Sarcopenia
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  • ||||||||||  Clinical, Journal:  Dynapenic abdominal obesity and the incidence of falls in older women: a prospective study. (Pubmed Central) -  Sep 30, 2020   
    D/AO is more closely related to falls than either dynapenia or abdominal obesity alone, and is independently associated with an increased incidence of falls in older women. These results provide support for the concept that the combined evaluation of muscle strength and central obesity may be clinically relevant in this population.
  • ||||||||||  Review, Journal:  The brown bear as a translational model for sedentary lifestyle related diseases. (Pubmed Central) -  Sep 30, 2020   
    Bears are close to humans physiology-wise, much closer than rodents, the preferred experimental animals in medical research, and may better serve as translational model to develop treatments for lifestyle-related diseases. In this review aspects of brown bear hibernation survival strategies are outlined and conceivable experimental strategies to learn from bears are described.
  • ||||||||||  Review, Journal:  Parkinson's disease and the non-motor symptoms: hyposmia, weight loss, osteosarcopenia. (Pubmed Central) -  Sep 30, 2020   
    A strict collaboration between general practitioners, clinicians, geriatricians and neurologists can be one approach towards the diagnosis of pre-PD. Waiting until the motor symptoms develop and the patient is finally visited by the neurologist could be too late, considering the catastrophic prognosis of the disease.
  • ||||||||||  Review, Journal:  The Role of Physical Activity for the Management of Sarcopenia in People Living with HIV. (Pubmed Central) -  Sep 30, 2020   
    Despite none of these studies having specifically addressed the benefits of physical exercise on sarcopenia, there is evidence that exercise is effective to increase aerobic capacity and muscle strength, and to improve body composition and inflammatory outcomes in PLWH. Therefore, the expected benefits of physical exercise are likely to translate into a successful and specific intervention for prevention and treatment of sarcopenia in this population.
  • ||||||||||  sirolimus / Generic mfg.
    Review, Journal:  The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player? (Pubmed Central) -  Sep 30, 2020   
    This is of particular interest as the TOR pathway has been implicated in aging, but its role at the NMJ is still ill-defined. We highlight the respective functions of the two TOR-associated complexes, TORC1 and TORC2, and discuss the role of localized protein synthesis and autophagy regulation in motor neuron terminals and sub-synaptic regions of muscle fibers and their possible effects on NMJ maintenance.
  • ||||||||||  cisplatin / Generic mfg., gemcitabine / Generic mfg.
    Clinical, Journal:  Prognostic Significance of Sarcopenia in Advanced Biliary Tract Cancer Patients. (Pubmed Central) -  Sep 30, 2020   
    In addition, sarcopenia accompanied by inflammation was associated with poor prognosis. Conservative treatments such as nutritional support, exercise, and pharmacologic intervention could help metastatic biliary tract cancer patients to overcome sarcopenia and the inflammatory status.
  • ||||||||||  doxycycline / Generic mfg., Pierre Fabre
    Clinical, Journal:  Inducible Rpt3, a Proteasome Component, Knockout in Adult Skeletal Muscle Results in Muscle Atrophy. (Pubmed Central) -  Sep 30, 2020   
    Herein, we generated skeletal-muscle-specific Rpt3 knockout mice, in which genetic inactivation of Rpt3 could be induced by doxycycline administration...Analysis of the autophagy pathway in the Rpt3-deficient mice showed that the upregulation of LC3II, p62, Atg5, Atg7, and Beclin-1 in protein levels, which supposed to be compensatory proteolysis activation. Our results suggest that the proteasome inhibition in adult muscle severely deteriorates myofiber integrity and results in muscle atrophy.
  • ||||||||||  Clinical, Journal:  Muscle loss: The new malnutrition challenge in clinical practice. (Pubmed Central) -  Sep 27, 2020   
    Malnutrition needs to be addressed clinically as a muscle-related disorder and clinicians should integrate nutritional assessment with muscle mass measurements for optimal evaluation of these two interrelated entities to tailor interventions appropriately. The design of monitoring/evaluation and discharge plans need to include multimodal interventions with nutrition and physical exercise that are key to preserve patient's muscle mass and function in clinical and community settings.
  • ||||||||||  Journal:  Sarcopenia: Relevance and Assessment. (Pubmed Central) -  Sep 27, 2020   
    Intervention to arrest or reverse frailty merits exploration as a potentially modifiable risk factor for improving transplant respiratory outcomes. No abstract available
  • ||||||||||  Journal:  Effects of High-Intensity Resistance Training on Fitness and Fatness in Older Men With Osteosarcopenia. (Pubmed Central) -  Sep 27, 2020   
    Carefully introduced, continuously supervised HIT-RT is an effective, attractive, feasible, and safe method to improve body composition and muscle strength in older community-dwelling men with sarcopenia. However, even when consequently applying principles of exercise intensity progression within the RT protocol, only slight further positive changes were observed after 8 months of exercise.
  • ||||||||||  Clinical, Journal:  Effect of levocarnitine administration in patients with chronic liver disease. (Pubmed Central) -  Sep 27, 2020   
    The median ΔIMAC/year and Δ lumbar spine BMD were not significantly different between the LAG and controls. L-carnitine administration may prevent the loss of skeletal muscle mass and BMD; therefore, it may be used as a new treatment option for osteoporosis and sarcopenia in patients with CLD.
  • ||||||||||  Biomarker, Review, Journal:  Promising biomarkers of human aging: in search of a multi-omics panel to understand the aging process from a multidimensional perspective. (Pubmed Central) -  Sep 26, 2020   
    Aging biomarkers reflect the physiological state of individuals and the underlying mechanisms related to homeostatic changes throughout an individual lifespan; they demonstrated that aging could be measured independently of time (that may explain its heterogeneity) and to be helpful to predict age-related syndromes and mortality. In summary, we highlight the areas of opportunity and gaps of knowledge that must be addressed to fully integrate biomedical findings into clinically useful tools and interventions.
  • ||||||||||  Biomarker, Clinical, Journal:  Systemic and Metabolic Signature of Sarcopenia in Community-Dwelling Older Adults. (Pubmed Central) -  Sep 26, 2020   
    Differentially expressed genes and Ingenuity pathway analysis supported the association of nutrition with sarcopenia. Herein, the characterization of a nutritional and metabolic signature of sarcopenia provides a firm basis and potential identification of specific targets and directions for the nutritional approach to the prevention and treatment of sarcopenia in ageing populations.
  • ||||||||||  Journal:  Sarcopenia and variation in the Human Leukocyte Antigen complex. (Pubmed Central) -  Sep 26, 2020   
    Variation in specific HLA types and non-coding SNPs are also associated with sarcopenia in older carriers free of diagnosed autoimmune diseases. Patients with sarcopenia might benefit from targeted treatment of autoimmune processes.
  • ||||||||||  Clinical, Journal:  Associations of Sarcopenia and Its Components with Bone Structure and Incident Falls in Swedish Older Adults. (Pubmed Central) -  Sep 26, 2020   
    Compared with probable sarcopenia, confirmed sarcopenic participants had significantly lower lumbar spine and total hip aBMD, distal radius and tibia total vBMD, and proximal radius and tibia cortical vBMD, area and thickness (all P < 0.05). Swedish 70-year olds with confirmed sarcopenia demonstrate poorer BMD and bone architecture than those with probable and no sarcopenia, and have increased likelihood of incident falls.
  • ||||||||||  Journal:  The value of sarcopenia in the prevention of disability. (Pubmed Central) -  Sep 26, 2020   
    The fat and fish dietary pattern was associated with lower odds of sarcopenia in this population of patients with gastrointestinal cancer. No abstract available
  • ||||||||||  Journal:  Myosteatosis in a systemic inflammation-dependent manner predicts favorable survival outcomes in locally advanced esophageal cancer. (Pubmed Central) -  Sep 26, 2020   
    The combination of myosteatosis with systemic inflammation revealed that the subgroup of patients with myosteatosis and without inflammation presented less than half the risk of disease progression (HR: 0.47; 95% CI: 0.26-0.85; P = .013) and death (HR: 0.39; 95% CI, 0.21-0.72; P = .003) compared with patients with inflammation. This study demonstrated that myosteatosis without systemic inflammation was independently associated with favorable PFS and OS in LAEC patients treated with dCRT.
  • ||||||||||  Journal:  Relationship between COVID-19 and obesity. (Pubmed Central) -  Sep 26, 2020   
    This finding raises the potential use of body composition assessment to predict the risk of chemotherapy toxicity and determine an individualized treatment strategy. N/A.
  • ||||||||||  Journal, HEOR:  Effects of weight loss and sarcopenia on response to chemotherapy, quality of life, and survival. (Pubmed Central) -  Sep 25, 2020   
    Muscle abnormalities are highly prevalent (ranging from 10-90%, depending on cancer site and the diagnostic criteria used). Both low muscle mass and low muscle attenuation have been associated with poorer tolerance to chemotherapy; increased risk of postoperative complications; significant deterioration in a patients' performance status, and poorer psychological well-being, overall quality of life, and survival.
  • ||||||||||  Journal:  Polish Translation and Validation of the SARC-F Tool for the Assessment of Sarcopenia. (Pubmed Central) -  Sep 25, 2020   
    Sensitivity, specificity, and negative predictive values were 92.9%, 98.1%, and 98.1%, respectively. The process of validating the SARC-F questionnaire against Polish conditions demonstrated its applicability as a simple and reliable tool for diagnosing sarcopenia in daily clinical practice with older adults.
  • ||||||||||  Clinical, Journal:  Interaction of Skeletal and Left Ventricular Mass in Older Adults with Low Muscle Performance. (Pubmed Central) -  Sep 25, 2020   
    In a sample of older persons with low muscle mass and physical performance, LVM was positively and significantly correlated with ALM, independently from blood pressure, physical activity, and other potential confounders. Future studies are needed to address the effect of interventions targeting LVM and SMM.
  • ||||||||||  Journal:  (Pro)renin receptor accelerates development of sarcopenia via activation of Wnt/YAP signaling axis. (Pubmed Central) -  Sep 24, 2020   
    Finally, we show that Yes-associated protein (YAP) signaling, which is coordinately regulated by Wnt/β-catenin, contributed to the development of (P)RR-induced sarcopenia. The present study demonstrates the use of (P)RR-Tg mice as a novel sarcopenia model, and shows that (P)RR-Wnt-YAP signaling plays a pivotal role in the pathogenesis of this disease.
  • ||||||||||  Clinical, Review, Journal:  Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation? (Pubmed Central) -  Sep 24, 2020   
    In contrast, creatine supplementation as an adjunct to exercise training seems to augment the muscle adaptive response to the training stimulus, potentially through increasing capacity for higher intensity exercise, and/or by enhancing post-exercise recovery and adaptation. As such, creatine may be an effective dietary strategy to combat age-related muscle atrophy and sarcopenia when used to complement the benefits of exercise training.
  • ||||||||||  Clinical, Journal:  Prevalence and features of geriatric syndromes treatment in old patients (clinical and epidemiological study). (Pubmed Central) -  Sep 24, 2020   
    It turned out that in the structure of CND in geriatric patients dominated: arterial hypertension, coronary heart disease, and their complications - chronic heart failure and atrial fibrillation their incidence has a pronounced age dependence and increases in patients with senile asthenia. Patients of older age groups of both sexes are characterized by an increase in the incidence of sarcopenia and the associated increased risk of falls syndrome, which must be taken into account when planning treatment and rehabilitation measures both in the hospital and when providing primary medical and social care.