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|||||||||| The impact of different diagnostic criteria on the association of sarcopenia with injurious falls in the CLSA https://t.co/YIyOYdxOad Sarcopenia definitions based on different combinations of muscle variables and methods of adjusting lean mass are not equally associated with (Twitter) - Sep 17, 2020

|||||||||| The impact of different diagnostic criteria on the association of sarcopenia with injurious falls in the CLSA https://t.co/YIyOYdxOad Who with 'sarcopenia' falls? Depends on how you define sarcopenia! How do you treat sarcopenia when you can't define what it is? (Twitter) - Sep 17, 2020

|||||||||| Clinical: The combination of variables used to ascertain sarcopenia and many of the ALM adjustment techniques have insufficient agreement to be considered equivalent. This is a problem, both for investigators and clinicians @drjohnmorley (Twitter) - Sep 17, 2020

|||||||||| Clinical: Do Different Ascertainment Techniques Identify the Same Individuals as Sarcopenic in the CLSA https://t.co/gALFdhkn3t The combination of variables used to ascertain sarcopenia and many of the ALM adjustment techniques have insufficient agreement to be considered equivalent. (Twitter) - Sep 17, 2020

|||||||||| Journal: mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. (Pubmed Central) - Sep 17, 2020
Inhibition of mTORC1 in aging mouse decreases the expression of GDFs and STAT3's phosphorylation in skeletal muscle, reducing oxidative stress and muscle fiber damage and loss. Thus, chronically increased mTORC1 activity contributes to age-related muscle atrophy, and GDF signaling is a proposed mechanism.

|||||||||| Clinical, Journal: Comparison of multifrequency bioimpedance measured lean mass to that calculated from anthropomometric measurements in patients with chronic kidney disease. (Pubmed Central) - Sep 17, 2020
Apart from one equation, there was a systematic bias, with bias increasing with increasing fat mass (ranging from r = 0.17, p = 0.044 to r = 0.65, p < 0.001). For CKD patients we found that most of the previously proposed equations based on anthropometric equations over-estimated muscle mass compared to MFBIA.

|||||||||| [VIRTUAL] Phase Angle as an Indicator of Sarcopenia, Undernutrition, and Cachexia in Inpatients With Cardiovascular Diseases (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_3037;
For CKD patients we found that most of the previously proposed equations based on anthropometric equations over-estimated muscle mass compared to MFBIA. This study provides the evidence showing that PA can be highly useful as a marker for sarcopenia, malnutrition and then cachexia in hospitalized patients with cardiovascular disease.

|||||||||| [VIRTUAL] Effects of Low Intensity Resistance Exercise Under Kaatsu Condition on Skeletal Muscle Size and Its Safety inCardiovascular Surgery Patients (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_3011;
These results suggest that KAATSU training safely increased muscle mass in patients in the early perioperative period of cardiovascular surgery. KAATSU training appears to be a promising and effective method for cardiac rehabilitation in patients with cardiovascular surgery.

|||||||||| [VIRTUAL] Impact of Loop Diuretics Use on Skeletal Muscle Depletion Among Patients Being Evaluated for Known or Suspected Coronary Artery Disease a Propensity Score Matching Analysis (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_2990;
KAATSU training appears to be a promising and effective method for cardiac rehabilitation in patients with cardiovascular surgery. Our study suggested that the use of loop diuretics can be related with skeletal muscle loss among patients being evaluated for known or suspected coronary artery disease.

|||||||||| [VIRTUAL] Usefulness of Sarcopenia Index for Predicting Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_2712;
SI, a novel-non-invasive method for assessing SMM was able to predict mid-term mortality and CHF readmissions. We suggest careful consideration of sarcopenia prior to TAVR in order to decide the best treatment approaches.

|||||||||| [VIRTUAL] Skeletal Muscle Mass Recovery Early After Left Ventricular Assist Device Implantation in Patients With Advanced Systolic Heart Failure (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_2361;
We suggest careful consideration of sarcopenia prior to TAVR in order to decide the best treatment approaches. Among patients with advanced systolic HF and a high baseline prevalence of muscle wasting, there was a significant gain in skeletal muscle mass, as represented by both FFM and ALM, over the first 6 months of LVAD support.

|||||||||| [VIRTUAL] Sarcopenia (Live on Zoom) - Sep 17, 2020 - Abstract #AHA2020AHA_2269;

|||||||||| [VIRTUAL] Sarcopenia Defined by Computed Tomography Psoas Muscle Area Predicts Morbidity and Mortality in Patients Undergoing Left Ventricular Assist Device Implantation (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_2106;
Among patients with advanced systolic HF and a high baseline prevalence of muscle wasting, there was a significant gain in skeletal muscle mass, as represented by both FFM and ALM, over the first 6 months of LVAD support. Sarcopenia (TPAI<7.5 cm2/m2) was a predictor for postoperative AKI and in-hospital mortality in patients undergoing a LVAD implantation.

|||||||||| [VIRTUAL] Prognostic Impact of Sarcopenia in Men versus Women With Acute Decompensated Heart Failure and Preserved Left Ventricular Ejection Fraction (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_2064;
Sarcopenia (TPAI<7.5 cm2/m2) was a predictor for postoperative AKI and in-hospital mortality in patients undergoing a LVAD implantation. In this multicenter study, sarcopenia diagnosed by FFMI was shown to be associated with poor clinical outcome in HFpEF patients admitted with ADHF in both genders.

|||||||||| [VIRTUAL] Sarcopenia in Heart Failure Patients Without Dementia is Associated With Local Brain Atrophy and Predicts Poor Prognosis (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_2062;
In this multicenter study, sarcopenia diagnosed by FFMI was shown to be associated with poor clinical outcome in HFpEF patients admitted with ADHF in both genders. HF patients with sarcopenia without dementia have potential risk of CI and poor prognosis.

|||||||||| [VIRTUAL] The Association Between Central Obesity and Myocardial Ageing: Traditional Body Mass Index (bmi) Falls Short of Expectation (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_1813;
Among Asians, waist circumference identifies higher prevalence of obesity, possibly related to central adiposity. While impact of age-related sarcopenia and BMI in older adults require deeper study, WC may better characterize the impact of obesity on myocardial ageing.

|||||||||| [VIRTUAL] Association of Serum Growth Differentiation Factor-15 With Egfr, Hemoglobin and Sarcopenia in Healthy Community-dwelling Older Females (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_1799;
Both Hb and eGFR were predictors for serum GDF-15 concentration in healthy older females. In these community-dwelling older females, renal dysfunction via GDF-15 might be accompanied by anemia, but not sarcopenia.

|||||||||| [VIRTUAL] Secondary Sarcopenia Assessed by Computed Tomography Can Predict Hospitalization for Heart Failure in Adults With Fontan Circulation (OnDemand) - Sep 17, 2020 - Abstract #AHA2020AHA_591;
In these community-dwelling older females, renal dysfunction via GDF-15 might be accompanied by anemia, but not sarcopenia. Available on Tuesday, July 01, 2025 at 08:00am CST.

|||||||||| Clinical, Journal: The clinical impact and biological mechanisms of skeletal muscle aging. (Pubmed Central) - Sep 17, 2020
The objective of this review is to highlight the clinical consequences of skeletal muscle aging, and provide insights into potential biological mechanisms. In light of population aging, strategies to improve muscle health in older adults promise to have a profound public health impact.

|||||||||| Journal: Update of the European consensus on sarcopenia: what has changed in diagnosis and prevalence in peritoneal dialysis? (Pubmed Central) - Sep 16, 2020
Fifty subjects on PD were included, mean age 55.74 ± 16.22 years old, 52% female. The prevalence of sarcopenia ranged from 4 to 10% according to cut points and references used.

|||||||||| Clinical, Journal: Southampton Arm Fracture Frailty and Sarcopenia Study (SAFFSS): a study protocol for the feasibility of assessing frailty and sarcopenia among older patients with an upper limb fracture. (Pubmed Central) - Sep 16, 2020
Findings will be published in scientific journals and presented to local, national and international conferences. ISRCTN13848445.

|||||||||| Journal: Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants. (Pubmed Central) - Sep 16, 2020
Genetically determined telomere length was associated with increased risk of cancer and reduced risk of CHD but little change in other age-related health outcomes. Telomere lengthening may offer little gain in later-life health status and face increasing cancer risks.

|||||||||| New trial: Randomized Clinical Trial of HMR(Home Meal Replacement)-Type Omega-3-balanced-diet (clinicaltrials.gov) - Sep 16, 2020
P=N/A, N=76, Recruiting, Sponsor: Chungbuk National University Hospital

|||||||||| Journal: Sex Differences in People Aging With HIV. (Pubmed Central) - Sep 16, 2020
Despite the fact that women have better immunological recovery measured by CD4 T-cell count and CD4/CD8 ratio, and fewer CV disease and CV risk factors than men, their physical function and their QOL are worse. Therefore, older HIV-infected women have special characteristics, and the assessment of physical function in this group seems to be crucial.

|||||||||| “Fourth, dynapenia but not sarcopenia is statistically associated with increased mortality.” (The author is wrong about #4, but the correlation is stronger & ⬆️functionally = pertinent for ⬆️QOL) — Human Biological Aging: From Macromolecules to Organ Systems by Glenda E. Bilder (Twitter) - Sep 16, 2020

|||||||||| “Second, improvement in muscle mass does not result in a parallel increase in muscle strength. [...] Third, the association between physical disabilities and dynapenia is statistically stronger than the association between physical disabilities and sarcopenia.” (Twitter) - Sep 16, 2020

|||||||||| “First, age-related loss of muscle strength is far greater than can be accounted for by sarcopenia. It is estimated that sarcopenia can explain only 10% of the loss of muscle strength.” https://t.co/Oz4pPUEMAB (Twitter) - Sep 16, 2020

|||||||||| There is inadequate focus in the literature in differentiating between sarcopenia & dynapenia. The CR literature is the quintessential e.g. of physiologic uncoupling of quantity vs. quality: Preservation of the latter is robust https://t.co/ro1VkAJOcK https://t.co/pS9rvpLjPT (Twitter) - Sep 16, 2020

|||||||||| Journal: Chile stronger! New perspectives to fight dynapenia, sarcopenia and fragility (Pubmed Central) - Sep 16, 2020
Therefore, older HIV-infected women have special characteristics, and the assessment of physical function in this group seems to be crucial. No abstract available

|||||||||| Clinical, Journal: Association between preoperative potential sarcopenia and survival of cancer patients undergoing major surgical procedures. (Pubmed Central) - Sep 16, 2020
No abstract available patients bearing PS submitted to major oncological surgery have less probability of short term survival and preoperative PS is an independent risk for postoperative mortality.

|||||||||| Clinical, Journal: Sarcopenia Coexisting with High Adiposity Exacerbates Insulin Resistance and Dyslipidemia in Saudi Adult Men. (Pubmed Central) - Sep 16, 2020
Our study shows that obesity associated with sarcopenia exhibits significantly greater insulin resistance and dyslipidemia than sarcopenia or obesity per se. Therefore, sarcopenic obesity might be an independent risk factor for metabolic disease progression.

|||||||||| Review, Journal: Association of Sarcopenia and NAFLD: An Overview. (Pubmed Central) - Sep 16, 2020
Therefore, sarcopenic obesity might be an independent risk factor for metabolic disease progression. No abstract available

|||||||||| [VIRTUAL] The Clinical Impact of Malnutrition on the Postoperative Outcomes of Patients With Gastric Cancer Undergoing Gastrectomy () - Sep 15, 2020 - Abstract #ACG2020ACG_3368;
The malnutrition cohort was older (67.3 vs 65.6y p< 0.01) but had a similar gender distribution (female 44.9 vs 44.6% p=0.92). Mortality was higher in the malnutrition cohort (6.97 vs 2.57% p< 0.01, OR 2.84 95%CI 2.06-3.91), as were the LOS (17.3 vs 10.2d p< 0.01) and hospitalization costs ($201,429 vs $114,264 p< 0.01).

|||||||||| [VIRTUAL] The Clinical Impact of Malnutrition on the Infectious Outcomes of Hospitalized Patients With Cirrhosis and Primary Liver Cancer () - Sep 15, 2020 - Abstract #ACG2020ACG_2545;
The malnutrition cohort was older (62.9 vs 62.3y p< 0.01) and was more likely to be male (78 vs 75.7% p< 0.01). The mortality rate was higher in the malnutrition cohort (12.8 vs 8.30% p< 0.01, OR 1.62 95%CI 1.49-1.76), as were the LOS (8.03 vs 5.51d p< 0.01) and hospitalization costs ($96,424 vs $69,962 p< 0.01).

|||||||||| [VIRTUAL] Tolerance and Safety of Meal Replacement Program in Nonalcoholic Steatohepatitis With Fibrosis and Cirrhosis: A Case Series () - Sep 15, 2020 - Abstract #ACG2020ACG_2529;
Of these, 4 had cirrhosis, and 2 had decompensated disease (ascites and edema) and average mean MELD score 11.9 (Table 1). All patients had at least 2 associated comorbid metabolic diseases and reported improvement.

|||||||||| [VIRTUAL] The Effect of Malnutrition on the Clinical Outcomes of Hospitalized Patients With Esophageal Cancer () - Sep 15, 2020 - Abstract #ACG2020ACG_1419;
The malnutrition cohort (n=16207, 34.7%) was younger (66.2 vs 66.7y p< 0.01) and more likely to be female (23.4 vs 20.7% p< 0.01). The mortality rate was higher in the malnutrition cohort (11.1 vs 8.09% p< 0.01, OR 1.42 95%CI 1.33-1.51), as were the LOS (8.73 vs 6.11d p< 0.01) and total hospitalization costs ($83,815 vs $62,957 p< 0.01).

|||||||||| [VIRTUAL] Sarcopenia Assessed by Psoas Muscle Index Predicts Pseudocyst Development in Patients With Acute Pancreatitis () - Sep 15, 2020 - Abstract #ACG2020ACG_627;
Mean age of participants was 44.99 years (SD: 16.70), and 134 participants (61.8%) were male. Twenty patients fulfilled criteria for sarcopenia (9.2%) while 197 patients (90.8%) were included in the non-sarcopenia group.

|||||||||| [VIRTUAL] The Clinical Impact of Malnutrition on the Infectious Outcomes of Hospitalized Patients With Pancreatic Cancer: A Nationwide Analysis () - Sep 15, 2020 - Abstract #ACG2020ACG_603;
Compared to the control cohort, the malnutrition cohort was older (68.1 vs 67.8y p< 0.01) and more likely to be male (52.1 vs 50.9% p< 0.01). The mortality rate was higher in the malnutrition cohort (9.93 vs 6.98% p< 0.01, OR 1.47 95%CI 1.40-1.54) as were the LOS (8.22 vs 5.69d p< 0.01) and hospitalization costs ($75,123 vs $54,539 p< 0.01).

|||||||||| Trial completion date, Trial primary completion date: STRONG: Sarcopenia Prevention With a Targeted Exercise and Protein Supplementation Program (clinicaltrials.gov) - Sep 14, 2020
P=N/A, N=800, Recruiting, Sponsor: University of Zurich
The mortality rate was higher in the malnutrition cohort (9.93 vs 6.98% p< 0.01, OR 1.47 95%CI 1.40-1.54) as were the LOS (8.22 vs 5.69d p< 0.01) and hospitalization costs ($75,123 vs $54,539 p< 0.01). Trial completion date: Oct 2021 --> Dec 2023 | Trial primary completion date: Oct 2021 --> Dec 2023

|||||||||| Trial completion date, Trial primary completion date: DART: Dual-benefits of Aerobic and Resistance Training (clinicaltrials.gov) - Sep 14, 2020
P=N/A, N=30, Suspended, Sponsor: Ohio University
Trial completion date: Oct 2021 --> Dec 2023 | Trial primary completion date: Oct 2021 --> Dec 2023 Trial completion date: Sep 2020 --> Sep 2021 | Trial primary completion date: Sep 2020 --> Sep 2021

|||||||||| Clinical: Mobility Impairment in Patients New to Dialysis ✍️ Ranjani N. Moorthi @IUMedSchool 📄 https://t.co/Wtrx33VWpc #AmJNephrol #dialysis #sarcopenia #VisualAbstract @edgarvlermamd (Twitter) - Sep 14, 2020

|||||||||| Clinical, Journal: Insomnia, low sleep quality, and sleeping little are associated with frailty in Mexican women. (Pubmed Central) - Sep 14, 2020
In older adult women, the presence of insomnia, low sleep quality, and sleeping less than five hours could promote frailty. Therefore, treatment of sleep problems among women should be prioritized to avoid the onset of this condition.

|||||||||| Preclinical, Journal: Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model. (Pubmed Central) - Sep 14, 2020
There was a trend for lower muscle grip strength in the 44 w group, but there was no change in 44 w + Ex. The phosphorylation levels of Akt and p70S6K as a protein synthesis marker were decreased in 44 w. Cytochrome c oxidase subunit IV (CoxIV) mRNA and protein levels decreased in 44 w. These results suggested that long-term habitual exercise attenuates muscle mass and strength decline, possibly through maintenance of muscle protein synthesis and mitochondrial maintenance.

|||||||||| New trial: L1 M1 of LDCT for Low Muscle Mass Measurement (clinicaltrials.gov) - Sep 13, 2020
P, N=3304, Completed, Sponsor: Far Eastern Memorial Hospital

|||||||||| Clinical, Journal: Close Relationship Between Immunological/Inflammatory Markers and Myopenia and Myosteatosis in Patients With Colorectal Cancer: A Propensity Score Matching Analysis. (Pubmed Central) - Sep 13, 2020
The phosphorylation levels of Akt and p70S6K as a protein synthesis marker were decreased in 44 w. Cytochrome c oxidase subunit IV (CoxIV) mRNA and protein levels decreased in 44 w. These results suggested that long-term habitual exercise attenuates muscle mass and strength decline, possibly through maintenance of muscle protein synthesis and mitochondrial maintenance. Quantification of preoperative CRP could identify patients at high risk for development of myopenia who will likely require individualized treatment plans, including postoperative nutrition intervention, rehabilitation, and oncological follow-up in patients with CRC.

|||||||||| Journal: Depression is Associated With Sarcopenia Due to Low Muscle Strength: Results From the ELSA-Brasil Study. (Pubmed Central) - Sep 13, 2020
Depression is associated with sarcopenia defined by the FNIH criteria mainly because of its association with weakness. Future studies are needed to clarify the temporal relationship between both conditions.

|||||||||| Journal: Normative Data for Lean Mass Using FNIH Criteria in an Australian Setting. (Pubmed Central) - Sep 13, 2020
For individuals aged 65+ years, cross-classification of low lean mass according to FNIH criteria (ALM/BMI < 0.789 m men and < 0.512 m women) in comparison with our cutpoints for ALM/BMI showed overall agreement of 94.6% for men and 99.0% for women (κ 0.73 and 0.89, respectively). We report good agreement for low ALM indexed to BMI, particularly for women, between classifications based on recommendations from the FNIH Sarcopenia Project for identifying clinically significant weakness, with low values identified within our population distribution of ALM/BMI.

|||||||||| Clinical, Journal: Deterioration of nutritional status of patients with locally advanced cervical cancer during treatment with concomitant chemoradiotherapy. (Pubmed Central) - Sep 13, 2020
We report good agreement for low ALM indexed to BMI, particularly for women, between classifications based on recommendations from the FNIH Sarcopenia Project for identifying clinically significant weakness, with low values identified within our population distribution of ALM/BMI. The nutritional status of cervical cancer patients deteriorates during treatment with concomitant chemoradiotherapy and, most importantly, muscle loss impacts the clinical outcome of patients.

|||||||||| Biomarker, Review, Journal: Involvement of plasma miRNAs, muscle miRNAs and mitochondrial miRNAs in the pathophysiology of frailty. (Pubmed Central) - Sep 13, 2020
Multiple studies revised here suggest that several miRs can be considered as possible markers of frailty, including miR-1, miR-21, miR-34a, miR-146a, miR-185, and miR-206, miR-223, among others. Normalization of miRNAs data and standardization of the protocols used for their measurement to avoid confounding variables influencing the results, are important to use miRNAs as disease biomarkers.

|||||||||| Review, Journal: Gut microbiota and physical frailty through the mediation of sarcopenia. (Pubmed Central) - Sep 13, 2020
In this article, the link between gut microbiota and physical frailty is discussed. It is especially explained the role that sarcopenia may play in this likely bidirectional relationship.



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