Sarcopenia
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  • ||||||||||  Journal:  Muscle-bone crosstalk and potential therapies for sarco-osteoporosis. (Pubmed Central) -  Aug 19, 2020   
    Aside from the biochemical and mechanical interaction, additional factors including aging, circadian rhythm, nervous system network, nutrition intake, and exosomes also have effects on bone-muscle crosstalk. Here, we summarize the current research progress in the area, which may be conductive to identify potential novel therapies for the osteoporosis and sarcopenia, especially when they develop in parallel.
  • ||||||||||  methotrexate / Generic mfg.
    Journal:  Lower urinary tract symptoms in systemic sclerosis: a detailed investigation. (Pubmed Central) -  Aug 18, 2020   
    For the first time urinary tract involvement was found to be significantly higher in SSc patients than in healthy matched controls. In addition, sarcopenia, bone damage and calcinosis appeared significantly correlated with LUTS, suggesting a possible interplay.
  • ||||||||||  Biomarker, Review, Journal:  Anabolism to Catabolism: Serologic Clues to Nutritional Status in Heart Failure. (Pubmed Central) -  Aug 18, 2020   
    Novel biomarkers including ghrelin, myostatin, C-terminal agrin fragment, and adiponectin have been identified as possible substrates and/or therapeutic targets in cardiac patients with sarcopenia and cachexia, though clinical trial data is limited to date. Increased focus on nutritional deficiency syndromes in heart failure has led to the use of established markers of malnutrition as well as the identification of novel biomarkers in the management of these patients, though to date, their usage has been confined to the academic domain and further research is required to establish their role in the clinical setting.
  • ||||||||||  Journal:  Effects of tannase-converted green tea extract on skeletal muscle development. (Pubmed Central) -  Aug 18, 2020   
    Taken together, our findings describe that the high levels of EC, EGC, and GA in the tannase-converted green tea extract are attributable to the morphological changes in C2C12 cells and intercellular signaling pathways. Therefore, tannase-converted green tea extract can be used in the treatment of sarcopenia.
  • ||||||||||  Journal:  Confronting Presbyphagia and Oropharyngeal Dysphagia (Pubmed Central) -  Aug 18, 2020   
    Chewing and swallowing-related knowledge and care skills and positive attitudes may still be insufficient if knowledge and action are not united. When knowledge and action are united, the body may maintain to a good state of function and patients may enjoy peace through their life journey.
  • ||||||||||  Review, Journal:  Cardiometabolic disease in the older person: prediction and prevention for the generalist physician. (Pubmed Central) -  Aug 18, 2020   
    Increased muscle visceral fat leads to increased secretion of harmful proinflammatory adipokines and reduced muscle mass leads to reduced secretion of the protective myokines creating an abnormal cardiometabolic state increasing the risk of cardiovascular disease. This review: (1) explore traditional and newly emerging cardiometabolic risk factors in older people; (2) investigate methods of prediction and prevention of cardiovascular disease in those with diabetes; and (3) concludes that the development of a subspeciality of Cardiometabolic Medicine should be considered.
  • ||||||||||  Journal:  AGS and NIA Bench-to Bedside Conference Summary: Osteoporosis and Soft Tissue (Muscle and Fat) Disorders. (Pubmed Central) -  Aug 15, 2020   
    Presenters described factors that contribute to these disorders; health disparities experienced by various subpopulations; and promising biological, pharmacologic, and behavioral interventions to prevent or treat these disorders. The workshop identified many research gaps and questions along with research recommendations that have the potential to enhance the prospect of healthy aging and improved quality of life for older adults.
  • ||||||||||  Clinical, Journal:  Macrophage Subpopulations and the Acute Inflammatory Response of Elderly Human Skeletal Muscle to Physiological Resistance Exercise. (Pubmed Central) -  Aug 15, 2020   
    Cells expressing CD68, CD11b, and CD206 simultaneously were the most frequently observed cell type, which raises the possibility that pure pro- and anti-inflammatory macrophages populations do not exist in healthy human skeletal muscle within the spectrum of tissue remodeling induced by physiological exercise designed to induce hypertrophy. Together these data provide insight into the time course of macrophage activity and associated molecular targets in human skeletal muscle in the context of aging and exercise.
  • ||||||||||  Review, Journal:  Optimizing Skeletal Muscle Anabolic Response to Resistance Training in Aging. (Pubmed Central) -  Aug 15, 2020   
    Additionally, the following supplemental therapies with potential to synergize with resistance training to increase muscle mass are discussed: nutrition, creatine, anti-inflammatory drugs, testosterone, and growth hormone (GH). Although these interventions hold some promise, further research is necessary to optimize the response to exercise in elderly patients.
  • ||||||||||  Clinical, Retrospective data, Journal:  Sarcopenia as a predictor of survival in patients undergoing bland transarterial embolization for unresectable hepatocellular carcinoma. (Pubmed Central) -  Aug 14, 2020   
    Sarcopenia, estimated by the L3SMI method, is an emerging prognostic factor in patients with HCC undergoing bland TAE therapy as it is associated with increased mortality, without impairing the safety of the locoregional treatment. Measures to ameliorate the SMI, such as nutritional support and physical exercise, should be evaluated in clinical trials for HCC patients receiving liver embolization to determine their impact on overall survival.
  • ||||||||||  Journal:  Total Dietary Antioxidant Capacity and Longitudinal Trajectories of Body Composition. (Pubmed Central) -  Aug 14, 2020   
    Additional adjustment for adherence to dietary guidelines and exclusion of individuals with comorbid disease at baseline did not change our results. In conclusion, dietary intake of antioxidants may positively affect the amount of lean mass and overall body composition among the middle-aged and elderly.
  • ||||||||||  Journal:  An Overview of the Beneficial Effects of Exercise on Health and Performance. (Pubmed Central) -  Aug 13, 2020   
    In contrast to medication, physical exercise has no negative side effects, costs very little, and targets many health issues at once. If the multitude of beneficial effects of regular exercise were to be combined in a single low-cost drug, it would be prescribed for almost all types of physical and mental health issues.
  • ||||||||||  Clinical, Journal, HEOR:  Effects of Exercise on the Immune Function, Quality of Life, and Mental Health in HIV/AIDS Individuals. (Pubmed Central) -  Aug 13, 2020   
    Moderate- to high-intensity aerobic exercise, progressive resistance exercise, or a combination of both is considered as a complementary part of medical care and treatment of HIV-infected individuals. In the present chapter, the results of recent investigations regarding the effects of physical activity on muscle strength and function, mental health, and immune system of HIV infected individuals will be discussed.
  • ||||||||||  Review, Journal:  Sarcopenia and Its Implications for Metabolic Health. (Pubmed Central) -  Aug 11, 2020   
    On the other hand, increased obesity, decreased quality of life, and reduced metabolic health also contribute to sarcopenia. The purpose of this mini-review is to discuss the implications sarcopenia has for the development of obesity and comorbidities that occur with aging.
  • ||||||||||  Clinical, Journal:  Sarcopenia is common in adults with complex congenital heart disease. (Pubmed Central) -  Aug 11, 2020   
    Contrary to men, the women had increased body fat and a higher BMI. Further research is required to assess the cause, possible adverse long-term effects and whether sarcopenia is preventable or treatable.
  • ||||||||||  Clinical, Journal:  Nutritional Considerations in Frail Older Patients with COVID-19. (Pubmed Central) -  Aug 11, 2020   
    Early nutritional support should be guaranteed in order to improve several malnutrition-related adverse outcomes. The evaluation of the nutritional status is today even more crucial than in normal times given the delicate status of older patients with COVID-19.
  • ||||||||||  Clinical, Journal:  What are the factors associated with sarcopenia-related variables in adult women with severe obesity? (Pubmed Central) -  Aug 11, 2020   
    In severely obese women, muscle mass and function were inversely associated with age, smoking status, endocrine parameters, hypercholesterolemia, and comorbidities such as diabetes. Thus, the results of this investigation are relevant in supporting the development of clinical interventions to aid in the prevention of sarcopenia in adult women with severe obesity.
  • ||||||||||  Journal:  Comment on article by Abe et al. (Pubmed Central) -  Aug 10, 2020   
    Thus, the results of this investigation are relevant in supporting the development of clinical interventions to aid in the prevention of sarcopenia in adult women with severe obesity. No abstract available