Sarcopenia
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  • ||||||||||  Retrospective data, Review, Journal:  Prevalence of stroke-related sarcopenia: A systematic review and meta-analysis. (Pubmed Central) -  Nov 3, 2020   
    This study would be useful for researchers to design sarcopenia studies in this population. Further prospective longitudinal studies for sarcopenia and their prognostic outcomes in stroke survivors are urgently needed to propose appropriate physical and nutritional strategies in geriatric rehabilitation.
  • ||||||||||  Review, Journal:  Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition. (Pubmed Central) -  Nov 3, 2020   
    Emerging evidence suggests that green tea catechins play an important role in maintaining healthy joints and skeletal muscle. This review covers (i) the prevalence and etiology of osteoarthritis and sarcopenia, such as excessive inflammation and oxidative stress, mitochondrial dysfunction, and reduced autophagy; (ii) the effects of green tea catechins on joint health by downregulating inflammatory signaling mediators, upregulating anabolic mediators, and modulating miRNAs expression, resulting in reduced chondrocyte death, collagen degradation, and cartilage protection; (iii) the effects of green tea catechins on skeletal muscle health via maintaining a dynamic balance between protein synthesis and degradation and boosting the synthesis of mitochondrial energy metabolism, resulting in favorable muscle homeostasis and mitigation of muscle atrophy with aging; and (iv) the current study limitations and future research directions.
  • ||||||||||  Clinical, Journal:  Surgery and Perioperative Management of Esophageal Cancer Patients with Malnutrition (Pubmed Central) -  Nov 3, 2020   
    During surgery for such malnourished patient, it is necessary to minimize the surgical invasion and to avoid complications. It is important to have continuous nutritional evaluation, intervention and rehabilitation by various occupations from the initial diagnosis to the perioperative period as well as during outpatient follow-up after discharge.
  • ||||||||||  Review, Journal:  Branched chain amino acids, aging and age-related health. (Pubmed Central) -  Nov 3, 2020   
    The effects of BCAAs are also influenced by the background nutritional composition such as macronutrient ratios and imbalance with other amino acids. Understanding the interaction between BCAAs and other components of the diet may provide new opportunities for influencing age-related outcomes through manipulation of dietary BCAAs together with titration of macronutrient ratios and other amino acids.
  • ||||||||||  Biomarker, Trial completion, Trial completion date, MRI:  SarcoImage: Imaging Biomarkers of the Effects of a Mixed Exercise Program (clinicaltrials.gov) -  Nov 3, 2020   
    P=N/A,  N=60, Completed, 
    Trial completion date: Dec 2022 --> Mar 2023 | Trial primary completion date: Dec 2021 --> Dec 2022 Recruiting --> Completed | Trial completion date: May 2020 --> Nov 2020
  • ||||||||||  Trial completion:  Krill Oil and Muscle in Older Adults (clinicaltrials.gov) -  Nov 3, 2020   
    P=N/A,  N=102, Completed, 
    Recruiting --> Completed | Trial completion date: May 2020 --> Nov 2020 Recruiting --> Completed
  • ||||||||||  Trial completion, Trial completion date:  OART: Short-Term Resistance Training in Older Adults (clinicaltrials.gov) -  Nov 2, 2020   
    P=N/A,  N=73, Completed, 
    Not yet recruiting --> Recruiting Active, not recruiting --> Completed | Trial completion date: Apr 2020 --> Oct 2020
  • ||||||||||  Preclinical, Journal:  Metabolomic Analysis of Skeletal Muscle in Aged Mice. (Pubmed Central) -  Nov 2, 2020   
    The increase in acetylcholine might compensate for age-associated dropout of neuromuscular junctions, whereas the increases in histamine and serotonin might be due to muscle injury associated with aging. Further analysis focusing on the altered metabolites observed in this study will provide essential data for understanding aging muscles.
  • ||||||||||  Biomarker, Clinical, Journal:  Serum progranulin levels are associated with frailty in middle-aged individuals. (Pubmed Central) -  Nov 1, 2020   
    Our findings suggest that serum progranulin levels may be a candidate biomarker for physical frailty, independent of sarcopenia. Further studies are needed to validate this association and assess the utility of serum progranulin levels as a potential biomarker for prevalent frailty, for risk for developing incident frailty, and for mortality risk over and above the effect of baseline frailty.
  • ||||||||||  Review, Journal:  Optimal Delivery of Follow-Up Care After Radical Cystectomy for Bladder Cancer. (Pubmed Central) -  Nov 1, 2020   
    Continued smoking increases the risk of complications, but the effects of a smoking and alcohol intervention remain unclear (level 3 evidence). The results of this review provide guidance for future directions in research and further attempts to develop and test an evidence-based program for follow-up care after radical cystectomy.
  • ||||||||||  Preclinical, Journal:  Apelin affects the mouse aging urinary peptidome with minimal effects on kidney. (Pubmed Central) -  Oct 31, 2020   
    In conclusion, treatment of aged mice with apelin had a limited effect on kidney lesions although modifying the urinary peptidome towards a younger signature. This supports evidence of apelin inducing more general beneficial effects on other aging organs, muscles in particular, as recently shown for sarcopenia, markers of which end up via the glomerular filtration in urine.
  • ||||||||||  Journal:  Protein and amino acids for skeletal muscle health in aging. (Pubmed Central) -  Oct 30, 2020   
    Defining an adequate amount of dietary protein that is appropriate to maintain the availability of amino acids for biological needs is necessary but is still widely debated for older adults. This chapter will provide (i) an overview of dietary protein and amino acids and their role in skeletal muscle health; (ii) an overview of skeletal muscle structure and function and the deterioration of muscle that occurs with advancing age; (iii) a discussion of the relationship between protein/amino acid metabolism and skeletal muscle decline with aging; and (iv) a brief discussion of optimal protein intakes for older adults to maintain skeletal muscle health in aging.
  • ||||||||||  Journal:  Impact of skeletal muscle mass on complications following expander breast reconstruction. (Pubmed Central) -  Oct 30, 2020   
    Seroma was significantly associated with high BMI (P < 0.001, OR = 8.00 per 5-kg/m increase) and blood loss (P = 0.003, OR = 1.18 per 10 g increase). These results show that patients with a large adipose tissue volume and lower SMM (sarcopenic obesity) have more complications after expander surgery than those with high BMI, or TATI alone.
  • ||||||||||  Review, Journal:  Regulatory roles of microRNAs in sarcopenia and exercise intervention (Pubmed Central) -  Oct 30, 2020   
    Furthermore, exercise can combat age-related changes in muscle mass, composition and function, which is associated with the changes in the expression and biological functions of miRNAs in skeletal muscle cells. In this article, we systematically review the regulatory mechanisms of miRNAs in skeletal muscle aging, and discuss the regulatory roles and molecular targets of exercise-mediated miRNAs in muscular atrophy during aging process, which may provide novel insights into the prevention and treatment of sarcopenia.
  • ||||||||||  Journal:  Effects of exercise training on the biochemical pathways associated with sarcopenia. (Pubmed Central) -  Oct 30, 2020   
    This study briefly introduces current knowledge on the signaling pathways involved in the development of sarcopenia, effects of aerobic exercise on mitochondria-related parameters and mitochondrial function, and role of resistance exercise in the regulation of muscle protein synthesis against sarcopenia. This review suggested that the beneficial effects of exercise are still under-explored, and accelerated research will help develop better modalities for the prevention, management, and treatment of sarcopenia.
  • ||||||||||  NN1213 / Novo Nordisk
    Enrollment closed, Trial completion date, Trial primary completion date:  Role of MicroRNAs on Age and Contraction-induced Skeletal Muscle Growth (clinicaltrials.gov) -  Oct 29, 2020   
    P=N/A,  N=30, Active, not recruiting, 
    This review suggested that the beneficial effects of exercise are still under-explored, and accelerated research will help develop better modalities for the prevention, management, and treatment of sarcopenia. Recruiting --> Active, not recruiting | Trial completion date: Jan 2020 --> Jan 2021 | Trial primary completion date: Jan 2020 --> Jan 2021