletal system in compensated cirrhotic patients. Greater sample sizes will be necessary to determine the superiority of resistance training in future studies.

|||||||||| [VIRTUAL] SARCOPENIA IS A PREDICTOR FOR SEVERE DISEASE COURSE IN PEDIATRIC INFLAMMATORY BOWEL DISEASE (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_491;
Greater sample sizes will be necessary to determine the superiority of resistance training in future studies. This abstract will be published on October 11, 2020

|||||||||| [VIRTUAL] NUTRITIONAL EVALUATION AND MANAGEMENT IN PATIENTS WITH COVID-19 FOLLOWING HOSPITALIZATION IN INTENSIVE CARE UNITS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_375;
Critical illpatients with COVID 19 pneumonia are malnourished and have severe sarcopenia following ICU stay despite adequate nutrition management. Optimal nutrition therapy remains crucial during the rehabilitation period.

|||||||||| Clinical, Journal: Phase Angle Is Associated With Handgrip Strength but Not With Sarcopenia in Kidney Transplantation Patients. (Pubmed Central) - Jul 18, 2020
PhA was associated with HGS but not with sarcopenia and its other components. These results suggest that PhA can be used as a possible predictor of muscle strength in kidney transplantation patients.

|||||||||| Clinical, Journal: Association between structural changes in brain with muscle function in sarcopenic older women: the women's healthy ageing project (WHAP). (Pubmed Central) - Jul 18, 2020
These results suggest that PhA can be used as a possible predictor of muscle strength in kidney transplantation patients. Brain structure was not associated with functional changes or falls in this population of older women.

|||||||||| Preclinical, Journal: Age-related changes in histone modification in rat gastrocnemius muscle. (Pubmed Central) - Jul 18, 2020
Histone modification status (acetylation at K9 and K27 and tri-methylation at K9) was positively associated with relative gastrocnemius muscle weight, the percentage of type IIb myosin heavy chain isoform, myosin heavy chain type IIb protein expression, and the level of Myh4 mRNA. Thus, global histone H3 methylation and acetylation decrease with age, and the latter might be associated with age-related muscle atrophy of rat gastrocnemius muscle.

|||||||||| Biomarker, Journal: Pharmacological investigation of 'HIM-CHX': A herbal combination in the experimental muscle wasting condition. (Pubmed Central) - Jul 18, 2020
HIM-CHX exerts its effect by reducing the levels of TNF-α, IL-6, and Myostatin while increasing the IGF-1 levels which are the typical biomarkers of muscle wasting. Furthermore, the study findings indicate that HIM-CHX has the potential to correct the pathophysiological changes associated with sarcopenia.

|||||||||| Clinical, Journal: The usefulness of muscle architecture assessed with ultrasound to identify hospitalized older adults with physical decline. (Pubmed Central) - Jul 18, 2020
Thus, ultrasound seems to be a potential useful and objective screening tool for clinicians to assess/prevent physical decline during hospitalization. Larger and/or longitudinal studies are needed to confirm our findings from a pilot pragmatic study.

|||||||||| Journal: The impact of age and frailty on skeletal muscle autophagy markers and specific strength: A cross-sectional comparison. (Pubmed Central) - Jul 18, 2020
Higher levels of heat shock proteins might represent an auto-protective mechanism against increased levels of misfolded proteins, possibly due to inefficient degradation. In conclusion, the reduction in specific strength with aging and frailty may partly be caused by alterations in muscle protein quality control.

|||||||||| Clinical, Journal: Is skeletal muscle radiodensity able to indicate physical function impairment in older adults with gastrointestinal cancer? (Pubmed Central) - Jul 18, 2020
In conclusion, the reduction in specific strength with aging and frailty may partly be caused by alterations in muscle protein quality control. Low SMD has negatively impacted physical function in older adults with gastrointestinal cancer, especially in males.

|||||||||| Clinical, Journal: Prevalence of sarcopenia and associated factors in climacteric women of the Colombian Caribbean. (Pubmed Central) - Jul 18, 2020
Low SMD has negatively impacted physical function in older adults with gastrointestinal cancer, especially in males. Sarcopenia was present in this middle-aged female Colombian Caribbean sample and associated with various factors such as ethnicity, age, and menopausal symptoms and status.

|||||||||| Clinical, Journal: Body Composition in Pediatric Solid Tumors: State of the Science and Future Directions. (Pubmed Central) - Jul 18, 2020
The following review presents an in-depth discussion of body composition analysis and its potential role in the care of pediatric solid tumor patients. Integration of body tissue measurement into standard practice has broad clinical implications and may improve quality of life and treatment outcomes in this at-risk population.

|||||||||| Journal: Physical Exercise in the Oldest Old. (Pubmed Central) - Jul 18, 2020
© 2019 American Physiological Society. Compr Physiol 9:1281-1304, 2019

|||||||||| Clinical, Journal: Sarcopenia index based on serum creatinine and cystatin C is associated with 3-year mortality in hospitalized older patients. (Pubmed Central) - Jul 18, 2020
The SI was not significantly associated with readmission (HR per 1-SD = 0.97, 95% CI: 0.77-1.25). In conclusion, the SI is associated with 3-year all-cause mortality but not readmission in a study population of hospitalized older patients.

|||||||||| Clinical, Journal: Correlation between sarcopenia and albuminuria in patients with type 2 diabetes (Pubmed Central) - Jul 17, 2020
In conclusion, the SI is associated with 3-year all-cause mortality but not readmission in a study population of hospitalized older patients. Sarcopenia is probably an independent risk factor for albuminuria in patients with T2DM.

|||||||||| Clinical, Retrospective data, Journal, HEOR: Sarcopenia and health-related quality of life in older adults after transcatheter aortic valve replacement. (Pubmed Central) - Jul 17, 2020
Higher SMI is associated with shorter LOS and better 1-year HR-QOL. To achieve optimal TAVR benefits, further study into how body composition influences post-TAVR recovery and durable improvement in QOL is warranted.

|||||||||| Journal: Important Points to Consider During Practical Application and in the Validation Studies of SARC-F Tool to Screen Sarcopenia [Letter]. (Pubmed Central) - Jul 17, 2020
To achieve optimal TAVR benefits, further study into how body composition influences post-TAVR recovery and durable improvement in QOL is warranted. No abstract available

|||||||||| Journal: Important Points to Consider During Practical Application and in the Validation Studies of SARC-F Tool to Screen Sarcopenia [Response to Letter]. (Pubmed Central) - Jul 17, 2020
No abstract available No abstract available

|||||||||| Clinical, Journal: Preserved Capacity for Adaptations in Strength and Muscle Regulatory Factors in Elderly in Response to Resistance Exercise Training and Deconditioning. (Pubmed Central) - Jul 17, 2020
No difference was seen in expression of muscle regulatory factors between elderly and young in response to exercise training and deconditioning. In conclusion, the capacity to gain muscle strength with resistance exercise training in elderly was not impaired, highlighting this as a potent tool to combat age-related loss of muscle function, possibly due to preserved regulation of myogenic factors in elderly compared with young muscle.

|||||||||| Clinical, Journal: Effects of Elastic Resistance Exercise on Postoperative Outcomes Linked to the ICF Core Sets for Osteoarthritis after Total Knee Replacement in Overweight and Obese Older Women with Sarcopenia Risk: A Randomized Controlled Trial. (Pubmed Central) - Jul 17, 2020
Early intervention of elastic RET after TKR yielded positive postoperative outcomes based on the Brief-ICF-OA. The findings of this study may facilitate clinical decision-making regarding the optimal post-TKR rehabilitation strategy for older women with KOA.

|||||||||| Clinical, Review, Journal: Correlation between sarcopenia and left ventricular myocardial mass in chronic heart failure patients. (Pubmed Central) - Jul 17, 2020
This will be conducive to the screening of sarcopenia in people with chronic HF to better guide clinical treatments. This review describes the definition and diagnostic criteria of sarcopenia, the characteristics of HF with sarcopenia, and the related study of myocardial quality.

|||||||||| Journal: Low one-repetition-maximum knee extension is significantly associated with poor grip strength, female sex, and various aging-related syndromes. (Pubmed Central) - Jul 17, 2020
The 1-RM knee extension has only moderate correlation with grip strength. A lower 1-RM knee extension value is significantly associated with female sex and various geriatric conditions, such as malnutrition, dementia, depression, frailty, and sarcopenia.

|||||||||| Monorem (isosorbide Mononitrate) / Remedica
Clinical, Review, Journal: Where does TIPS fit in the management of patients with cirrhosis? (Pubmed Central) - Jul 17, 2020
In patients with PVT, TIPS placement not only controls complications of portal hypertension, but also promotes portal vein recanalisation. Although the severity of portal hypertension correlates with poor outcomes after extrahepatic surgery, there is no evidence to recommend preoperative TIPS placement.

|||||||||| New trial: Malnutrition in Chronic Pancreatitis, Trans-sectoral Study (clinicaltrials.gov) - Jul 16, 2020
P=N/A, N=40, Recruiting, Sponsor: University Medicine Greifswald



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