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|||||||||| [VIRTUAL] Predictors of Functional Status Change in Patients with CKD Between Two Hip Fracture Events: A 6-Year Prospective Study (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_593;
Frailty assessment tools (CFS, HFS and CKD FI-LAB) had the best predictive performance for functional status change. Frailty measures may be utilized as risk prediction tools of functional status change from first Hip# admission.

|||||||||| veverimer (TRC101) / Tricida
[VIRTUAL] Correlation Between Patient-Reported Physical Limitation and Objective Physical Performance on the Repeated Chair Stand Test Among Patients with Non-Dialysis Dependent CKD and Metabolic Acidosis (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_577;
Routine identification of pts with physical functional decline might allow for earlier implementation of interventions to forestall further impairment. Funding: Commercial Support

|||||||||| Clinical, Journal: Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer. (Pubmed Central) - Oct 11, 2020
Funding: Commercial Support Our data support the importance of sarcopenia assessment, in addition to BMI, among patients with HNSCC.

|||||||||| Journal: Associations between sarcopenia and nonalcoholic fatty liver disease and advanced fibrosis in the USA. (Pubmed Central) - Oct 11, 2020
Sarcopenia was independently associated with increased odds of NAFLD and NAFLD-associated advanced fibrosis independent of well-defined risk factors. Interventions to strengthen muscle mass may reduce the burden of NAFLD and advanced fibrosis.

|||||||||| Clinical, Observational data, Journal, HEOR: Relationship between pre-sarcopenia and quality of life in patients with chronic liver disease: a cross-sectional study. (Pubmed Central) - Oct 11, 2020
Female sex and RP were independent predictors of PS according to the multivariate analysis. Maintaining and increasing muscle mass in patients with CLD may contribute toward improving physical QOL.

|||||||||| [VIRTUAL] THE EFFECTS OF PROTEIN-CALORIE MALNUTRITION AND MALNUTRITION-RELATED COMPLICATIONS ON THE HOSPITAL OUTCOMES OF PATIENTS WITH CIRRHOSIS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1861;
Protein-calorie malnutrition, malnutrition-related pathologic weight loss, and sarcopenia are associated with increased mortality in patients with cirrhosis. These patients therefore require early risk-assessment, followed by multidisciplinary management of malnutrition with goal-directed nutritional therapy.

|||||||||| [VIRTUAL] THE EFFECT OF MALNUTRITION ON THE INFECTIOUS OUTCOMES OF HOSPITALIZED PATIENTS WITH CIRRHOSIS: A NATIONWIDE ANALYSIS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1858;
Malnutrition is associated with increased hospital mortality and infectious outcomes in patients with cirrhosis. These patients therefore require early risk-assessment, followed by goal-directed nutritional therapy and proactive surveillance/treatment of infectious complications.

|||||||||| [VIRTUAL] THE EFFECT OF CIRRHOSIS AND CIRRHOSIS-RELATED ASCITES ON THE POSTOPERATIVE OUTCOMES OF PATIENTS UNDERGOING HERNIA REPAIR () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1856;
Cirrhosis and cirrhosis-related ascites are associated with increased mortality and postoperative complications in patients undergoing hernia repair. Therefore, these patients require risk-benefit discussion prior to surgery, and management of postoperative complications following hernia repair.

|||||||||| [VIRTUAL] HIGH NT-PROBNP VALUES AS A PREDICTIVE BIOMARKER OF ACUTE-ON-CHRONIC LIVER FAILURE DEVELOPMENT AND MORTALITY ON THE LIVER TRANSPLANT WAITING LIST () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1846;
Higher levels of NT-proBNP are strongly associated with the development of ACLF and mortality on the WL. The assessment of this risk factor may allow identifying a group of patients with a high risk of death while awaiting LT.

|||||||||| [VIRTUAL] PERFORMANCE OF RENAL FUNCTION EQUATIONS IN A NATIONAL COHORT OF VETERANS WITH CIRRHOSIS: SHOULD RACE ADJUSTMENT BE REMOVED? () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1830;
Race adjustment in eGFR equations does not enhance risk estimation for AKI in patients with cirrhosis and may lead to unintended negative consequences, as overestimated eGFR in Black patients may potentially mask renal dysfunction. Further study is warranted to define novel eGFR equations specifically for patients with cirrhosis, and to comprehensively assess the impacts of removing race adjustment from eGFR equations.

|||||||||| [VIRTUAL] BODY COMPOSITION OF CHILDREN WITH END STAGE LIVER DISEASE AWAITING LIVER TRANSPLANTATION () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1797;
Remarkably all FM and FMI SDS remained within the normal range. Sarcopenia, lower albumin, and higher bilirubin correlated with longer stay in hospital after liver transplantation.

|||||||||| [VIRTUAL] CLINICALLY EVIDENT PORTAL HYPERTENSION ASSOCIATED WITH LOW IGF-1 IN CHILDREN WITH CHRONIC LIVER DISEASE () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1789;
Patients with low MUAC also had low IGF-1. Children with chronic liver disease have a greater burden of fatigue compared to healthy children and child report of fatigue is associated with low IGF-1 levels.

|||||||||| [VIRTUAL] THE ROLE OF TELEPHONIC REINFORCEMENT OF NUTRITIONAL COUNSELLING AS AN INTERVENTION TO REDUCE MORTALITY AND COMPLICATIONS OF CIRRHOSIS. A RANDOMIZED CONTROL TRIAL. () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1785;
However, it significantly reduced episodes of infections and hepatic encephalopathy in patients with decompensated chronic liver disease. The intervention improved sarcopenia in the CHILD B sub group, but not in CHILD C.

|||||||||| [VIRTUAL] THE PLASMA FREE AMINO ACIDS ASSOCIATED WITH THE SARCOPENIA IN THE COURSE OF HEPATOCELLULAR CARCINOMA RECURRENCE () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1784;
Among the PFAAs, the level of BCAAs, especially Leu, in peripheral blood was associated with sarcopenia in the course of HCC recurrence. The BCAAs formulation is useful for preventing sarcopenia of patients with HCC.

|||||||||| [VIRTUAL] SARCOPENIA IN CIRRHOSIS IS TANTAMOUNT TO SEPSIS AND MORTALITY IN THE INTENSIVE CARE UNIT () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1779;
Two-thirds of the critically ill cirrhotics have sarcopenia at ICU admission, making them three times more susceptible to sepsis. Sarcopenia negatively impacts survival of CICs in LICU, mainly among males.

|||||||||| [VIRTUAL] MYOSTATIN IS AN INDEPENDENT VARIABLE OF LOW SKELETAL MASS INDEX IN LIVER CIRRHOSIS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1767;
Myostatin was proved to be an important emerging biomarker independently associated with muscle mass in liver cirrhosis. It would be useful if myostatin was evaluated alone or in combination with other biomarkers as a screening tool for sarcopenia.

|||||||||| [VIRTUAL] MALNUTRITION IS A MAJOR RISK FACTOR FOR FALL-RELATED INJURY DURING HOSPITALIZATION IN PATIENTS WITH LIVER CIRRHOSIS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1765;
In addition to that, longer hospitalization is an indicator of falling risk. As malnutrition is an independent risk factor in the primary assessment of patients, it should be regularly calculated and hospital stays shortened as possible.

|||||||||| [VIRTUAL] HIGHER PREVALENCE OF MUSCLE LOSS PHENOTYPE IN AGED HOSPITALIZED CIRRHOTIC PATIENTS WORSENS CLINICAL OUTCOMES () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1761;
Aging is associated with increased mortality and CoH in cirrhotics with muscle loss compared to GMP with muscle loss. Aging is associated with greater in-hospital mortality, LoS, and CoH in cirrhosis patients than GMP.

|||||||||| [VIRTUAL] DYNAMIC EVALUATION OF AMINO ACID CONCENTRATIONS IN PATIENTS WITH HEPATITIS C REVEALED ELEVATION OF AROMATIC AMINO ACIDS IN CIRRHOTIC PATIENTS AND AN ASSOCIATION WITH SARCOPENIA () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1748;
When a standard meal was given and an influx of metabolites passed through the liver, Cir patients had higher concentrations of AAA when compared to NC patients. The relationship between serum AAA and lean muscle mass was revealed only after a meal challenge.

|||||||||| [VIRTUAL] BRANCHED CHAIN AMINO ACID SUPPLEMENTATION HELPS MAINTAIN PHYSICAL ACTIVITY AND IMPROVES FATIGUE IN CIRRHOTIC PATIENTS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1737;
Patients with cirrhosis who received a 12-week course of BCAA supplementation showed less decline in moderate PA and in HRQOL domains. Most patients remained very sedentary.

|||||||||| [VIRTUAL] ASSOCIATION BETWEEN DIETARY FACTORS AND SARCOPENIA IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE (NAFLD) () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1714;
Particular dietary contributors to this benefit include, seafood and plant protein and a low fatty acid ratio. In the NAFLD population, it is imperative to identify people with sarcopenia because treatment can be provided that could potentially improve function, quality of life and survival.

|||||||||| [VIRTUAL] THE CROSS-SECTIONAL ASSOCIATION BETWEEN HEPATIC STEATOSIS AND SARCOPENIA: THE FRAMINGHAM HEART STUDY () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1641;
In our community-based cohort study, we observed significant associations between liver fat and sarcopenia as defined by low muscle mass and poor physical performance. Further studies are needed to illustrate the role of shared common risk factors on the association between liver fat and measures of sarcopenia.

|||||||||| [VIRTUAL] MYOSTEATOSIS BUT NOT SARCOPENIA IS ASSOCIATED WITH NASH IN OBESE PATIENTS WITH NAFLD : A LARGE BIOPSY-PROVEN STUDY () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1532;
By contrast, myosteatosis, rather than sarcopenia, is strongly and independently associated with NASH. These data propel the exploration of myosteatosis as a potential pathophysiological contributor of NASH.

|||||||||| [VIRTUAL] AN UNSUSPECTED LINK BETWEEN MYOSTEATOSIS AND NAFLD GRADING IN A PROSPECTIVE NUTRITIONAL INTERVENTION STUDY IN OBESE PATIENTS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1477;
A significant decrease in liver stiffness is observed only in patients with reduced myosteatosis, following a 3-month intervention. The potential role of myosteatosis as an independent contributor to liver disease progression and perhaps as a novel therapeutic target in NAFLD should be investigated.

|||||||||| [VIRTUAL] SARCOPENIA SEVERITY BASED ON COMPUTED TOMOGRAPHY IMAGE ANALYSIS IN PATIENTS WITH CIRRHOSIS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1404;
The frequency of complications, inflammation, poor nutritional status, and abnormal body composition features was significantly higher in patients with severe sarcopenia compared to sarcopenic and non-sarcopenic patients. The stage between sarcopenia and severe sarcopenia may be the opportune window in which to intervene and mitigate sarcopenia to improve patients’ outcomes.

|||||||||| [VIRTUAL] PREVALENCE AND IMPACT OF SARCOPENIA ON PATIENTS WITH CHRONIC LIVER DISEASE UNDERGOING LIVER TRANSPLANTATION () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1392;
Pre-LT sarcopenia is common in LT recipients. Despite having worse pre-LT liver function, sarcopenic recipients have comparable post-LT graft survival and less early allograft dysfunction and ICU readmissions compared to non-sarcopenic recipients.

|||||||||| [VIRTUAL] SARCOPENIA AND HEPATOLITHIASIS WAS ASSOCIATED WITH POOR PROGNOSIS IN INTRAHEPATIC CHOLANGIOCARCINOMA (ICC) PATIENTS AFTER RESECTION: A RETROSPECTIVE COHORT STUDY () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1170;
Sarcopenia combined with hepatolithiasis, age, diabetes and CEA are independent predictors of ICC prognosis.ICC patients accompany with sarcopenia and hepatolithiasis have the worst survival. Our nomogram is a simple and practical instrument to stratify high risk ICC patients for poor prognosis.

|||||||||| [VIRTUAL] ALBI SCORE, PALBI SCORE, LOCOREGIONAL THERAPY PROGNOSTIC SCORES AND SARCOPENIC SCORES IN PREDICTING TRANSPLANT-FREE SURVIVAL IN PATIENTS WITH HEPATOCELLULAR CARCINOMA UNDERGOING LOCOREGIONAL THERAPY () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1140;
Both sarcopenia and obesity lower median TFS significantly (lowest with sarcopenia), independent of BCLC stages. Natural MELD-Na modified for sarcopenia (MELD-sarcopenia and MELD-SMI) have higher accuracy than natural MELD-Na and LRT prognostic scores for predicting TFS.

|||||||||| [VIRTUAL] THE EFFECT OF MALNUTRITION ON THE POSTPROCEDURAL OUTCOMES OF PATIENTS UNDERGOING LIVER ABSCESS DRAINAGE () - Oct 11, 2020 - Abstract #AASLD2020AASLD_1029;
Malnutrition is associated with increased postprocedural mortality and bowel complications in patients undergoing liver abscess drainage. These patients therefore require early risk-assessment, followed by goal-directed nutritional therapy and proactive surveillance of postprocedural complications.

|||||||||| [VIRTUAL] MULTIOMIC INTEGRATED MOLECULAR LANDSCAPE OF HYPERAMMONEMIA SHOW A TIME-DEPENDENT CHANGE IN CHROMATIN ACCESSIBILITY AND THE TRANSLATOME OF SARCOPENIA OF CIRRHOSIS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_374;
Time dependent alterations in the molecular landscape during hyperammonemia showed an initial adaptive response followed by maladaptive changes. Cellular stress and senescence responses provide the rationale for developing interventions to limit these injury responses.

|||||||||| [VIRTUAL] SARCOPENIA IS HIGHLY PREVALENT IN CHILDREN WITH AUTOIMMUNE LIVER DISEASE AND IS LINKED TO VISCERAL FAT AND OVERALL WELL-BEING () - Oct 11, 2020 - Abstract #AASLD2020AASLD_308;
Sarcopenia was not linked to steroid use but was associated with increased visceral fat and lower well-being. The pathophysiology and natural history of these findings needs to be elucidated.

|||||||||| [VIRTUAL] INTEGRATED OMICS APPROACH BASED INTERVENTION TO RESTORE ETHANOL-INDUCED DYSREGULATED SKELETAL MUSCLE PROTEOSTASIS AND SARCOPENIC PHENOTYPE IN ALCOHOLIC LIVER DISEASE () - Oct 11, 2020 - Abstract #AASLD2020AASLD_253;
The pathophysiology and natural history of these findings needs to be elucidated. HMB reversed ethanol-induced dysregulated protein homeostasis, mitochondrial oxidative dysfunction and intermediary metabolite concentrations and consequent sarcopenic phenotype and has the potential for clinical application in ALD.

|||||||||| Niagen (nicotinamide riboside) / ChromaDex
[VIRTUAL] ETHANOL-INDUCED HYPERACETYLATION OF SKELETAL MUSCLE PROTEINS IN ALCOHOLIC LIVER DISEASE IS MEDIATED VIA NAD+ DEPENDENT SIRTUINS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_236;
These novel data show that ethanol inhibits sirtuins in multiple compartments with acetylation of proteins with dysregulated proteostasis and sarcopenic phenotype. Targeting the SIRT/HAT axis is a novel therapeutic approach for sarcopenia in ALD.

|||||||||| [VIRTUAL] ADDITION OF TESTOSTERONE THERAPY TO NUTRITION AND STRUCTURED EXERCISE IS SUPERIOR TO NUTRITION AND STRUCTURED EXERCISE ALONE IN IMPROVING SARCOPENIA IN MEN WITH CIRRHOSIS: A RANDOMIZED CONTROLLED TRIAL () - Oct 11, 2020 - Abstract #AASLD2020AASLD_74;
Targeting the SIRT/HAT axis is a novel therapeutic approach for sarcopenia in ALD. Addition of testosterone therapy to nutrition and structured exercise protocols, significantly improves better the appendicular muscle mass, bone mass and improves fraility,and need of hospitalization in cirrhotic patients with sarcopenia compared to nutrition and structured exercise alone.

|||||||||| [VIRTUAL] THE EFFECT OF MALNUTRITION ON THE INFECTIOUS OUTCOMES OF HOSPITALIZED PATIENTS WITH ALCOHOLIC HEPATITIS () - Oct 11, 2020 - Abstract #AASLD2020AASLD_37;
Malnutrition is associated with increased hospital mortality and infections in patients with alcoholic hepatitis. These patients therefore require early risk-assessment, followed by goal-directed nutritional therapy and proactive surveillance/treatment of infectious complications.

|||||||||| Clinical, Journal: Adipopenia correlates with higher portal pressure in patients with cirrhosis. (Pubmed Central) - Oct 11, 2020
In compensated patients, TATI improves non-invasive prediction of decompensation. In decompensated patients, IMATI independently predicted mortality.

|||||||||| Journal: Cellular and morphological changes with EAA supplementation before and after total knee arthroplasty. (Pubmed Central) - Oct 11, 2020
In decompensated patients, IMATI independently predicted mortality. EAAs starting 7 days before surgery increased satellite cells on the day of surgery and promoted a more favorable inflammatory environment post-surgery.

|||||||||| Clinical, Journal: Natural aging course of paraspinal muscle and back extensor strength in community-dwelling older adults (sarcopenia of spine, SarcoSpine): a prospective cohort study protocol. (Pubmed Central) - Oct 11, 2020
P=N/A
The study results will be disseminated in peer-reviewed publications and conference presentations. NCT03962530.

|||||||||| [VIRTUAL] Measured versus Estimated Resting Metabolic Rate in Heart Failure With Preserved Ejection Fraction (OnDemand) - Oct 10, 2020 - Abstract #AHA2020AHA_5176;
Estimations of resting metabolic rate in patients with HFpEF demonstrated a fixed bias towards overestimation when compared to measured RMR by metabolic cart. Given HFpEF populations are often obese and are counseled routinely on weight loss, understanding the implicit bias of equations estimating RMR is vital when providing nutritional and dietary counseling.

|||||||||| 13th International Conference on Cachexia, Sarcopenia and Wasting Disorders is going virtual - 11-13 December 2020 LAST WEEK TO SUBMIT YOUR ABSTRACT ! FREE REGISTRATION FOR ALL MEMBERS @SCWDnews #Cachexia, #Sarcopenia #Muscle #Wasting https://t.co/K1Bk9a4Pea (Twitter) - Oct 10, 2020

|||||||||| Retrospective data, Journal: Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study. (Pubmed Central) - Oct 9, 2020
Thus, we strongly recommend the assessment of the key components of the diagnosis of osteosarcopenia in an osteoporosis clinic for patients with low body mass index. Furthermore, appropriate assessments, including comorbidities, will help in identifying patients at greater risk of developing osteosarcopenia.

|||||||||| Clinical, Journal: Reply to the comments on "Utility of the sarcopenia index for assessment of muscle mass and nutritional status in patients with chronic heart failure: Comparison with anthropometric parameters". (Pubmed Central) - Oct 9, 2020
Furthermore, appropriate assessments, including comorbidities, will help in identifying patients at greater risk of developing osteosarcopenia. No abstract available

|||||||||| Journal: Reply to comments on "Is sarcopenia primarily age- or renin-angiotensin system-related disorder?" (Pubmed Central) - Oct 9, 2020
No abstract available No abstract available

|||||||||| Journal: Sarcopenia in Cirrhosis: Fallout on Liver Transplantation. (Pubmed Central) - Oct 9, 2020
Almost 50% of LT recipients had sarcopenia, who had a higher incidence of postoperative sepsis, neurological complications, longer ICU stay and ventilatory support. Low SMI, ACLF presentation, and intraoperative blood loss were the independent predictors of early mortality.

|||||||||| Journal: ROMANIAN TRANSLATION AND VALIDATION OF THE SARC-F QUESTIONNAIRE. (Pubmed Central) - Oct 9, 2020
Using the more conservative diagnostic criteria the negative predictive value was: 85.4%, sufficient to rule out those not at risk of having sarcopenia and eliminate the need for further investigations. A valid Romanian Sarc-F questionnaire is now available to simply detect patients at risk/no risk of sarcopenia.

|||||||||| Retrospective data, Review, Journal: Factors influencing the efficacy of nutritional interventions on muscle mass in older adults: a systematic review and meta-analysis. (Pubmed Central) - Oct 9, 2020
Overall, several nutritional interventions could be effective to improve muscle mass measures in older adults. Because of the substantial variability of the intervention factors among studies, the optimum profile is yet to be established.

|||||||||| [VIRTUAL] Sarcopenia Negatively Impacts Recurrence Rates of CRLM after Liver Resection () - Oct 9, 2020 - Abstract #ACSCLINCON2020ACS_CLINCON_2741;
Because of the substantial variability of the intervention factors among studies, the optimum profile is yet to be established. Sarcopenia seems to influence the prognosis of patients with CRLM, especially in case of KRAS mutations.

|||||||||| [VIRTUAL] Sarcopenia as a Predictor of Survival for Patients with Pancreatic Adenocarcinoma after Pancreatectomy () - Oct 9, 2020 - Abstract #ACSCLINCON2020ACS_CLINCON_984;
Sarcopenia seems to influence the prognosis of patients with CRLM, especially in case of KRAS mutations. Pre-operative SMI and IMAC were associated with poor outcomes in patients undergoing pancreatectomy for PDAC, were independent survival predictors in PDAC patients, and therefore may be used to improve prognostic models.

|||||||||| [VIRTUAL] Sarcopenia and Neutrophil-Lymphocyte Ratio are Associated with Overall Survival after Surgery for Localized Renal Cell Carcinoma () - Oct 9, 2020 - Abstract #ACSCLINCON2020ACS_CLINCON_665;
Independently and in combination, sarcopenia and high NLR predict lower OS in patients with localized RCC. These findings emphasize the interplay of muscle mass and systemic inflammation for prognostication and interventions for patients with RCC.

|||||||||| [VIRTUAL] The Concordance of Using MRI versus CT Images for Linear Measurement Analysis in the Quantitation of Abdominal Skeletal Muscle: Implications for Sarcopenia Measurement () - Oct 9, 2020 - Abstract #ACSCLINCON2020ACS_CLINCON_661;
CT and MRI images were shown to be concordant for linear measurement analysis of abdominal muscle mass. T2w MRI sequences can be used interchangeably with CT for assessment of sarcopenia.



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